Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
Scl/Tal1 interrupting locus
Synonyms:
Sil

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Stil mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Stil by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Semilobar Holoprosencephaly
Short stature, Hydrocephalus, Growth delay, Neural tube defect ORPHA:220386
Alobar Holoprosencephaly
Short stature, Hydrocephalus, Growth delay, Neural tube defect ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Short stature, Hydrocephalus, Growth delay, Neural tube defect ORPHA:93926
Lobar Holoprosencephaly
Short stature, Hydrocephalus, Growth delay, Neural tube defect ORPHA:93924
Autosomal Recessive Primary Microcephaly
Growth delay, Short stature ORPHA:2512
Microcephaly 7, Primary, Autosomal Recessive
OMIM:612703
Septopreoptic Holoprosencephaly
ORPHA:280195

The table below shows human diseases predicted to be associated to Stil by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Holoprosencephaly With Fetal Akinesia/Hypokinesia Sequence
Holoprosencephaly, Intrauterine growth retardation OMIM:306990
Acalvaria
Holoprosencephaly, Spina bifida, Hydrocephalus ORPHA:945
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Vissers-Bodmer Syndrome
Holoprosencephaly, Intrauterine growth retardation, Short stature OMIM:619033
Microcephaly-Brain Defect-Spasticity-Hypernatremia Syndrome
Holoprosencephaly ORPHA:2523
Holoprosencephaly 5
Lobar holoprosencephaly, Holoprosencephaly, Syntelencephaly, Hydrocephalus, Alobar holoprosenceph... OMIM:609637
Hydrocephalus, Congenital, 3, With Brain Anomalies
Holoprosencephaly, Hydranencephaly, Hydrocephalus OMIM:617967
Mental retardation, x-linked, syndromic, Turner type
Holoprosencephaly OMIM:300706
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Microphthalmia, Isolated, With Coloboma 5
Holoprosencephaly OMIM:611638
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Holoprosencephaly, Hydranencephaly, Intrauterine growth retardation ORPHA:2570
Muscle-Eye-Brain Disease
Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:588
Aminopterin/Methotrexate Embryofetopathy
Meningocele, Intrauterine growth retardation, Anencephaly, Short stature, Holoprosencephaly, Hydr... ORPHA:1908
Chromosome 1Q41-Q42 Deletion Syndrome
Holoprosencephaly, Short stature OMIM:612530
Hartsfield Syndrome
Intrauterine growth retardation, Lobar holoprosencephaly ORPHA:2117
Hydrocephalus With Stenosis Of The Aqueduct Of Sylvius
Holoprosencephaly, Hydrocephalus, Aqueductal stenosis ORPHA:2182
Holoprosencephaly 11
Holoprosencephaly OMIM:614226
Thanatophoric Dysplasia Type 2
Holoprosencephaly, Short stature, Hydrocephalus, Patent ductus arteriosus ORPHA:93274
Lambotte Syndrome
Intrauterine growth retardation, Semilobar holoprosencephaly OMIM:245552
Ring Chromosome 21 Syndrome
Holoprosencephaly, Short stature ORPHA:1445
Distal Monosomy 13Q
Holoprosencephaly, Anencephaly, Short stature ORPHA:1590
Distal Monosomy 7Q36
Holoprosencephaly, Short stature ORPHA:1636
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Triploidy
Meningocele, Intrauterine growth retardation, Holoprosencephaly, Hydrocephalus ORPHA:3376
Holoprosencephaly, Recurrent Infections, And Monocytosis
Holoprosencephaly OMIM:610680
Microtia-Anotia
Holoprosencephaly OMIM:600674
Holoprosencephaly, Semilobar, With Craniosynostosis
Semilobar holoprosencephaly OMIM:601370
Brachial Amelia, Cleft Lip, And Holoprosencephaly
Holoprosencephaly OMIM:601357
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Holoprosencephaly, Hydrocephalus, Growth delay, Patent ductus arteriosus ORPHA:77298
Monosomy 18P
Holoprosencephaly, Short stature ORPHA:1598
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Chromosome 3Q13.31 Deletion Syndrome
Alobar holoprosencephaly OMIM:615433
1Q41Q42 Microdeletion Syndrome
Holoprosencephaly, Growth delay, Short stature ORPHA:250999
Agnathia-Otocephaly Complex
Holoprosencephaly OMIM:202650
Holoprosencephaly-Caudal Dysgenesis Syndrome
Holoprosencephaly ORPHA:2165
Holoprosencephaly-Craniosynostosis Syndrome
Holoprosencephaly, Short stature ORPHA:2163
Microtia
Holoprosencephaly ORPHA:83463
Iniencephaly
Anencephaly, Myelomeningocele, Holoprosencephaly, Rhizomelia, Spina bifida, Hydrocephalus, Spinal... ORPHA:63259
Solitary Median Maxillary Central Incisor
Holoprosencephaly, Short stature OMIM:147250
Aplasia Cutis Congenita
Spinal dysraphism ORPHA:1114
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Holoprosencephaly ORPHA:990
Microform Holoprosencephaly
Holoprosencephaly, Intrauterine growth retardation, Short stature ORPHA:280200
Craniorachischisis
Sirenomelia, Anencephaly, Myelomeningocele, Cervical spina bifida, Spinal dysraphism ORPHA:63260
Trisomy 18
Intrauterine growth retardation, Anencephaly, Short stature, Growth delay, Holoprosencephaly, Spi... ORPHA:3380
Pancreatic Agenesis-Holoprosencephaly Syndrome
Holoprosencephaly, Intrauterine growth retardation, Semilobar holoprosencephaly ORPHA:556955
Holoprosencephaly 4
Semilobar holoprosencephaly OMIM:142946
Short-Rib Thoracic Dysplasia 12
Intrauterine growth retardation, Anencephaly, Holoprosencephaly, Neonatal death, Patent ductus ar... OMIM:269860
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
16P13.11 Microdeletion Syndrome
Holoprosencephaly, Short stature ORPHA:261236
Halperin-Birk Syndrome
Intrauterine growth retardation, Semilobar holoprosencephaly, Umbilical hernia OMIM:618651
Endocrine-Cerebroosteodysplasia
Holoprosencephaly, Hydrocephalus OMIM:612651
49,Xxxxy Syndrome
Holoprosencephaly, Arrhinencephaly, Short stature ORPHA:96264
Pallister-Hall Syndrome
Intrauterine growth retardation, Short stature, Holoprosencephaly, Neonatal death, Patent ductus ... OMIM:146510
Pseudotrisomy 13 Syndrome
Holoprosencephaly, Hydrocephalus OMIM:264480
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects
Lobar holoprosencephaly, Short stature OMIM:614701
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Holoprosencephaly, Hydrocephalus OMIM:253800
Jacobsen Syndrome
Holoprosencephaly, Intrauterine growth retardation, Hydrocephalus OMIM:147791
Holoprosencephaly
Holoprosencephaly, Spinal dysraphism, Hydrocephalus, Branchial anomaly ORPHA:2162
Arachnoid Cyst
Holoprosencephaly, Hydrocephalus ORPHA:2356
Isolated Exencephaly
Holoprosencephaly ORPHA:563612
Monosomy 13Q14
Holoprosencephaly, Intrauterine growth retardation, Short stature ORPHA:1587
Holoprosencephaly-Postaxial Polydactyly Syndrome
Holoprosencephaly, Hydrocephalus, Umbilical hernia ORPHA:2166
Mosaic Variegated Aneuploidy Syndrome
Holoprosencephaly, Intrauterine growth retardation, Growth delay, Short stature ORPHA:1052
Holoprosencephaly 3
Holoprosencephaly OMIM:142945
Steinfeld Syndrome
Holoprosencephaly OMIM:184705
Holoprosencephaly 7
Alobar holoprosencephaly, Hydrocephalus, Semilobar holoprosencephaly OMIM:610828
Smith-Lemli-Opitz Syndrome
Intrauterine growth retardation, Growth delay, Short stature, Holoprosencephaly, Patent ductus ar... OMIM:270400
Smith-Lemli-Opitz Syndrome
Intrauterine growth retardation, Growth delay, Short stature, Holoprosencephaly, Rhizomelia, Pate... ORPHA:818
Holoprosencephaly 13, X-Linked
Alobar holoprosencephaly, Semilobar holoprosencephaly, Patent ductus arteriosus OMIM:301043
Alg3-Cdg
Neural tube defect ORPHA:79321
Charge Syndrome
Intrauterine growth retardation, Short stature, Holoprosencephaly, Patent ductus arteriosus, Post... ORPHA:138
Holoprosencephaly 9
Holoprosencephaly, Hydrocephalus, Short stature OMIM:610829
Posterior Meningocele
Meningocele, Occipital meningocele, Neural tube defect, Hydrocephalus, Lipomyelomeningocele ORPHA:268810
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Intrauterine growth retardation, Lobar holoprosencephaly, Severe short stature ORPHA:468631
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome
Holoprosencephaly ORPHA:3186
Holoprosencephaly 2
Holoprosencephaly OMIM:157170
Genitourinary And/Or Brain Malformation Syndrome
Holoprosencephaly OMIM:618820
Ring Chromosome 7 Syndrome
Holoprosencephaly, Severe intrauterine growth retardation, Short stature ORPHA:1449
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Proboscis Lateralis
Holoprosencephaly, Patent ductus arteriosus ORPHA:141099
Meckel Syndrome
Lobar holoprosencephaly, Hydrocephalus, Anencephaly ORPHA:564
Pallister-Hall Syndrome
Arrhinencephaly, Intrauterine growth retardation, Short stature, Holoprosencephaly, Patent ductus... ORPHA:672
Combined Pituitary Hormone Deficiencies, Genetic Forms
Holoprosencephaly, Pituitary dwarfism, Delayed puberty, Growth delay ORPHA:95494
Hartsfield Syndrome
Lobar holoprosencephaly OMIM:615465
Orofaciodigital Syndrome Xiv
Holoprosencephaly, Patent ductus arteriosus OMIM:615948
Charge Syndrome
Arrhinencephaly, Holoprosencephaly, Patent ductus arteriosus, Delayed puberty, Postnatal growth r... OMIM:214800
Holoprosencephaly 1
Alobar holoprosencephaly, Ethmocephaly, Short stature OMIM:236100
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Intrauterine growth retardation, Semilobar holoprosencephaly, Growth delay OMIM:301044
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Semilobar holoprosencephaly OMIM:129900
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly OMIM:601374
Semilobar Holoprosencephaly
Short stature, Hydrocephalus, Growth delay, Neural tube defect ORPHA:220386
Alobar Holoprosencephaly
Short stature, Hydrocephalus, Growth delay, Neural tube defect ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Short stature, Hydrocephalus, Growth delay, Neural tube defect ORPHA:93926
Lobar Holoprosencephaly
Short stature, Hydrocephalus, Growth delay, Neural tube defect ORPHA:93924
Schinzel-Giedion Syndrome
Umbilical hernia, Neural tube defect ORPHA:798
Autosomal Recessive Primary Microcephaly
Growth delay, Short stature ORPHA:2512
Septopreoptic Holoprosencephaly
ORPHA:280195
Microcephaly 7, Primary, Autosomal Recessive
OMIM:612703

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Stil

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Stil.

No publications found that use IMPC mice or data for Stil.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Stiltm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Stiltm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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