Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
Scl/Tal1 interrupting locus
Synonyms:
Sil

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Stil mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Stil by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Semilobar Holoprosencephaly
Short stature, Growth delay, Hydrocephalus, Neural tube defect ORPHA:220386
Alobar Holoprosencephaly
Short stature, Growth delay, Hydrocephalus, Neural tube defect ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Short stature, Growth delay, Hydrocephalus, Neural tube defect ORPHA:93926
Lobar Holoprosencephaly
Short stature, Growth delay, Hydrocephalus, Neural tube defect ORPHA:93924
Septopreoptic Holoprosencephaly
Ethmoidal encephalocele ORPHA:280195
Autosomal Recessive Primary Microcephaly
Short stature, Growth delay ORPHA:2512
Microcephaly 7, Primary, Autosomal Recessive
OMIM:612703

The table below shows human diseases predicted to be associated to Stil by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Microhydranencephaly, X-Linked
Intrauterine growth retardation, Holoprosencephaly OMIM:306990
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Acalvaria
Holoprosencephaly, Hydrocephalus, Spina bifida ORPHA:945
Vissers-Bodmer Syndrome
Short stature, Intrauterine growth retardation, Holoprosencephaly OMIM:619033
Holoprosencephaly 5
Alobar holoprosencephaly, Semilobar holoprosencephaly, Syntelencephaly, Hydrocephalus, Holoprosen... OMIM:609637
Hydrocephalus, Congenital, 3, With Brain Anomalies
Hydranencephaly, Holoprosencephaly, Hydrocephalus OMIM:617967
Microcephaly-Brain Defect-Spasticity-Hypernatremia Syndrome
Holoprosencephaly ORPHA:2523
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Mental retardation, x-linked, syndromic, Turner type
Holoprosencephaly OMIM:300706
Microphthalmia/Coloboma 5
Holoprosencephaly OMIM:611638
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Muscle-Eye-Brain Disease
Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:588
Hartsfield Syndrome
Intrauterine growth retardation, Encephalocele, Lobar holoprosencephaly ORPHA:2117
Aminopterin/Methotrexate Embryofetopathy
Spinal dysraphism, Intrauterine growth retardation, Encephalocele, Hydrocephalus, Short stature, ... ORPHA:1908
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Intrauterine growth retardation, Hydranencephaly, Holoprosencephaly ORPHA:2570
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Thanatophoric Dysplasia Type 2
Encephalocele, Hydrocephalus, Short stature, Holoprosencephaly, Patent ductus arteriosus ORPHA:93274
Distal Deletion 13Q
Short stature, Holoprosencephaly, Anencephaly, Encephalocele ORPHA:1590
Brachial Amelia, Cleft Lip, And Holoprosencephaly
Holoprosencephaly, Anterior encephalocele OMIM:601357
Hydrocephalus With Stenosis Of The Aqueduct Of Sylvius
Aqueductal stenosis, Holoprosencephaly, Hydrocephalus ORPHA:2182
Holoprosencephaly 11
Holoprosencephaly OMIM:614226
Lambotte Syndrome
Intrauterine growth retardation, Semilobar holoprosencephaly OMIM:245552
Distal Monosomy 7Q36
Short stature, Holoprosencephaly ORPHA:1636
Ring Chromosome 21 Syndrome
Short stature, Holoprosencephaly ORPHA:1445
Triploidy
Intrauterine growth retardation, Meningocele, Holoprosencephaly, Hydrocephalus ORPHA:3376
Microtia-Anotia
Holoprosencephaly OMIM:600674
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Patent ductus arteriosus, Holoprosencephaly, Growth delay, Hydrocephalus ORPHA:77298
Holoprosencephaly, Semilobar, With Craniosynostosis
Semilobar holoprosencephaly OMIM:601370
Chromosome 3Q13.31 Deletion Syndrome
Alobar holoprosencephaly OMIM:615433
Monosomy 18P
Short stature, Holoprosencephaly ORPHA:1598
1Q41Q42 Microdeletion Syndrome
Short stature, Holoprosencephaly, Growth delay ORPHA:250999
Iniencephaly
Rhizomelia, Spinal dysraphism, Myelomeningocele, Encephalocele, Hydrocephalus, Spina bifida, Holo... ORPHA:63259
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Holoprosencephaly-Caudal Dysgenesis Syndrome
Holoprosencephaly ORPHA:2165
Holoprosencephaly-Craniosynostosis Syndrome
Short stature, Holoprosencephaly ORPHA:2163
Microtia
Holoprosencephaly ORPHA:83463
Agnathia-Otocephaly Complex
Holoprosencephaly OMIM:202650
Solitary Median Maxillary Central Incisor
Short stature, Holoprosencephaly OMIM:147250
Short-Rib Thoracic Dysplasia 12
Intrauterine growth retardation, Neonatal death, Hydrocephalus, Holoprosencephaly, Anencephaly, P... OMIM:269860
Microform Holoprosencephaly
Short stature, Intrauterine growth retardation, Holoprosencephaly ORPHA:280200
Pancreatic Agenesis-Holoprosencephaly Syndrome
Intrauterine growth retardation, Holoprosencephaly, Semilobar holoprosencephaly ORPHA:556955
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Holoprosencephaly ORPHA:990
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Hydrocephalus, Holoprosencephaly, Encephalocele OMIM:253800
Chromosome 1Q41-Q42 Deletion Syndrome
Short stature, Holoprosencephaly OMIM:612530
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Pseudotrisomy 13 Syndrome
Hydrocephalus, Holoprosencephaly, Encephalocele OMIM:264480
Trisomy 18
Growth delay, Intrauterine growth retardation, Spina bifida, Short stature, Holoprosencephaly, An... ORPHA:3380
49,Xxxxy Syndrome
Short stature, Holoprosencephaly ORPHA:96264
Holoprosencephaly 4
Semilobar holoprosencephaly OMIM:142946
Meckel Syndrome 14
Holoprosencephaly, Occipital encephalocele OMIM:619879
Halperin-Birk Syndrome
Intrauterine growth retardation, Semilobar holoprosencephaly, Umbilical hernia OMIM:618651
Holoprosencephaly 7
Alobar holoprosencephaly, Semilobar holoprosencephaly, Hydrocephalus, Holoprosencephaly, Occipita... OMIM:610828
Arachnoid Cyst
Hydrocephalus, Holoprosencephaly, Encephalocele ORPHA:2356
Craniorachischisis
Spinal dysraphism, Myelomeningocele, Sirenomelia, Cervical spina bifida, Anencephaly ORPHA:63260
16P13.11 Microdeletion Syndrome
Short stature, Holoprosencephaly ORPHA:261236
Holoprosencephaly-Postaxial Polydactyly Syndrome
Hydrocephalus, Holoprosencephaly, Encephalocele, Umbilical hernia ORPHA:2166
Pallister-Hall Syndrome
Intrauterine growth retardation, Neonatal death, Short stature, Holoprosencephaly, Growth delay, ... OMIM:146510
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects
Short stature, Lobar holoprosencephaly OMIM:614701
Holoprosencephaly
Spinal dysraphism, Branchial anomaly, Encephalocele, Hydrocephalus, Holoprosencephaly ORPHA:2162
Holoprosencephaly 14
Holoprosencephaly, Aqueductal stenosis, Alobar holoprosencephaly, Hydrocephalus OMIM:619895
Holoprosencephaly 12 With Or Without Pancreatic Agenesis
Semilobar holoprosencephaly, Intrauterine growth retardation, Neonatal death, Growth delay, Lobar... OMIM:618500
Jacobsen Syndrome
Intrauterine growth retardation, Holoprosencephaly, Hydrocephalus OMIM:147791
Endocrine-Cerebroosteodysplasia
Holoprosencephaly, Hydrocephalus OMIM:612651
Mosaic Variegated Aneuploidy Syndrome
Short stature, Intrauterine growth retardation, Holoprosencephaly, Growth delay ORPHA:1052
Monosomy 13Q14
Short stature, Intrauterine growth retardation, Holoprosencephaly ORPHA:1587
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Holoprosencephaly 3
Holoprosencephaly OMIM:142945
Isolated Exencephaly
Holoprosencephaly ORPHA:563612
Hartsfield Syndrome
Alobar holoprosencephaly, Growth delay, Lobar holoprosencephaly, Semilobar holoprosencephaly OMIM:615465
Smith-Lemli-Opitz Syndrome
Rhizomelia, Intrauterine growth retardation, Short stature, Holoprosencephaly, Growth delay, Pate... ORPHA:818
Holoprosencephaly 9
Alobar holoprosencephaly, Hydrocephalus, Short stature, Holoprosencephaly, Occipital meningocele OMIM:610829
Steinfeld Syndrome
Holoprosencephaly OMIM:184705
Chromosome 13Q14 Deletion Syndrome
Holoprosencephaly, Growth delay, Umbilical hernia OMIM:613884
Charge Syndrome
Umbilical hernia, Postnatal growth retardation, Intrauterine growth retardation, Delayed puberty,... ORPHA:138
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Occipital meningocele, Neural tube defect ORPHA:268810
Smith-Lemli-Opitz Syndrome
Intrauterine growth retardation, Hydrocephalus, Short stature, Holoprosencephaly, Growth delay, P... OMIM:270400
Holoprosencephaly 13, X-Linked
Alobar holoprosencephaly, Patent ductus arteriosus, Semilobar holoprosencephaly OMIM:301043
Meckel Syndrome
Hydrocephalus, Anencephaly, Encephalocele, Lobar holoprosencephaly ORPHA:564
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Severe short stature, Intrauterine growth retardation, Lobar holoprosencephaly ORPHA:468631
Ring Chromosome 7 Syndrome
Short stature, Holoprosencephaly, Severe intrauterine growth retardation ORPHA:1449
Orofaciodigital Syndrome Xiv
Holoprosencephaly, Occipital encephalocele, Patent ductus arteriosus OMIM:615948
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome
Holoprosencephaly ORPHA:3186
Genitourinary And/Or Brain Malformation Syndrome
Holoprosencephaly OMIM:618820
Holoprosencephaly 1
Short stature, Alobar holoprosencephaly, Ethmocephaly OMIM:236100
Combined Pituitary Hormone Deficiencies, Genetic Forms
Holoprosencephaly, Delayed puberty, Pituitary dwarfism, Growth delay ORPHA:95494
Proboscis Lateralis
Holoprosencephaly, Patent ductus arteriosus ORPHA:141099
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Intrauterine growth retardation, Semilobar holoprosencephaly, Growth delay OMIM:301044
Holoprosencephaly 2
Holoprosencephaly, Alobar holoprosencephaly, Semilobar holoprosencephaly OMIM:157170
Pallister-Hall Syndrome
Umbilical hernia, Intrauterine growth retardation, Short stature, Holoprosencephaly, Patent ductu... ORPHA:672
Charge Syndrome
Umbilical hernia, Postnatal growth retardation, Delayed puberty, Holoprosencephaly, Patent ductus... OMIM:214800
Townes-Brocks Syndrome 1
Holoprosencephaly, Hydrocephalus, Umbilical hernia OMIM:107480
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Semilobar holoprosencephaly OMIM:129900
Semilobar Holoprosencephaly
Short stature, Growth delay, Hydrocephalus, Neural tube defect ORPHA:220386
Alobar Holoprosencephaly
Short stature, Growth delay, Hydrocephalus, Neural tube defect ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Short stature, Growth delay, Hydrocephalus, Neural tube defect ORPHA:93926
Lobar Holoprosencephaly
Short stature, Growth delay, Hydrocephalus, Neural tube defect ORPHA:93924
Septopreoptic Holoprosencephaly
Ethmoidal encephalocele ORPHA:280195
Autosomal Recessive Primary Microcephaly
Short stature, Growth delay ORPHA:2512
Microcephaly 7, Primary, Autosomal Recessive
OMIM:612703

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Stil

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Stil.

No publications found that use IMPC mice or data for Stil.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Stiltm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Stiltm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter