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Gene: Stil MGI:107477

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
Scl/Tal1 interrupting locus
Synonyms:
Sil

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Stil mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Stil by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Semilobar Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:220386
Alobar Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:93926
Lobar Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:93924
Septopreoptic Holoprosencephaly
Ethmoidal encephalocele ORPHA:280195
Autosomal Recessive Primary Microcephaly
Growth delay, Short stature ORPHA:2512
Microcephaly 7, Primary, Autosomal Recessive
OMIM:612703

The table below shows human diseases predicted to be associated to Stil by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Microhydranencephaly, X-Linked
Intrauterine growth retardation, Holoprosencephaly OMIM:306990
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Acalvaria
Hydrocephalus, Holoprosencephaly, Spina bifida ORPHA:945
Vissers-Bodmer Syndrome
Intrauterine growth retardation, Short stature, Holoprosencephaly OMIM:619033
Holoprosencephaly 5
Syntelencephaly, Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly, Holoprosenceph... OMIM:609637
Hydrocephalus, Congenital, 3, With Brain Anomalies
Hydranencephaly, Hydrocephalus, Holoprosencephaly OMIM:617967
Microcephaly-Brain Defect-Spasticity-Hypernatremia Syndrome
Holoprosencephaly ORPHA:2523
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Mental retardation, x-linked, syndromic, Turner type
Holoprosencephaly OMIM:300706
Microphthalmia, Isolated, With Coloboma 5
Holoprosencephaly OMIM:611638
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Muscle-Eye-Brain Disease
Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:588
Hartsfield Syndrome
Encephalocele, Intrauterine growth retardation, Lobar holoprosencephaly ORPHA:2117
Aminopterin/Methotrexate Embryofetopathy
Encephalocele, Short stature, Hydrocephalus, Meningocele, Anencephaly, Spinal dysraphism, Holopro... ORPHA:1908
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Hydranencephaly, Intrauterine growth retardation, Holoprosencephaly ORPHA:2570
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Thanatophoric Dysplasia Type 2
Encephalocele, Short stature, Hydrocephalus, Patent ductus arteriosus, Holoprosencephaly ORPHA:93274
Distal Deletion 13Q
Encephalocele, Anencephaly, Holoprosencephaly, Short stature ORPHA:1590
Brachial Amelia, Cleft Lip, And Holoprosencephaly
Holoprosencephaly, Anterior encephalocele OMIM:601357
Hydrocephalus With Stenosis Of The Aqueduct Of Sylvius
Aqueductal stenosis, Hydrocephalus, Holoprosencephaly ORPHA:2182
Holoprosencephaly 11
Holoprosencephaly OMIM:614226
Lambotte Syndrome
Intrauterine growth retardation, Semilobar holoprosencephaly OMIM:245552
Ring Chromosome 21 Syndrome
Short stature, Holoprosencephaly ORPHA:1445
Distal Monosomy 7Q36
Short stature, Holoprosencephaly ORPHA:1636
Triploidy
Intrauterine growth retardation, Hydrocephalus, Meningocele, Holoprosencephaly ORPHA:3376
Microtia-Anotia
Holoprosencephaly OMIM:600674
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Patent ductus arteriosus, Hydrocephalus, Growth delay, Holoprosencephaly ORPHA:77298
Holoprosencephaly, Semilobar, With Craniosynostosis
Semilobar holoprosencephaly OMIM:601370
Chromosome 3Q13.31 Deletion Syndrome
Alobar holoprosencephaly OMIM:615433
1Q41Q42 Microdeletion Syndrome
Growth delay, Short stature, Holoprosencephaly ORPHA:250999
Monosomy 18P
Short stature, Holoprosencephaly ORPHA:1598
Microtia
Holoprosencephaly ORPHA:83463
Iniencephaly
Encephalocele, Rhizomelia, Spina bifida, Hydrocephalus, Myelomeningocele, Anencephaly, Spinal dys... ORPHA:63259
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Holoprosencephaly-Caudal Dysgenesis Syndrome
Holoprosencephaly ORPHA:2165
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Holoprosencephaly-Craniosynostosis Syndrome
Short stature, Holoprosencephaly ORPHA:2163
Solitary Median Maxillary Central Incisor
Short stature, Holoprosencephaly OMIM:147250
Agnathia-Otocephaly Complex
Holoprosencephaly OMIM:202650
Short-Rib Thoracic Dysplasia 12
Patent ductus arteriosus, Hydrocephalus, Anencephaly, Holoprosencephaly, Neonatal death, Intraute... OMIM:269860
Pancreatic Agenesis-Holoprosencephaly Syndrome
Intrauterine growth retardation, Holoprosencephaly, Semilobar holoprosencephaly ORPHA:556955
Microform Holoprosencephaly
Intrauterine growth retardation, Short stature, Holoprosencephaly ORPHA:280200
Agnathia-Holoprosencephaly-Situs Inversus Syndrome
Holoprosencephaly ORPHA:990
Chromosome 1Q41-Q42 Deletion Syndrome
Short stature, Holoprosencephaly OMIM:612530
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Encephalocele, Hydrocephalus, Holoprosencephaly OMIM:253800
Pseudotrisomy 13 Syndrome
Encephalocele, Hydrocephalus, Holoprosencephaly OMIM:264480
Trisomy 18
Short stature, Spina bifida, Anencephaly, Growth delay, Holoprosencephaly, Intrauterine growth re... ORPHA:3380
49,Xxxxy Syndrome
Short stature, Holoprosencephaly ORPHA:96264
Holoprosencephaly 4
Semilobar holoprosencephaly OMIM:142946
Meckel Syndrome 14
Occipital encephalocele, Holoprosencephaly OMIM:619879
Arachnoid Cyst
Encephalocele, Hydrocephalus, Holoprosencephaly ORPHA:2356
Halperin-Birk Syndrome
Umbilical hernia, Intrauterine growth retardation, Semilobar holoprosencephaly OMIM:618651
16P13.11 Microdeletion Syndrome
Short stature, Holoprosencephaly ORPHA:261236
Holoprosencephaly 7
Alobar holoprosencephaly, Hydrocephalus, Lobar holoprosencephaly, Holoprosencephaly, Occipital me... OMIM:610828
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Pallister-Hall Syndrome
Short stature, Patent ductus arteriosus, Holoprosencephaly, Neonatal death, Intrauterine growth r... OMIM:146510
Holoprosencephaly-Postaxial Polydactyly Syndrome
Encephalocele, Umbilical hernia, Hydrocephalus, Holoprosencephaly ORPHA:2166
Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects
Short stature, Lobar holoprosencephaly OMIM:614701
Holoprosencephaly
Encephalocele, Hydrocephalus, Spinal dysraphism, Branchial anomaly, Holoprosencephaly ORPHA:2162
Holoprosencephaly 14
Aqueductal stenosis, Hydrocephalus, Holoprosencephaly, Alobar holoprosencephaly OMIM:619895
Holoprosencephaly 12 With Or Without Pancreatic Agenesis
Lobar holoprosencephaly, Growth delay, Neonatal death, Intrauterine growth retardation, Semilobar... OMIM:618500
Jacobsen Syndrome
Intrauterine growth retardation, Hydrocephalus, Holoprosencephaly OMIM:147791
Endocrine-Cerebroosteodysplasia
Hydrocephalus, Holoprosencephaly OMIM:612651
Mosaic Variegated Aneuploidy Syndrome
Growth delay, Intrauterine growth retardation, Short stature, Holoprosencephaly ORPHA:1052
Monosomy 13Q14
Intrauterine growth retardation, Short stature, Holoprosencephaly ORPHA:1587
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Isolated Exencephaly
Holoprosencephaly ORPHA:563612
Holoprosencephaly 3
Holoprosencephaly OMIM:142945
Hartsfield Syndrome
Growth delay, Semilobar holoprosencephaly, Lobar holoprosencephaly, Alobar holoprosencephaly OMIM:615465
Smith-Lemli-Opitz Syndrome
Rhizomelia, Short stature, Patent ductus arteriosus, Growth delay, Holoprosencephaly, Intrauterin... ORPHA:818
Steinfeld Syndrome
Holoprosencephaly OMIM:184705
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Neural tube defect, Occipital meningocele ORPHA:268810
Chromosome 13Q14 Deletion Syndrome
Growth delay, Umbilical hernia, Holoprosencephaly OMIM:613884
Holoprosencephaly 9
Hydrocephalus, Short stature, Holoprosencephaly OMIM:610829
Charge Syndrome
Short stature, Aqueductal stenosis, Postnatal growth retardation, Patent ductus arteriosus, Holop... ORPHA:138
Smith-Lemli-Opitz Syndrome
Short stature, Patent ductus arteriosus, Hydrocephalus, Growth delay, Holoprosencephaly, Intraute... OMIM:270400
Holoprosencephaly 13, X-Linked
Patent ductus arteriosus, Semilobar holoprosencephaly, Alobar holoprosencephaly OMIM:301043
Meckel Syndrome
Encephalocele, Hydrocephalus, Anencephaly, Lobar holoprosencephaly ORPHA:564
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Intrauterine growth retardation, Severe short stature, Lobar holoprosencephaly ORPHA:468631
Ring Chromosome 7 Syndrome
Severe intrauterine growth retardation, Short stature, Holoprosencephaly ORPHA:1449
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome
Holoprosencephaly ORPHA:3186
Orofaciodigital Syndrome Xiv
Occipital encephalocele, Patent ductus arteriosus, Holoprosencephaly OMIM:615948
Genitourinary And/Or Brain Malformation Syndrome
Holoprosencephaly OMIM:618820
Holoprosencephaly 1
Ethmocephaly, Short stature, Alobar holoprosencephaly OMIM:236100
Holoprosencephaly 2
Semilobar holoprosencephaly, Holoprosencephaly, Alobar holoprosencephaly OMIM:157170
Proboscis Lateralis
Patent ductus arteriosus, Holoprosencephaly ORPHA:141099
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Growth delay, Intrauterine growth retardation, Semilobar holoprosencephaly OMIM:301044
Pallister-Hall Syndrome
Short stature, Patent ductus arteriosus, Holoprosencephaly, Umbilical hernia, Intrauterine growth... ORPHA:672
Combined Pituitary Hormone Deficiencies, Genetic Forms
Growth delay, Pituitary dwarfism, Holoprosencephaly, Delayed puberty ORPHA:95494
Charge Syndrome
Postnatal growth retardation, Patent ductus arteriosus, Holoprosencephaly, Delayed puberty, Umbil... OMIM:214800
Townes-Brocks Syndrome 1
Umbilical hernia, Hydrocephalus, Holoprosencephaly OMIM:107480
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1
Semilobar holoprosencephaly OMIM:129900
Semilobar Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:220386
Alobar Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:93926
Lobar Holoprosencephaly
Growth delay, Neural tube defect, Hydrocephalus, Short stature ORPHA:93924
Septopreoptic Holoprosencephaly
Ethmoidal encephalocele ORPHA:280195
Autosomal Recessive Primary Microcephaly
Growth delay, Short stature ORPHA:2512
Microcephaly 7, Primary, Autosomal Recessive
OMIM:612703

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Stil

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Stil.

No publications found that use IMPC mice or data for Stil.

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MGI Allele Allele Type Produced
Stiltm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Stiltm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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