banner
Genes Phenotypes Help, News, Blog

Gene: Serpinf2 MGI:107173

Log in to follow
Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
serine (or cysteine) peptidase inhibitor, clade F, member 2
Synonyms:
alpha 2 antiplasmin,  Pli

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Serpinf2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Serpinf2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Congenital Alpha2-Antiplasmin Deficiency
ORPHA:79
Alpha-2-Plasmin Inhibitor Deficiency
OMIM:262850

The table below shows human diseases predicted to be associated to Serpinf2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Von Willebrand Disease, X-Linked Form
Prolonged bleeding time OMIM:314560
Athrombia, Essential
Impaired platelet aggregation, Prolonged bleeding time, Impaired platelet adhesion OMIM:209050
Tatsumi Factor Deficiency
Prolonged bleeding time OMIM:272650
Pseudo-Von Willebrand Disease
Prolonged bleeding time OMIM:177820
Glanzmann Thrombasthenia 2
Prolonged bleeding time, Decreased platelet glycoprotein IIb-IIIa, Impaired ADP-induced platelet ... OMIM:619267
Bleeding Disorder, Platelet-Type, 18
Prolonged bleeding time, Impaired ADP-induced platelet aggregation, Impaired epinephrine-induced ... OMIM:615888
Platelet Glycoprotein Iv Deficiency
Prolonged bleeding time OMIM:608404
Bleeding Disorder, Platelet-Type, 11
Impaired collagen-induced platelet aggregation, Prolonged bleeding time, Impaired ristocetin-indu... OMIM:614201
Glanzmann Thrombasthenia
Prolonged bleeding time, Impaired thrombin-induced platelet aggregation, Impaired ADP-induced pla... ORPHA:849
Glanzmann Thrombasthenia 1
Prolonged bleeding time, Decreased platelet glycoprotein IIb-IIIa, Impaired ADP-induced platelet ... OMIM:273800
Bleeding Disorder, Platelet-Type, 14
Prolonged bleeding time OMIM:614158
Platelet Disorder, Undefined
Prolonged bleeding time, Impaired platelet aggregation OMIM:173420
Factor V Deficiency
Prolonged bleeding time, Prolonged prothrombin time OMIM:227400
Aplasia Cutis Congenita
Prolonged bleeding time ORPHA:1114
Thrombocytopenia, Paris-Trousseau Type
Prolonged bleeding time OMIM:188025
Macrothrombocytopenia And Granulocyte Inclusions With Or Without Nephritis Or Sensorineural Hearing Loss
Prolonged bleeding time, Impaired ADP-induced platelet aggregation, Impaired epinephrine-induced ... OMIM:155100
Storage Pool Platelet Disease
Prolonged bleeding time OMIM:185050
Bernard-Soulier Syndrome
Prolonged bleeding time, Impaired ristocetin-induced platelet aggregation OMIM:231200
Gray Platelet Syndrome
Impaired collagen-induced platelet aggregation, Prolonged bleeding time, Impaired thrombin-induce... OMIM:139090
Blue Rubber Bleb Nevus
Prolonged bleeding time ORPHA:1059
Prothrombin Deficiency, Congenital
Prolonged bleeding time, Prolonged prothrombin time OMIM:613679
Von Willebrand Disease, Type 3
Prolonged bleeding time, Impaired platelet aggregation OMIM:277480
Hermansky-Pudlak Syndrome 7
Prolonged bleeding time, Impaired platelet aggregation OMIM:614076
Platelet Disorder, Familial, With Associated Myeloid Malignancy
Prolonged bleeding time, Impaired platelet aggregation OMIM:601399
Thrombocytopenia With Beta-Thalassemia, X-Linked
Prolonged bleeding time OMIM:314050
Bleeding Disorder, Platelet-Type, 17
Impaired collagen-induced platelet aggregation, Prolonged bleeding time, Impaired epinephrine-ind... OMIM:187900
Hermansky-Pudlak Syndrome 5
Prolonged bleeding time, Impaired ADP-induced platelet aggregation OMIM:614074
Von Willebrand Disease, Type 1
Prolonged bleeding time, Impaired platelet aggregation OMIM:193400
Congenital Alpha2-Antiplasmin Deficiency
ORPHA:79
Alpha-2-Plasmin Inhibitor Deficiency
OMIM:262850

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Serpinf2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Serpinf2.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Venous stasis-induced fibrinolysis prevents thrombosis in mice: role of α2-antiplasmin. Blood (August 2019) Serpinf2tm1(KOMP)Vlcg 31395599
Releasing the Brakes on the Fibrinolytic System in Pulmonary Emboli: Unique Effects of Plasminogen Activation and α2-Antiplasmin Inactivation. Circulation (December 2016) Serpinf2tm1(KOMP)Vlcg PMC5423358

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Serpinf2tm255188(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Serpinf2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Serpinf2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter