Hmx3 | H6 homeobox 3

GeneMGI:107160Synonyms: Nkx5.1, Nkx5-1

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Digestive/alimentary Nervous system Behavior/neurological

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

decreased grip strength3 supporting datasetsHmx3tm1EbohomozygoteEarly adult1.21x10-5 
abnormal locomotor activation1 supporting datasetHmx3tm1EbohomozygoteEarly adult4.21x10-5 
decreased body weight1 supporting datasetHmx3tm1EbohomozygoteEarly adult1.52x10-21 
hyperactivity1 supporting datasetHmx3tm1EbohomozygoteEarly adult5.26x10-5 
abnormal gait1 supporting datasetHmx3tm1EbohomozygoteEarly adult4.11x10-5 
abnormal defecation1 supporting datasetHmx3tm1EbohomozygoteEarly adult2.49x10-5 
decreased prepulse inhibition1 supporting datasetHmx3tm1EbohomozygoteEarly adult1.48x10-5 
decreased circulating triglyceride level1 supporting datasetHmx3tm1EbohomozygoteEarly adult7.31x10-7 
abnormal behavior1 supporting datasetHmx3tm1EbohomozygoteEarly adult8.97x10-5 
decreased circulating free fatty acids level1 supporting datasetHmx3tm1EbohomozygoteEarly adult1.95x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Hmx3tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Hmx3tm97282(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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