Hmx3 | H6 homeobox 3

GeneMGI:107160Synonyms: Nkx5.1, Nkx5-1

Physiological systems

19 / 24 physiological systems tested

5 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Digestive/alimentary Nervous system Behavior/neurological

14 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:10Significant phenotypes

0Associated diseases

Expression examined in:0Adult tissues

0Embryo tissues

Phenotypes

Zygosity:

Phy. System:



decreased grip strength	3 supporting datasets	Hmx3^tm1Ebo	homozygote	Early adult	1.21x10^-5
abnormal locomotor activation	1 supporting dataset	Hmx3^tm1Ebo	homozygote	Early adult	4.21x10^-5
decreased body weight	1 supporting dataset	Hmx3^tm1Ebo	homozygote	Early adult	1.52x10^-21
hyperactivity	1 supporting dataset	Hmx3^tm1Ebo	homozygote	Early adult	5.26x10^-5
abnormal gait	1 supporting dataset	Hmx3^tm1Ebo	homozygote	Early adult	4.11x10^-5
abnormal defecation	1 supporting dataset	Hmx3^tm1Ebo	homozygote	Early adult	2.49x10^-5
decreased prepulse inhibition	1 supporting dataset	Hmx3^tm1Ebo	homozygote	Early adult	1.48x10^-5
decreased circulating triglyceride level	1 supporting dataset	Hmx3^tm1Ebo	homozygote	Early adult	7.31x10^-7
abnormal behavior	1 supporting dataset	Hmx3^tm1Ebo	homozygote	Early adult	8.97x10^-5
decreased circulating free fatty acids level	1 supporting dataset	Hmx3^tm1Ebo	homozygote	Early adult	1.95x10^-5

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Hmx3.

Associated images

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Histopathology

There is no histopathology data found for Hmx3.

IMPC related publications

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External links

No external links available for Hmx3.

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*Hmx3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell
*Hmx3^{tm97282(L1L2_Bact_P)}*	KO first allele (reporter-tagged insertion with conditional potential)	‌	targeting vector

My Genes