Gene: Aff3

Name
AF4/FMR2 family, member 3
MGI ID
MGI:106927
Synonyms
Laf4 3222402O04Rik LAF-4
Viability
Homozygous - Viable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Aff3tm1a(EUCOMM)Wtsi HOM postnatal 2.09×10-07
increased or absent threshold for auditory brainstem response Aff3tm1a(EUCOMM)Wtsi HOM postnatal 3.72×10-05
fusion of vertebral arches Aff3tm1a(EUCOMM)Wtsi HOM postnatal 6.44×10-06
abnormal vertebral arch morphology Aff3tm1a(EUCOMM)Wtsi HET postnatal 6.83×10-08
abnormal incisor morphology Aff3tm1a(EUCOMM)Wtsi HOM postnatal 5.14×10-07
decreased caudal vertebrae number Aff3tm1a(EUCOMM)Wtsi HET postnatal 0.00
decreased circulating fructosamine level Aff3tm1a(EUCOMM)Wtsi HOM postnatal 2.76×10-05
abnormal vertebral arch morphology Aff3tm1a(EUCOMM)Wtsi HOM postnatal 3.27×10-07
decreased circulating serum albumin level Aff3tm1a(EUCOMM)Wtsi HOM postnatal 1.30×10-05
abnormal snout morphology Aff3tm1a(EUCOMM)Wtsi HOM postnatal 9.32×10-05
decreased caudal vertebrae number Aff3tm1a(EUCOMM)Wtsi HOM postnatal 1.00×10-06
vertebral transformation Aff3tm1a(EUCOMM)Wtsi HOM postnatal 1.15×10-06

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Esophagus 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No  (2/2) N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Brain Histopathology: Striatal Section
3 Images
Brain Histopathology: Hippocampal section
1 Images
X-ray: XRay Images Lateral Orientation
52 Images
X-ray: XRay Images Dorso Ventral
77 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
28 Images
X-ray: XRay Images Forepaw
21 Images
X-ray: XRay Images Skull Lateral Orientation
25 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Aff3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Aff3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter