Aff3 | AF4/FMR2 family, member 3
Physiological systems
17 / 24 physiological systems tested
5 Significantly impacted by the knock-out
Homeostasis/metabolism Growth/size/body region Behavior/neurological Skeleton Craniofacial
12 No significant impact
7 Not tested
Data collections
Gene metrics:11Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues
fusion of vertebral arches | 1 supporting dataset | Aff3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 7.64x10-6 | ||
abnormal incisor morphology | 1 supporting dataset | Aff3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.74x10-7 | ||
abnormal snout morphology | 1 supporting dataset | Aff3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.93x10-5 | ||
increased circulating chloride level | 1 supporting dataset | Aff3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.7x10-5 | ||
abnormal vertebral arch morphology | 1 supporting dataset | Aff3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.07x10-7 | ||
decreased grip strength | 1 supporting dataset | Aff3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 5.01x10-5 | ||
vertebral transformation | 1 supporting dataset | Aff3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 1.79x10-6 | ||
abnormal tooth morphology | 1 supporting dataset | Aff3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 2.26x10-6 | ||
decreased circulating serum albumin level | 1 supporting dataset | Aff3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 6.15x10-6 | ||
decreased circulating fructosamine level | 1 supporting dataset | Aff3tm1a(EUCOMM)Wtsi | homozygote | Early adult | 3.74x10-5 |
| | | | | | | | | |
adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
aorta | heterozygote | n/a | n/a | 0.19% (1/533) |
blood vessel | heterozygote | n/a | 0% (0/2) | 0% (0/173) |
bone | heterozygote | n/a | 0% (0/2) | 0% (0/394) |
brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | n/a | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 0% (0/2) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
cerebellum | heterozygote | n/a | n/a | 0.56% (3/532) |
cerebral cortex | heterozygote | n/a | n/a | 0.41% (2/491) |
External links
No external links available for Aff3.
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Aff3tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
Aff3tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Aff3tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | | ES Cell |