Gene: Aff3

AF4/FMR2 family, member 3
Laf4 3222402O04Rik LAF-4
Homozygous - Viable
Other links
View data by physiological system
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Aff3tm1a(EUCOMM)Wtsi HOM postnatal 2.09×10-07
increased or absent threshold for auditory brainstem response Aff3tm1a(EUCOMM)Wtsi HOM postnatal 3.72×10-05
fusion of vertebral arches Aff3tm1a(EUCOMM)Wtsi HOM postnatal 6.44×10-06
abnormal vertebral arch morphology Aff3tm1a(EUCOMM)Wtsi HET postnatal 6.83×10-08
abnormal incisor morphology Aff3tm1a(EUCOMM)Wtsi HOM postnatal 5.14×10-07
decreased caudal vertebrae number Aff3tm1a(EUCOMM)Wtsi HET postnatal 0.00
decreased circulating fructosamine level Aff3tm1a(EUCOMM)Wtsi HOM postnatal 2.76×10-05
abnormal vertebral arch morphology Aff3tm1a(EUCOMM)Wtsi HOM postnatal 3.27×10-07
decreased circulating serum albumin level Aff3tm1a(EUCOMM)Wtsi HOM postnatal 1.30×10-05
abnormal snout morphology Aff3tm1a(EUCOMM)Wtsi HOM postnatal 9.32×10-05
decreased caudal vertebrae number Aff3tm1a(EUCOMM)Wtsi HOM postnatal 1.00×10-06
vertebral transformation Aff3tm1a(EUCOMM)Wtsi HOM postnatal 1.15×10-06

Download data as:  TSV  XLS

Filtered by: all phenotypes


IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Esophagus 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No  (2/2) N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Brain Histopathology: Striatal Section
3 Images
Brain Histopathology: Hippocampal section
1 Images
X-ray: XRay Images Lateral Orientation
52 Images
X-ray: XRay Images Dorso Ventral
77 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
28 Images
X-ray: XRay Images Forepaw
21 Images
X-ray: XRay Images Skull Lateral Orientation
25 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Aff3tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Aff3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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