Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
thymopoietin
Synonyms:
TP,  5630400D24Rik,  LAP2,  lamina-associated polypeptide 2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Tmpo mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Tmpo by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Familial Isolated Dilated Cardiomyopathy
Abnormality of neutrophils, Palmoplantar keratoderma ORPHA:154

The table below shows human diseases predicted to be associated to Tmpo by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Polycythemia Vera
Thrombocytosis, Increased hematocrit, Gastrointestinal hemorrhage, Leukocytosis, Increased hemogl... OMIM:263300
Erythrocytosis, Familial, 3
Increased red blood cell mass, Increased hematocrit, Increased hemoglobin OMIM:609820
Erythrocytosis, Familial, 6
Polycythemia, Increased hematocrit, Increased hemoglobin OMIM:617980
Erythrocytosis, Familial, 5
Polycythemia, Increased hematocrit, Increased hemoglobin OMIM:617907
Erythrocytosis, Familial, 4
Polycythemia, Increased hematocrit, Increased hemoglobin OMIM:611783
Erythrocytosis, Familial, 7
Polycythemia, Increased hematocrit OMIM:617981
Erythrocytosis, Familial, 1
Increased red blood cell mass, Increased hematocrit, Increased hemoglobin, Splenomegaly OMIM:133100
Erythrocytosis, Familial, 2
Increased red blood cell mass, Increased hematocrit, Increased hemoglobin OMIM:263400
Tempi Syndrome
Polycythemia, Increased hematocrit ORPHA:284227
Duodenal Neuroendocrine Tumor
Iron deficiency anemia, Intestinal carcinoid, Increased hematocrit, Elevated circulating growth h... ORPHA:100076
Fanconi Anemia, Complementation Group E
Cryptorchidism, Neutropenia, Reticulocytopenia, Pancytopenia, Thrombocytopenia, Complete duplicat... OMIM:600901
Fanconi Anemia, Complementation Group A
Cryptorchidism, Neutropenia, Reticulocytopenia, Pancytopenia, Thrombocytopenia, Complete duplicat... OMIM:227650
Fanconi Anemia, Complementation Group D2
Cryptorchidism, Aplasia of the 1st metacarpal, Preaxial hand polydactyly, Neutropenia, Esophageal... OMIM:227646
Fanconi Anemia, Complementation Group C
Cryptorchidism, Neutropenia, Reticulocytopenia, Pancytopenia, Thrombocytopenia, Complete duplicat... OMIM:227645
Acute Interstitial Pneumonia
Reduced hematocrit ORPHA:79126
Tubulointerstitial Nephritis And Uveitis Syndrome
Reduced hematocrit, Normochromic anemia, Normocytic anemia ORPHA:91500
Familial Isolated Dilated Cardiomyopathy
Abnormality of neutrophils, Palmoplantar keratoderma ORPHA:154

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tmpo

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tmpo.

No publications found that use IMPC mice or data for Tmpo.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Tmpotm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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