Registered for phenotyping at IMPC
Phenotyping is planned for a knockout strain of this gene but data is not currently available.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is planned for a knockout strain of this gene but data is not currently available.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Spg21 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Mast Syndrome | Athetosis, Gait disturbance, Dysdiadochokinesis | OMIM:248900 | |
Autosomal Recessive Spastic Paraplegia Type 21 | Gait disturbance, Difficulty walking | ORPHA:101001 |
The table below shows human diseases predicted to be associated to Spg21 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Mast Syndrome | Athetosis, Gait disturbance, Dysdiadochokinesis | OMIM:248900 | |
Autosomal Recessive Spastic Paraplegia Type 21 | Gait disturbance, Difficulty walking | ORPHA:101001 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Spg21.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. | G3 (Bethesda, Md.) (June 2020) | Spg21em1(IMPC)Wtsi | PMC7263671 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
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MGI Allele | Allele Type | Produced |
---|---|---|
Spg21em1(IMPC)Wtsi | Exon Deletion | Mice |
Spg21tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Spg21tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
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