Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
preweaning lethality, complete penetrance | Zmiz2tm1.1(KOMP)Vlcg | HOM | Early adult | 0.00 | ||
decreased exploration in new environment | Zmiz2tm1.1(KOMP)Vlcg | HET | Early adult | 3.77×10-05 | ||
embryonic lethality prior to organogenesis | Zmiz2tm1.1(KOMP)Vlcg | HOM | E9.5 | 0.00 | ||
embryonic lethality prior to tooth bud stage | Zmiz2tm1.1(KOMP)Vlcg | HOM | E12.5 | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Section images | heterozygote | 50% (1 of 2) |
Aorta | Section images | heterozygote | 50% (1 of 2) |
Bone marrow | Section images | heterozygote | 100% (1 of 1) |
Brain | Section images | heterozygote | 100% (2 of 2) |
Brainstem | Section images | heterozygote | 100% (2 of 2) |
Cartilage tissue | Section images | heterozygote | 50% (1 of 2) |
Cerebellum | Section images | heterozygote | 100% (2 of 2) |
Cerebral cortex | Section images | heterozygote | 100% (2 of 2) |
Esophagus | Section images | heterozygote | 50% (1 of 2) |
Eye | Section images | heterozygote | 50% (1 of 2) |
Heart | Section images | heterozygote | 50% (1 of 2) |
Hippocampus | Section images | heterozygote | 100% (2 of 2) |
Hypothalamus | Section images | heterozygote | 50% (1 of 2) |
Kidney | Section images | heterozygote | 50% (1 of 2) |
Liver | Section images | heterozygote | 50% (1 of 2) |
Lung | Section images | heterozygote | 50% (1 of 2) |
Midbrain | Section images | heterozygote | 100% (2 of 2) |
Olfactory lobe | Section images | heterozygote | 50% (1 of 2) |
Ovary | Section images | heterozygote | 50% (1 of 2) |
Oviduct | Section images | heterozygote | 50% (1 of 2) |
Pancreas | Section images | heterozygote | 50% (1 of 2) |
Pituitary gland | Section images | heterozygote | 50% (1 of 2) |
Skin | Section images | heterozygote | 50% (1 of 2) |
Spinal cord | Section images | heterozygote | 50% (1 of 2) |
Spleen | Section images | heterozygote | 50% (1 of 2) |
Striatum | Section images | heterozygote | 50% (1 of 2) |
Submandibular gland | Section images | heterozygote | 100% (2 of 2) |
Testis | Section images | heterozygote | 50% (1 of 2) |
Thalamus | Section images | heterozygote | 100% (2 of 2) |
Thymus | Section images | heterozygote | 50% (1 of 2) |
Trachea | Section images | heterozygote | 50% (1 of 2) |
Uterus | Section images | heterozygote | 50% (1 of 2) |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Epididymis | N/A | heterozygote | 0.0% (0 of 2) |
Large intestine | N/A | heterozygote | 0.0% (0 of 2) |
Lower urinary tract | N/A | heterozygote | Not available |
Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
Peripheral nervous system | N/A | heterozygote | 0.0% (0 of 2) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
Prostate gland | N/A | heterozygote | Not available |
Skeletal muscle | N/A | heterozygote | 0.0% (0 of 2) |
Small intestine | N/A | heterozygote | 0.0% (0 of 2) |
Stomach | N/A | heterozygote | 0.0% (0 of 2) |
Thyroid gland | N/A | heterozygote | 0.0% (0 of 2) |
Urinary bladder | N/A | heterozygote | 0.0% (0 of 2) |
Vascular system | N/A | heterozygote | 0.0% (0 of 2) |
Vesicular gland | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Embryo | N/A | heterozygote | 100% (2 of 2) |
Brain | N/A | heterozygote | 100% (2 of 2) |
Dorsal root ganglion | N/A | heterozygote | Ambiguous |
Ear | N/A | heterozygote | 50% (1 of 2) |
Eye | N/A | heterozygote | 100% (2 of 2) |
Footplate | N/A | heterozygote | 50% (1 of 2) |
Forebrain | N/A | heterozygote | 100% (2 of 2) |
Forelimb | N/A | heterozygote | 100% (2 of 2) |
Fronto-nasal process | N/A | heterozygote | Ambiguous |
Handplate | N/A | heterozygote | 50% (1 of 2) |
Head | N/A | heterozygote | 100% (2 of 2) |
Heart | N/A | heterozygote | Ambiguous |
Hindbrain | N/A | heterozygote | 100% (2 of 2) |
Hindlimb | N/A | heterozygote | 100% (2 of 2) |
Liver | N/A | heterozygote | Ambiguous |
Lung | N/A | heterozygote | Ambiguous |
Mandibular process | N/A | heterozygote | 100% (2 of 2) |
Maxillary process | N/A | heterozygote | 100% (2 of 2) |
Midbrain | N/A | heterozygote | 100% (2 of 2) |
Nose | N/A | heterozygote | 100% (2 of 2) |
Oral cavity | N/A | heterozygote | 50% (1 of 2) |
Skin | N/A | heterozygote | 100% (2 of 2) |
Spinal cord | N/A | heterozygote | 100% (2 of 2) |
Tail somite | N/A | heterozygote | 50% (1 of 2) |
Tail | N/A | heterozygote | 100% (2 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.7% (4 of 575) |
aorta | 0.0% |
bone marrow | 0.0% |
brain | 0.87% (5 of 577) |
brainstem | 0.35% (2 of 579) |
brown adipose tissue | 0.0% |
cartilage tissue | 0.17% (1 of 579) |
cerebellum | 0.52% (3 of 581) |
cerebral cortex | 0.35% (2 of 574) |
epididymis | 13.79% (20 of 145) |
esophagus | 1.73% (7 of 404) |
eye | 0.0% |
heart | 0.35% (2 of 571) |
hippocampus | 0.34% (2 of 586) |
hypothalamus | 0.35% (2 of 577) |
kidney | 4.66% (27 of 580) |
large intestine | 5.15% (30 of 583) |
liver | 0.0% |
lower urinary tract | 0.17% (1 of 583) |
lung | 0.34% (2 of 588) |
lymph node | 0.17% (1 of 587) |
mammary gland | 0.0% |
midbrain | 0.0% |
olfactory lobe | 0.17% (1 of 579) |
ovary | 0.17% (1 of 576) |
oviduct | 0.0% |
pancreas | 0.87% (5 of 578) |
peripheral nervous system | 0.34% (2 of 580) |
peyers patch | 0.0% |
pituitary gland | 0.17% (1 of 576) |
prostate gland | 1.89% (11 of 583) |
skeletal muscle | 0.0% |
skin | 0.17% (1 of 577) |
small intestine | 5.34% (31 of 581) |
spinal cord | 0.52% (3 of 576) |
spleen | 0.52% (3 of 581) |
stomach | 3.61% (21 of 582) |
striatum | 0.52% (3 of 582) |
submandibular gland | 1.43% (2 of 140) |
testis | 1.03% (6 of 584) |
thalamus | 0.0% |
thymus | 0.17% (1 of 582) |
thyroid gland | 3.1% (18 of 581) |
trachea | 0.34% (2 of 589) |
urinary bladder | 0.0% |
uterus | 0.35% (2 of 579) |
vascular system | 0.0% |
vesicular gland | 0.0% |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
brain | 1.17% (6 of 511) |
dorsal root ganglion | 1.67% (1 of 60) |
ear | 0.2% (1 of 511) |
embryo | 0.39% (2 of 512) |
eye | 0.2% (1 of 511) |
footplate | 0.2% (1 of 511) |
forebrain | 0.2% (1 of 511) |
forelimb | 0.2% (1 of 511) |
fronto-nasal process | 1.64% (1 of 61) |
handplate | 0.2% (1 of 511) |
head | 0.98% (5 of 511) |
heart | 0.2% (1 of 511) |
hindbrain | 1.17% (6 of 511) |
hindlimb | 0.2% (1 of 511) |
liver | 0.2% (1 of 506) |
lung | 0.2% (1 of 506) |
mandibular process | 0.2% (1 of 511) |
maxillary process | 0.2% (1 of 511) |
midbrain | 0.2% (1 of 511) |
nose | 1.28% (1 of 78) |
oral cavity | 0.2% (1 of 506) |
skin | 0.2% (1 of 511) |
spinal cord | 1.39% (1 of 72) |
tail | 0.2% (1 of 511) |
tail somite group | 0.2% (1 of 511) |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Zmiz2 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Monoamine Oxidase A Deficiency | Cognitive impairment | ORPHA:3057 |
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Zmiz2
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MGI Allele | Allele Type | Produced |
---|---|---|
Zmiz2tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice |
Zmiz2tm263109(L1L2_Bact_P) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Zmiz2tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
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