The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|preweaning lethality, complete penetrance||Tomm70aem1(IMPC)J||HOM||Early adult||0.00|
|decreased exploration in new environment||Tomm70aem1(IMPC)J||HET||Early adult||8.46×10-05|
|embryonic lethality prior to organogenesis||Tomm70aem1(IMPC)J||HOM||E9.5||0.00|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
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|MGI Allele||Allele Type||Produced|
|Tomm70atm1(KOMP)Vlcg||Reporter-tagged deletion allele (with selection cassette)||ES Cells|
|Tomm70atm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Tomm70atm1e(EUCOMM)Wtsi||Targeted, non-conditional allele||ES Cells|