The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to G6pd2 by orthology or direct annotation.
The table below shows human diseases predicted to be associated to G6pd2 by phenotypic similarity.
|Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency||
|Immunodeficiency 38 With Basal Ganglia Calcification||
||Hepatosplenomegaly, Follicular hyperplasia, Lymphadenopathy||OMIM:619126|
|Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)||
||Abnormality of the lymph nodes||OMIM:136580|
||Follicular hyperplasia, Lymphadenopathy||ORPHA:482|
|Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation||
||Absent tonsils, Lymph node hypoplasia, Aplasia of the thymus||OMIM:602450|
||Lymph node hypoplasia, Absence of lymph node germinal center||ORPHA:90186|
|T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency||
||Absent tonsils, Lymph node hypoplasia||ORPHA:276|
|Purine Nucleoside Phosphorylase Deficiency||
||Lymph node hypoplasia, Splenomegaly||OMIM:613179|
||Lymph node hypoplasia||OMIM:300755|
|Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency||
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for G6pd2
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to G6pd2.
There are 1 publication which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Proteotyping of knockout mouse strains reveals sex- and strain-specific signatures in blood plasma.||NPJ systems biology and applications (May 2021)||G6pd2em1(IMPC)Tcp||PMC8163790|
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|MGI Allele||Allele Type||Produced|
|G6pd2tm1(KOMP)Vlcg||Reporter-tagged deletion allele (with selection cassette)||Targeting vectors, ES Cells|
|G6pd2em1(IMPC)Tcp||Intra-exon deletion||Mice, Tissue|