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Gene: Npy4r MGI:105374

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
neuropeptide Y receptor Y4
Synonyms:
Ppyr1,  NYYR-D,  Y4

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Npy4r mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Npy4r by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hereditary Central Diabetes Insipidus
Weight loss, Polydipsia, Diabetes insipidus, Irritability ORPHA:30925
Central Diabetes Insipidus
Depression, Polydipsia, Failure to thrive, Weight loss, Anorexia, Diabetes insipidus ORPHA:178029
Kleine-Levin Syndrome
Depression, Polydipsia, Decreased libido, Abnormal eating behavior, Sweet craving, Irritability, ... ORPHA:33543
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity, Hyperinsulinemia, Reduced social reciprocity, Aggressive behavior, Polyphagia ORPHA:329249
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia, Diabetes mellitus OMIM:222100
Acquired Central Diabetes Insipidus
Weight loss, Polydipsia, Diabetes insipidus ORPHA:95626
Obesity Due To Melanocortin 4 Receptor Deficiency
Obesity, Hyperinsulinemia, Type II diabetes mellitus, Polyphagia, Childhood-onset truncal obesity... ORPHA:71529
Renal Glucosuria
Polyphagia, Polydipsia OMIM:233100
Body Mass Index Quantitative Trait Locus 20
Polyphagia, Obesity, Increased bone mineral density, Hyperinsulinemia OMIM:618406
Bardet-Biedl Syndrome 9
Irregular menstruation, Polydipsia, Obesity, Polyphagia, Truncal obesity OMIM:615986
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Diabetes insipidus, Polydipsia, Failure to thrive, Irritability OMIM:304800
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Nephrogenic diabetes insipidus, Polydipsia, Failure to thrive, Irritability OMIM:125800
Leptin Receptor Deficiency
Decreased response to growth hormone stimulation test, Obesity, Abnormal eating behavior, Emotion... OMIM:614963
Pediatric-Onset Graves Disease
Polydipsia, Failure to thrive, Graves disease, Goiter, Puberty and gonadal disorders, Emotional l... ORPHA:525731
Panhypophysitis
Secondary growth hormone deficiency, Decreased serum estradiol, Polydipsia, Decreased male libido... ORPHA:95513
Familial Hyperaldosteronism Type I
Polydipsia, Secretory adrenocortical adenoma, Dexamethasone-suppressible primary hyperaldosteroni... ORPHA:403
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Apparent Mineralocorticoid Excess
Polydipsia, Failure to thrive, Abnormality of circulating cortisol level, Decreased circulating r... ORPHA:320
Cystinosis
Type I diabetes mellitus, Polydipsia, Failure to thrive, Hypothyroidism, Delayed puberty, Nephrog... ORPHA:213
Nephronophthisis-Like Nephropathy 2
Polydipsia OMIM:619468
Hyperaldosteronism, Familial, Type Iii
Hyperaldosteronism, Polydipsia, Adrenal hyperplasia, Decreased circulating renin level OMIM:613677
Pituitary Dermoid And Epidermoid Cysts
Polydipsia, Increased circulating prolactin concentration, Hypogonadism, Panhypopituitarism, Amen... ORPHA:91351
Nephronophthisis 9
Polydipsia OMIM:613824
Familial Hyperaldosteronism Type Iii
Abnormal circulating renin, Polydipsia, Adrenal hyperplasia, Glucocortocoid-insensitive primary h... ORPHA:251274
Septo-Optic Dysplasia Spectrum
Polydipsia, Obesity, Cryptorchidism, Maternal diabetes, Anterior pituitary hypoplasia, Diabetes i... ORPHA:3157
Familial Cold Urticaria
Polydipsia ORPHA:47045
Ochoa Syndrome
Polydipsia, Cryptorchidism ORPHA:2704
Parathyroid Carcinoma
Chondrocalcinosis, Polydipsia, Parathyroid carcinoma, Elevated circulating parathyroid hormone le... ORPHA:143
Whipple Disease
Depression, Polydipsia, Cachexia, Hypothyroidism, Anorexia, Erectile dysfunction ORPHA:3452
Rabson-Mendenhall Syndrome
Precocious puberty, Polydipsia, Insulin-resistant diabetes mellitus, Hypertrichosis, Premature gr... ORPHA:769
Nephrogenic Diabetes Insipidus
Nephrogenic diabetes insipidus, Polydipsia, Failure to thrive, Anorexia ORPHA:223
Bardet-Biedl Syndrome 17
Hypogonadism, Obesity, Polydipsia OMIM:615994
Primary Unilateral Adrenal Hyperplasia
Glucocortocoid-insensitive primary hyperaldosteronism, Polydipsia, Adrenal hyperplasia, Decreased... ORPHA:231580
East Syndrome
Hyperaldosteronism, Salt craving, Polydipsia, Increased circulating renin level ORPHA:199343
Hyperparathyroidism, Neonatal Severe
Polydipsia, Failure to thrive, Elevated circulating parathyroid hormone level, Primary hyperparat... OMIM:239200
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Hyperaldosteronism, Abnormal circulating renin, Polydipsia, Adrenal hyperplasia ORPHA:369929
Hyperparathyroidism-Jaw Tumor Syndrome
Chondrocalcinosis, Polydipsia, Elevated circulating parathyroid hormone level, Pancreatic adenoca... ORPHA:99880
Tumoral Calcinosis, Hyperphosphatemic, Familial, 3
Polydipsia, Parathyroid hyperplasia, Elevated circulating parathyroid hormone level OMIM:617994
Teratoma, Pineal
Polydipsia OMIM:273120
Gitelman Syndrome
Chondrocalcinosis, Polydipsia, Failure to thrive, Salt craving, Delayed puberty, Increased circul... OMIM:263800
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Self-injurious behavior, Premature adrenarche, Depression, Polydipsia, Central hypothyroidism, In... ORPHA:293987
Brain-Lung-Thyroid Syndrome
Failure to thrive, Elevated circulating thyroid-stimulating hormone concentration, Congenital hyp... ORPHA:209905
Nephronophthisis 3
Polydipsia, Failure to thrive OMIM:604387
Renal Hypoplasia
Polydipsia, Small for gestational age ORPHA:93101
Oligomeganephronia
Congenital diaphragmatic hernia, Polydipsia, Small for gestational age ORPHA:2260
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Hyperaldosteronism, Salt craving, Polydipsia, Increased circulating renin level OMIM:612780
Nephronophthisis 4
Polydipsia OMIM:606966
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Gitelman Syndrome
Type I diabetes mellitus, Chondrocalcinosis, Polydipsia, Failure to thrive, Graves disease, Type ... ORPHA:358
Wolfram Syndrome
Male hypogonadism, Polydipsia, Hypogonadism, Delayed puberty, Diabetes insipidus, Diabetes mellitus ORPHA:3463
Erdheim-Chester Disease
Hypogonadotropic hypogonadism, Weight loss, Polydipsia, Diabetes insipidus ORPHA:35687
Helix Syndrome
Hyperparathyroidism, Polydipsia OMIM:617671
Nephronophthisis 1
Polydipsia OMIM:256100
Cystinosis, Nephropathic
Male hypogonadism, Polydipsia, Failure to thrive, Failure to thrive in infancy, Primary hypothyro... OMIM:219800
Infantile Nephropathic Cystinosis
Abnormality of thyroid physiology, Polydipsia, Failure to thrive ORPHA:411629
Nephronophthisis 11
Polydipsia OMIM:613550
Toxic Epidermal Necrolysis
Polydipsia, Weight loss, Dysphagia ORPHA:537
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Polydipsia, Abnormality of endocrine pancreas physiology, Hypothyroidism, Aplasia/Hypoplasia of t... ORPHA:93111
Bartter Syndrome, Type 2, Antenatal
Chondrocalcinosis, Polydipsia, Failure to thrive, Hyperaldosteronism, Hyperactive renin-angiotens... OMIM:241200
Senior-Boichis Syndrome
Aggressive behavior, Attention deficit hyperactivity disorder, Polydipsia, Agitation ORPHA:84081
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Hyperaldosteronism, Polydipsia, Failure to thrive OMIM:602522
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Juvenile Nephropathic Cystinosis
Hypothyroidism, Polydipsia, Failure to thrive ORPHA:411634
Distal Renal Tubular Acidosis
Polydipsia, Failure to thrive ORPHA:18
Hypomagnesemia 3, Renal
Polydipsia, Failure to thrive, Elevated circulating parathyroid hormone level, Hypomature enamel,... OMIM:248250
Proximal Renal Tubular Acidosis
Enamel hypomineralization, Polydipsia, Failure to thrive ORPHA:47159
Arima Syndrome
Polydipsia OMIM:243910
Autosomal Recessive Polycystic Kidney Disease
Biliary hyperplasia, Pancreatic cysts, Polydipsia ORPHA:731

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Npy4r

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Npy4r.

No publications found that use IMPC mice or data for Npy4r.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Npy4rtm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Npy4rtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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