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Gene: Npy4r MGI:105374

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
neuropeptide Y receptor Y4
Synonyms:
Ppyr1,  NYYR-D,  Y4

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Npy4r mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Npy4r by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Hereditary Central Diabetes Insipidus
Irritability, Polydipsia, Diabetes insipidus, Weight loss ORPHA:30925
Central Diabetes Insipidus
Anorexia, Weight loss, Depression, Polydipsia, Failure to thrive, Diabetes insipidus ORPHA:178029
Kleine-Levin Syndrome
Abnormal eating behavior, Repetitive compulsive behavior, Sweet craving, Hypersexuality, Decrease... ORPHA:33543
Type 1 Diabetes Mellitus
Polydipsia, Diabetes mellitus, Polyphagia OMIM:222100
Acquired Central Diabetes Insipidus
Polydipsia, Diabetes insipidus, Weight loss ORPHA:95626
Obesity Due To Melanocortin 4 Receptor Deficiency
Increased adipose tissue, Hyperinsulinemia, Obesity, Type II diabetes mellitus, Polyphagia, Child... ORPHA:71529
Obesity Due To Prohormone Convertase I Deficiency
Decreased response to growth hormone stimulation test, Increased adipose tissue, Gonadotropin def... ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Decreased response to growth hormone stimulation test, Increased adipose tissue, Gonadotropin def... ORPHA:71526
Body Mass Index Quantitative Trait Locus 20
Increased bone mineral density, Hyperinsulinemia, Polyphagia, Obesity OMIM:618406
Renal Glucosuria
Polydipsia, Polyphagia OMIM:233100
Bardet-Biedl Syndrome 9
Irregular menstruation, Obesity, Truncal obesity, Polydipsia, Polyphagia OMIM:615986
Leptin Receptor Deficiency
Diabetes mellitus, Hypergonadotropic hypogonadism, Decreased response to growth hormone stimulati... OMIM:614963
Diabetes Insipidus, Nephrogenic, 1, X-Linked
Irritability, Polydipsia, Failure to thrive, Diabetes insipidus OMIM:304800
Diabetes Insipidus, Nephrogenic, 2, Autosomal
Nephrogenic diabetes insipidus, Irritability, Polydipsia, Failure to thrive OMIM:125800
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Aggressive behavior, Hyperinsulinemia, Obesity, Impaired social interactions, Polyphagia ORPHA:329249
Pediatric-Onset Graves Disease
Hyperactivity, Puberty and gonadal disorders, Thyrotoxicosis with diffuse goiter, Increased circu... ORPHA:525731
Panhypophysitis
Decreased serum testosterone concentration, Decreased circulating cortisol level, Decreased femal... ORPHA:95513
Familial Hyperaldosteronism Type I
Adrenal hyperplasia, Abnormal circulating renin, Dexamethasone-suppressible primary hyperaldoster... ORPHA:403
Huntington Disease
Abnormal libido, Aggressive behavior, Oral-pharyngeal dysphagia, Weight loss, Depression, Irritab... ORPHA:399
Senior-Loken Syndrome 4
Polydipsia OMIM:606996
Cystinosis
Nephrogenic diabetes insipidus, Abnormal repetitive mannerisms, Delayed puberty, Type I diabetes ... ORPHA:213
Hyperaldosteronism, Familial, Type Iii
Polydipsia, Adrenal hyperplasia, Hyperaldosteronism, Decreased circulating renin level OMIM:613677
Apparent Mineralocorticoid Excess
Abnormality of circulating cortisol level, Polydipsia, Failure to thrive, Decreased circulating a... ORPHA:320
Pituitary Dermoid And Epidermoid Cysts
Enlarged pituitary gland, Neoplasm of the anterior pituitary, Panhypopituitarism, Oligozoospermia... ORPHA:91351
Nephronophthisis-Like Nephropathy 2
Polydipsia OMIM:619468
Familial Hyperaldosteronism Type Iii
Adrenal hyperplasia, Glucocortocoid-insensitive primary hyperaldosteronism, Abnormal circulating ... ORPHA:251274
Familial Cold Urticaria
Polydipsia ORPHA:47045
Septo-Optic Dysplasia Spectrum
Anterior pituitary hypoplasia, Maternal diabetes, Cryptorchidism, Obesity, Polydipsia, Abnormalit... ORPHA:3157
Ochoa Syndrome
Cryptorchidism, Polydipsia ORPHA:2704
Rabson-Mendenhall Syndrome
Reduced subcutaneous adipose tissue, Enlarged ovaries, Thick hair, Precocious puberty, Hypothyroi... ORPHA:769
Nephrogenic Diabetes Insipidus
Nephrogenic diabetes insipidus, Polydipsia, Failure to thrive, Anorexia ORPHA:223
Parathyroid Carcinoma
Pancreatic adenocarcinoma, Testicular neoplasm, Primary hyperparathyroidism, Abnormal parathyroid... ORPHA:143
Primary Unilateral Adrenal Hyperplasia
Glucocortocoid-insensitive primary hyperaldosteronism, Polydipsia, Adrenal hyperplasia, Decreased... ORPHA:231580
Whipple Disease
Cachexia, Anorexia, Depression, Erectile dysfunction, Polydipsia, Hypothyroidism ORPHA:3452
Bardet-Biedl Syndrome 17
Polydipsia, Hypogonadism, Obesity OMIM:615994
East Syndrome
Polydipsia, Salt craving, Increased circulating renin level, Hyperaldosteronism ORPHA:199343
Hyperparathyroidism, Neonatal Severe
Failure to thrive, Polydipsia, Primary hyperparathyroidism, Elevated circulating parathyroid horm... OMIM:239200
Primary Hyperaldosteronism-Seizures-Neurological Abnormalities Syndrome
Adrenal hyperplasia, Abnormal circulating renin, Hyperaldosteronism, Dexamethasone-suppressible p... ORPHA:369929
Hyperparathyroidism-Jaw Tumor Syndrome
Pancreatic adenocarcinoma, Testicular neoplasm, Primary hyperparathyroidism, Abnormal parathyroid... ORPHA:99880
Teratoma, Pineal
Polydipsia OMIM:273120
Gitelman Syndrome
Salt craving, Increased circulating renin level, Delayed puberty, Polydipsia, Failure to thrive, ... OMIM:263800
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Decreased response to growth hormone stimulation test, Central diabetes insipidus, Aggressive beh... ORPHA:293987
Brain-Lung-Thyroid Syndrome
Thyroid dysgenesis, Hypoparathyroidism, Hyperactivity, Thyroid hemiagenesis, Abnormal eating beha... ORPHA:209905
Seizures, Sensorineural Deafness, Ataxia, Impaired Intellectual Development, And Electrolyte Imbalance
Polydipsia, Salt craving, Increased circulating renin level, Hyperaldosteronism OMIM:612780
Renal Hypoplasia
Polydipsia, Small for gestational age ORPHA:93101
Oligomeganephronia
Polydipsia, Small for gestational age, Congenital diaphragmatic hernia ORPHA:2260
Secondary Non-Traumatic Avascular Necrosis
Addictive alcohol use, Abnormality of connective tissue ORPHA:399180
Hypomagnesemia 3, Renal
Polydipsia, Failure to thrive, Elevated circulating parathyroid hormone level OMIM:248250
Nephronophthisis 4
Polydipsia OMIM:606966
Senior-Loken Syndrome 3
Polydipsia OMIM:606995
Gitelman Syndrome
Neoplasm of the pancreas, Salt craving, Maternal diabetes, Diabetic ketoacidosis, Type I diabetes... ORPHA:358
Wolfram Syndrome
Diabetes mellitus, Hypogonadism, Delayed puberty, Male hypogonadism, Polydipsia, Diabetes insipidus ORPHA:3463
Helix Syndrome
Polydipsia, Hyperparathyroidism OMIM:617671
Nephronophthisis 3
Polydipsia OMIM:604387
Nephronophthisis 1
Polydipsia OMIM:256100
Erdheim-Chester Disease
Polydipsia, Hypogonadotropic hypogonadism, Diabetes insipidus, Weight loss ORPHA:35687
Cystinosis, Nephropathic
Male infertility, Hypopigmentation of hair, Diabetes mellitus, Failure to thrive in infancy, Oral... OMIM:219800
Infantile Nephropathic Cystinosis
Polydipsia, Failure to thrive, Abnormality of thyroid physiology ORPHA:411629
Nephronophthisis 11
Polydipsia OMIM:613550
Marchiafava-Bignami Disease
Depression, Addictive alcohol use, Abnormal emotion, Aggressive behavior ORPHA:221074
Hnf1B-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Diabetes mellitus, Aplasia/Hypoplasia of the pancreas, Abnormality of endocrine pancreas physiolo... ORPHA:93111
Bartter Syndrome, Type 2, Antenatal
Small for gestational age, Hyperactive renin-angiotensin system, Hyperaldosteronism, Increased ci... OMIM:241200
Toxic Epidermal Necrolysis
Polydipsia, Weight loss, Dysphagia ORPHA:537
Senior-Boichis Syndrome
Polydipsia, Agitation, Attention deficit hyperactivity disorder, Aggressive behavior ORPHA:84081
Bartter Syndrome, Type 4A, Neonatal, With Sensorineural Deafness
Polydipsia, Failure to thrive, Hyperaldosteronism OMIM:602522
Methanol Poisoning
Type I diabetes mellitus, Addictive alcohol use, Type II diabetes mellitus ORPHA:31825
Senior-Loken Syndrome 1
Polydipsia OMIM:266900
Isolated Osteopoikilosis
Abnormality of the endocrine system, Keloids, Addictive alcohol use ORPHA:166119
Juvenile Nephropathic Cystinosis
Polydipsia, Failure to thrive, Hypothyroidism ORPHA:411634
Distal Renal Tubular Acidosis
Polydipsia, Failure to thrive ORPHA:18
Proximal Renal Tubular Acidosis
Failure to thrive, Polydipsia, Enamel hypomineralization ORPHA:47159
Acute Promyelocytic Leukemia
Metrorrhagia, Addictive alcohol use, Anorexia, Weight loss ORPHA:520
Porphyria Cutanea Tarda
Diabetes mellitus, Scarring, Corneal scarring, Addictive alcohol use, Hirsutism, Hypertrichosis ORPHA:101330
Staphylococcal Necrotizing Pneumonia
Diabetes mellitus, Addictive alcohol use, Increased circulating procalcitonin concentration ORPHA:36238
Arima Syndrome
Polydipsia OMIM:243910
Acquired Aneurysmal Subarachnoid Hemorrhage
Hypothyroidism, Hypopituitarism, Addictive alcohol use ORPHA:90065
Autosomal Recessive Polycystic Kidney Disease
Biliary hyperplasia, Polydipsia, Pancreatic cysts ORPHA:731
Acute Lung Injury
Addictive alcohol use ORPHA:178320
Herpes Simplex Virus Encephalitis
Addictive alcohol use ORPHA:1930
Ethylene Glycol Poisoning
Addictive alcohol use, Euphoria ORPHA:31826
Cirrhotic Cardiomyopathy
Addictive alcohol use ORPHA:57777

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Npy4r

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Npy4r.

No publications found that use IMPC mice or data for Npy4r.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Npy4rtm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Npy4rtm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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