The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
Legacy Phenotype Associated Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cbx1.
There are 4 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.||Nature communications (August 2019)||Cbx1tm1a(EUCOMM)Wtsi||PMC6671969|
|Mouse screen reveals multiple new genes underlying mouse and human hearing loss.||PLoS biology (April 2019)||Cbx1tm1a(EUCOMM)Wtsi||PMC6459510|
|An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers.||Nucleic acids research (December 2017)||Cbx1tm1a(EUCOMM)Wtsi||PMC5716182|
|Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner.||Molecular cell (March 2015)||Cbx1tm1a(EUCOMM)Wtsi||25801166|
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|MGI Allele||Allele Type||Produced|
|Cbx1tm1(KOMP)Vlcg||Reporter-tagged deletion allele (with selection cassette)||ES Cells|
|Cbx1tm1e(EUCOMM)Wtsi||Targeted, non-conditional allele||ES Cells|
|Cbx1tm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Mice, Targeting vectors, ES Cells|