Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

placental growth factor
PLGF,  PIGF,  placenta growth factor

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Pgf mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Pgf by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Spondyloepiphyseal Dysplasia With Punctate Corneal Dystrophy
Punctate corneal dystrophy OMIM:183850
Megalocornea OMIM:249300
Corneal Dystrophy, Band-Shaped
Band-shaped corneal dystrophy OMIM:217500
Corneal Dystrophy, Fuchs Endothelial, 8
Corneal dystrophy OMIM:615523
Corneal Dystrophy, Lisch Epithelial
Corneal dystrophy OMIM:300778
Corneal Degeneration, Band-Shaped Spheroid
Corneal degeneration OMIM:217520
Anterior Segment Dysgenesis 6
Developmental glaucoma, Corneal opacity, Corneal neovascularization, Posterior synechiae of the a... OMIM:617315
Vernal Keratoconjunctivitis
Corneal neovascularization, Abnormal cornea morphology, Abnormal conjunctiva morphology, Punctate... ORPHA:70476
Limbal Stem Cell Deficiency
Decreased corneal reflex, Generalized opacification of the cornea, Opacification of the corneal e... ORPHA:171673
Corneal Hypesthesia, Familial
Decreased corneal sensation, Recurrent corneal erosions OMIM:122450
Autosomal Dominant Keratitis
Aniridia, Cataract, Keratitis, Microcornea, Opacification of the corneal stroma, Hypoplastic iris... ORPHA:2334
Cornea Plana 1, Autosomal Dominant
Flat cornea OMIM:121400
Corneal Dystrophy, Posterior Polymorphous, 2
Corneal opacity, Corneal dystrophy OMIM:609140
Corneal Dystrophy, Epithelial Basement Membrane
Map-dot-fingerprint corneal dystrophy, Recurrent corneal erosions, Corneal dystrophy OMIM:121820
Schnyder Corneal Dystrophy
Crystalline corneal dystrophy, Corneal dystrophy OMIM:121800
Central Cloudy Dystrophy Of Francois
Central corneal dystrophy, Corneal dystrophy OMIM:217600
Corneal Dystrophy, Endothelial, X-Linked
Band keratopathy, Corneal opacity, Corneal dystrophy OMIM:300779
Dermoids Of Cornea
Corneal opacity OMIM:304730
Atopic Keratoconjunctivitis
Chemosis, Corneal opacity, Keratitis, Keratoconjunctivitis sicca, Corneal neovascularization ORPHA:163934
Multiple Symmetric Lipomatosis
Abnormal adipose tissue morphology, Multiple lipomas ORPHA:2398
Palmoplantar Carcinoma, Multiple Self-Healing
Limbal stem cell deficiency, Corneal neovascularization OMIM:615225
Xeroderma Pigmentosum, Complementation Group D
Cataract, Conjunctivitis, Keratitis, Keratoconjunctivitis sicca, Corneal neovascularization, Tela... OMIM:278730
Placental Insufficiency
Maternal hypertension, Preeclampsia, Eclampsia, Small for gestational age, Abnormal placenta morp... ORPHA:439167
Corneal Dystrophy, Fuchs Endothelial, 1
Descemet Membrane Folds, Corneal degeneration, Corneal stromal edema, Corneal guttata, Corneal dy... OMIM:136800
Aniridia 1
Aniridia, Anterior subcapsular cataract, Corneal erosion, Ectopia lentis, Hypoplasia of the iris,... OMIM:106210
Autoinflammation With Arthritis And Dyskeratosis
Keratoconjunctivitis sicca, Corneal neovascularization, Punctate keratitis OMIM:617388
Mucoepithelial Dysplasia, Hereditary
Melena, Cataract, Opacification of the corneal stroma, Corneal neovascularization, Keratoconjunct... OMIM:158310
Membranoproliferative Glomerulonephritis, X-Linked
Lipodystrophy OMIM:305800
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Polyhydramnios, Large placenta, Omphalocele, Umbilical hernia, Small for gestational age, Large f... ORPHA:254534
Silver-Russell Syndrome Due To A Point Mutation
Small placenta, Inguinal hernia, Small for gestational age, Oligohydramnios ORPHA:397590
Corneal Endothelial Dystrophy
Increased corneal thickness, Congenital corneal dystrophy, Opacification of the corneal stroma, A... OMIM:217700
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Low anterior hairline, Truncal obesity, Small for gestational age, Failure to thrive, Small place... ORPHA:73272
Kid Syndrome
Keratitis, Corneal neovascularization, Corneal erosion ORPHA:477
Sclerocornea, Autosomal Dominant
Sclerocornea OMIM:181700
Brain Small Vessel Disease 1 With Or Without Ocular Anomalies
Developmental cataract, Ischemic stroke, Polycoria, Corneal opacity, Hypoplasia of the iris, Ecto... OMIM:175780
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Corneal scarring, Corneal neovascularization ORPHA:404454
Lacrimoauriculodentodigital Syndrome
Decreased corneal sensation, Limbal stem cell deficiency, Increased corneal thickness, Keratoconj... ORPHA:2363
Warburg-Cinotti Syndrome
Symblepharon, Limbal stem cell deficiency, Decreased corneal thickness, Corneal neovascularization OMIM:618175
22Q11.2 Deletion Syndrome
Gastrointestinal hemorrhage, Posterior embryotoxon, Hypertensive crisis, Cataract, Corneal neovas... ORPHA:567
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Polyhydramnios, Flexion contracture of finger, Camptodactyly, Flexion contracture, Large placenta... ORPHA:254528
Fetal Akinesia Deformation Sequence 1
Polyhydramnios, Camptodactyly of finger, Arthrogryposis multiplex congenita, Short umbilical cord... OMIM:208150
Restrictive Dermopathy
Polyhydramnios, Camptodactyly of finger, Arthrogryposis multiplex congenita, Short umbilical cord... ORPHA:1662
Neu-Laxova Syndrome 1
Polyhydramnios, Spina bifida, Short umbilical cord, Absent eyelashes, Yellow subcutaneous tissue ... OMIM:256520
Kagami-Ogata Syndrome
Polyhydramnios, Large placenta, Omphalocele, Inguinal hernia, Premature birth, Frontal hirsutism,... ORPHA:254519
Trichohepatoenteric Syndrome 1
Polyhydramnios, Sparse hair, Curly hair, Large placenta, Abnormalities of placenta or umbilical c... OMIM:222470
Restrictive Dermopathy, Lethal
Polyhydramnios, Short umbilical cord, Premature rupture of membranes, Absent eyelashes, Flexion c... OMIM:275210
Mosaic Trisomy 16
Maternal diabetes, Preeclampsia, Large placenta, Single umbilical artery, Premature birth, Small ... ORPHA:1708
Beckwith-Wiedemann Syndrome
Polyhydramnios, Large placenta, Omphalocele, Umbilical hernia, Subchorionic septal cyst, Inguinal... ORPHA:116
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Polyhydramnios, Flexion contracture of thumb, Camptodactyly, Flexion contracture, Large placenta,... ORPHA:96334
Meckel Syndrome, Type 1
Oligohydramnios, Large placenta, Omphalocele, Single umbilical artery, Breech presentation OMIM:249000


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Pgf

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pgf.

No publications found that use IMPC mice or data for Pgf.

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MGI Allele Allele Type Produced
Pgftm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Pgfem1(IMPC)Ccpcz Inter-exon deletion Mice
Pgftm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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