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Gene: Pgf MGI:105095

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Registered for phenotyping at IMPC

Phenotyping is planned for a knockout strain of this gene but data is not currently available.

Gene Summary

Name:
placental growth factor
Synonyms:
placenta growth factor,  PIGF,  PLGF

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Pgf mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Pgf by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Spondyloepiphyseal Dysplasia With Punctate Corneal Dystrophy
Punctate corneal dystrophy OMIM:183850
Corneal Dystrophy, Band-Shaped
Band-shaped corneal dystrophy OMIM:217500
Anterior Segment Dysgenesis 6
Corneal opacity, Abnormal Descemet membrane morphology, Developmental glaucoma, Posterior synechi... OMIM:617315
Corneal Dystrophy, Lisch Epithelial
Corneal dystrophy OMIM:300778
Vernal Keratoconjunctivitis
Corneal neovascularization, Abnormal cornea morphology, Abnormal conjunctiva morphology, Punctate... ORPHA:70476
Cornea Plana 1, Autosomal Dominant
Flat cornea OMIM:121400
Limbal Stem Cell Deficiency
Opacification of the corneal epithelium, Generalized opacification of the cornea, Keratitis, Corn... ORPHA:171673
Autosomal Dominant Keratitis
Cataract, Keratitis, Abnormal corneal limbus morphology, Microcornea, Hypoplastic iris stroma, Op... ORPHA:2334
Corneal Dystrophy, Posterior Polymorphous, 2
Corneal opacity, Corneal dystrophy OMIM:609140
Gelatinous Drop-Like Corneal Dystrophy
Subepithelial corneal opacities, Conjunctival amyloidosis, Corneal neovascularization, Central op... ORPHA:98957
Corneal Dystrophy, Punctiform And Polychromatic Pre-Descemet
Posterior corneal stroma punctiform multicolored opacities OMIM:619871
Schnyder Corneal Dystrophy
Corneal dystrophy, Crystalline corneal dystrophy OMIM:121800
Central Cloudy Dystrophy Of Francois
Central corneal dystrophy, Corneal dystrophy OMIM:217600
Corneal Dystrophy, Endothelial, X-Linked
Corneal opacity, Corneal dystrophy, Band keratopathy OMIM:300779
Dermoids Of Cornea
Corneal opacity OMIM:304730
Atopic Keratoconjunctivitis
Corneal opacity, Keratitis, Keratoconjunctivitis sicca, Chemosis, Corneal neovascularization ORPHA:163934
Multiple Symmetric Lipomatosis
Multiple lipomas, Abnormal adipose tissue morphology ORPHA:2398
Xeroderma Pigmentosum, Complementation Group D
Cataract, Keratitis, Telangiectasia, Keratoconjunctivitis sicca, Conjunctivitis, Corneal neovascu... OMIM:278730
Palmoplantar Carcinoma, Multiple Self-Healing
Corneal neovascularization, Limbal stem cell deficiency OMIM:615225
Corneal Dystrophy, Fuchs Endothelial, 1
Corneal dystrophy, Corneal stromal edema, Corneal guttata, Corneal degeneration, Descemet Membran... OMIM:136800
Aniridia 1
Anterior subcapsular cataract, Cataract, Ectopia lentis, Corneal erosion, Hypoplasia of the iris,... OMIM:106210
Autoinflammation With Arthritis And Dyskeratosis
Keratoconjunctivitis sicca, Corneal neovascularization, Punctate keratitis OMIM:617388
Corneal Dystrophy, Fuchs Endothelial, 8
Corneal dystrophy, Corneal guttata OMIM:615523
Placental Insufficiency
Abnormal placenta morphology, Abnormal umbilical cord blood vessel morphology, Small for gestatio... ORPHA:439167
Membranoproliferative Glomerulonephritis, X-Linked
Lipodystrophy OMIM:305800
Mucoepithelial Dysplasia, Hereditary
Cataract, Keratoconjunctivitis, Melena, Opacification of the corneal stroma, Corneal neovasculari... OMIM:158310
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Hypermethylation
Omphalocele, Small for gestational age, Polyhydramnios, Large for gestational age, Large placenta... ORPHA:254534
Corneal Endothelial Dystrophy
Abnormal Descemet membrane morphology, Increased corneal thickness, Corneal dystrophy, Opacificat... OMIM:217700
Silver-Russell Syndrome Due To A Point Mutation
Inguinal hernia, Small for gestational age, Small placenta, Oligohydramnios ORPHA:397590
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Small for gestational age, Low anterior hairline, Low posterior hairline, Truncal obesity, Small ... ORPHA:73272
Kid Syndrome
Keratitis, Corneal erosion, Keratoconjunctivitis sicca, Conjunctivitis, Corneal neovascularizatio... ORPHA:477
Brain Small Vessel Disease 1 With Or Without Ocular Anomalies
Corneal opacity, Cerebral hemorrhage, Polycoria, Retinal hemorrhage, Developmental cataract, Micr... OMIM:175780
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome
Corneal neovascularization, Corneal scarring ORPHA:404454
22Q11.2 Deletion Syndrome
Gastrointestinal hemorrhage, Cataract, Posterior embryotoxon, Corneal neovascularization, Hyperte... ORPHA:567
Warburg-Cinotti Syndrome
Corneal neovascularization, Limbal stem cell deficiency, Symblepharon, Decreased corneal thickness OMIM:618175
Lacrimoauriculodentodigital Syndrome
Increased corneal thickness, Keratoconjunctivitis, Keratoconjunctivitis sicca, Recurrent corneal ... ORPHA:2363
Fetal Akinesia Deformation Sequence 1
Hip contracture, Decreased fetal movement, Premature birth, Elbow contracture, Camptodactyly of f... OMIM:208150
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
Omphalocele, Inguinal hernia, Polyhydramnios, Large placenta, Flexion contracture, Camptodactyly,... ORPHA:254528
Restrictive Dermopathy
Decreased fetal movement, Multiple joint contractures, Premature birth, Camptodactyly of finger, ... ORPHA:1662
Neu-Laxova Syndrome 1
Decreased fetal movement, Polyhydramnios, Fetal akinesia sequence, Spina bifida, Absent eyelashes... OMIM:256520
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Keratitis, Hypertension, Recurrent corneal erosions, Opacification of the corneal stroma, Corneal... OMIM:308205
Kagami-Ogata Syndrome
Omphalocele, Inguinal hernia, Premature birth, Polyhydramnios, Large for gestational age, Large p... ORPHA:254519
Trichohepatoenteric Syndrome 1
Curly hair, Brittle hair, Small for gestational age, Polyhydramnios, Large placenta, Abnormalitie... OMIM:222470
Restrictive Dermopathy 1
Spontaneous chorioamniotic separation, Decreased fetal movement, Limb joint contracture, Prematur... OMIM:275210
Beckwith-Wiedemann Syndrome
Omphalocele, Inguinal hernia, Premature birth, Polyhydramnios, Congenital diaphragmatic hernia, L... ORPHA:116
Meckel Syndrome, Type 1
Omphalocele, Occipital encephalocele, Camptodactyly of finger, Breech presentation, Large placent... OMIM:249000
Mosaic Trisomy 16
Small for gestational age, Large placenta, Single umbilical artery, Premature birth ORPHA:1708
Greenberg Dysplasia
Nonimmune hydrops fetalis, Polyhydramnios, Echogenic fetal bowel, Large placenta, Increased nucha... OMIM:215140
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
Omphalocele, Premature birth, Interphalangeal joint contracture of finger, Polyhydramnios, Large ... ORPHA:96334

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Pgf

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Pgf.

No publications found that use IMPC mice or data for Pgf.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Pgftm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Pgftm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Pgfem1(IMPC)Ccpcz Inter-exon deletion Mice, Tissue
Pgftm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Pgftm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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