Gene: Hsd17b4

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Name
hydroxysteroid (17-beta) dehydrogenase 4
MGI ID
MGI:105089
Synonyms
perMFE-2 multifunctional protein 2 D-bifunctional protein MFE-2 MFP2 17[b]-HSD Mfp-2
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Hsd17b4em1(IMPC)Tcp HOM n/a 0.00
small uterus Hsd17b4em1(IMPC)Tcp HOM postnatal 0.00
abnormal spleen morphology Hsd17b4em1(IMPC)Tcp HOM postnatal 0.00
increased or absent threshold for auditory brainstem response Hsd17b4em1(IMPC)Tcp HOM postnatal 3.30×10-05
abnormal sternum morphology Hsd17b4em1(IMPC)Tcp HOM postnatal 0.00
abnormal eye morphology Hsd17b4em1(IMPC)Tcp HOM postnatal 0.00
enlarged adrenal glands Hsd17b4em1(IMPC)Tcp HOM postnatal 0.00

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Viewing: all phenotypes

 Expression

Expression data not available

 Associated Images

X-ray: XRay Images Dorso Ventral
15 Images
Histopathology
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
15 Images
X-ray: XRay Images Lateral Orientation
15 Images
X-ray: XRay Images Skull Lateral Orientation
15 Images
Eye Morphology: Images Slit Lamp
4 Images
Combined SHIRPA and Dysmorphology
1 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Ovary - defective growth and differentiation process Hsd17b4em1(IMPC)Tcp HOM postnatal
Eye with optic nerve - MPATH diagnostic term cataract Hsd17b4em1(IMPC)Tcp HOM postnatal
Eye with optic nerve - process of degenerative change Hsd17b4em1(IMPC)Tcp HOM postnatal
Epididymis - intracellular and extracellular depletion Hsd17b4em1(IMPC)Tcp HOM postnatal
Testes - hypoplasia Hsd17b4em1(IMPC)Tcp HOM postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Hsd17b4em1(IMPC)Tcp Indel causing a Frameshift Mutation Mice, Tissue
Hsd17b4tm40163(L1L2_gt1) Targeting vectors

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