Gene: Hsd17b4

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Name
hydroxysteroid (17-beta) dehydrogenase 4
MGI ID
MGI:105089
Synonyms
MFE-2 MFP2 multifunctional protein 2 Mfp-2 17[b]-HSD perMFE-2 D-bifunctional protein
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
small uterus Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00
abnormal eye morphology Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00
preweaning lethality, incomplete penetrance Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00
increased or absent threshold for auditory brainstem response Hsd17b4em1(IMPC)Tcp HOM Early adult 3.16×10-05
abnormal sternum morphology Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00
abnormal spleen morphology Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00
enlarged adrenal glands Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00

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Viewing: all phenotypes

 Expression

Expression data not available

 Associated Images

Histopathology
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
15 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images
X-ray: XRay Images Whole Body Lateral Orientation
15 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
15 Images
Eye Morphology: Images Ophthalmoscopy
177 Images
Eye Morphology: Images Slit Lamp
25 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - MPATH diagnostic term cataract Hsd17b4em1(IMPC)Tcp HOM Early adult
Epididymis - intracellular and extracellular depletion Hsd17b4em1(IMPC)Tcp HOM Early adult
Eye with optic nerve - process of degenerative change Hsd17b4em1(IMPC)Tcp HOM Early adult
Ovary - defective growth and differentiation process Hsd17b4em1(IMPC)Tcp HOM Early adult
Testes - hypoplasia Hsd17b4em1(IMPC)Tcp HOM Early adult

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MGI Allele Allele Type Produced
Hsd17b4em1(IMPC)Tcp Indel causing a Frameshift Mutation Mice, Tissue
Hsd17b4tm40163(L1L2_gt1) Targeting vectors

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