Gene: Hsd17b4

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Name
hydroxysteroid (17-beta) dehydrogenase 4
MGI ID
MGI:105089
Synonyms
17[b]-HSD perMFE-2 MFE-2 Mfp-2 D-bifunctional protein multifunctional protein 2 MFP2
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal eye morphology Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00
limb grasping Hsd17b4em1(IMPC)Tcp HOM Early adult 6.42×10-13
abnormal auditory brainstem response Hsd17b4em1(IMPC)Tcp HOM Early adult 0.0840
enlarged adrenal glands Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00
increased grip strength Hsd17b4em1(IMPC)Tcp HET Middle aged adult 2.61×10-09
small uterus Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00
abnormal iris morphology Hsd17b4em1(IMPC)Tcp HOM Early adult 3.53×10-06
abnormal tooth morphology Hsd17b4em1(IMPC)Tcp HOM Early adult 1.72×10-06
abnormal sternum morphology Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00
abnormal gait Hsd17b4em1(IMPC)Tcp HOM Early adult 6.42×10-13
cataract Hsd17b4em1(IMPC)Tcp HET Late adult 1.96×10-05
abnormal spleen morphology Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00
irregularly shaped pupil Hsd17b4em1(IMPC)Tcp HOM Early adult 3.98×10-06
preweaning lethality, incomplete penetrance Hsd17b4em1(IMPC)Tcp HOM Early adult 0.00

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 Expression

Expression data not available

 Associated Images

Gross Pathology and Tissue Collection
15 Images
Histopathology
12 Images
Eye Morphology: Images Ophthalmoscopy
177 Images
Immunophenotyping: Panel B FCS file(s)
6 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Eye Morphology: Images Slit Lamp
25 Images
Combined SHIRPA and Dysmorphology
1 Images
X-ray: XRay Images Skull Lateral Orientation
15 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Testes - hypoplasia Hsd17b4em1(IMPC)Tcp HOM Early adult
Eye with optic nerve - process of degenerative change Hsd17b4em1(IMPC)Tcp HOM Early adult
Eye with optic nerve - MPATH diagnostic term cataract Hsd17b4em1(IMPC)Tcp HOM Early adult
Ovary - defective growth and differentiation process Hsd17b4em1(IMPC)Tcp HOM Early adult
Epididymis - intracellular and extracellular depletion Hsd17b4em1(IMPC)Tcp HOM Early adult

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MGI Allele Allele Type Produced
Hsd17b4em1(IMPC)Tcp Indel causing a Frameshift Mutation Mice, Tissue
Hsd17b4tm40163(L1L2_gt1) Targeting vectors

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