Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

testin LIM domain protein
testin,  Tes2,  testin2,  D6Ertd352e,  Tes1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Tes mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tes by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Colorectal Cancer, Susceptibility To, 12
Colorectal polyposis, Carcinoma OMIM:615083
Lymphoma, Mucosa-Associated Lymphoid Type
Gastric lymphoma OMIM:137245
Li-Fraumeni Syndrome 2
Glioma, Meningioma, Breast carcinoma, Stomach cancer, Sarcoma OMIM:609265
Gastric Cancer
Stomach cancer OMIM:613659
Polyposis of gastric fundus without polyposis coli
Multiple gastric polyps, Abnormal gastric mucosa morphology OMIM:175505
Serrated Polyposis Syndrome
Melanoma, Prostate cancer, Biliary tract neoplasm, Colorectal polyposis, Breast carcinoma, Bladde... ORPHA:157798
Colorectal Cancer
Renal cell carcinoma, Neoplasm of the stomach, Uterine leiomyosarcoma, Hereditary nonpolyposis co... OMIM:114500
Pyloric Atresia
Congenital pyloric atresia OMIM:265950
Intrinsic Factor And R Binder, Combined Congenital Deficiency Of
Absence of intrinsic factor OMIM:243320
Melanoma-Pancreatic Cancer Syndrome
Melanoma, Pancreatic squamous cell carcinoma, Oropharyngeal squamous cell carcinoma, Pancreatic a... OMIM:606719
Reticulum Cell Sarcoma
Neoplasm, Sarcoma OMIM:267730
Gist-Plus Syndrome
Gastrointestinal stroma tumor, Intussusception, Intestinal polyposis OMIM:175510
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Gastric Adenocarcinoma And Proximal Polyposis Of The Stomach
Gastric adenocarcinoma, Melena, Fundic gland polyposis OMIM:619182
Familial Adenomatous Polyposis 1
Carcinoma, Adrenocortical adenoma, Colon cancer, Small intestine carcinoid, Multiple gastric poly... OMIM:175100
Li-Fraumeni Syndrome
Choriocarcinoma, Colon cancer, Neoplasm of the pancreas, Prostate cancer, Breast carcinoma, Osteo... OMIM:151623
Chronic Intestinal Pseudoobstruction
Intestinal malrotation, Abnormal intestine morphology, Pyloric stenosis ORPHA:2978
Muir-Torre Syndrome
Adenoma sebaceum, Renal neoplasm, Malignant genitourinary tract tumor, Neoplasm of the liver, Col... ORPHA:587
Diffuse Gastric And Lobular Breast Cancer Syndrome
Stomach cancer, Atrophic gastritis, Cleft palate OMIM:137215
Nut Midline Carcinoma
Neoplasm, Ewing sarcoma, Pancreatic squamous cell carcinoma, Leukemia, Oropharyngeal squamous cel... ORPHA:443167
Cheilitis Glandularis
Squamous cell carcinoma, Neoplasm, Abnormal salivary gland morphology ORPHA:1221
Gastrointestinal Stromal Tumor
Neoplasm of the rectum, Intestinal obstruction, Neoplasm of the stomach, Dysphagia, Gastrointesti... ORPHA:44890
Nthl1-Related Attenuated Familial Adenomatous Polyposis
Bladder neoplasm, Neoplasm of the rectum, Endometrial carcinoma, Colon cancer, Seborrheic keratos... ORPHA:454840
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Gastrointestinal Stromal Tumor
Dysphagia, Gastrointestinal stroma tumor, Intestinal obstruction, Neurofibroma OMIM:606764
Li-Fraumeni Syndrome
Colorectal polyposis, Acute lymphoblastic leukemia, Astrocytoma, Neoplasm of the central nervous ... ORPHA:524
Attenuated Familial Adenomatous Polyposis
Papilloma, Colorectal polyposis, Duodenal polyposis, Large intestinal polyposis, Neoplasm of the ... ORPHA:220460
Epidermodysplasia Verruciformis, Susceptibility To, 3
Squamous cell carcinoma, Verrucae, Basal cell carcinoma OMIM:618267
Squamous Cell Carcinoma, Head And Neck
Squamous cell carcinoma OMIM:275355
Msh3-Related Attenuated Familial Adenomatous Polyposis
Neoplasm of the rectum, Papilloma, Colon cancer, Juvenile gastrointestinal polyposis, Multiple ga... ORPHA:480536
Muir-Torre Syndrome
Benign gastrointestinal tract tumors, Benign genitourinary tract neoplasm, Adenoma sebaceum, Mali... OMIM:158320
Familial Adenomatous Polyposis 3
Bladder neoplasm, Colon cancer, Meningioma, Prostate cancer, Breast carcinoma, Pancreatic adenoca... OMIM:616415
Carney-Stratakis Syndrome
Intestinal obstruction, Dysphagia, Gastrointestinal stroma tumor, Gastrointestinal hemorrhage, Pa... ORPHA:97286
Familial Melanoma
Neoplasm of the pancreas, Melanoma, Neoplasm of the breast, Neoplasm of the stomach ORPHA:618
Apc-Related Attenuated Familial Adenomatous Polyposis
Adrenocortical adenoma, Astrocytoma, Pilomatrixoma, Papillary thyroid carcinoma, Odontoma, Adenom... ORPHA:247806
Pyloric Stenosis, Infantile Hypertrophic, 1
Pyloric stenosis OMIM:179010
Disseminated Superficial Actinic Porokeratosis
Squamous cell carcinoma ORPHA:79152
Nk-Cell Enteropathy
Lymphoproliferative disorder, Gastric ulcer, Intestinal polyp, Gastroesophageal reflux, Hematoche... ORPHA:263665
Punctate Palmoplantar Keratoderma Type 1
Renal cell carcinoma, Melanoma, Adenocarcinoma of the small intestine, Brain neoplasm, Breast car... ORPHA:79501
Maffucci Syndrome
Neoplasm of the parathyroid gland, Neoplasm of the adrenal cortex, Hemangiomatosis, Breast carcin... ORPHA:163634
Alpha-1-Antitrypsin Deficiency
Hepatocellular carcinoma, Gastric varix OMIM:613490
Infantile Myofibromatosis
Abnormal intestine morphology, Neoplasm of the pancreas, Intestinal obstruction, Neoplasm of the ... ORPHA:2591
Syndromic Recessive X-Linked Ichthyosis
Abnormal stomach morphology, Testicular seminoma, Acute leukemia ORPHA:281090
Hereditary Mixed Polyposis Syndrome
Neoplasm of the rectum, Hyperplastic colonic polyposis, Hematochezia, Juvenile colonic polyposis,... ORPHA:157794
Epidermolysis Bullosa Simplex 5C, With Pyloric Atresia
Congenital pyloric atresia OMIM:612138
Polymerase Proofreading-Related Adenomatous Polyposis
Neoplasm of the rectum, Brain neoplasm, Colorectal polyposis, Breast carcinoma, Adenomatous colon... ORPHA:447877
Esophageal Ring, Lower
Dysphagia, Hiatus hernia OMIM:133240
Familial Adenomatous Polyposis 4
Gastric adenocarcinoma, Astrocytoma, Duodenal polyposis, Uterine leiomyoma, Adenomatous colonic p... OMIM:617100
Multiple Endocrine Neoplasia, Type Iv
Carcinoma, Pancreatic endocrine tumor, Renal angiomyolipoma, Carcinoid tumor, Pituitary adenoma, ... OMIM:610755
Cowden Syndrome 1
High palate, Carcinoma, Meningioma, Breast carcinoma, Ovarian carcinoma, Hamartomatous polyposis,... OMIM:158350
Paragangliomas 4
Renal cell carcinoma, Glomus jugular tumor, Adrenal pheochromocytoma, Chemodectoma, Extraadrenal ... OMIM:115310
Gardner Syndrome
Adrenocortical adenoma, Astrocytoma, Pilomatrixoma, Papillary thyroid carcinoma, Odontoma, Adenom... ORPHA:79665
Epidermolysis Bullosa, Junctional 6, With Pyloric Atresia
Congenital pyloric atresia, Esophageal stenosis OMIM:619817
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease
Hepatocellular carcinoma, Burkitt lymphoma, Colon cancer, T-cell lymphoma, Acute lymphoblastic le... ORPHA:158057
Oculogastrointestinal Muscular Dystrophy
Abnormality of the gastrointestinal tract, Malabsorption, Spontaneous esophageal perforation, Int... ORPHA:1876
Juvenile Polyposis Syndrome
Hematochezia, Colon cancer, Multiple gastric polyps, Neoplasm of the stomach, Intussusception, Re... OMIM:174900
Ménétrier Disease
Gastroesophageal reflux, Multiple gastric polyps, Helicobacter pylori infection, Stomach cancer, ... ORPHA:2494
Hyperkeratosis Lenticularis Perstans
Squamous cell carcinoma, Basal cell carcinoma ORPHA:409
Sucrosuria, Hiatus Hernia, And Impaired Intellectual Development
Hiatus hernia OMIM:272000
Intrinsic Factor Deficiency
Absence of intrinsic factor OMIM:261000
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Squamous cell carcinoma OMIM:613736
Palmoplantar Carcinoma, Multiple Self-Healing
Squamous cell carcinoma, Carcinoma OMIM:615225
Junctional Epidermolysis Bullosa Inversa
Gastrointestinal inflammation, Squamous cell carcinoma, Cutaneous melanoma, Basal cell carcinoma ORPHA:79405
Ornithine Transcarbamylase Deficiency
Pyloric stenosis ORPHA:664
Oncogenic Osteomalacia
Giant cell tumor of bone, Carcinoma, Neoplasm of head and neck, Osteosarcoma, Neurofibroma, Neopl... ORPHA:352540
Paraneoplastic Pemphigus
Thymoma, B-cell lymphoma, Sarcoma ORPHA:63455
Combined Immunodeficiency Due To Dock8 Deficiency
Squamous cell carcinoma, Verrucae, Anal canal squamous carcinoma, Squamous cell carcinoma of the ... ORPHA:217390
Familial Adenomatous Polyposis
Adenocarcinoma of the small intestine, Colorectal polyposis, Astrocytoma, Papillary thyroid carci... ORPHA:733
Xeroderma Pigmentosum Variant
Squamous cell carcinoma, Melanoma, Basal cell carcinoma ORPHA:90342
Late-Onset Junctional Epidermolysis Bullosa
Gastrointestinal inflammation, Squamous cell carcinoma, Cutaneous melanoma, Basal cell carcinoma ORPHA:79406
Desmoplastic Small Round Cell Tumor
Ileus, Neoplasm of the pancreas, Neoplasm of the lung, Ovarian neoplasm, Neoplasm of the central ... ORPHA:83469
Schöpf-Schulz-Passarge Syndrome
Ovarian neoplasm, Squamous cell carcinoma, Basal cell carcinoma ORPHA:50944
Carney Triad
Adrenocortical adenoma, Pheochromocytoma, Gastrointestinal stroma tumor, Gastrointestinal hemorrh... ORPHA:139411
Bronchogenic Cyst
Dysphagia, Abnormal esophagus morphology, Abnormal stomach morphology ORPHA:2357
Recessive Dystrophic Epidermolysis Bullosa Inversa
Gastrointestinal inflammation, Cutaneous melanoma, Esophageal stricture, Basal cell carcinoma, Sq... ORPHA:79409
Epidermolysis Bullosa Dystrophica, Autosomal Recessive
Squamous cell carcinoma, Esophageal stricture, Dysphagia, Abnormal esophagus morphology, Spontane... OMIM:226600
Dubin-Johnson Syndrome
Abnormal gastric mucosa morphology ORPHA:234
Aicardi Syndrome
Hemangioma, Carcinoma, Metastatic angiosarcoma, Hiatus hernia, Hepatoblastoma, Cleft palate, Lipo... OMIM:304050
Dyskeratosis Congenita, X-Linked
Oral leukoplakia, Carcinoma, Anal mucosal leukoplakia, Esophageal stricture, Myelodysplasia, Orop... OMIM:305000
Palmoplantar Hyperkeratosis With Squamous Cell Carcinoma Of Skin And 46,Xx Sex Reversal
Carcinoma, Laryngeal carcinoma OMIM:610644
Hepatoportal Sclerosis
Gastric varix, Gastrointestinal hemorrhage, Esophageal varix, Hepatocellular carcinoma ORPHA:64743
Abnormality of the gastrointestinal tract, Gastroesophageal reflux, Abnormal small intestine morp... ORPHA:801
Lymphoma, Pinealoma, Ewing sarcoma, Leukemia, Cleft palate, Osteosarcoma, Retinoblastoma OMIM:180200
Systemic Sclerosis
Abnormality of the gastrointestinal tract, Gastroesophageal reflux, Abnormal small intestine morp... ORPHA:90291
Common Variable Immunodeficiency
Gastrointestinal stroma tumor, Anal atresia, Lymphoma ORPHA:1572
Epidermodysplasia Verruciformis
Squamous cell carcinoma, Verrucae ORPHA:302
Epidermolysis Bullosa, Junctional 5B, With Pyloric Atresia
Congenital pyloric atresia, Esophageal atresia OMIM:226730
Microgastria-Limb Reduction Defect Syndrome
Esophageal atresia, Anal atresia, Gastroesophageal reflux, Intestinal malrotation, Rectal atresia... ORPHA:2538
Congenital Tracheal Stenosis
Anal atresia, Duodenal atresia, Abnormal stomach morphology, Morphological abnormality of the gas... ORPHA:141127
Metachromatic Leukodystrophy
Neoplasm of the gallbladder, Intussusception, Abnormal stomach morphology, Abnormal duodenum morp... ORPHA:512
Xeroderma Pigmentosum, Variant Type
Squamous cell carcinoma, Cutaneous melanoma, Basal cell carcinoma OMIM:278750
17Q11 Microdeletion Syndrome
Optic nerve glioma, Cerebellar glioma, Glioma, Brain neoplasm, Glomus jugular tumor, Multiple muc... ORPHA:97685
Neoplasm, Breast carcinoma, Gastrointestinal stroma tumor, Lymphoma, Lung adenocarcinoma ORPHA:221
Necrotizing Encephalomyelopathy, Subacute, Of Leigh, Adult
Gastric ulcer, Gastric hypertrophy OMIM:161700
Junctional Epidermolysis Bullosa With Pyloric Atresia
Congenital pyloric atresia, Intestinal atresia ORPHA:79403
Hardikar Syndrome
Bilateral cleft lip and palate, Unilateral cleft palate, Celiac disease, Esophageal varix, Hemate... OMIM:301068
Viss Syndrome
Macroglossia, High palate, Gastroesophageal reflux, Broad uvula, Bifid uvula, Duodenitis, High, n... OMIM:619472


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tes

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tes.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Thymic-specific regulation of TCR signaling by Tespa1. Cellular & molecular immunology (July 2019) Tespa1tm2a(EUCOMM)Hmgu 31316154

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MGI Allele Allele Type Produced
Testm43185(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Testm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Testm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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