Gene: Hsd17b1

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Name
hydroxysteroid (17-beta) dehydrogenase 1
MGI ID
MGI:105077
Synonyms
17beta-HSD Hsd17ba
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
improved glucose tolerance Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 7.74×10-05
abnormal sleep behavior Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 4.61×10-12
increased circulating alkaline phosphatase level Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 1.76×10-06
abnormal motor coordination/balance Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 1.45×10-06
abnormal lens morphology Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 1.74×10-14
impaired righting response Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 3.45×10-11
decreased circulating chloride level Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 3.67×10-05
decreased circulating glucose level Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 3.50×10-06
male infertility Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 0.00
increased circulating potassium level Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 2.75×10-08
decreased exploration in new environment Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 2.05×10-05
abnormal behavior Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 3.85×10-09
decreased mean corpuscular hemoglobin Hsd17b1tm1.1(KOMP)Vlcg HOM Early adult 2.81×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Epididymis 2 No  (18/134) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Submandibular gland 2 No  (2/132)  (1/2) N/A
Testis 2 No  (2/584) N/A
Thalamus 2 No N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No  (2/2) N/A
Urinary bladder 2 No N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504) N/A
Dorsal root ganglion 2  (1/57) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505) N/A
Eye 2  (1/504) N/A
Foot 2  (1/504) N/A
Forebrain 2  (1/504) N/A
Forelimb 2  (1/504) N/A
Fronto-nasal process 2  (1/58) N/A
Hand 2  (1/503) N/A
Head 2  (5/504) N/A
Heart 2  (1/504) N/A
Hindbrain 2  (6/504) N/A
Hindlimb 2  (1/503) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500) N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504) N/A
Nose 2  (1/70) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/504) N/A
Spinal cord 2  (1/69) N/A
Tail 2  (1/504) N/A
Tail somite 2  (1/504) N/A

 Associated Images

Sleep Wake: Wake state (bmp file)
16 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
Eye Morphology: Images Ophthalmoscopy
22 Images
Electroretinography 2: Rod and cone PDF
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Hsd17b1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Hsd17b1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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