Gene: Lepr

Name
leptin receptor
MGI ID
MGI:104993
Synonyms
OB-RGRP leptin receptor gene-related protein Obr obl Modb1 Leprb LEPROT obese-like
Viability
Homozygous - Viable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
male infertility Leprtm1b(EUCOMM)Wtsi HOM postpartum stage 0.00
abnormal behavior Leprtm1b(EUCOMM)Wtsi HOM postnatal 1.44×10-27
increased hematocrit Leprtm1b(EUCOMM)Wtsi HOM postnatal 1.01×10-11
trunk curl Leprtm1b(EUCOMM)Wtsi HOM postnatal 6.15×10-23
abnormal gait Leprtm1b(EUCOMM)Wtsi HOM postnatal 7.69×10-18
female infertility Leprtm1b(EUCOMM)Wtsi HOM postpartum stage 0.00
increased neutrophil cell number Leprtm1b(EUCOMM)Wtsi HOM postnatal 2.28×10-05
thrombocytopenia Leprtm1b(EUCOMM)Wtsi HOM postnatal 2.12×10-11
increased hemoglobin content Leprtm1b(EUCOMM)Wtsi HOM postnatal 1.68×10-06
impaired righting response Leprtm1b(EUCOMM)Wtsi HOM postnatal 2.83×10-21
hypoactivity Leprtm1b(EUCOMM)Wtsi HOM postnatal 4.07×10-29
decreased leukocyte cell number Leprtm1b(EUCOMM)Wtsi HOM postnatal 6.70×10-08
decreased lymphocyte cell number Leprtm1b(EUCOMM)Wtsi HOM postnatal 1.59×10-11
abnormal locomotor behavior Leprtm1b(EUCOMM)Wtsi HOM postnatal 1.24×10-16
increased mean platelet volume Leprtm1b(EUCOMM)Wtsi HOM postnatal 1.58×10-11
limb grasping Leprtm1b(EUCOMM)Wtsi HOM postnatal 6.13×10-23
tremors Leprtm1b(EUCOMM)Wtsi HOM postnatal 8.54×10-16
increased monocyte cell number Leprtm1b(EUCOMM)Wtsi HOM postnatal 1.26×10-18

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Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No N/A
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (1/2)  Wholemount images
Brainstem 2 No  (1/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No N/A
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (2/4) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (4/4) N/A
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (4/4) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485)  (1/4) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485)  (2/4) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485)  (3/4) N/A
Tail somite 2  (1/485) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
8 Images
Adult LacZ: LacZ Images Wholemount
8 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Liver - lipid deposition Leprtm1b(EUCOMM)Wtsi HOM postnatal
Pancreas - hypertrophy Leprtm1b(EUCOMM)Wtsi HOM postnatal
Skin - hypertrophy Leprtm1b(EUCOMM)Wtsi HOM postnatal
Skeletal muscle - fatty infiltration Leprtm1b(EUCOMM)Wtsi HOM postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Leprtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Leprtm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Leprtm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells