Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
adenosine A3 receptor
Synonyms:
A3R,  ARA3,  1700001D09Rik,  Gpcr 2,  A3AR,  AA3R,  4930578J19Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Adora3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Adora3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Pseudoxanthomatous Diffuse Cutaneous Mastocytosis
Cutaneous mastocytosis ORPHA:280794
Neutrophil Immunodeficiency Syndrome
Abnormality of neutrophil physiology, Leukocytosis ORPHA:183707
Carbimazole Sensitivity
Drug-induced agranulocytosis OMIM:212060
Granulomatous disease with defect in neutrophil chemotaxis
Impaired neutrophil killing of staphylococci OMIM:233670
Immunodeficiency 86
Decreased circulating IgG level, Impaired oxidative burst, Increased circulating IgM level OMIM:619549
Undritz Anomaly
Hypersegmentation of neutrophil nuclei OMIM:191500
Mastocytosis, Cutaneous
Cutaneous mastocytosis OMIM:154800
Indolent Systemic Mastocytosis
Mastocytosis, Increased proportion of CD25+ mast cells, Splenomegaly, Abnormal mast cell morphology ORPHA:98848
Renal Failure, Progressive, With Hypertension
Nephritis, Elevated circulating creatinine concentration, Stage 5 chronic kidney disease, Renal i... OMIM:161900
Mast Cell Sarcoma
Mastocytosis, Splenomegaly ORPHA:66661
Specific Granule Deficiency 1
Increased neutrophil mitochondria, Increased neutrophil ribosomes, Absent neutrophil lactoferrin,... OMIM:245480
Supravalvular Aortic Stenosis
Supravalvular aortic stenosis, Angina pectoris, Arrhythmia, Syncope, Hypertension, Systolic heart... ORPHA:3193
Bullous Diffuse Cutaneous Mastocytosis
Cutaneous mastocytosis ORPHA:280785
Tubulointerstitial Kidney Disease, Autosomal Dominant, 5
Focal segmental glomerulosclerosis, Nephropathy, Chronic kidney disease, Elevated circulating cre... OMIM:617056
Focal Facial Dermal Dysplasia Type Iv
Abnormal mast cell morphology ORPHA:398189
Interstitial Nephritis, Karyomegalic
Nephronophthisis, Glycosuria, Renal tubular cyst, Elevated circulating creatinine concentration, ... OMIM:614817
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5
Acute kidney injury, Anuria, Microangiopathic hemolytic anemia, Elevated circulating creatinine c... OMIM:612925
C3 Glomerulopathy
Chronic kidney disease, Acute kidney injury, Glomerular extracapillary hypercellularity, Paraprot... ORPHA:329918
Aggressive Systemic Mastocytosis
Hepatosplenomegaly, Pancytopenia, Hypersplenism, Leukocytosis, Increased proportion of CD25+ mast... ORPHA:98850
Idiopathic Non-Lupus Full-House Nephropathy
Acute kidney injury, Elevated circulating creatinine concentration, Abnormal glomerular mesangium... ORPHA:567544
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 4
Acute kidney injury, Anuria, Microangiopathic hemolytic anemia, Elevated circulating creatinine c... OMIM:612924
Thrombotic Thrombocytopenic Purpura
Acute kidney injury, Microangiopathic hemolytic anemia, Renal insufficiency, Reticulocytosis, Hem... ORPHA:54057
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 3
Acute kidney injury, Anuria, Microangiopathic hemolytic anemia, Elevated circulating creatinine c... OMIM:612923
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 2
Acute kidney injury, Anuria, Microangiopathic hemolytic anemia, Elevated circulating creatinine c... OMIM:612922
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6
Acute kidney injury, Anuria, Microangiopathic hemolytic anemia, Elevated circulating creatinine c... OMIM:612926
Cardiomyopathy, Familial Hypertrophic, 2
Hypertrophic cardiomyopathy, Reduced left ventricular ejection fraction, Angina pectoris, Atrial ... OMIM:115195
Glaucoma 1, Primary Open Angle, C
Ocular hypertension OMIM:601682
Cardiomyopathy, Familial Hypertrophic, 13
Left anterior fascicular block, Concentric hypertrophic cardiomyopathy, Hypertrophic cardiomyopat... OMIM:613243
Adenine Phosphoribosyltransferase Deficiency
Oliguria, Elevated circulating creatinine concentration, Urolithiasis, Renal insufficiency, 2,8-d... OMIM:614723
Immunodeficiency 73A With Defective Neutrophil Chemotaxis And Leukocytosis
Abnormally low T cell receptor excision circle level, Reduction of neutrophil motility, Rectal ab... OMIM:608203
Cardiomyopathy, Familial Hypertrophic, 11
Left anterior fascicular block, Atrial flutter, Congestive heart failure, Hypertrophic cardiomyop... OMIM:612098
Nephronophthisis-Like Nephropathy 2
Elevated circulating creatinine concentration, Stage 5 chronic kidney disease, Renal insufficienc... OMIM:619468
Cutaneous Mastocytosis, Conductive Hearing Loss And Microtia
Cutaneous mastocytosis OMIM:248910
Hypouricemia, Renal, 1
Hypouricemia, Acute kidney injury, Oliguria, Renal cortical hyperechogenicity, Elevated circulati... OMIM:220150
Ichthyosis, Impaired Intellectual Development, Dwarfism, And Renal Impairment
Nephropathy, Elevated circulating creatinine concentration, Decreased glomerular filtration rate OMIM:242530
Immunodeficiency, Developmental Delay, And Hypohomocysteinemia
Hypohomocysteinemia, Hypocystinemia, Decreased circulating IgA level, Decreased serum creatinine,... OMIM:617744
Pulmonary Hypertension, Primary, 5
Angina pectoris, Pulmonary arterial hypertension, Syncope, Right ventricular failure OMIM:265400
Systemic Mastocytosis With Associated Hematologic Neoplasm
Normocytic anemia, Chronic myelomonocytic leukemia, Leukocytosis, Splenomegaly, Chronic lymphatic... ORPHA:98849
Glaucoma 1, Open Angle, F
Ocular hypertension OMIM:603383
Immunodeficiency 81
Abnormally low T cell receptor excision circle level, Autoimmune hemolytic anemia, Abscess, Decre... OMIM:619374
Immunodeficiency 32B
Hypoalbuminemia, Impaired oxidative burst, Abnormal circulating IgG level, Splenomegaly, Eosinoph... OMIM:226990
Cardiomyopathy, Familial Hypertrophic, 17
Hypertrophic cardiomyopathy, Palpitations, Angina pectoris, Ventricular tachycardia, Atrial fibri... OMIM:613873
Glaucoma 3, Primary Congenital, E
Ocular hypertension OMIM:617272
Familial Cutaneous Collagenoma
Angina pectoris, Cardiomyopathy, Congestive heart failure ORPHA:53296
Hypoxanthine Guanine Phosphoribosyltransferase Partial Deficiency
Nephropathy, Acute kidney injury, Elevated circulating creatinine concentration, Renal insufficie... ORPHA:79233
Multifocal Atrial Tachycardia
Hypotension, Atrial flutter, Hypertrophic cardiomyopathy, Effort-induced polymorphic ventricular ... ORPHA:3282
Senior-Loken Syndrome 1
Nephronophthisis, Elevated circulating creatinine concentration, Stage 5 chronic kidney disease, ... OMIM:266900
Tako-Tsubo Cardiomyopathy
Atrial fibrillation, Hypotension, Cardiogenic shock, Prolonged QTc interval, Palpitations, Mitral... ORPHA:66529
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Impaired renal uric acid clearance, Tubular basement membrane disintegration, Renal hypoplasia, E... OMIM:174000
Coronary Arterial Fistula
Aortic valve stenosis, Bacterial endocarditis, Continuous heart murmur, Congestive heart failure,... ORPHA:2041
Congenital Disorder Of Glycosylation, Type Iic
Reduction of neutrophil motility, Neutrophilia OMIM:266265
Renal Tubular Acidosis, Distal, 1
Nephrocalcinosis, Elevated circulating creatinine concentration, Distal renal tubular acidosis, H... OMIM:179800
Fixed Subaortic Stenosis
Aortic regurgitation, Bacterial endocarditis, Congestive heart failure, Paroxysmal atrial fibrill... ORPHA:3092
Microphthalmia, Isolated 6
Ocular hypertension OMIM:613517
Nephrogenic Syndrome Of Inappropriate Antidiuresis
Hypernatriuria, Decreased circulating renin level, Hyponatremia, Hyposthenuria, Reduced blood ure... OMIM:300539
Attrv122I Amyloidosis
Aortic valve stenosis, Abnormal atrioventricular conduction, Restrictive cardiomyopathy, Congesti... ORPHA:85451
Cryoglobulinemia, Familial Mixed
Chronic kidney disease, Elevated circulating creatinine concentration, Hematuria, Proteinuria, Ab... OMIM:123550
Relapsing Fever
Acute kidney injury, Abnormality of the urinary system, Increased total bilirubin, Elevated circu... ORPHA:91547
Fanconi Renotubular Syndrome 3
Aminoaciduria, Glycosuria, Elevated circulating creatinine concentration, Low-molecular-weight pr... OMIM:615605
Congenital Aortic Valve Stenosis
Aortic valve stenosis, Abnormal pulse pressure, Increased QRS voltage, Abnormal T-wave, Reduced l... ORPHA:3093
Congenital Tricuspid Stenosis
Hypotension, Congestive heart failure, Tricuspid regurgitation, Pulmonary arterial hypertension, ... ORPHA:95459
Hemolytic Uremic Syndrome, Atypical, 8, With Rhizomelic Short Stature
Hyperechogenic kidneys, Lymphopenia, Leukopenia, Elevated circulating creatinine concentration, R... OMIM:301110
Macrophage Activation Syndrome
Abnormal circulating interleukin concentration, Hemophagocytosis, Abnormality of tumor necrosis f... ORPHA:158061
Hyperlipidemia Due To Hepatic Triacylglycerol Lipase Deficiency
Angina pectoris ORPHA:140905
Necrobiosis Lipoidica
Abnormality of neutrophil physiology, Granuloma ORPHA:542592
Cardiomyopathy, Familial Restrictive, 3
Hypotension, Restrictive cardiomyopathy, Reduced left ventricular ejection fraction, Left axis de... OMIM:612422
Nephronophthisis 2
Nephronophthisis, Hyperechogenic kidneys, Elevated circulating creatinine concentration, Stage 5 ... OMIM:602088
Preeclampsia
Chronic kidney disease, Acute kidney injury, Elevated circulating creatinine concentration, Renal... ORPHA:275555
Thrombotic Thrombocytopenic Purpura, Hereditary
Microangiopathic hemolytic anemia, Elevated circulating creatinine concentration, Reticulocytosis... OMIM:274150
Immunodeficiency 108 With Autoinflammation
Impaired neutrophil chemotaxis, Hyposegmentation of neutrophil nuclei OMIM:260570
Partial Atrioventricular Septal Defect
Aortic valve stenosis, Bacterial endocarditis, Atrial flutter, Transient ischemic attack, Palpita... ORPHA:1330
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Acute kidney injury, Anuria, Microangiopathic hemolytic anemia, Elevated circulating creatinine c... OMIM:235400
Brachydactyly, Coloboma, And Anterior Segment Dysgenesis
Ocular hypertension OMIM:610023
Combined Oxidative Phosphorylation Deficiency 34
Elevated circulating creatinine concentration, Pancytopenia, Increased blood urea nitrogen OMIM:617872
Hepatic Lipase Deficiency
Angina pectoris OMIM:614025
Pseudoxanthoma Elasticum
Gastrointestinal hemorrhage, Restrictive cardiomyopathy, Congestive heart failure, Mitral stenosi... OMIM:264800
Hutchinson-Gilford Progeria Syndrome
Angina pectoris, Myocardial infarction, Congestive heart failure OMIM:176670
Obesity Due To Sim1 Deficiency
Hypotension, Postural hypotension with compensatory tachycardia ORPHA:369873
Autosomal Dominant Polycystic Kidney Disease
Chronic kidney disease, Abnormal urinary electrolyte concentration, Recurrent urinary tract infec... ORPHA:730
Irvan Syndrome
Ocular hypertension ORPHA:209943
Osteopetrosis, Autosomal Recessive 9
Anemia, Elevated circulating creatinine concentration, Hyperkalemia, Stage 3 chronic kidney disease OMIM:620366
Chédiak-Higashi Syndrome
Abnormality of neutrophil physiology, Hemophagocytosis, Abnormal natural killer cell morphology, ... ORPHA:167
Familial Hemophagocytic Lymphohistiocytosis
Hemophagocytosis, Abnormality of tumor necrosis factor secretion, Increased circulating interfero... ORPHA:540
Megalocornea
Abnormal intraocular pressure OMIM:309300
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Granuloma, Lymphopenia, Hepatosplenomegaly, Impaired oxidative burst, Abscess, Splenomegaly, Peri... OMIM:618935
Hereditary Amyloidosis With Primary Renal Involvement
Nephropathy, Abnormal urinary electrolyte concentration, Elevated circulating creatinine concentr... ORPHA:85450
Renal Tubular Acidosis, Proximal
Elevated circulating creatinine concentration, Hypercalciuria, Proximal renal tubular acidosis OMIM:179830
Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency
Nonspherocytic hemolytic anemia, Spontaneous hemolytic crises, Splenomegaly, Impaired neutrophil ... OMIM:613470
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease
Recurrent urinary tract infections, Elevated circulating creatinine concentration, Stage 5 chroni... OMIM:613095
Aapoaiv Amyloidosis
Chronic kidney disease, Renal amyloidosis, Paraproteinemia, Elevated circulating creatinine conce... ORPHA:439232
Fish-Eye Disease
Angina pectoris ORPHA:79292
Diffuse Alveolar Hemorrhage
Elevated circulating creatinine concentration, Leukocytosis, Hematuria, Proteinuria, Thrombocytop... ORPHA:90060
Coenzyme Q10 Deficiency, Primary, 8
Elevated circulating creatinine concentration, Abnormal renal corticomedullary differentiation, R... OMIM:616733
Nipah Virus Disease
Hypotension, Infectious encephalitis ORPHA:99825
Microcoria, Congenital
Ocular hypertension OMIM:156600
Cerebral Creatine Deficiency Syndrome 2
Elevated circulating guanidinoacetic acid concentration, Decreased serum creatinine OMIM:612736
Catastrophic Antiphospholipid Syndrome
Pulmonary embolism, Arterial occlusion, Transient ischemic attack, Abnormal heart valve physiolog... ORPHA:464343
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Hennekam-Beemer Syndrome
Mastocytosis ORPHA:2135
Oligomeganephronia
Unilateral renal agenesis, Abnormal nephron morphology, Glomerulomegaly, Bilateral renal hypoplas... ORPHA:2260
Multiple Myeloma
Nephropathy, Nephrotic syndrome, Acute kidney injury, Elevated circulating creatinine concentrati... ORPHA:29073
Adult Acute Respiratory Distress Syndrome
Increased circulating interleukin 6 concentration, Abnormal circulating interleukin concentration... ORPHA:70578
Weill-Marchesani Syndrome 3
Ocular hypertension OMIM:614819
Neovascular Glaucoma
Ocular hypertension ORPHA:94058
Juvenile Nephropathic Cystinosis
Hypouricemia, Aminoaciduria, Renal phosphate wasting, Chronic kidney disease, Proximal tubulopath... ORPHA:411634
Neuhauser Syndrome
Abnormal intraocular pressure, Hypercholesterolemia OMIM:249310
Short-Rib Thoracic Dysplasia 5 With Or Without Polydactyly
Renal hypoplasia, Elevated circulating creatinine concentration, Stage 5 chronic kidney disease, ... OMIM:614376
Infant Acute Respiratory Distress Syndrome
Pneumonia, Hypotension, Bradycardia, Tachycardia, Cardiac arrest ORPHA:70587
Hypomagnesemia 3, Renal
Chronic kidney disease, Hyperphosphatemia, Hematuria, Macroscopic hematuria, Abnormal circulating... OMIM:248250
Birdshot Chorioretinopathy
Ocular hypertension ORPHA:179
Cardiogenic Shock
Hypotension, Right ventricular failure, Abnormal left ventricular function, Congestive heart fail... ORPHA:97292
Acute Lung Injury
Increased circulating interleukin 6 concentration, Abnormal circulating cytokine concentration, A... ORPHA:178320
Papillorenal Syndrome
Chronic kidney disease, Multicystic kidney dysplasia, Renal hypoplasia, Horseshoe kidney, Elevate... OMIM:120330
Igg4-Related Retroperitoneal Fibrosis
Normocytic anemia, Acute kidney injury, Elevated circulating creatinine concentration, Unilateral... ORPHA:49041
Coach Syndrome 2
Elevated circulating creatinine concentration, Hyperechogenic kidneys OMIM:619111
Pseudoxanthoma Elasticum
Acne, Gastrointestinal hemorrhage, Restrictive cardiomyopathy, Skin rash, Angina pectoris, Telang... ORPHA:758
Fabry Disease
Congestive heart failure, Transient ischemic attack, Angina pectoris, Arrhythmia, Hypertension, M... OMIM:301500
Congenital Disorder Of Glycosylation, Type Iit
Urinary incontinence, Hypotriglyceridemia, Iron deficiency anemia, Decreased HDL cholesterol conc... OMIM:618885
Perry Syndrome
Hypotension ORPHA:178509
Chediak-Higashi Syndrome
Hemophagocytosis, Leukopenia, Giant neutrophil granules, Splenomegaly, Abnormal dense granules, N... OMIM:214500
Snakebite Envenomation
Epistaxis, Hypotension, Cardiogenic shock, Cerebral ischemia, Tachycardia, Intracranial hemorrhag... ORPHA:449285
Juvenile Dermatomyositis
Vasculitis, Gastrointestinal hemorrhage, Cardiomyopathy, Bundle branch block, Skin rash, Myositis... ORPHA:93672
Sweet Syndrome
Abnormal circulating interleukin concentration, Abnormality of tumor necrosis factor secretion, L... ORPHA:3243
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Abnormally low T cell receptor excision circle level, Decreased circulating IgG level, Lymphopeni... OMIM:618986
Analbuminemia
Hypotension OMIM:616000
Cutaneous Mastocytoma
Telangiectasia of the skin, Hypotension, Telangiectasia macularis eruptiva perstans, Maculopapula... ORPHA:79455
Hydroxykynureninuria
Tachycardia, Hypotension, Stomatitis ORPHA:79155
Dengue Fever
Epistaxis, Hypotension, Gastrointestinal hemorrhage, Skin rash, Cerebral hemorrhage ORPHA:99828
Glaucoma, Primary Closed-Angle
Ocular hypertension OMIM:618880
Car T Cell Therapy-Associated Cytokine Release Syndrome
Hypotension, Reduced left ventricular ejection fraction, Skin rash, Increased inflammatory respon... ORPHA:542323
Polycythemia Vera
Epistaxis, Gastrointestinal hemorrhage, Pulmonary embolism, Budd-Chiari syndrome, Portal hyperten... ORPHA:729
Igg4-Related Kidney Disease
Chronic kidney disease, Increased circulating IgE level, Urethritis, Hematuria, Elevated circulat... ORPHA:449395
Pauci-Immune Glomerulonephritis
Acute kidney injury, Elevated circulating creatinine concentration, Decreased glomerular filtrati... ORPHA:93126
Apolipoprotein A-I Deficiency
Angina pectoris ORPHA:425
Tubulointerstitial Nephritis And Uveitis Syndrome
Normocytic anemia, Aminoaciduria, Beta 2-microglobulinuria, Sterile pyuria, Elevated circulating ... ORPHA:91500
Glaucoma 3, Primary Congenital, A
Ocular hypertension OMIM:231300
Scrub Typhus
Hypotension, Skin rash, Infectious encephalitis, Myocarditis, Anterior uveitis ORPHA:83317
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Renal dysplasia, Increased total bilirubin, Elevated circulating creatinine concentration, Decrea... OMIM:608836
Congenital Disorder Of Glycosylation, Type Ih
Anemia, Elevated circulating creatinine concentration, Thrombocytopenia, Hypoalbuminemia OMIM:608104
Granulomatosis With Polyangiitis
Vasculitis, Gastrointestinal hemorrhage, Epistaxis, Cerebral ischemia, Otitis media, Skin rash, H... ORPHA:900
Systemic Capillary Leak Syndrome
Hypotension, Arrhythmia, Pancreatitis, Myocarditis, Pericarditis ORPHA:188
Congenital Isolated Acth Deficiency
Hypotension, Hepatitis ORPHA:199296
Pseudoxanthoma Elasticum, Forme Fruste
Retinal hemorrhage, Angina pectoris, Gastrointestinal hemorrhage, Cerebral hemorrhage OMIM:177850
Corticosteroid-Binding Globulin Deficiency
Hypotension, Hypertension OMIM:611489
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Acute kidney injury, Anuria, Microangiopathic hemolytic anemia, Elevated circulating creatinine c... ORPHA:90038
Myopathy With Myalgia, Increased Serum Creatine Kinase, And With Or Without Episodic Rhabdomyolysis
Elevated circulating creatinine concentration, Myoglobinuria, Elevated circulating creatine kinas... OMIM:620138
Hereditary Arterial And Articular Multiple Calcification Syndrome
Decreased serum creatinine ORPHA:289601
Sickle Cell Anemia
Splenic infarction, Hypochromic anemia, Increased mean corpuscular volume, Persistence of hemoglo... ORPHA:232
Bacterial Toxic-Shock Syndrome
Pneumonia, Hypotension, Septic arthritis, Hepatitis, Fasciitis, Shock, Osteomyelitis, Skin rash, ... ORPHA:36234
Carnitine-Acylcarnitine Translocase Deficiency
Hypotension, Atrioventricular block, Cardiomyopathy, Premature ventricular contraction, Ventricul... OMIM:212138
Malignant Hyperthermia, Susceptibility To, 1
Tachycardia, Hypotension OMIM:145600
Acquired Von Willebrand Syndrome
Aortic valve stenosis, Aortic regurgitation, Gastrointestinal hemorrhage, Hypotension, Epistaxis,... ORPHA:99147
Inhalational Anthrax
Hypotension, Internal hemorrhage ORPHA:247257
Hyperostosis Cranialis Interna
Ocular hypertension OMIM:144755
Bronchial Neuroendocrine Tumor
Pneumonia, Hypotension, Cardiogenic shock, Right ventricular failure, Tricuspid regurgitation, Pa... ORPHA:97287
Pseudohypoaldosteronism, Type Ib2, Autosomal Recessive
Hypotension OMIM:620125
Renal Cysts And Diabetes Syndrome
Unilateral renal agenesis, Renal hypoplasia, Glycosuria, Elevated circulating creatinine concentr... OMIM:137920
Neuroendocrine Tumor Of The Colon
Hypotension, Right ventricular failure, Tricuspid regurgitation, Palpitations, Facial telangiecta... ORPHA:100080
1P31P32 Microdeletion Syndrome
Ocular hypertension, Abnormality of the urinary system ORPHA:401986
Erythrocytosis, Familial, 2
Hypotension, Pulmonary arterial hypertension, Cerebral hemorrhage OMIM:263400
Primary Triglyceride Deposit Cardiomyovasculopathy
Inflammatory abnormality of the skin, Cardiomyopathy, Palpitations, Angina pectoris, Arrhythmia, ... ORPHA:565612
Mercury Poisoning
Interstitial pneumonitis, Tachycardia, Hypotension, Hypertension ORPHA:330021
Infant Botulism
Hypotension, Keratoconjunctivitis sicca, Cardiac arrest, Hypertension, Chronic otitis media ORPHA:178478
Late-Onset Familial Hypoaldosteronism
Hypotension, Orthostatic hypotension ORPHA:556037
Legionnaires Disease
Hypotension, Hepatitis, Infectious encephalitis, Arrhythmia, Pancreatitis, Myocarditis, Endocardi... ORPHA:549
Hemorrhagic Fever-Renal Syndrome
Chronic kidney disease, Acute kidney injury, Oliguria, Hyperphosphatemia, Anuria, Elevated circul... ORPHA:340
Neuroendocrine Tumor Of The Rectum
Hematochezia, Hypotension, Right ventricular failure, Tricuspid regurgitation, Palpitations, Faci... ORPHA:100081
Neuroendocrine Tumor Of Anal Canal
Hematochezia, Hypotension, Right ventricular failure, Tricuspid regurgitation, Palpitations, Faci... ORPHA:100082
Meningococcal Meningitis
Shock, Hypotension, Skin rash, Infectious encephalitis ORPHA:33475
Exfoliation Syndrome
Asymmetry of intraocular pressure OMIM:177650
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
Hypotension ORPHA:91354
Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations
Normocytic anemia, Nephropathy, Elevated circulating creatinine concentration, Proteinuria, Glome... ORPHA:247691
Whipple Disease
Hypotension, Gastrointestinal hemorrhage, Uveitis, Infectious encephalitis, Myositis, Arthritis, ... ORPHA:3452
Gaisböck Syndrome
Elevated diastolic blood pressure, Gout, Cholecystitis, Angina pectoris, Hypertension, Myocardial... ORPHA:90041
Dopamine Beta-Hydroxylase Deficiency
Elevated urinary dopamine level, Elevated circulating creatinine concentration, Increased blood u... ORPHA:230
Dysbetalipoproteinemia
Acute pancreatitis, Angina pectoris, Gout ORPHA:412
Early-Onset Familial Hypoaldosteronism
Hypotension, Orthostatic hypotension ORPHA:556030
Nail-Patella Syndrome
Thickened glomerular basement membrane, Nephritis, Stage 5 chronic kidney disease, Renal insuffic... ORPHA:2614
Mitochondrial Trifunctional Protein Deficiency 2
Hypotension, Dilated cardiomyopathy, Tricuspid regurgitation, Mitral regurgitation, Cerebral hemo... OMIM:620300
Macrophthalmia, Colobomatous, With Microcornea
Ocular hypertension OMIM:602499
46,Xy Sex Reversal 4
Elevated circulating creatinine concentration, Ureteropelvic junction obstruction, Hydronephrosis... OMIM:154230
Corticosterone Methyloxidase Type I Deficiency
Hypotension OMIM:203400
Eisenmenger Syndrome
Bacterial endocarditis, Right ventricular failure, Right-to-left shunt, Tricuspid regurgitation, ... ORPHA:97214
Cardiac Diverticulum
Aortic valve stenosis, Congestive heart failure, Abnormal EKG, Palpitations, Mitral stenosis, Pre... ORPHA:1686
Wagro Syndrome
Proteinuria, Ocular hypertension, Nephroblastoma OMIM:612469
Pseudohypoaldosteronism, Type Ib1, Autosomal Recessive
Hypotension OMIM:264350
Fabry Disease
Atrioventricular block, Congestive heart failure, Hypertrophic cardiomyopathy, Bundle branch bloc... ORPHA:324
Staphylococcal Necrotizing Pneumonia
Shock, Hypotension, Pneumonia, Acute infectious pneumonia ORPHA:36238
Musculocontractural Ehlers-Danlos Syndrome
Functional abnormality of the bladder, Horseshoe kidney, Nephrolithiasis, Hydronephrosis, Ocular ... ORPHA:2953
Diffuse Cutaneous Mastocytosis
Hypotension, Gastrointestinal hemorrhage, Erythroderma ORPHA:79456
Aromatic L-Amino Acid Decarboxylase Deficiency
Hypotension ORPHA:35708
Acute Radiation Syndrome
Telangiectasia, Hypotension, Inflammatory abnormality of the skin, Interstitial pneumonitis ORPHA:454831
Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism
Splenomegaly, Splenic cyst, Renal cyst, Ocular hypertension, Polycystic kidney dysplasia, Increas... OMIM:610199
Congenital Enterovirus Infection
Hypotension, Hepatitis, Cardiomyopathy, Skin rash, Infectious encephalitis, Myocarditis ORPHA:292
Uveal Melanoma
Ocular hypertension ORPHA:39044
Acute Interstitial Pneumonia
Elevated circulating C-reactive protein concentration, Elevated circulating creatinine concentrat... ORPHA:79126
Herpes Simplex Virus Stromal Keratitis
Ocular hypertension ORPHA:137599
Chromosome 5Q12 Deletion Syndrome
Hypotension OMIM:615668
Hurler Syndrome
Angina pectoris, Rhinitis, Hypertension, Cardiomyopathy ORPHA:93473
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Impaired oxidative burst, Splenomegaly, Granulomatosis, Rectal abscess, Liver abscess OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Impaired oxidative burst, Splenomegaly, Granulomatosis, Rectal abscess, Liver abscess OMIM:233710
Neuropathy, Hereditary Sensory And Autonomic, Type Iii
Elevated circulating creatinine concentration, Glomerular sclerosis, Increased blood urea nitroge... OMIM:223900
Glycogen Storage Disease Of Heart, Lethal Congenital
Hypotension, Cardiomyopathy, Congestive heart failure, Hypertrophic cardiomyopathy, Left axis dev... OMIM:261740
Cystinosis, Adult Nonnephropathic
Elevated circulating creatinine concentration OMIM:219750
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Impaired oxidative burst, Splenomegaly, Granulomatosis, Rectal abscess, Liver abscess OMIM:233690
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Hypotension OMIM:177735
Cocaine Intoxication
Diffuse alveolar hemorrhage, Hypotension, Prolonged QRS complex, Ischemic stroke, Tubulointerstit... ORPHA:90068
Renal Tubular Dysgenesis
Hypotension OMIM:267430
Post-Traumatic Pituitary Deficiency
Hypotension ORPHA:95619
Anterior Segment Dysgenesis 7
Ocular hypertension OMIM:269400
Neuroendocrine Tumor Of Stomach
Hypotension, Cardiogenic shock, Right ventricular failure, Tricuspid regurgitation, Palpitations,... ORPHA:100075
Bannayan-Riley-Ruvalcaba Syndrome
Telangiectasia, Angina pectoris, Intracranial hemorrhage, Hashimoto thyroiditis ORPHA:109
Colchicine Poisoning
Hypotension, Cardiogenic shock, Congestive heart failure, Arrhythmia, Myocarditis, Hypovolemia ORPHA:31824
Familial Hypoaldosteronism
Hypotension, Orthostatic hypotension, Hypovolemia ORPHA:427
Crimean-Congo Hemorrhagic Fever
Morbilliform rash, Erythema nodosum, Tachycardia, Epididymitis, Diffuse alveolar hemorrhage, Bund... ORPHA:99827
Craniofacial Anomalies And Anterior Segment Dysgenesis Syndrome
Ocular hypertension OMIM:614195
Cerebrotendinous Xanthomatosis
Angina pectoris, Myocardial infarction OMIM:213700
Aa Amyloidosis
Hypotension ORPHA:85445
Necrotizing Enterocolitis
Shock, Hypotension, Peritonitis, Bradycardia ORPHA:391673
Granulomatous Disease, Chronic, X-Linked
Granuloma, Impaired oxidative burst, Splenomegaly, Granulomatosis, Rectal abscess, Liver abscess OMIM:306400
Alkaptonuria
Aminoaciduria, Elevated urinary homogentisic acid, Dark urine, Nephrolithiasis, Methemoglobinemia... ORPHA:56
Juvenile Glaucoma
Ocular hypertension ORPHA:98977
Carnitine-Acylcarnitine Translocase Deficiency
Hypotension, Arrhythmia, Ventricular tachycardia, Cardiomyopathy ORPHA:159
Anterior Segment Dysgenesis 1
Ocular hypertension OMIM:107250
Weill-Marchesani Syndrome 4
Ocular hypertension OMIM:613195
Lujo Hemorrhagic Fever
Hypotension, Shock, Skin rash, Maculopapular exanthema, Bradycardia, Myocarditis, Subconjunctival... ORPHA:319213
Leukocyte Adhesion Deficiency
Bone marrow hypocellularity, Abnormality of neutrophil physiology, Polycythemia, Recurrent urinar... ORPHA:2968
Ethylene Glycol Poisoning
Hypotension, Congestive heart failure, Shock, Gastritis, Prolonged QT interval, Atrial fibrillati... ORPHA:31826
Dural Sinus Malformation
Ocular hypertension ORPHA:97339
Yellow Fever
Acute kidney injury, Anuria, Elevated circulating creatinine concentration, Hyperbilirubinemia, L... ORPHA:99829
Poliomyelitis
Hypovolemic shock, Hypotension, Myelitis, Infectious encephalitis, Hypertension ORPHA:2912
Marburg Hemorrhagic Fever
Neutrophilia in presence of infection, Hypoalbuminemia, Lymphopenia, Abnormal lymphocyte morpholo... ORPHA:99826
Shwachman-Diamond Syndrome
Normocytic anemia, Bone marrow hypocellularity, Hypoamylasemia, Aplastic anemia, Increased mean c... ORPHA:811
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Ocular hypertension, Iron deficiency anemia, Increased urinary type 1 collagen N-terminal telopep... ORPHA:93315
Serotonin Syndrome
Tachycardia, Hypotension, Hypertension ORPHA:43116
Ileal Neuroendocrine Tumor
Hypotension, Cardiogenic shock, Right ventricular failure, Arterial occlusion, Palpitations, Arrh... ORPHA:100078
Pde4D Haploinsufficiency Syndrome
Hypotension ORPHA:439822
Aromatic L-Amino Acid Decarboxylase Deficiency
Hypotension, Exaggerated startle response OMIM:608643
Cholera
Tachycardia, Hypotension, Hypovolemic shock, Aspiration pneumonia ORPHA:173
Autosomal Dominant Hypocalcemia
Hypotension, Arrhythmia, Eczematoid dermatitis, Congestive heart failure ORPHA:428
Posterior Polymorphous Corneal Dystrophy
Ocular hypertension ORPHA:98973
Structural Heart Defects And Renal Anomalies Syndrome
Elevated circulating creatinine concentration, Renal insufficiency, Renal cyst OMIM:617478
Idiopathic Panuveitis
Ocular hypertension ORPHA:280921
Neuroleptic Malignant Syndrome
Hypertensive crisis, Hypotension, Pulmonary embolism, Aspiration pneumonia, Arrhythmia, Bradycard... ORPHA:94093
Anterior Segment Dysgenesis 2
Ocular hypertension OMIM:610256
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Hypotension, Recurrent pneumonia, Recurrent otitis media, Psoriasiform dermatitis, Recurrent sinu... ORPHA:293978
Hutchinson-Gilford Progeria Syndrome
Aortic valve stenosis, Aortic regurgitation, Transient ischemic attack, Left ventricular systolic... ORPHA:740
Late-Onset Isolated Acth Deficiency
Hashimoto thyroiditis, Hypotension, Hepatitis, Orthostatic hypotension ORPHA:199299
Interstitial Cystitis
Abnormality of tumor necrosis factor secretion ORPHA:37202
Traboulsi Syndrome
Homocystinuria, Ocular hypertension OMIM:601552
Beta-Ketothiolase Deficiency
Hypotension, Hypertension ORPHA:134
Sepsis In Premature Infants
Tachycardia, Hypotension, Enterocolitis, Bradycardia ORPHA:90051
3-Hydroxy-3-Methylglutaric Aciduria
Cardiac arrest, Hypotension, Dilated cardiomyopathy, Acute pancreatitis ORPHA:20
Leptospirosis
Hypotension, Uveitis, Hepatitis, Pulmonary hemorrhage, Skin rash, Arrhythmia, Optic neuritis, Fir... ORPHA:509
Fuchs Heterochromic Iridocyclitis
Ocular hypertension ORPHA:263479
Plague
Hypotension, Inflammation of the large intestine, Lymphadenitis, Chapped lip, Skin rash, Arrhythm... ORPHA:707
Late-Onset Retinal Degeneration
Ocular hypertension ORPHA:67042
Homozygous Familial Hypercholesterolemia
Supravalvular aortic stenosis, Mitral regurgitation, Hypertension, Angina pectoris, Heart murmur,... ORPHA:391665
Alexander Disease
Hypertension, Hypotension, Sudden cardiac death, Infectious encephalitis ORPHA:58
Hellp Syndrome
Hypotension, Internal hemorrhage, Cerebral hemorrhage ORPHA:244242
Familial Glucocorticoid Deficiency
Hypertrophic cardiomyopathy, Hypotension ORPHA:361
Congenital Microcoria
Ocular hypertension ORPHA:566
Gitelman Syndrome
Prolonged QT interval, Hypotension, Palpitations, Ventricular tachycardia OMIM:263800
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Hypotension, Pulmonary arterial hypertension, Bradycardia, Tachycardia, Cardiac arrest OMIM:277400
Acute Adrenal Insufficiency
Myocardial infarction, Hypotension, Orthostatic hypotension, Hypovolemia ORPHA:95409
Pituitary Apoplexy
Hypotension, Hypertension ORPHA:95613
Neuroendocrine Neoplasm Of Appendix
Hypotension, Tricuspid stenosis, Palpitations, Heart murmur ORPHA:100079
Fragile X-Associated Tremor/Ataxia Syndrome
Hypotension, Hypertension ORPHA:93256
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
Hypotension ORPHA:90791
Non-Functioning Pituitary Adenoma
Hypotension ORPHA:91349
Bartter Syndrome, Type 3
Hypotension OMIM:607364
Hereditary Angioedema Type 1
Hypotension ORPHA:100050
Say-Barber-Miller Syndrome
Decreased circulating IgG level, Transient hypogammaglobulinemia of infancy, Impaired neutrophil ... ORPHA:3132
Oculoauricular Syndrome
Ocular hypertension OMIM:612109
Gitelman Syndrome
Prominent U wave, Abnormal T-wave, Palpitations, Gout, ST segment depression, Hashimoto thyroidit... ORPHA:358
Prolactinoma
Hypotension ORPHA:2965
Exercise-Induced Malignant Hyperthermia
Hypotension, Abnormal pulse pressure, Sinus tachycardia, Abnormal T-wave, ST segment depression, ... ORPHA:466650
Tsh-Secreting Pituitary Adenoma
Hypotension, Congestive heart failure, Palpitations, Supraventricular arrhythmia, Ventricular arr... ORPHA:91347
Biliary, Renal, Neurologic, And Skeletal Syndrome
Hypoalbuminemia, Dilatation of the renal pelvis, Increased circulating ferritin concentration, Hy... OMIM:619534
Lysosomal Acid Lipase Deficiency
Hypotension, Pulmonary arterial hypertension, Hypovolemia ORPHA:275761
Psoriasis-Related Juvenile Idiopathic Arthritis
Abnormality of tumor necrosis factor secretion ORPHA:85436
Acute Liver Failure
Hypotension, Gastrointestinal hemorrhage, Hepatitis, Shock, Skin rash, Intracranial hemorrhage ORPHA:90062
Addison Disease
Hashimoto thyroiditis, Hypotension, Orthostatic hypotension ORPHA:85138
46,Xy Difference Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Hypotension, Hypovolemia ORPHA:168558
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Hypotension, Hypovolemia ORPHA:289548
Sympathetic Ophthalmia
Ocular hypertension ORPHA:79098
Phacoanaphylactic Uveitis
Ocular hypertension ORPHA:209959
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Shock, Hypotension, Acne, Hypovolemia ORPHA:90794
Non-Acquired Panhypopituitarism
Hypotension ORPHA:90695
Pmm2-Cdg
Aspiration pneumonia, Hypertrophic cardiomyopathy, Angina pectoris, Intracranial hemorrhage, Peri... ORPHA:79318
Combined Pituitary Hormone Deficiencies, Genetic Forms
Hypotension ORPHA:95494
Bartter Syndrome, Type 1, Antenatal
Low-to-normal blood pressure OMIM:601678
Bartter Syndrome, Type 2, Antenatal
Low-to-normal blood pressure OMIM:241200

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adora3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adora3.

No publications found that use IMPC mice or data for Adora3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Adora3tm96705(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Adora3tm96705(L1L2_Pgk_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Adora3tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Adora3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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