Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
adenosine A3 receptor
Synonyms:
A3R,  ARA3,  1700001D09Rik,  Gpcr 2,  A3AR,  4930578J19Rik,  AA3R

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Adora3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Adora3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Pseudoxanthomatous Diffuse Cutaneous Mastocytosis
Cutaneous mastocytosis ORPHA:280794
Neutrophil Immunodeficiency Syndrome
Leukocytosis, Abnormality of neutrophil physiology ORPHA:183707
Carbimazole Sensitivity
Drug-induced agranulocytosis OMIM:212060
Granulomatous disease with defect in neutrophil chemotaxis
Impaired neutrophil killing of staphylococci OMIM:233670
Immunodeficiency 86
Decreased circulating IgG level, Impaired oxidative burst, Increased circulating IgM level OMIM:619549
Specific Granule Deficiency 1
Increased neutrophil ribosomes, Increased neutrophil mitochondria, Impaired neutrophil bactericid... OMIM:245480
Undritz Anomaly
Hypersegmentation of neutrophil nuclei OMIM:191500
Mastocytosis, Cutaneous
Cutaneous mastocytosis OMIM:154800
Indolent Systemic Mastocytosis
Abnormal mast cell morphology, Mastocytosis, Increased proportion of CD25+ mast cells, Splenomegaly ORPHA:98848
Mast Cell Sarcoma
Mastocytosis, Splenomegaly ORPHA:66661
Renal Failure, Progressive, With Hypertension
Elevated circulating creatinine concentration, Proteinuria, Nephritis, Microscopic hematuria, Ren... OMIM:161900
Neutropenia-Monocytopenia-Deafness Syndrome
Abnormality of neutrophils, Abnormal macrophage morphology ORPHA:2690
Bullous Diffuse Cutaneous Mastocytosis
Cutaneous mastocytosis ORPHA:280785
Thrombotic Thrombocytopenic Purpura
Hematuria, Acute kidney injury, Decreased serum creatinine, Proteinuria, Dyspnea, Renal insuffici... ORPHA:54057
Nephronophthisis-Like Nephropathy 2
Periglomerular fibrosis, Elevated circulating creatinine concentration, Polyuria, Cough, Bronchie... OMIM:619468
Focal Facial Dermal Dysplasia Type Iv
Abnormal mast cell morphology ORPHA:398189
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 3
Elevated circulating creatinine concentration, Hematuria, Acute kidney injury, Increased blood ur... OMIM:612923
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 2
Elevated circulating creatinine concentration, Hematuria, Acute kidney injury, Increased blood ur... OMIM:612922
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 5
Elevated circulating creatinine concentration, Hematuria, Acute kidney injury, Increased blood ur... OMIM:612925
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 4
Elevated circulating creatinine concentration, Hematuria, Acute kidney injury, Increased blood ur... OMIM:612924
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 6
Elevated circulating creatinine concentration, Hematuria, Acute kidney injury, Increased blood ur... OMIM:612926
Interstitial Nephritis, Karyomegalic
Glycosuria, Nephronophthisis, Elevated circulating creatinine concentration, Hematuria, Proteinur... OMIM:614817
Idiopathic Non-Lupus Full-House Nephropathy
Nephrotic syndrome, Elevated circulating creatinine concentration, Acute kidney injury, Abnormal ... ORPHA:567544
C3 Glomerulopathy
Glomerular extracapillary hypercellularity, Nephrotic syndrome, Elevated circulating creatinine c... ORPHA:329918
Aggressive Systemic Mastocytosis
Pancytopenia, Abnormal mast cell morphology, Hepatosplenomegaly, Leukemia, Leukocytosis, Increase... ORPHA:98850
Tubulointerstitial Nephritis With Uveitis
Acute tubulointerstitial nephritis, Elevated circulating creatinine concentration, Glomerulonephr... OMIM:607665
Glaucoma 1, Primary Open Angle, C
Ocular hypertension OMIM:601682
Immunodeficiency 73A With Defective Neutrophil Chemotaxis And Leukocytosis
Reduction of neutrophil motility, Leukocytosis, Impaired neutrophil chemotaxis, Rectal abscess, N... OMIM:608203
Diffuse Alveolar Hemorrhage
Respiratory failure requiring assisted ventilation, Restrictive ventilatory defect, Hypoxemia, El... ORPHA:90060
Cutaneous Mastocytosis, Conductive Hearing Loss And Microtia
Cutaneous mastocytosis OMIM:248910
Hypoxanthine Guanine Phosphoribosyltransferase Partial Deficiency
Elevated circulating creatinine concentration, Acute kidney injury, Dysuria, Macroscopic hematuri... ORPHA:79233
Glaucoma 3, Primary Congenital, E
Ocular hypertension OMIM:617272
Adenine Phosphoribosyltransferase Deficiency
Oliguria, Elevated circulating creatinine concentration, Hematuria, Nephrolithiasis, Renal insuff... OMIM:614723
Systemic Mastocytosis With Associated Hematologic Neoplasm
Eosinophilia, Abnormal mast cell morphology, Leukocytosis, Normocytic anemia, Chronic myelomonocy... ORPHA:98849
Ichthyosis, Mental Retardation, Dwarfism, And Renal Impairment
Decreased glomerular filtration rate, Elevated circulating creatinine concentration, Nephropathy OMIM:242530
Pulmonary Hypertension, Primary, 5
Pulmonary arterial hypertension, Angina pectoris, Syncope, Right ventricular failure OMIM:265400
Glaucoma 1, Open Angle, F
Ocular hypertension OMIM:603383
Nephronophthisis 2
Nephronophthisis, Enlarged kidney, Renal cortical microcysts, Elevated circulating creatinine con... OMIM:602088
Preeclampsia
Elevated circulating creatinine concentration, Acute kidney injury, Proteinuria, Abnormality of t... ORPHA:275555
Familial Cutaneous Collagenoma
Angina pectoris, Cardiomyopathy, Congestive heart failure ORPHA:53296
Relapsing Fever
Leukopenia, Elevated circulating creatinine concentration, Hematuria, Acute kidney injury, Leukoc... ORPHA:91547
Mastocytosis
Chronic leukemia, Mastocytosis, Hypercalcemia, Asthma, Splenomegaly, Cough, Acute leukemia, Respi... ORPHA:98292
Congenital Disorder Of Glycosylation, Type Iic
Reduction of neutrophil motility, Neutrophilia, Pneumonia OMIM:266265
Coronary Arterial Fistula
Continuous heart murmur, Elevated jugular venous pressure, Systolic heart murmur, Arrhythmia, Abn... ORPHA:2041
Thrombotic Thrombocytopenic Purpura, Hereditary
Schistocytosis, Elevated circulating creatinine concentration, Hemolytic-uremic syndrome, Protein... OMIM:274150
Tubulointerstitial Kidney Disease, Autosomal Dominant, 2
Glomerular sclerosis, Elevated circulating creatinine concentration, Decreased glomerular filtrat... OMIM:174000
Renal Tubular Acidosis, Distal, 1
Hypokalemia, Nephrocalcinosis, Elevated circulating creatinine concentration, Nephrolithiasis, Di... OMIM:179800
Microphthalmia, Isolated 6
Ocular hypertension OMIM:613517
Tako-Tsubo Cardiomyopathy
ST segment elevation, Ventricular fibrillation, Arrhythmia, Bradycardia, T-wave inversion, ST seg... ORPHA:66529
Metachromatic Leukodystrophy, Adult-Onset, With Normal Arylsulfatase A
Hypotension OMIM:156310
Immunodeficiency 81
Reduced antigen-specific T cell proliferation, Impaired neutrophil chemotaxis, Reduced natural ki... OMIM:619374
Sickle Cell Anemia
Microcytic anemia, Hypochromic anemia, Reticulocytosis, Leukocytosis, Hypoxemia, Elevated circula... ORPHA:232
X-Linked Lymphoproliferative Disease
Pancytopenia, Decreased circulating IgG level, Absent natural killer cells, Histiocytosis, Increa... ORPHA:2442
Weill-Marchesani Syndrome 4
Ocular hypertension OMIM:613195
Fixed Subaortic Stenosis
Paroxysmal atrial fibrillation, Aortic regurgitation, Systolic heart murmur, Congestive heart fai... ORPHA:3092
Macrophthalmia, Colobomatous, With Microcornea
Ocular hypertension OMIM:602499
Hydroxykynureninuria
Tachycardia, Hypotension OMIM:236800
Cryoglobulinemia, Familial Mixed
Elevated circulating creatinine concentration, Hematuria, Proteinuria, Chronic kidney disease, Ab... OMIM:123550
Attrv122I Amyloidosis
Reduced ejection fraction, Arrhythmia, Congestive heart failure, Abnormal EKG, Abnormal atriovent... ORPHA:85451
Congenital Tricuspid Stenosis
Congestive heart failure, Tricuspid stenosis, Hypotension, Pulmonary arterial hypertension, Heart... ORPHA:95459
Necrobiosis Lipoidica
Granuloma, Abnormality of neutrophil physiology ORPHA:542592
Congenital Aortic Valve Stenosis
Abnormal T-wave, Abnormal pulse pressure, Reduced ejection fraction, Abnormal left ventricular fu... ORPHA:3093
Hyperlipidemia Due To Hepatic Triacylglycerol Lipase Deficiency
Angina pectoris ORPHA:140905
Macrophage Activation Syndrome
Increased circulating interleukin 6 concentration, Abnormal circulating interleukin concentration... ORPHA:158061
Acute Interstitial Pneumonia
Nonproductive cough, Hypoxemia, Elevated circulating creatinine concentration, Crackles, Tachypne... ORPHA:79126
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Recurrent pneumonia, Nephrotic syndrome, Hepatosplenomegaly, Splenomegaly, Pleural effusion, Absc... OMIM:618935
Coenzyme Q10 Deficiency, Primary, 8
Renal dysplasia, Elevated circulating creatinine concentration, Respiratory distress, Abnormal re... OMIM:616733
Chédiak-Higashi Syndrome
Pancytopenia, Increased circulating ferritin concentration, Hypoproteinemia, Hyponatremia, Abnorm... ORPHA:167
Nephrogenic Syndrome Of Inappropriate Antidiuresis
Hypernatriuria, Hyponatremia, Decreased circulating renin level, Decreased serum creatinine OMIM:300539
Brachydactyly, Coloboma, And Anterior Segment Dysgenesis
Ocular hypertension OMIM:610023
Corticosteroid-Binding Globulin Deficiency
Hypotension, Hypertension OMIM:611489
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Schistocytosis, Hyperlipidemia, Elevated circulating creatinine concentration, Hemolytic-uremic s... OMIM:235400
Partial Atrioventricular Septal Defect
Atrial flutter, Bacterial endocarditis, Atrial arrhythmia, Palpitations, Syncope, Transient ische... ORPHA:1330
Irvan Syndrome
Ocular hypertension ORPHA:209943
Hepatic Lipase Deficiency
Angina pectoris OMIM:614025
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease
Elevated circulating creatinine concentration, Polycystic kidney dysplasia, Recurrent urinary tra... OMIM:613095
Pseudoxanthoma Elasticum
Gastrointestinal hemorrhage, Retinal hemorrhage, Congestive heart failure, Restrictive cardiomyop... OMIM:264800
Obesity Due To Sim1 Deficiency
Hypotension, Postural hypotension with compensatory tachycardia ORPHA:369873
Hutchinson-Gilford Progeria Syndrome
Angina pectoris, Myocardial infarction, Congestive heart failure OMIM:176670
Aapoaiv Amyloidosis
Hyperlipidemia, Elevated circulating creatinine concentration, Glomerular sclerosis, Proteinuria,... ORPHA:439232
Coach Syndrome 2
Apneic episodes in infancy, Hyperechogenic kidneys, Elevated circulating creatinine concentration OMIM:619111
Autosomal Dominant Polycystic Kidney Disease
Enlarged kidney, Pyelonephritis, Renal cyst, Elevated circulating creatinine concentration, Hemat... ORPHA:730
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Pancytopenia, Decreased circulating IgG level, Recurrent pneumonia, T lymphocytopenia, Leukopenia... OMIM:618986
Neovascular Glaucoma
Ocular hypertension ORPHA:94058
Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency
Impaired neutrophil bactericidal activity, Nonspherocytic hemolytic anemia, Splenomegaly, Spontan... OMIM:613470
Microcoria, Congenital
Ocular hypertension OMIM:156600
Short-Rib Thoracic Dysplasia 5 With Or Without Polydactyly
Restrictive ventilatory defect, Elevated circulating creatinine concentration, Proteinuria, Renal... OMIM:614376
Hereditary Amyloidosis With Primary Renal Involvement
Decreased circulating apolipoprotein AI concentration, Elevated circulating creatinine concentrat... ORPHA:85450
Multiple Myeloma
Nephrotic syndrome, Elevated circulating creatinine concentration, Hypercalcemia, Acute kidney in... ORPHA:29073
Familial Hemophagocytic Lymphohistiocytosis
Increased circulating interleukin 6 concentration, Abnormality of serum cytokine level, Reduced n... ORPHA:540
Weill-Marchesani Syndrome 3
Ocular hypertension OMIM:614819
Cardiogenic Shock
ST segment elevation, Impaired myocardial contractility, Cardiac arrest, Elevated jugular venous ... ORPHA:97292
Fish-Eye Disease
Angina pectoris ORPHA:79292
Primary Lipodystrophy
Congestive heart failure, Cardiomyopathy, Hypertension, Pancreatitis, Angina pectoris ORPHA:90970
Hennekam-Beemer Syndrome
Respiratory insufficiency, Mastocytosis, Pneumonia ORPHA:2135
Polycythemia Vera
Portal hypertension, Gastrointestinal hemorrhage, Pulmonary embolism, Hypertension, Budd-Chiari s... ORPHA:729
Pauci-Immune Glomerulonephritis
Glomerular sclerosis, Elevated circulating creatinine concentration, Proteinuria, Acute kidney in... ORPHA:93126
Oligomeganephronia
Unilateral renal agenesis, Abnormality of medullary pyramid morphology, Elevated circulating crea... ORPHA:2260
Nipah Virus Disease
Infectious encephalitis, Hypotension ORPHA:99825
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Juvenile Nephropathic Cystinosis
Glycosuria, Hypokalemia, Hyponatremia, Elevated circulating creatinine concentration, Renal Fanco... ORPHA:411634
Chediak-Higashi Syndrome
Leukopenia, Giant neutrophil granules, Hemophagocytosis, Spontaneous, recurrent epistaxis, Spleno... OMIM:214500
Car T Cell Therapy-Associated Cytokine Release Syndrome
Hypoxemia, Elevated circulating creatinine concentration, Decreased urine output, Acute kidney in... ORPHA:542323
Birdshot Chorioretinopathy
Ocular hypertension ORPHA:179
Catastrophic Antiphospholipid Syndrome
Pulmonary embolism, Myocarditis, Myocardial infarction, Pulmonary arterial hypertension, Transien... ORPHA:464343
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Enlarged kidney, Decreased plasma total carnitine, Elevated circulating creatinine concentration,... OMIM:608836
Hemorrhagic Fever-Renal Syndrome
Acute tubulointerstitial nephritis, Elevated circulating creatinine concentration, Proteinuria, A... ORPHA:340
Infant Acute Respiratory Distress Syndrome
Cardiac arrest, Pneumonia, Hypotension, Bradycardia, Tachycardia ORPHA:70587
Adult Acute Respiratory Distress Syndrome
Increased circulating interleukin 6 concentration, Abnormal circulating interleukin concentration... ORPHA:70578
Fabry Disease
Arrhythmia, Congestive heart failure, Myocardial infarction, Transient ischemic attack, Hypertens... OMIM:301500
Acute Lung Injury
Increased circulating interleukin 6 concentration, Abnormality of serum cytokine level, Abnormali... ORPHA:178320
Bacterial Toxic-Shock Syndrome
Increased circulating metamyelocyte count, Sinusitis, Pneumonia, Elevated circulating creatinine ... ORPHA:36234
Igg4-Related Retroperitoneal Fibrosis
Nephrotic syndrome, Elevated circulating creatinine concentration, Unilateral renal hypoplasia, A... ORPHA:49041
Pseudoxanthoma Elasticum
Gastrointestinal hemorrhage, Retinal hemorrhage, Sudden cardiac death, Acne, Telangiectasia of th... ORPHA:758
Igg4-Related Kidney Disease
Elevated circulating creatinine concentration, Proteinuria, Hydronephrosis, Membranous nephropath... ORPHA:449395
Chromosome 5Q12 Deletion Syndrome
Hypotension OMIM:615668
Juvenile Dermatomyositis
Myositis, Gastrointestinal hemorrhage, Arrhythmia, Mucosal telangiectasiae, Bundle branch block, ... ORPHA:93672
Perry Syndrome
Hypotension ORPHA:178509
Analbuminemia
Hypotension OMIM:616000
Dopamine Beta-Hydroxylase Deficiency
Elevated circulating creatinine concentration, Elevated urinary dopamine, Increased blood urea ni... ORPHA:230
Snakebite Envenomation
Cardiogenic shock, Hypotension, Myocardial infarction, Cerebral ischemia, Tachycardia, Intracrani... ORPHA:449285
Glaucoma, Primary Closed-Angle
Ocular hypertension OMIM:618880
Glaucoma 3, Primary Congenital, A
Ocular hypertension OMIM:231300
Dengue Fever
Gastrointestinal hemorrhage, Hypotension, Cerebral hemorrhage, Epistaxis, Skin rash ORPHA:99828
Sweet Syndrome
Increased circulating interleukin 6 concentration, Sterile abscess, Abnormal circulating interleu... ORPHA:3243
Tubulointerstitial Nephritis And Uveitis Syndrome
Renal interstitial edema, Renal Fanconi syndrome, Elevated circulating creatinine concentration, ... ORPHA:91500
Cutaneous Mastocytoma
Telangiectasia macularis eruptiva perstans, Telangiectasia of the skin, Maculopapular exanthema, ... ORPHA:79455
Apolipoprotein A-I Deficiency
Angina pectoris ORPHA:425
Granulomatous Disease, Chronic, X-Linked
Recurrent pneumonia, Rectal abscess, Splenomegaly, Pleural effusion, Cough, Atelectasis, Granulom... OMIM:306400
Granulomatosis With Polyangiitis
Sinusitis, Recurrent intrapulmonary hemorrhage, Gastrointestinal hemorrhage, Arrhythmia, Inflamma... ORPHA:900
Hereditary Arterial And Articular Multiple Calcification Syndrome
Decreased serum creatinine ORPHA:289601
Hyperostosis Cranialis Interna
Ocular hypertension OMIM:144755
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Hypokalemia, Schistocytosis, Hyponatremia, Elevated circulating creatinine concentration, Leukocy... ORPHA:90038
Pseudoxanthoma Elasticum, Forme Fruste
Cerebral hemorrhage, Angina pectoris, Gastrointestinal hemorrhage, Retinal hemorrhage OMIM:177850
Hydroxykynureninuria
Tachycardia, Stomatitis, Hypotension ORPHA:79155
Scrub Typhus
Infectious encephalitis, Hypotension, Myocarditis, Anterior uveitis, Skin rash ORPHA:83317
Congenital Isolated Acth Deficiency
Hypotension, Hepatitis ORPHA:199296
Renal Cysts And Diabetes Syndrome
Unilateral renal agenesis, Glycosuria, Renal cyst, Elevated circulating creatinine concentration,... OMIM:137920
Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations
Pneumonia, Glomerular sclerosis, Elevated circulating creatinine concentration, Proteinuria, Norm... ORPHA:247691
Infant Botulism
Cardiac arrest, Hypotension, Keratoconjunctivitis sicca, Hypertension, Chronic otitis media ORPHA:178478
Malignant Hyperthermia, Susceptibility To, 1
Tachycardia, Hypotension OMIM:145600
Systemic Capillary Leak Syndrome
Arrhythmia, Myocarditis, Hypotension, Pancreatitis, Pericarditis ORPHA:188
Congenital Disorder Of Glycosylation, Type Iit
Decreased serum creatinine, Hypotriglyceridemia, Iron deficiency anemia, Urinary incontinence, De... OMIM:618885
Triglyceride Deposit Cardiomyovasculopathy
Arrhythmia, Cardiomyopathy, Low-output congestive heart failure, Pancreatitis, Palpitations, Angi... ORPHA:565612
Erythrocytosis, Familial, 2
Pulmonary arterial hypertension, Hypotension, Cerebral hemorrhage OMIM:263400
Carnitine-Acylcarnitine Translocase Deficiency
Cardiac arrest, Ventricular tachycardia, Premature ventricular contraction, Hypotension, Atrioven... OMIM:212138
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Recurrent pneumonia, Rectal abscess, Splenomegaly, Granulomatosis, Liver abscess, Impaired oxidat... OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Recurrent pneumonia, Rectal abscess, Splenomegaly, Granulomatosis, Liver abscess, Impaired oxidat... OMIM:233710
Acquired Von Willebrand Syndrome
Aortic valve stenosis, Gastrointestinal hemorrhage, Aortic regurgitation, Hypotension, Pulmonic s... ORPHA:99147
Anterior Segment Dysgenesis 7
Ocular hypertension OMIM:269400
Nail-Patella Syndrome
Nephrotic syndrome, Hematuria, Proteinuria, Abnormality of the kidney, Ocular hypertension, Thick... ORPHA:2614
Neuropathy, Hereditary Sensory And Autonomic, Type Iii
Decreased sensitivity to hypoxemia, Glomerular sclerosis, Elevated circulating creatinine concent... OMIM:223900
Exfoliation Syndrome
Asymmetry of intraocular pressure OMIM:177650
Leukocyte Adhesion Deficiency
Sinusitis, Pneumonia, Leukocytosis, Hemolytic-uremic syndrome, Impaired platelet aggregation, Thr... ORPHA:2968
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Recurrent pneumonia, Rectal abscess, Splenomegaly, Granulomatosis, Liver abscess, Impaired oxidat... OMIM:233690
Musculocontractural Ehlers-Danlos Syndrome
Horseshoe kidney, Nephrolithiasis, Functional abnormality of the bladder, Hydronephrosis, Ocular ... ORPHA:2953
Late-Onset Familial Hypoaldosteronism
Orthostatic hypotension, Hypotension ORPHA:556037
Neuroendocrine Tumor Of The Colon
Hypotension, Melena, Right ventricular failure, Palpitations, Tricuspid regurgitation, Facial tel... ORPHA:100080
Bronchial Neuroendocrine Tumor
Pneumonia, Cardiogenic shock, Hypotension, Right ventricular failure, Palpitations, Tricuspid reg... ORPHA:97287
Mercury Poisoning
Tachycardia, Hypotension, Interstitial pneumonitis, Hypertension ORPHA:330021
Legionnaires Disease
Arrhythmia, Infectious encephalitis, Endocarditis, Myocarditis, Hypotension, Pancreatitis, Hepati... ORPHA:549
Meningococcal Meningitis
Shock, Infectious encephalitis, Hypotension, Skin rash ORPHA:33475
Whipple Disease
Myositis, Uveitis, Gastrointestinal hemorrhage, Infectious encephalitis, Myocardial infarction, H... ORPHA:3452
Neurodevelopmental Disorder With Seizures And Speech And Walking Impairment
Hypotension OMIM:618480
Glycogen Storage Disease Of Heart, Lethal Congenital
Shortened PR interval, Congestive heart failure, Hypotension, Cardiomyopathy, Bradycardia OMIM:261740
Facial Dysmorphism, Lens Dislocation, Anterior Segment Abnormalities, And Spontaneous Filtering Blebs
Low intraocular pressure OMIM:601552
Dysbetalipoproteinemia
Gout, Angina pectoris, Acute pancreatitis ORPHA:412
Gaisböck Syndrome
Hypovolemia, Elevated diastolic blood pressure, Cholecystitis, Myocardial infarction, Hypertensio... ORPHA:90041
Inhalational Anthrax
Hypotension, Internal hemorrhage ORPHA:247257
Neuroendocrine Tumor Of The Rectum
Hematochezia, Hypotension, Melena, Right ventricular failure, Palpitations, Tricuspid regurgitati... ORPHA:100081
Neuroendocrine Tumor Of Anal Canal
Hematochezia, Hypotension, Melena, Right ventricular failure, Palpitations, Tricuspid regurgitati... ORPHA:100082
Early-Onset Familial Hypoaldosteronism
Orthostatic hypotension, Hypotension ORPHA:556030
Eisenmenger Syndrome
Right-to-left shunt, Elevated jugular venous pressure, Ventricular tachycardia, Left-to-right shu... ORPHA:97214
Uveal Melanoma
Ocular hypertension ORPHA:39044
46,Xy Sex Reversal 4
Elevated circulating creatinine concentration, Increased blood urea nitrogen, Hydronephrosis, Ren... OMIM:154230
Corticosterone Methyloxidase Type I Deficiency
Hypotension OMIM:203400
Cardiac Diverticulum
Ventricular fibrillation, Ventricular tachycardia, Arrhythmia, Premature ventricular contraction,... ORPHA:1686
Pituitary Deficiency Due To Empty Sella Turcica Syndrome
Hypotension ORPHA:91354
Fabry Disease
Mucosal telangiectasiae, Arrhythmia, Congestive heart failure, Bundle branch block, Hypertrophic ... ORPHA:324
Congenital Enterovirus Infection
Infectious encephalitis, Hypotension, Myocarditis, Cardiomyopathy, Hepatitis, Skin rash ORPHA:292
Pseudohypoaldosteronism, Type I, Autosomal Recessive
Hypotension OMIM:264350
Diffuse Cutaneous Mastocytosis
Erythroderma, Hypotension, Gastrointestinal hemorrhage ORPHA:79456
Hurler Syndrome
Angina pectoris, Hypertension, Rhinitis, Cardiomyopathy ORPHA:93473
Staphylococcal Necrotizing Pneumonia
Shock, Hypotension, Acute infectious pneumonia, Pneumonia ORPHA:36238
Cerebrotendinous Xanthomatosis
Angina pectoris, Myocardial infarction OMIM:213700
Necrotizing Enterocolitis
Bradycardia, Peritonitis, Shock, Hypotension ORPHA:391673
Cocaine Intoxication
Hypovolemia, Diffuse alveolar hemorrhage, Colitis, Glomerulonephritis, Hypotension, Myocardial in... ORPHA:90068
Renal Tubular Dysgenesis
Hypotension OMIM:267430
Pseudohypoaldosteronism, Type I, Autosomal Dominant
Hypotension OMIM:177735
Anterior Segment Dysgenesis 1
Ocular hypertension OMIM:107250
Crimean-Congo Hemorrhagic Fever
Subconjunctival hemorrhage, Bundle branch block, Subdural hemorrhage, Hypertension, Hematemesis, ... ORPHA:99827
Colchicine Poisoning
Hypovolemia, Arrhythmia, Congestive heart failure, Cardiogenic shock, Myocarditis, Hypotension ORPHA:31824
Bannayan-Riley-Ruvalcaba Syndrome
Hashimoto thyroiditis, Telangiectasia, Angina pectoris, Intracranial hemorrhage ORPHA:109
Marburg Hemorrhagic Fever
Nonproductive cough, Hypokalemia, Abnormal lymphocyte morphology, Leukopenia, Elevated circulatin... ORPHA:99826
Familial Hypoaldosteronism
Hypovolemia, Orthostatic hypotension, Hypotension ORPHA:427
Post-Traumatic Pituitary Deficiency
Hypotension ORPHA:95619
Shwachman-Diamond Syndrome
Pancytopenia, Sinusitis, Pneumonia, Increased serum bile acid concentration, Leukopenia, Normocyt... ORPHA:811
Juvenile Glaucoma
Ocular hypertension ORPHA:98977
Aa Amyloidosis
Hypotension ORPHA:85445
Congenital Hypothyroidism
Sinusitis, Hypotension, Hypertension, Arrhythmia ORPHA:442
Neuroendocrine Tumor Of Stomach
Cardiogenic shock, Hypotension, Hematemesis, Melena, Right ventricular failure, Palpitations, Tri... ORPHA:100075
Ethylene Glycol Poisoning
Congestive heart failure, Hypotension, Prolonged QT interval, Atrial fibrillation, Hypertension, ... ORPHA:31826
Dural Sinus Malformation
Ocular hypertension ORPHA:97339
Idiopathic Anterior Uveitis
Ocular hypertension ORPHA:280914
Yellow Fever
Leukocytosis, Elevated circulating creatinine concentration, Acute kidney injury, Anuria, Increas... ORPHA:99829
Carnitine-Acylcarnitine Translocase Deficiency
Cardiomyopathy, Hypotension, Ventricular tachycardia, Arrhythmia ORPHA:159
Spondylometaphyseal Dysplasia, 'Corner Fracture' Type
Increased urinary type 1 collagen N-terminal telopeptide level, Iron deficiency anemia, Ocular hy... ORPHA:93315
Ileal Neuroendocrine Tumor
Arrhythmia, Cardiogenic shock, Tricuspid stenosis, Hypotension, Pulmonic stenosis, Palpitations, ... ORPHA:100078
Jejunal Neuroendocrine Tumor
Arrhythmia, Cardiogenic shock, Tricuspid stenosis, Hypotension, Pulmonic stenosis, Palpitations, ... ORPHA:100077
Poliomyelitis
Hypovolemic shock, Infectious encephalitis, Hypotension, Hypertension, Myelitis ORPHA:2912
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Recurrent pneumonia, Recurrent otitis media, Hypotension, Bronchiectasis, Recurrent sinusitis, Ps... ORPHA:293978
Lujo Hemorrhagic Fever
Subconjunctival hemorrhage, Maculopapular exanthema, Hypotension, Myocarditis, Rhinitis, Fulminan... ORPHA:319213
Serotonin Syndrome
Tachycardia, Hypotension, Hypertension ORPHA:43116
Pde4D Haploinsufficiency Syndrome
Hypotension ORPHA:439822
Posterior Polymorphous Corneal Dystrophy
Ocular hypertension ORPHA:98973
Homozygous Familial Hypercholesterolemia
Abnormal left ventricular function, Sudden cardiac death, Myocardial infarction, Supravalvular ao... ORPHA:391665
Anterior Segment Dysgenesis 2
Ocular hypertension OMIM:610256
Duodenal Neuroendocrine Tumor
Arrhythmia, Cardiogenic shock, Tricuspid stenosis, Hypotension, Pulmonic stenosis, Hematemesis, M... ORPHA:100076
Structural Heart Defects And Renal Anomalies Syndrome
Renal cyst, Elevated circulating creatinine concentration, Renal insufficiency OMIM:617478
Hutchinson-Gilford Progeria Syndrome
Left ventricular systolic dysfunction, Left ventricular diastolic dysfunction, Aortic valve steno... ORPHA:740
Cholera
Aspiration pneumonia, Tachycardia, Hypovolemic shock, Hypotension ORPHA:173
Idiopathic Panuveitis
Ocular hypertension ORPHA:280921
Aromatic L-Amino Acid Decarboxylase Deficiency
Hypotension, Exaggerated startle response OMIM:608643
Autosomal Dominant Hypocalcemia
Eczema, Hypotension, Arrhythmia, Congestive heart failure ORPHA:428
Neuroleptic Malignant Syndrome
Arrhythmia, Pulmonary embolism, Hypotension, Hypertensive crisis, Hypertension, Bradycardia, Tach... ORPHA:94093
Late-Onset Isolated Acth Deficiency
Hashimoto thyroiditis, Orthostatic hypotension, Hypotension, Hepatitis ORPHA:199299
Sepsis In Premature Infants
Bradycardia, Tachycardia, Enterocolitis, Hypotension ORPHA:90051
Late-Onset Retinal Degeneration
Ocular hypertension ORPHA:67042
Congenital Microcoria
Ocular hypertension ORPHA:566
Leptospirosis
Subconjunctival hemorrhage, Optic neuritis, Uveitis, Arrhythmia, Retinal hemorrhage, First degree... ORPHA:509
Beta-Ketothiolase Deficiency
Hypotension, Hypertension ORPHA:134
3-Hydroxy-3-Methylglutaric Aciduria
Acute pancreatitis, Dilated cardiomyopathy, Hypotension, Cardiac arrest ORPHA:20
Plague
Lymphadenitis, Erythema nodosum, Arrhythmia, Inflammatory abnormality of the eye, Hypotension, In... ORPHA:707
Gitelman Syndrome
Palpitations, Prolonged QT interval, Hypotension, Ventricular tachycardia OMIM:263800
Alexander Disease
Infectious encephalitis, Hypotension, Hypertension, Sudden cardiac death ORPHA:58
Pituitary Apoplexy
Hypotension, Hypertension ORPHA:95613
Acute Adrenal Insufficiency
Hypovolemia, Orthostatic hypotension, Hypotension, Myocardial infarction ORPHA:95409
Familial Glucocorticoid Deficiency
Hypertrophic cardiomyopathy, Hypotension ORPHA:361
Hellp Syndrome
Cerebral hemorrhage, Hypotension, Internal hemorrhage ORPHA:244242
Fragile X-Associated Tremor/Ataxia Syndrome
Hypotension, Hypertension ORPHA:93256
Biliary, Renal, Neurologic, And Skeletal Syndrome
Increased circulating ferritin concentration, Elevated circulating creatinine concentration, Hype... OMIM:619534
Neuroendocrine Neoplasm Of Appendix
Palpitations, Tricuspid stenosis, Hypotension, Heart murmur ORPHA:100079
Bartter Syndrome, Type 3
Hypotension OMIM:607364
Non-Functioning Pituitary Adenoma
Hypotension ORPHA:91349
Oculoauricular Syndrome
Ocular hypertension OMIM:612109
Hereditary Angioedema Type 1
Hypotension ORPHA:100050
Congenital Adrenal Hyperplasia Due To 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
Hypotension ORPHA:90791
Prolactinoma
Hypotension ORPHA:2965
Gitelman Syndrome
Prolonged PR interval, Abnormal T-wave, Ventricular fibrillation, Hashimoto thyroiditis, Tubuloin... ORPHA:358
Tsh-Secreting Pituitary Adenoma
Congestive heart failure, Hypotension, Ventricular arrhythmia, Hypertension, Palpitations, Suprav... ORPHA:91347
Say-Barber-Miller Syndrome
Decreased circulating IgG level, Transient hypogammaglobulinemia of infancy, Impaired neutrophil ... ORPHA:3132
Psoriasis-Related Juvenile Idiopathic Arthritis
Abnormality of tumor necrosis factor secretion ORPHA:85436
Exercise-Induced Malignant Hyperthermia
Abnormal T-wave, Sinus tachycardia, Abnormal pulse pressure, Hypotension, Prolonged QT interval, ... ORPHA:466650
Acute Liver Failure
Gastrointestinal hemorrhage, Hypotension, Intracranial hemorrhage, Hepatitis, Shock, Skin rash ORPHA:90062
Addison Disease
Hashimoto thyroiditis, Orthostatic hypotension, Hypotension ORPHA:85138
46,Xy Disorder Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Hypovolemia, Hypotension ORPHA:168558
Lysosomal Acid Lipase Deficiency
Pulmonary arterial hypertension, Hypovolemia, Hypotension ORPHA:275761
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Hypovolemia, Hypotension ORPHA:289548
Hepatocellular Carcinoma
Portal hypertension, Hypotension, Budd-Chiari syndrome, Internal hemorrhage ORPHA:88673
Phacoanaphylactic Uveitis
Ocular hypertension ORPHA:209959
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Shock, Hypovolemia, Hypotension, Acne ORPHA:90794
Non-Acquired Panhypopituitarism
Hypotension ORPHA:90695
Pmm2-Cdg
Hypertrophic cardiomyopathy, Pericarditis, Angina pectoris, Aspiration pneumonia, Intracranial he... ORPHA:79318
Bartter Syndrome, Type 1, Antenatal
Low-to-normal blood pressure OMIM:601678
Combined Pituitary Hormone Deficiencies, Genetic Forms
Hypotension ORPHA:95494
Bartter Syndrome, Type 2, Antenatal
Low-to-normal blood pressure OMIM:241200

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Adora3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Adora3.

No publications found that use IMPC mice or data for Adora3.

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MGI Allele Allele Type Produced
Adora3tm96705(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Adora3tm96705(L1L2_Pgk_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Adora3tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Adora3tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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