Myo6 | myosin VI
Physiological systems
21 / 24 physiological systems tested
13 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Adipose tissue Growth/size/body region Digestive/alimentary Hearing/vestibular/ear Nervous system Hematopoietic system Behavior/neurological Skeleton Cardiovascular system Renal/urinary system
8 No significant impact
3 Not tested
Data collections
Gene metrics:38Significant phenotypes
5Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal gait | 1 supporting dataset | Myo6em1(IMPC)Tcp | homozygote | Early adult | 1.81x10-11 | ||
| hyperactivity | 9 supporting datasets | Myo6em1(IMPC)Tcp | homozygote | Early adult | 7.4x10-158 | ||
| abnormal sternum morphology | 1 supporting dataset | Myo6em1(IMPC)Tcp | homozygote | Early adult | N/A * | ||
| prolonged PR interval | 1 supporting dataset | Myo6em1(IMPC)Tcp | homozygote | Early adult | 4.78x10-6 | ||
| hyperactivity | 1 supporting dataset | Myo6Tlc | heterozygote | Early adult | 2.77x10-11 | ||
| abnormal auditory brainstem response | 4 supporting datasets | Myo6em1(IMPC)Tcp | homozygote | Early adult | 1.61x10-6 | ||
| decreased prepulse inhibition | 7 supporting datasets | Myo6em1(IMPC)Tcp | homozygote | Early adult | 1.15x10-72 | ||
| decreased circulating triglyceride level | 1 supporting dataset | Myo6Tlc | heterozygote | Early adult | 8.59x10-7 | ||
| decreased total body fat amount | 1 supporting dataset | Myo6em1(IMPC)Tcp | homozygote | Early adult | 6.83x10-5 | ||
| abnormal startle reflex | 1 supporting dataset | Myo6em1(IMPC)Tcp | homozygote | Early adult | 2.32x10-16 |
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Human diseases caused by Myo6 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Myo6.
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| Myo6em1(IMPC)Tcp | Exon Deletion | | mouse |
| Myo6tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Myo6tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Myo6tm2a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | ES Cell |
| Myo6tm2e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Myo6tm40489(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |