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Gene: Plcb3 MGI:104778

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
phospholipase C, beta 3
Synonyms:
N/A

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Plcb3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Plcb3 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Spondylometaphyseal Dysplasia With Corneal Dystrophy
OMIM:618961

The table below shows human diseases predicted to be associated to Plcb3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Nevus Comedonicus
Nevus comedonicus OMIM:617025
Capillary Malformations, Congenital
Nevus flammeus OMIM:163000
Knuckle Pads
Subcutaneous nodule OMIM:149100
Milia, Multiple Eruptive
Milia OMIM:157400
Elastosis Perforans Serpiginosa
Nevus OMIM:130100
Proliferating Trichilemmal Cyst
Skin ulcer, Epidermoid cyst ORPHA:492
Dyschromatosis Universalis Hereditaria 3
Hypopigmented macule, Hypermelanotic macule OMIM:615402
Nevus, Epidermal
Melanocytic nevus, Numerous nevi OMIM:162900
Diffuse Palmoplantar Keratoderma, Bothnian Type
Erythema, Papule, Skin ulcer ORPHA:2337
Immunodeficiency 107, Susceptibility To Invasive Staphylococcus Aureus Infection
Pyoderma gangrenosum OMIM:619986
Dermatofibrosarcoma Protuberans
Erythema, Subcutaneous nodule, Skin ulcer ORPHA:31112
Aplasia Cutis Congenita Of Limbs, Autosomal Recessive
Congenital absence of skin of limbs, Aplasia cutis congenita OMIM:600360
Hyperkeratosis Lenticularis Perstans
Aplasia/Hypoplasia of the skin, Papule, Skin ulcer ORPHA:409
Congenital Factor Xii Deficiency
Penetrating foot ulcers ORPHA:330
Necrobiosis Lipoidica
Erythema, Indurated nodule, Skin ulcer, Skin nodule, Atrophic scars, Skin plaque, Papule, Annular... ORPHA:542592
Aplasia Cutis Congenita
Erythema, Skin ulcer, Aplasia cutis congenita, Aplasia cutis congenita over the scalp vertex, Con... ORPHA:1114
Juvenile Hyaline Fibromatosis
Aplasia/Hypoplasia of the skin, Subcutaneous nodule, Papule, Skin ulcer ORPHA:2028
Chilblain Lupus 1
Skin ulcer OMIM:610448
Aplasia Cutis-Myopia Syndrome
Aplasia cutis congenita, Skin ulcer ORPHA:1117
Severe Hereditary Thrombophilia Due To Congenital Protein S Deficiency
Aplasia/Hypoplasia of the skin, Purpura, Skin ulcer, Thin skin ORPHA:743
Familial Keratoacanthoma
Subcutaneous nodule, Papule, Skin ulcer ORPHA:493
Neuropathy, Hereditary Sensory, Type Iic
Acral ulceration OMIM:614213
Dracunculiasis
Subcutaneous nodule, Skin ulcer ORPHA:231
Striae Distensae, Familial
Striae distensae OMIM:185200
Pruritic Urticarial Papules And Plaques Of Pregnancy
Striae distensae OMIM:178995
Cervical Hypertrichosis-Peripheral Neuropathy Syndrome
Skin ulcer ORPHA:2218
Acrogeria
Aplasia/Hypoplasia of the skin, Skin ulcer, Excessive wrinkled skin, Thin skin ORPHA:2500
Classic Mycosis Fungoides
Erythema, Skin ulcer, Hypopigmented skin patches, Dry skin, Skin plaque ORPHA:2584
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia
Acral ulceration, Skin ulcer ORPHA:139578
Lichen Planopilaris
Dermal atrophy, Papule, Skin ulcer, Hypopigmented skin patches ORPHA:525
Ichthyosis, Congenital, Autosomal Recessive 12
White scaling skin OMIM:617320
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Erythematous plaque, Erythematous papule, Skin ulcer ORPHA:86884
Brooke-Spiegler Syndrome
Skin nodule, Skin-colored papule, Skin ulcer, Nodular changes affecting the eyelids ORPHA:79493
Chilblain Lupus
Erythematous papule, Skin ulcer ORPHA:90280
Pyoderma Gangrenosum
Atrophic scars, Papule, Skin vesicle, Skin ulcer ORPHA:48104
Buerger Disease
Skin ulcer ORPHA:36258
Limited Cutaneous Systemic Sclerosis
Skin ulcer, Hypopigmented skin patches ORPHA:220402
Ollier Disease
Subcutaneous nodule, Skin ulcer ORPHA:296
Familial Multiple Nevi Flammei
Papule, Skin ulcer, Hypermelanotic macule, Nevus flammeus ORPHA:624
Autosomal Dominant Epidermolytic Ichthyosis
Skin ulcer ORPHA:312
Leishmaniasis
Skin plaque, Papule, Pallor, Skin ulcer ORPHA:507
Mhc Class I Deficiency 1
Skin ulcer OMIM:604571
Neuropathy, Hereditary Sensory And Autonomic, Type Iib
Acral ulceration OMIM:613115
Reticular Dysgenesis
Skin ulcer ORPHA:33355
Polyarteritis Nodosa
Erythema, Subcutaneous nodule, Skin ulcer ORPHA:767
Hereditary Sensory And Autonomic Neuropathy Type 1
Skin ulcer, Penetrating foot ulcers ORPHA:36386
Acquired Purpura Fulminans
Pyoderma gangrenosum, Macular purpura, Macule, Erythematous macule ORPHA:49566
Disabling Pansclerotic Morphea Of Childhood
Skin ulcer OMIM:620443
Flynn-Aird Syndrome
Dermal atrophy, Skin ulcer ORPHA:2047
Beta-Thalassemia
Pallor, Skin ulcer ORPHA:848
Combined Immunodeficiency Due To Dock8 Deficiency
Skin ulcer ORPHA:217390
Attenuated Chédiak-Higashi Syndrome
Skin ulcer ORPHA:352723
Adult Polyglucosan Body Disease
Skin ulcer ORPHA:206583
Isolated Agammaglobulinemia
Skin ulcer ORPHA:229717
Immunodeficiency 114, Folate-Responsive
Skin ulcer OMIM:620603
Prolidase Deficiency
Erythema, Skin ulcer, Dry skin, Aplasia/Hypoplasia of the skin, Papule, Thin skin ORPHA:742
Dermatoosteolysis, Kirghizian Type
Aplasia/Hypoplasia of the skin, Skin ulcer ORPHA:1657
Neuropathy, Hereditary Sensory And Autonomic, Type Ic
Skin ulcer OMIM:613640
Immunodeficiency, Common Variable, 12, With Autoimmunity
Pyoderma gangrenosum OMIM:616576
Papa Syndrome
Skin ulcer ORPHA:69126
Squamous Cell Carcinoma Of The Anal Canal
Skin ulcer ORPHA:424019
Takayasu Arteritis
Subcutaneous nodule, Skin ulcer ORPHA:3287
Free Sialic Acid Storage Disease
Skin ulcer ORPHA:834
Calciphylaxis
Skin ulcer ORPHA:280062
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Pyoderma gangrenosum OMIM:604416
Meige Disease
Atypical scarring of skin, Skin ulcer, Skin erosion, Skin dimple ORPHA:90186
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques
Erythema, Skin ulcer, Skin fissure ORPHA:659
Infantile Myofibromatosis
Subcutaneous nodule, Skin ulcer ORPHA:2591
Acute Radiation Syndrome
Dermal atrophy, Skin ulcer, Scaling skin ORPHA:454831
Cryoglobulinemic Vasculitis
Petechiae, Purpura, Skin ulcer ORPHA:91138
Epidermolysis Bullosa, Junctional 2C, Laryngoonychocutaneous
Skin ulcer OMIM:245660
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Pyoderma gangrenosum OMIM:150550
X-Linked Agammaglobulinemia
Skin ulcer, Hypopigmented skin patches ORPHA:47
Prolidase Deficiency
Petechiae, Skin ulcer OMIM:170100
Neutrophilic Dermatosis, Acute Febrile
Pyoderma gangrenosum, Erythema OMIM:608068
Autosomal Dominant Hyper-Ige Syndrome Due To Stat3 Deficiency
Skin vesicle, Papule, Skin ulcer ORPHA:2314
Chronic Granulomatous Disease
Hypermelanotic macule, Skin ulcer, Macule ORPHA:379
Adult Syndrome
Dry skin, Melanocytic nevus, Skin ulcer, Thin skin ORPHA:978
Chronic Mucocutaneous Candidiasis
Erythema, Papule, Skin ulcer ORPHA:1334
Neuropathy, Hereditary Sensory And Autonomic, Type Ia
Acral ulceration OMIM:162400
Livedoid Vasculopathy
Erythematous papule, Skin ulcer, Macular purpura, Atrophic scars, Ecchymosis ORPHA:542643
Werner Syndrome
Aplasia/Hypoplasia of the skin, Skin ulcer, Lack of skin elasticity ORPHA:902
Microscopic Polyangiitis
Erythema, Subcutaneous nodule, Skin ulcer ORPHA:727
Reynolds Syndrome
Skin ulcer ORPHA:779
Acrodermatitis Enteropathica
Erythema, Skin ulcer, Dry skin ORPHA:37
Ectodermal Dysplasia-Blindness Syndrome
Skin ulcer ORPHA:1806
Infantile Systemic Hyalinosis
Subcutaneous nodule, Skin ulcer ORPHA:2176
Diffuse Cutaneous Systemic Sclerosis
Skin ulcer ORPHA:220393
Hereditary Spherocytosis
Pallor, Skin ulcer ORPHA:822
Beta-Thalassemia Intermedia
Pallor, Skin ulcer ORPHA:231222
Autosomal Dominant Severe Congenital Neutropenia
Pyoderma gangrenosum ORPHA:486
Hereditary Acrokeratotic Poikiloderma
Erythema, Skin ulcer, Hypopigmented skin patches, Papule, Thin skin ORPHA:2907
Sweet Syndrome
Erythematous papule, Erythematous plaque, Skin vesicle, Pyoderma gangrenosum, Skin nodule ORPHA:3243
Malakoplakia
Subcutaneous nodule, Papule, Skin ulcer ORPHA:556
Fusariosis
Subcutaneous nodule, Papule, Skin detachment, Skin ulcer ORPHA:228119
Dyskeratosis Congenita
Skin ulcer, Hypopigmented skin patches, Skin vesicle, Aplasia/Hypoplasia of the skin, Macule, Hyp... ORPHA:1775
Neuropathy, Hereditary Sensory And Autonomic, Type Iia
Acral ulceration OMIM:201300
Catastrophic Antiphospholipid Syndrome
Skin ulcer ORPHA:464343
Dominant Beta-Thalassemia
Pallor, Skin ulcer ORPHA:231226
Immunoglobulin A Vasculitis
Erythema, Purpura, Macule, Skin ulcer ORPHA:761
Giant Cell Arteritis
Skin ulcer ORPHA:397
Neuropathy, Hereditary Sensory, With Spastic Paraplegia, Autosomal Recessive
Acral ulceration OMIM:256840
Juvenile Dermatomyositis
Erythema, Skin ulcer, Dry skin ORPHA:93672
Toxic Epidermal Necrolysis
Erythema, Skin ulcer, Macule ORPHA:537
Incontinentia Pigmenti
Erythema, Skin ulcer, Hypopigmented skin patches ORPHA:464
Parkes Weber Syndrome
Capillary malformation, Erythematous plaque, Skin ulcer, Scaling skin ORPHA:90307
Leukocyte Adhesion Deficiency, Type I
Skin ulcer OMIM:116920
Neuropathy, Hereditary Sensory And Autonomic, Type V
Acral ulceration OMIM:608654
Beta-Thalassemia Major
Pallor, Skin ulcer ORPHA:231214
Systemic Sclerosis
Digital ulcer, Acral ulceration, Spotty hypopigmentation, Cutaneous sclerotic plaque, Digital pit... ORPHA:90291
Pgm3-Cdg
Skin ulcer ORPHA:443811
Dermatomyositis
Erythema, Skin ulcer, V-sign, Dry skin, Aplasia/Hypoplasia of the skin, Facial erythema, Gottron'... ORPHA:221
Blau Syndrome
Intermittent generalized erythematous papular rash, Skin ulcer OMIM:186580
Hereditary Elliptocytosis
Skin ulcer ORPHA:288
Granulomatosis With Polyangiitis
Skin ulcer OMIM:608710
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Dry skin, Subcutaneous nodule, Skin ulcer, Scaling skin ORPHA:2526
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Purpura, Skin ulcer, Urticarial plaque OMIM:615688
Amoebiasis Due To Free-Living Amoebae
Subcutaneous nodule, Papule, Skin ulcer ORPHA:68
Leprosy
Penetrating foot ulcers, Hypopigmented macule, Urticarial plaque, Acral ulceration, Verrucous pap... ORPHA:548
Hajdu-Cheney Syndrome
Dry skin, Skin ulcer ORPHA:955
Wiskott-Aldrich Syndrome
Petechiae, Purpura, Skin ulcer ORPHA:906
Charcot-Marie-Tooth Disease Type 4B2
Penetrating foot ulcers ORPHA:99956
Adenocarcinoma Of The Anal Canal
Skin ulcer ORPHA:424016
Chime Syndrome
Erythema, Skin ulcer ORPHA:3474
Insensitivity To Pain, Congenital, With Anhidrosis
Acral ulceration OMIM:256800
Granulomatosis With Polyangiitis
Papule, Purpura, Skin ulcer ORPHA:900
Cushing Disease
Skin ulcer, Striae distensae, Ecchymosis, Purpura, Thin skin ORPHA:96253
Primary Sjögren Syndrome
Dry skin, Purpura, Lichenoid skin lesion, Skin ulcer ORPHA:289390
Simple Cryoglobulinemia
Localized skin lesion, Purpura, Acral ulceration ORPHA:91139
Oculocerebrorenal Syndrome Of Lowe
Atypical scarring of skin, Skin ulcer ORPHA:534
Blau Syndrome
Erythema, Papule, Skin ulcer, Dry skin ORPHA:90340
Atypical Werner Syndrome
Aplasia/Hypoplasia of the skin, Lack of skin elasticity, Skin ulcer, Thin skin ORPHA:79474
Chronic Graft Versus Host Disease
Erythema, Intermittent generalized erythematous papular rash, Skin vesicle, Skin ulcer ORPHA:99921
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Skin ulcer, Ecchymosis ORPHA:2072
Plague
Localized skin lesion, Skin ulcer, Dry skin ORPHA:707
Mitochondrial Dna Depletion Syndrome 6 (Hepatocerebral Type)
Acral ulceration OMIM:256810
Cushing Syndrome Due To Ectopic Acth Secretion
Skin ulcer, Striae distensae, Ecchymosis, Purpura, Thin skin ORPHA:99889
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis Spectrum
Atypical scarring of skin, Skin ulcer ORPHA:95455
Leukocyte Adhesion Deficiency
Pyoderma gangrenosum ORPHA:2968
Spondylometaphyseal Dysplasia With Corneal Dystrophy
OMIM:618961

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Plcb3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Plcb3.

No publications found that use IMPC mice or data for Plcb3.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Plcb3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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