Atn1 | atrophin 1

GeneMGI:104725Synonyms: Atr1, Drpla, +1 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system

13 No significant impact

4 Not tested

Gene metrics:17Significant phenotypes
3Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

increased heart rate variability1 supporting datasetAtn1tm1b(EUCOMM)WtsihomozygoteEarly adult2.86x10-7 
increased circulating triglyceride level1 supporting datasetAtn1tm1b(EUCOMM)WtsihomozygoteEarly adult1.02x10-5 
abnormal gait1 supporting datasetAtn1tm1b(EUCOMM)WtsihomozygoteEarly adult2.4x10-12 
decreased exploration in new environment1 supporting datasetAtn1tm1b(EUCOMM)WtsihomozygoteEarly adult1.81x10-6 
increased mean corpuscular hemoglobin1 supporting datasetAtn1tm1b(EUCOMM)WtsihomozygoteEarly adult3.14x10-5 
abnormal sinus arrhythmia1 supporting datasetAtn1tm1b(EUCOMM)WtsihomozygoteEarly adult3.89x10-5 
decreased erythrocyte cell number1 supporting datasetAtn1tm1b(EUCOMM)WtsihomozygoteEarly adult8.52x10-5 
abnormal skin morphology2 supporting datasetsAtn1tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
cataract1 supporting datasetAtn1tm1b(EUCOMM)WtsihomozygoteEarly adult9.35x10-5 
limb grasping1 supporting datasetAtn1tm1b(EUCOMM)WtsihomozygoteEarly adult8.45x10-14 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (2/2)0.7% (4/570)
aortaheterozygoten/a100% (2/2)0.19% (1/533)
boneheterozygoten/a100% (2/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a100% (2/2)0% (0/588)
cartilage tissueheterozygoten/a100% (2/2)0.22% (1/454)
cerebellumheterozygoten/a100% (2/2)0.56% (3/532)
cerebral cortexheterozygoten/a100% (2/2)0.41% (2/491)
esophagusheterozygoten/a100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Atn1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Atn1tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Atn1tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Atn1tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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