Atn1 | atrophin 1
Physiological systems
20 / 24 physiological systems tested
7 Significantly impacted by the knock-out
Homeostasis/metabolism Immune system Integument Vision/eye Hematopoietic system Behavior/neurological Cardiovascular system
13 No significant impact
4 Not tested
Data collections
Gene metrics:17Significant phenotypes
3Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues
increased heart rate variability | 1 supporting dataset | Atn1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.86x10-7 | ||
increased circulating triglyceride level | 1 supporting dataset | Atn1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.02x10-5 | ||
abnormal gait | 1 supporting dataset | Atn1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 2.4x10-12 | ||
decreased exploration in new environment | 1 supporting dataset | Atn1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 1.81x10-6 | ||
increased mean corpuscular hemoglobin | 1 supporting dataset | Atn1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.14x10-5 | ||
abnormal sinus arrhythmia | 1 supporting dataset | Atn1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 3.89x10-5 | ||
decreased erythrocyte cell number | 1 supporting dataset | Atn1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.52x10-5 | ||
abnormal skin morphology | 2 supporting datasets | Atn1tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
cataract | 1 supporting dataset | Atn1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 9.35x10-5 | ||
limb grasping | 1 supporting dataset | Atn1tm1b(EUCOMM)Wtsi | homozygote | Early adult | 8.45x10-14 |
| | | | | | | | | |
adrenal gland | heterozygote | n/a | 100% (2/2) | 0.7% (4/570) |
aorta | heterozygote | n/a | 100% (2/2) | 0.19% (1/533) |
bone | heterozygote | n/a | 100% (2/2) | 0% (0/394) |
brain | heterozygote | n/a | 100% (2/2) | 0.86% (5/579) |
brainstem | heterozygote | n/a | 100% (2/2) | 0.41% (2/490) |
brown adipose tissue | heterozygote | n/a | 100% (2/2) | 0% (0/588) |
cartilage tissue | heterozygote | n/a | 100% (2/2) | 0.22% (1/454) |
cerebellum | heterozygote | n/a | 100% (2/2) | 0.56% (3/532) |
cerebral cortex | heterozygote | n/a | 100% (2/2) | 0.41% (2/491) |
esophagus | heterozygote | n/a | 100% (2/2) | 1.67% (7/419) |
External links
No external links available for Atn1.
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Atn1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | | ES Cell |
Atn1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Atn1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Atn1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | | ES Cell |