Gene: Ptpn12

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Name
protein tyrosine phosphatase, non-receptor type 12
MGI ID
MGI:104673
Synonyms
P19-PTP PTP-P19 PTP-PEST
Viability
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal pericardium morphology Ptpn12tm1b(NCOM)Mfgc HOM E9.5 0.00
hypoactivity Ptpn12tm1b(NCOM)Mfgc HET Early adult 5.13×10-07
abnormal midbrain development Ptpn12tm1b(NCOM)Mfgc HET E9.5 0.00
preweaning lethality, complete penetrance Ptpn12tm1b(NCOM)Mfgc HOM   Early adult 0.00
abnormal hindbrain development Ptpn12tm1b(NCOM)Mfgc HET E9.5 0.00
embryonic lethality prior to tooth bud stage Ptpn12tm1b(NCOM)Mfgc HOM   E12.5 0.00
abnormal forebrain development Ptpn12tm1b(NCOM)Mfgc HET E9.5 0.00
increased anxiety-related response Ptpn12tm1b(NCOM)Mfgc HET Early adult 1.13×10-05
abnormal neural tube closure Ptpn12tm1b(NCOM)Mfgc HET E9.5 0.00
abnormal embryo size Ptpn12tm1b(NCOM)Mfgc HET E9.5 0.00
abnormal embryo size Ptpn12tm1b(NCOM)Mfgc HOM E9.5 0.00
increased thigmotaxis Ptpn12tm1b(NCOM)Mfgc HET Early adult 1.56×10-05
abnormal behavior Ptpn12tm1b(NCOM)Mfgc HET Early adult 1.56×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/65)  (2/2) N/A
Brain 5  (6/506)  (2/5) N/A
Central nervous system ganglion 2  (1/74)  (2/2) N/A
Ear 5  (1/506)  (2/5) N/A
Embryo 5  (1/507)  (2/5) N/A
Eye 5  (1/506)  (2/5) N/A
Foot 5  (1/506)  (2/5) N/A
Forebrain 5  (1/506)  (2/5) N/A
Forelimb 5  (1/506)  (2/5) N/A
Gut 2  (1/60)  (2/2) N/A
Hand 5  (1/506)  (2/5) N/A
Head 5  (5/506)  (2/5) N/A
Heart 5  (1/506)  (2/5) N/A
Hindbrain 5  (6/506)  (2/5) N/A
Hindlimb 5  (1/506)  (2/5) N/A
Liver 5  (1/504)  (2/5) N/A
Lung 5  (1/504)  (2/5) N/A
Mandibular process 5  (1/506)  (2/5) N/A
Maxillary process 5  (1/506)  (2/5) N/A
Midbrain 5  (1/506)  (2/5) N/A
Nose 2  (1/76)  (2/2) N/A
Oral cavity 5  (1/504)  (2/5) N/A
Skeleton 2  (1/76)  (2/2) N/A
Skin 5  (1/506)  (2/5) N/A
Spinal cord 2  (1/73)  (2/2) N/A
Tail 5  (1/506)  (2/5) N/A
Tail somite 5  (1/506)  (2/5) N/A
Trachea 2  (1/60)  (2/2) N/A
Urinary system 2  (1/60)  (2/2) N/A

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
10 Images
Gross Pathology and Tissue Collection
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Gross Morphology Embryo E9.5
7 Images
Embryo LacZ: LacZ images wholemount
20 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Eye Morphology: Images Ophthalmoscopy
1 Images
Immunophenotyping: Panel A FCS file(s)
1 Images
Eye Morphology: Images Slit Lamp
2 Images

 Disease Models

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MGI Allele Allele Type Produced
Ptpn12tm1b(NCOM)Mfgc Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Ptpn12tm1a(NCOM)Mfgc KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Ptpn12tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ptpn12tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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