Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
LIM-domain containing, protein kinase
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Limk1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Limk1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Williams Syndrome
Gait disturbance, Ataxia, Cerebral cortical atrophy, Abnormality of the diencephalon, Dysmetria, ... ORPHA:904

The table below shows human diseases predicted to be associated to Limk1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Familial Alzheimer-Like Prion Disease
Cognitive impairment, Deficit in phonologic short-term memory, Attention deficit hyperactivity di... ORPHA:280397
Mental Retardation, Autosomal Recessive 3
Progressive microcephaly, Hyperactivity OMIM:608443
Attention Deficit-Hyperactivity Disorder
Attention deficit hyperactivity disorder, Hyperactivity OMIM:143465
Mental Retardation, Autosomal Dominant 45
Attention deficit hyperactivity disorder, Hyperactivity OMIM:617600
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Attention deficit hyperactivity disorder, Hyperactivity OMIM:301008
Spastic Tetraplegia, Thin Corpus Callosum, And Progressive Microcephaly
Inability to walk, Hypoplasia of the corpus callosum, Cerebral atrophy, Hyperactivity, Microcepha... OMIM:616657
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Mental Retardation, Autosomal Recessive 54
Hyperactivity OMIM:617028
Schizophrenia 15
Hyperactivity OMIM:613950
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Immunodeficiency 8
Hyperactivity OMIM:615401
Mental Retardation, Autosomal Dominant 33
Microcephaly, Hyperactivity OMIM:616311
Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations
Pachygyria, Hypoplasia of the corpus callosum, Abnormal corpus callosum morphology, Polymicrogyri... OMIM:604317
Microcephaly, Seizures, And Developmental Delay
Hypoplasia of the corpus callosum, Ataxia, Simplified gyral pattern, Hyperactivity, Microcephaly,... OMIM:613402
Encephalopathy, Progressive, With Or Without Lipodystrophy
Dystonia, Cerebral atrophy, Ataxia, Hyperactivity, Mental deterioration OMIM:615924
Mental Retardation, Autosomal Dominant 52
Hyperactivity OMIM:617796
Spinocerebellar Ataxia 14
Gait ataxia, Progressive cerebellar ataxia, Dysmetria, Focal dystonia, Memory impairment, Mental ... OMIM:605361
Intellectual Developmental Disorder, X-Linked 109
Hyperactivity OMIM:309548
Juvenile Huntington Disease
Dystonia, Gait ataxia, Dementia, Abnormal cerebral white matter morphology, Ataxia, Bradykinesia,... ORPHA:248111
Mental Retardation, Autosomal Recessive 37
Hyperactivity OMIM:615493
Developmental And Epileptic Encephalopathy 43
Ataxia, Hyperactivity OMIM:617113
Epilepsy, Progressive Myoclonic, 12
Difficulty walking, Ataxia, Dysmetria, Mental deterioration, Attention deficit hyperactivity diso... OMIM:619191
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity ORPHA:356996
Insulin-Like Growth Factor I Deficiency
Microcephaly, Hyperactivity OMIM:608747
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity ORPHA:436151
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity OMIM:300271
Polymicrogyria Due To Tubb2B Mutation
Cavum septum pellucidum, Pachygyria, Abnormal caudate nucleus morphology, Lissencephaly, Hypoplas... ORPHA:300573
Hyperlysinemia, Type I
Cognitive impairment, Hyperactivity OMIM:238700
Neurodevelopmental Disorder With Epilepsy And Hypoplasia Of The Corpus Callosum
Inability to walk, Hypoplasia of the corpus callosum, Gait disturbance, Dysmetria, Hyperactivity OMIM:618090
Aminoacylase 1 Deficiency
Cerebral atrophy, Hyperactivity OMIM:609924
Lennox-Gastaut Syndrome
Mental deterioration, Falls, Hyperactivity ORPHA:2382
Dihydropyrimidine Dehydrogenase Deficiency
Lethargy, Cerebral atrophy, Hyperactivity, Microcephaly, Agenesis of corpus callosum OMIM:274270
Sotos Syndrome 3
Hyperactivity OMIM:617169
Intellectual Developmental Disorder, X-Linked 101
Hyperactivity OMIM:300928
Smith-Magenis syndrome
Hyperactivity DECIPHER:8
Cognitive Impairment With Or Without Cerebellar Ataxia
Cognitive impairment, Dysmetria, Attention deficit hyperactivity disorder, Ataxia OMIM:614306
Glycine Encephalopathy
Lethargy, Agenesis of corpus callosum, Hyperactivity OMIM:605899
Intellectual Developmental Disorder, X-Linked 104
Cerebral cortical atrophy, Hypoplasia of the corpus callosum, Ataxia, Hyperactivity OMIM:300983
Mental Retardation, Autosomal Dominant 43
Hypoplasia of the corpus callosum, Cerebral atrophy, Microcephaly, Hyperactivity OMIM:616977
Autosomal Recessive Non-Syndromic Intellectual Disability
Dystonia, Absent septum pellucidum, Hypoplasia of the corpus callosum, Cerebral atrophy, Polymicr... ORPHA:88616
Cln5 Disease
Dysdiadochokinesis, Inability to walk, Truncal ataxia, Corpus callosum atrophy, Ataxia, Cerebral ... ORPHA:228360
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia
Attention deficit hyperactivity disorder, Hyperactivity OMIM:617182
Intellectual Developmental Disorder, X-Linked 107
Hyperactivity OMIM:301013
Rasmussen Subacute Encephalitis
Inability to walk, Hyperactivity, Subcortical cerebral atrophy, Abnormality of the basal ganglia,... ORPHA:1929
X-Linked Intellectual Disability, Stocco Dos Santos Type
Hyperactivity ORPHA:85288
Severe Neurodegenerative Syndrome With Lipodystrophy
Gait ataxia, Cerebral atrophy, Ataxia, Progressive psychomotor deterioration, Limb dystonia, Hype... ORPHA:363400
Hyperprolinemia, Type I
Ataxia, Hyperactivity OMIM:239500
Landau-Kleffner Syndrome
Gait ataxia, Steppage gait, Social and occupational deterioration, Hyperactivity, Memory impairme... ORPHA:98818
Xq25 Microduplication Syndrome
Hypoplasia of the corpus callosum, Hyperactivity ORPHA:521258
Xq25 Duplication Syndrome
Hypoplasia of the corpus callosum, Hyperactivity OMIM:300979
Intellectual Developmental Disorder, X-Linked, Syndromic, Stocco Dos Santos Type
Microcephaly, Hyperactivity OMIM:300434
Mental Retardation, Autosomal Recessive 39
Microcephaly, Hyperactivity OMIM:615541
Pitt-Hopkins-Like Syndrome 1
Progressive language deterioration, Ataxia, Cortical dysplasia, Focal cortical dysplasia, Hyperac... OMIM:610042
Mannosidosis, Beta A, Lysosomal
Hyperactivity OMIM:248510
Chromosome 3Q29 Deletion Syndrome
Microcephaly, Gait ataxia, Hyperactivity OMIM:609425
Optic Atrophy 11
Ataxia, Leukoencephalopathy, Dysmetria, Hyperactivity, Microcephaly OMIM:617302
Alazami-Yuan Syndrome
Microcephaly, Hyperactivity OMIM:617126
Fraxe Intellectual Disability
Hyperactivity ORPHA:100973
X-Linked Intellectual Disability-Hypotonia-Movement Disorder Syndrome
Hypoplasia of the corpus callosum, Cortical dysplasia, Hyperactivity, Microcephaly, Broad-based gait ORPHA:457260
Ck Syndrome
Pachygyria, Polymicrogyria, Hyperactivity, Microcephaly, Abnormal cerebral cortex morphology ORPHA:251383
Phenylketonuria
Microcephaly, Cerebral calcification, Attention deficit hyperactivity disorder, Hyperactivity OMIM:261600
Mental Retardation, X-Linked 77
Hyperactivity OMIM:300454
Mental Retardation, Autosomal Recessive 61
Hypoplasia of the corpus callosum, Secondary microcephaly, Hyperactivity OMIM:617773
Childhood-Onset Motor And Cognitive Regression Syndrome With Extrapyramidal Movement Disorder
Inability to walk, Dystonia, Gait ataxia, Hypoplasia of the corpus callosum, Cerebral atrophy, Hy... ORPHA:500180
8p23.1 deletion syndrome
Hyperactivity DECIPHER:39
Infantile Neuroaxonal Dystrophy
Dystonia, Psychomotor deterioration, Gait disturbance, Abnormal cerebral white matter morphology,... ORPHA:35069
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency
Microcephaly, Dystonia, Ataxia, Hyperactivity OMIM:612716
Coffin-Siris Syndrome 8
Hyperactivity OMIM:618362
Intellectual Developmental Disorder With Abnormal Behavior, Microcephaly, And Short Stature
Microcephaly, Hyperactivity OMIM:618342
Neurodegeneration With Brain Iron Accumulation 2B
Dysdiadochokinesis, Dystonia, Gait ataxia, Neurofibrillary tangles, Cerebral atrophy, Lewy bodies... OMIM:610217
Late Infantile Neuronal Ceroid Lipofuscinosis
Inability to walk, Corpus callosum atrophy, Dementia, Gait disturbance, Cerebral atrophy, Ataxia,... ORPHA:168491
Mental Retardation, Autosomal Recessive 13
Hypoplasia of the corpus callosum, Secondary microcephaly, Hyperactivity OMIM:613192
Intellectual Developmental Disorder, X-Linked 30
Microcephaly, Hyperactivity OMIM:300558
Neurodevelopmental Disorder With Brain Abnormalities, Poor Growth, And Dysmorphic Facies
Microcephaly, Decreased response to growth hormone stimuation test, Agenesis of corpus callosum, ... OMIM:615286
Ck Syndrome
Microcephaly, Polymicrogyria, Pachygyria, Hyperactivity OMIM:300831
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Broad-based gait, Cessation of head growth, Ataxia, Hyperactivity ORPHA:411515
Severe Motor And Intellectual Disabilities-Sensorineural Deafness-Dystonia Syndrome
Cerebral white matter atrophy, Corpus callosum atrophy, Cerebral cortical atrophy, Hyperactivity,... ORPHA:369939
X-Linked Adrenoleukodystrophy
Dementia, Gait disturbance, Hyperactivity, Cognitive impairment, Attention deficit hyperactivity ... ORPHA:43
Neurodevelopmental Disorder With Movement Abnormalities, Abnormal Gait, And Autistic Features
Unsteady gait, Progressive microcephaly, Broad-based gait, Hyperactivity OMIM:617865
Clcn4-Related X-Linked Intellectual Disability Syndrome
Hypoplasia of the corpus callosum, Abnormal cerebral white matter morphology, Progressive cerebel... ORPHA:485350
Rubinstein-Taybi Syndrome 2
Microcephaly, Hyperactivity OMIM:613684
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia
Inability to walk, Microcephaly, Hyperactivity OMIM:618718
Gand Syndrome
Hyperactivity OMIM:615074
X-Linked Cerebral Adrenoleukodystrophy
Inability to walk, Abnormal periventricular white matter morphology, Difficulty walking, Gait dis... ORPHA:139396
Gomez-Lopez-Hernandez Syndrome
Cognitive impairment, Decreased response to growth hormone stimuation test, Ataxia, Hyperactivity OMIM:601853
Clark-Baraitser Syndrome
Hyperactivity OMIM:617752
Mucopolysaccharidosis, Type Iiib
Progressive neurologic deterioration, Hyperactivity OMIM:252920
Intellectual Developmental Disorder, X-Linked, Syndromic, Cabezas Type
Gait ataxia, Hypoplasia of the corpus callosum, Abnormal cerebral white matter morphology, Polymi... OMIM:300354
Intellectual Developmental Disorder, X-Linked, Syndromic, Snijders Blok Type
Hypoplasia of the corpus callosum, Microcephaly, Broad-based gait, Hyperactivity OMIM:300958
Intellectual Developmental Disorder, X-Linked 98
Microcephaly, Secondary microcephaly, Ataxia, Hyperactivity OMIM:300912
Succinic Semialdehyde Dehydrogenase Deficiency
Ataxia, Hyperactivity OMIM:271980
Guanidinoacetate Methyltransferase Deficiency
Dystonia, Athetosis, Ataxia, Hyperactivity ORPHA:382
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Broad-based gait, Shuffling gait, Hyperactivity ORPHA:3077
Mental Retardation, Autosomal Recessive 38
Unsteady gait, Hyperactivity OMIM:615516
Mucopolysaccharidosis, Type Iiic
Motor deterioration, Hyperactivity OMIM:252930
Mental Retardation, Autosomal Dominant 7
Gait disturbance, Ataxia, Cerebral cortical atrophy, Hyperactivity, Microcephaly OMIM:614104
Intellectual Developmental Disorder, Autosomal Recessive 71
Attention deficit hyperactivity disorder, Hyperactivity OMIM:618504
Intellectual Disability-Obesity-Prognathism-Eye And Skin Anomalies Syndrome
Hyperactivity ORPHA:397973
Neurodegeneration With Brain Iron Accumulation 1
Eye of the tiger anomaly of globus pallidus, Dystonia, Akinesia, Dementia, Gait disturbance, Blep... OMIM:234200
Severe Intellectual Disability-Short Stature-Behavioral Abnormalities-Facial Dysmorphism Syndrome
Hypoplasia of the corpus callosum, Abnormal cerebral white matter morphology, Microcephaly, Hyper... ORPHA:391307
Myoclonic-Astatic Epilepsy
Ataxia, Unsteady gait, Hyperactivity, Microcephaly, Attention deficit hyperactivity disorder ORPHA:1942
Intellectual Disability, Birk-Barel Type
Fatiguable weakness of proximal limb muscles, Fatigable weakness of skeletal muscles, Hyperactivity ORPHA:166108
Intellectual Developmental Disorder With Dysmorphic Facies And Behavioral Abnormalities
Microcephaly, Hyperactivity OMIM:618089
Chromosome 15Q25 Deletion Syndrome
Attention deficit hyperactivity disorder, Hyperactivity OMIM:614294
Neurodevelopmental Disorder With Or Without Autism Or Seizures
Microcephaly, Hyperactivity OMIM:619239
Mitochondrial Complex Iii Deficiency, Nuclear Type 7
Hyperactivity OMIM:615824
Fragile X Syndrome
Hyperactivity OMIM:300624
X-Linked Creatine Transporter Deficiency
Dystonia, Ataxia, Hyperactivity, Microcephaly, Athetosis ORPHA:52503
Lamb-Shaffer Syndrome
Microcephaly, Ataxia, Hyperactivity ORPHA:530983
Graves Disease, Susceptibility To, 1
Hyperactivity OMIM:275000
Intellectual Developmental Disorder, X-Linked 21
Hyperactivity OMIM:300143
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Elevated circulating growth hormone concentration, Hyperactivity ORPHA:85327
2Q23.1 Microdeletion Syndrome
Microcephaly, Ataxia, Hyperactivity ORPHA:228402
Female Restricted Epilepsy With Intellectual Disability
Hyperactivity ORPHA:101039
Macrocephaly-Intellectual Disability-Neurodevelopmental Disorder-Small Thorax Syndrome
Gait disturbance, Megalencephaly, Abnormal corpus callosum morphology, Polymicrogyria, Hyperactivity ORPHA:457485
Citrullinemia Type Ii
Memory impairment, Lethargy, Cerebral edema, Hyperactivity ORPHA:247585
Mend Syndrome
Hyperactivity OMIM:300960
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency
Microcephaly, Attention deficit hyperactivity disorder, Hyperactivity ORPHA:73272
Angelman Syndrome Due To Maternal 15Q11Q13 Deletion
Hypoplasia of the corpus callosum, Ataxia, Cessation of head growth, Hyperactivity, Secondary mic... ORPHA:98794
47,Xyy Syndrome
Increased circulating gonadotropin level, Azoospermia, Oligospermia, Hyperactivity, Attention def... ORPHA:8
Potocki-Lupski Syndrome
Hypoplasia of the corpus callosum, Microcephaly, Hyperactivity OMIM:610883
Adenylosuccinase Deficiency
Inability to walk, Gait ataxia, Cerebral atrophy, Hyperactivity, Microcephaly OMIM:103050
Acrodysostosis 2 With Or Without Hormone Resistance
Hyperactivity OMIM:614613
Angelman Syndrome
Progressive gait ataxia, Cerebral cortical atrophy, Hyperactivity, Secondary microcephaly, Broad-... OMIM:105830
Hypomagnesemia, Seizures, And Mental Retardation 2
Hyperactivity OMIM:618314
Mucopolysaccharidosis, Type Iiia
Hyperactivity OMIM:252900
Glass Syndrome
Microcephaly, Broad-based gait, Hyperactivity OMIM:612313
16P12.1P12.3 Triplication Syndrome
Decreased response to growth hormone stimuation test, Attention deficit hyperactivity disorder, H... ORPHA:485405
Choreoacanthocytosis
Frontal cortical atrophy, Hypoplastic hippocampus, Bradyphrenia, Blepharospasm, Bradykinesia, Cau... ORPHA:2388
Intellectual Developmental Disorder, X-Linked, Syndromic, Billuart Type
Gait ataxia, Hyperactivity OMIM:300486
Brain-Lung-Thyroid Syndrome
Cavum septum pellucidum, Dystonia, Elevated circulating thyroid-stimulating hormone concentration... ORPHA:209905
Spastic Paraplegia 29, Autosomal Dominant
Hyperactivity OMIM:609727
Intellectual Developmental Disorder, X-Linked, Syndromic, Lujan-Fryns Type
Agenesis of corpus callosum, Hyperactivity OMIM:309520
Angelman Syndrome
Inability to walk, Ataxia, Cerebral dysmyelination, Cerebral cortical atrophy, Hyperactivity, Mic... ORPHA:72
Hyperthyroidism, Nonautoimmune
Hyperactivity OMIM:609152
Wiedemann-Steiner Syndrome
Psychomotor deterioration, Abnormal corpus callosum morphology, Hyperactivity, Microcephaly, Decr... ORPHA:319182
Stankiewicz-Isidor Syndrome
Pineal cyst, Hyperactivity OMIM:617516
Purine Nucleoside Phosphorylase Deficiency
Ataxia, Hyperactivity ORPHA:760
Cerebellar Ataxia, Nonprogressive, With Mental Retardation
Ataxia, Cerebral cortical atrophy, Unsteady gait, Hippocampal atrophy, Dysmetria, Hyperactivity OMIM:614756
Symptomatic Form Of Fragile X Syndrome In Female Carrier
Attention deficit hyperactivity disorder, Hyperactivity ORPHA:449291
Dyggve-Melchior-Clausen Disease
Inability to walk, Microcephaly, Difficulty walking, Hyperactivity ORPHA:239
Mucopolysaccharidosis Type 3
Progressive neurologic deterioration, Fatigable weakness of swallowing muscles, Dementia, Gait di... ORPHA:581
Histidinemia
Hyperactivity ORPHA:2157
Hyperlysinemia
Microcephaly, Tip-toe gait, Dysmetria, Hyperactivity ORPHA:2203
Brooks-Wisniewski-Brown syndrome
Microcephaly, Cerebral atrophy, Agenesis of corpus callosum, Hyperactivity OMIM:300612
Insensitivity To Pain, Congenital, With Anhidrosis
Hyperactivity OMIM:256800
Familial Gestational Hyperthyroidism
Hyperactivity ORPHA:99819
Familial Hyperthyroidism Due To Mutations In Tsh Receptor
Hyperactivity ORPHA:424
Early Infantile Epileptic Encephalopathy
Diffuse white matter abnormalities, Dystonia, Episodic ataxia, Pachygyria, Hypoplasia of the corp... ORPHA:1934
Maternal Phenylketonuria
Hypoplasia of the corpus callosum, Microcephaly, Hyperactivity ORPHA:2209
Argininemia
Spastic gait, Hyperactivity OMIM:207800
Mucopolysaccharidosis Type 2
Cognitive impairment, Progressive neurologic deterioration, Mental deterioration, Hyperactivity ORPHA:580
Microcephaly-Corpus Callosum Hypoplasia-Intellectual Disability-Facial Dysmorphism Syndrome
Hypoplasia of the corpus callosum, Agenesis of corpus callosum, Hyperactivity ORPHA:457284
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome
Primary microcephaly, Hypoplasia of the corpus callosum, Secondary microcephaly, Hyperactivity ORPHA:447997
Tuberous Sclerosis Complex
Cortical dysplasia, Cortical tubers, Hyperactivity, Attention deficit hyperactivity disorder, Pit... ORPHA:805
Williams Syndrome
Gait disturbance, Ataxia, Cerebral cortical atrophy, Abnormality of the diencephalon, Dysmetria, ... ORPHA:904

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Limk1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Limk1.

No publications found that use IMPC mice or data for Limk1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Limk1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter