Genes Phenotypes

Gene: Cdkn1a

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Name
cyclin-dependent kinase inhibitor 1A (P21)
MGI ID
MGI:104556
Synonyms
P21 p21WAF Waf1 Cdkn1 CIP1 SDI1 CAP20 mda6 CDKI p21Cip1 p21
Viability
Homozygous - Viable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (13) Measurements chart (196) All data table (366)
Expression & images (73) Disease models (0) Order (5)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
enlarged heart Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00
abnormal lung morphology Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00
abnormal spleen morphology Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased circulating insulin level Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 8.69×10-06
enlarged epididymis Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00
abnormal testis morphology Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00
abnormal epididymis morphology Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00
abnormal seminal vesicle morphology Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00
small seminal vesicle Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00
enlarged spleen Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00
abnormal heart morphology Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00
small testis Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00
enlarged heart atrium Cdkn1atm1.1(KOMP)Vlcg HOM Early adult 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Section images
Aorta 2 No  (2/2)  Section images
Blood 2 No  (2/2)  Section images
Bone marrow 2 No  (2/2)  Section images
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No  (2/2)  Section images
Cartilage tissue 2 No N/A
Cecum 2 No  (12/379)  (2/2)  Section images
Cerebellum 2 No  (2/2)  Section images
Cerebral cortex 2 No N/A
Chest bone 2 No N/A
Colon 2 No  (12/127)  (2/2)  Section images
Diaphragm 2 No  (2/2)  Section images
Duodenum 2 No  (2/127)  (2/2)  Section images
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 2 No  (7/415)  (2/2)  Section images
Eye 2 No  (2/2)  Section images
Gall bladder 2 No N/A
Gonadal fat pad 2 No  (2/2)  Section images
Harderian gland 2 No  (2/2)  Section images
Heart 2 No N/A
Hindlimb 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Ileum 2 No  (14/127)  (2/2)  Section images
Jejunum 2 No  (6/127)  (2/2)  Section images
Kidney 2 No  (18/584)  (2/2)  Section images
Large intestine 2 No  (10/584) N/A
Liver 2 No  (2/2)  Section images
Lower urinary tract 2 No N/A
Lung 2 No  (2/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No  (1/2)  Section images
Mesenteric adipose tissue 2 No  (2/2)  Section images
Mesenteric lymph node 2 No  (2/2)  Section images
Midbrain 2 No  (2/2)  Section images
Olfactory lobe 2 No  (2/2)  Section images
Ovary 2 No  (1/584)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/584)  (2/2)  Section images
Parathyroid gland 2 No  (2/2)  Section images
Parotid gland 2 No  (2/2)  Section images
Penis 2 No  (1/2)  Section images
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/2)  Section images
Prostate gland 2 No  (12/584)  (1/2)  Section images
Quadriceps 2 No  (2/2)  Section images
Sciatic nerve 2 No  (2/2)  Section images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2)  Section images
Spleen 2 No  (2/584)  (2/2)  Section images
Stomach 2 No  (12/584)  (2/2)  Section images
Stomach pyloric region 2 No N/A
Striatum 2 No N/A
Sublingual gland 2 No  (2/2)  Section images
Submandibular gland 2 No  (2/132)  (2/2)  Section images
Testis 2 No  (2/584)  (1/2)  Section images
Thymus 2 No  (2/2)  Section images
Thyroid gland 2 No  (15/584)  (2/2)  Section images
Tongue 2 No  (5/127)  (2/2)  Section images
Trachea 2 No  (1/2)  Section images
Trigeminal V nerve 2 No  (2/2)  Section images
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vagina 2 No  (1/2)  Section images
Vas deferens 2 No  (15/388)  (1/2)  Section images
Vascular system 2 No N/A
Vesicular gland 2 No  (1/2)  Section images
White adipose tissue 2 No N/A
LacZ Wholemount Images
LacZ Section Images
Unassigned Top Level MA (30)
adipose tissue (11)
Brown adipose tissue expression
MA:0000057
cardiovascular system (8)
Aorta expression
MA:0000062
digestive system (58)
Cecum expression
MA:0000334
endocrine system (11)
Adrenal gland expression
MA:0000116
exocrine system (17)
Mammary gland expression
MA:0000145
immune system (18)
Bone Marrow expression
MA:0000134
integumental system (8)
Mammary gland expression
MA:0000145
limb (3)
Sciatic nerve expression
MA:0001172
musculoskeletal system (16)
Bone Marrow expression
MA:0000134
nervous system (19)
Cerebellum expression
MA:0000198
postnatal mouse (200)
Adrenal gland expression
MA:0000116
reproductive system (23)
Epididymis expression
MA:0000397
respiratory system (33)
Diaphragm expression
MA:0001904
sensory organ (18)
Eye expression
MA:0000261
set of connective tissues (11)
Brown adipose tissue expression
MA:0000057
trunk (105)
Adrenal gland expression
MA:0000116
urinary system (10)
Kidney expression
MA:0000368
No Embryo expression data was found for this gene.

 Associated Images

Adult LacZ: LacZ Images Section
230 Images
X-ray: XRay Images Whole Body Dorso Ventral
40 Images
X-ray: XRay Images Whole Body Lateral Orientation
20 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Cdkn1atm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Cdkn1aem1(IMPC)Cnrm Conditional Ready Mice
Cdkn1aem2(IMPC)Cnrm Exdel Mice
Cdkn1atm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Cdkn1atm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells