Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
N-ribosyldihydronicotinamide quinone reductase 2
Synonyms:
Ox2,  NRH: quinone oxidoreductase,  Ox-2,  Nmor2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nqo2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Nqo2 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Breast Cancer
Breast carcinoma OMIM:114480

The table below shows human diseases predicted to be associated to Nqo2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Specific Language Impairment 2
Deficit in phonologic short-term memory OMIM:606712
Specific Language Impairment 1
Deficit in phonologic short-term memory OMIM:606711
Presenile Dementia, Kraepelin Type
Dementia OMIM:176600
Schizophrenia 19
Cognitive impairment OMIM:617629
Monoamine Oxidase A Deficiency
Cognitive impairment ORPHA:3057
Microangiopathy And Leukoencephalopathy, Pontine, Autosomal Dominant
Dementia, Cognitive impairment OMIM:618564
Alzheimer Disease 10
Dementia, Memory impairment OMIM:609636
Schizophrenia
Social and occupational deterioration OMIM:181500
Neutropenia, Severe Congenital, 1, Autosomal Dominant
Thrombocytosis, Neutropenia, Monocytosis, Congenital agranulocytosis, Anemia, Acute monocytic leu... OMIM:202700
Thrombocythemia 2
Thrombocytosis OMIM:601977
Myelodysplastic Syndrome Associated With Isolated Del(5Q) Chromosome Abnormality
Thrombocytosis, Macrocytic anemia, Myelodysplasia, Leukopenia, Bone marrow hypocellularity, Multi... ORPHA:86841
Thrombocythemia 3
Thrombocytosis OMIM:614521
Thrombocythemia 1
Thrombocytosis, Impaired epinephrine-induced platelet aggregation, Impaired collagen-induced plat... OMIM:187950
Asplenia, Isolated Congenital
Thrombocytosis, Howell-Jolly bodies, Asplenia OMIM:271400
Chronic Myeloid Leukemia
Thrombocytosis, Abnormal basophil morphology, Leukocytosis, Abnormal granulocyte morphology, Sple... ORPHA:521
Juvenile Arthritis
Thrombocytosis, Leukocytosis OMIM:618795
Acquired Idiopathic Sideroblastic Anemia
Leukocytosis, Thrombocytosis, Neutropenia, Normocytic anemia, Megaloblastic erythroid hyperplasia... ORPHA:75564
Immunodeficiency 69
Thrombocytosis, Leukocytosis, Anemia, Splenomegaly, Hepatosplenomegaly, Pancytopenia OMIM:618963
Neutrophilia, Hereditary
Neutrophilia, Hepatosplenomegaly, Elevated leukocyte alkaline phosphatase, Myelodysplasia OMIM:162830
Polycythemia Vera
Thrombocytosis, Leukocytosis, Increased red blood cell mass, Splenomegaly, Increased hematocrit, ... OMIM:263300
Epilepsy, Progressive Myoclonic, 8
Dementia, Cognitive impairment OMIM:616230
Immunodeficiency 14B, Autosomal Recessive
Thrombocytosis, Leukocytosis, B lymphocytopenia, Monocytosis, Neutrophilia OMIM:619281
Sickle Cell Anemia
Leukocytosis, Abnormality of the spleen, Thrombocytosis, Increased mean corpuscular volume, Iron ... ORPHA:232
Thrombocytopenia, Cyclic
Thrombocytopenia, Neutropenia, Cyclic neutropenia OMIM:188020
Primary Myelofibrosis
Leukocytosis, Thrombocytosis, Hemangioma, Anemia, Splenomegaly, Increased circulating lactate deh... ORPHA:824
Glutathione Synthetase Deficiency Of Erythrocytes, Hemolytic Anemia Due To
Hemolytic anemia, Reduced glutathione synthetase level, Glyoxalase deficiency OMIM:231900
Combined Immunodeficiency And Megaloblastic Anemia With Or Without Hyperhomocysteinemia
Thrombocytosis, Macrocytic anemia, Megaloblastic anemia, Lymphopenia, Pancytopenia, Anemia of ina... OMIM:617780
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Thrombocytosis, Sterile abscess, Hepatosplenomegaly, Microcytic anemia, Pancytopenia OMIM:604416
Heme Oxygenase 1 Deficiency
Thrombocytosis, Asplenia, Coombs-positive hemolytic anemia, Elevated circulating aspartate aminot... OMIM:614034
Immunodeficiency 27A
Thrombocytosis, Leukocytosis, Anemia, Splenomegaly, Hepatosplenomegaly, Histiocytosis OMIM:209950
Epidermodysplasia Verruciformis, Susceptibility To, 5
Verrucae, T lymphocytopenia, Lymphopenia, Squamous cell carcinoma of the skin OMIM:618309
Immunodeficiency 92
Leukocytosis, B lymphocytopenia, Decreased proportion of class-switched memory B cells, Thrombocy... OMIM:619652
Anemia, Sideroblastic, 5
Reduced hematocrit, Neutropenia, Hypochromic microcytic anemia, Anemia, Thrombocytopenia, Refract... OMIM:619523
Erythroleukemia, Familial, Susceptibility To
Erythroid hyperplasia, Leukemia, Anemia, Splenomegaly, Acute myeloid leukemia, Thrombocytopenia, ... OMIM:133180
Thrombocytopenia 7
Reduced platelet dense granules, Impaired ristocetin-induced platelet aggregation, Impaired colla... OMIM:619130
Monosomy 7 Myelodysplasia And Leukemia Syndrome 1
Acute myeloid leukemia, Myelodysplasia, Increased mean corpuscular volume, Thrombocytopenia OMIM:252270
Monosomy 7 Myelodysplasia And Leukemia Syndrome 2
Neutropenia, Increased mean corpuscular volume, Myelodysplasia, Anemia, Bone marrow hypocellulari... OMIM:619041
Pancytopenia And Occlusive Vascular Disease
Pancytopenia, Thrombocytopenia, Anemia, Leukopenia OMIM:167850
Anemia, Congenital Dyserythropoietic, Type Ii
Reduced level of N-acetylglucosaminyltransferase II, Splenomegaly, Jaundice, Reticulocytosis, Ane... OMIM:224100
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 8
Frontotemporal dementia, Dementia, Memory impairment OMIM:619132
Neutropenia, Severe Congenital, 2, Autosomal Dominant
B lymphocytopenia, Neutropenia, Monocytosis OMIM:613107
Sebastian syndrome
Thrombocytopenia, Neutrophil inclusion bodies, Giant platelets, Leukocyte inclusion bodies OMIM:605249
Bleeding Disorder, Platelet-Type, 16
Anemia, Giant platelets, Thrombocytopenia, Macrothrombocytopenia, Platelet anisocytosis, Impaired... OMIM:187800
Interstitial Lung And Liver Disease
Thrombocytosis, Anemia, Elevated gamma-glutamyltransferase level, Elevated circulating aspartate ... OMIM:615486
Cutaneous Neuroendocrine Carcinoma
Multiple myeloma, Lymphoid leukemia, Brain neoplasm, Basal cell carcinoma, Squamous cell carcinom... ORPHA:79140
Familial Multinodular Goiter
Colorectal polyposis, Ovarian neoplasm, Testicular seminoma, Thyroid carcinoma, Sertoli cell neop... ORPHA:276399
Familial Thrombocytosis
Thrombocytosis, Myelodysplasia, Chronic myelogenous leukemia, Splenomegaly, Acute myeloid leukemia ORPHA:71493
Sting-Associated Vasculopathy, Infantile-Onset
Thrombocytosis, Anemia, Lymphopenia, Leukopenia OMIM:615934
Blackfan-Diamond Anemia
Thrombocytosis, Elevated red cell adenosine deaminase level, Neutropenia, Increased mean corpuscu... ORPHA:124
Overhydrated Hereditary Stomatocytosis
Stomatocytosis, Abnormal mean corpuscular volume, Splenomegaly, Increased circulating lactate deh... ORPHA:3203
Apc-Related Attenuated Familial Adenomatous Polyposis
Astrocytoma, Adenomatous colonic polyposis, Multiple gastric polyps, Papillary thyroid carcinoma,... ORPHA:247806
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Leukocytosis, Thrombocytosis, Pancytopenia, Leukopenia, Lymphoproliferative disorder, Anemia, Bon... OMIM:615688
Bleeding Disorder, Platelet-Type, 15
Thrombocytopenia, Increased mean platelet volume, Platelet anisocytosis OMIM:615193
Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities
Macrocytic anemia, Neutropenia, Abnormal reticulocyte morphology, Abnormal platelet morphology, A... OMIM:300835
Gardner Syndrome
Astrocytoma, Adenomatous colonic polyposis, Small intestine carcinoid, Brain neoplasm, Papillary ... ORPHA:79665
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
Iron deficiency anemia, Thrombocytosis OMIM:226300
Celiac Disease, Susceptibility To, 1
Thrombocytosis, Macrocytic anemia, Iron deficiency anemia, Lymphoma, Elevated hepatic transaminase OMIM:212750
3-Hydroxy-3-Methylglutaric Aciduria
Leukocytosis, Thrombocytosis, Leukopenia, Anemia, Elevated hepatic transaminase, Jaundice ORPHA:20
Autoerythrocyte Sensitization Syndrome
Thrombocytosis, Abnormal erythrocyte morphology, Autoimmune thrombocytopenia, Impaired platelet a... ORPHA:324636
Poems Syndrome
Polycythemia, Thrombocytosis, Hemangioma, Lymphoproliferative disorder ORPHA:2905
Idiopathic Hypereosinophilic Syndrome
Leukocytosis, Thrombocytosis, Myelodysplasia, Thrombocytopenia, Anemia, Splenomegaly, Myeloprolif... ORPHA:3260
Diamond-Blackfan Anemia 1
Thrombocytosis, Elevated red cell adenosine deaminase level, Neutropenia, Myelodysplasia, Congeni... OMIM:105650
Neuroleptic Malignant Syndrome
Leukocytosis, Thrombocytosis, Increased circulating lactate dehydrogenase concentration, Elevated... ORPHA:94093
Congenital Disorder Of Glycosylation, Type Ia
Elevated hepatic transaminase, Thrombocytosis OMIM:212065
Hepatocellular Carcinoma
Thrombocytosis, Polycythemia, Anemia, Neoplasm, Liver abscess, Elevated hepatic transaminase, Thr... ORPHA:88673
Beta-Ketothiolase Deficiency
Leukocytosis, Thrombocytosis ORPHA:134
Spherocytosis, Type 5
Splenomegaly, Spherocytosis, Reticulocytosis, Hemolytic anemia, Jaundice OMIM:612690
Cogan Syndrome
Thrombocytosis, Leukocytosis, Anemia ORPHA:1467
Epidermodysplasia Verruciformis, Susceptibility To, 2
Verruca plana, Squamous cell carcinoma of the skin OMIM:618231
Epidermodysplasia Verruciformis, X-Linked
Verrucae, Squamous cell carcinoma of the skin OMIM:305350
Turcot Syndrome With Polyposis
Astrocytoma, Thyroid carcinoma, Adenomatous colonic polyposis, Leukemia, Brain neoplasm, Basal ce... ORPHA:99818
Syndromic Diarrhea
Thrombocytosis, Increased mean platelet volume, Hypoplasia of the thymus, Hepatoblastoma, Splenom... ORPHA:84064
Trichohepatoenteric Syndrome 1
Thrombocytosis, Increased mean platelet volume, Hepatic failure, Jaundice OMIM:222470
Erythrocytosis, Familial, 6
Increased hematocrit, Polycythemia, Increased hemoglobin OMIM:617980
Erythrocytosis, Familial, 5
Increased hematocrit, Polycythemia, Increased hemoglobin OMIM:617907
Pilomatrixoma
Pilomatrixoma OMIM:132600
Brucellosis
Leukocytosis, Thrombocytosis, Lung abscess, Leukopenia, Anemia, Splenomegaly, Hypersplenism, Gran... ORPHA:1304
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy
Leukocytosis, Thrombocytosis, Perianal abscess, Hypochromic anemia OMIM:618213
Dyskeratosis Congenita, Autosomal Dominant 1
Myelodysplasia, Anemia, Bone marrow hypocellularity, Squamous cell carcinoma of the skin, Lymphop... OMIM:127550
Leukocyte Adhesion Deficiency
Leukocytosis, Thrombocytosis, Polycythemia, Bone marrow hypocellularity, Acute myeloid leukemia, ... ORPHA:2968
Palmoplantar Keratoderma-Xx Sex Reversal-Predisposition To Squamous Cell Carcinoma Syndrome
Squamous cell carcinoma of the skin ORPHA:85112
Porokeratosis
Squamous cell carcinoma of the skin ORPHA:79358
Doors Syndrome
Thrombocytosis, Capillary hemangioma ORPHA:79500
Huriez Syndrome
Squamous cell carcinoma of the skin OMIM:181600
Xeroderma Pigmentosum, Complementation Group E
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma OMIM:278740
Xeroderma Pigmentosum, Complementation Group C
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin OMIM:278720
Oculocutaneous Albinism Type 1B
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:79434
Xeroderma Pigmentosum, Complementation Group B
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin, Neoplasm OMIM:610651
Hermansky-Pudlak Syndrome
Basal cell carcinoma, Abnormality of thrombocytes, Neutropenia, Squamous cell carcinoma of the skin ORPHA:79430
Oculocutaneous Albinism Type 1A
Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79431
Xeroderma Pigmentosum-Cockayne Syndrome Complex
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:220295
Oculocutaneous Albinism
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:55
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Anemia, Squamous cell carcinoma of the skin ORPHA:79396
Oculocutaneous Albinism Type 2
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79432
Breast Cancer
Breast carcinoma OMIM:114480
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Spinal cord tumor, Pilomatrixoma, Meningioma, Neoplasm ORPHA:353281
Tetrasomy 9P
Pilomatrixoma, Jaundice ORPHA:3310
Lmna-Related Cardiocutaneous Progeria Syndrome
Papillary renal cell carcinoma, Basal cell carcinoma, Pulmonary carcinoid tumor, Squamous cell ca... ORPHA:363618
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Pilomatrixoma, Meningioma ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Pilomatrixoma, Meningioma ORPHA:353277

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nqo2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nqo2.

No publications found that use IMPC mice or data for Nqo2.

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MGI Allele Allele Type Produced
Nqo2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Nqo2tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Nqo2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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