Genes Phenotypes

Gene: Cxcl12

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Name
chemokine (C-X-C motif) ligand 12
MGI ID
MGI:103556
Synonyms
PBSF SDF-1 TLSF-a Sdf1 PBSF/SDF-1 Scyb12 TLSF-b Sdf1b TPAR1 Sdf1a
Viability
Homozygous - Lethal
View
N/A
Other links
MGI   Ensembl  
Significant phenotypes (6) Measurements chart (195) All data table (797)
Expression & images (114) Disease models (0) Order (4)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to organogenesis Cxcl12tm1.1(KOMP)Vlcg HOM embryonic day 9.5 0.00
hydrometra Cxcl12tm1.1(KOMP)Vlcg HET postnatal 0.00
preweaning lethality, complete penetrance Cxcl12tm1.1(KOMP)Vlcg HOM n/a 0.00
enlarged uterus Cxcl12tm1.1(KOMP)Vlcg HET postnatal 0.00
embryonic lethality prior to tooth bud stage Cxcl12tm1.1(KOMP)Vlcg HOM embryonic day 12.5 0.00
small superior vagus ganglion Cxcl12tm1.1(KOMP)Vlcg HET postnatal 0.00

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (1/2) N/A
Blood 2 No N/A
Bone marrow 2 No  (2/2) N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/383)  (2/2) N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No N/A
Chest bone 2 No N/A
Colon 2 No  (12/127)  (2/2) N/A
Diaphragm 2 No  (2/2) N/A
Duodenum 2 No  (2/127)  (2/2) N/A
Epididymis 2 No  (18/134)  (1/2) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No  (2/2) N/A
Gall bladder 2 No N/A
Gonadal fat pad 2 No  (2/2) N/A
Harderian gland 2 No  (2/2) N/A
Heart 2 No N/A
Hindlimb 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Ileum 2 No  (14/127)  (2/2) N/A
Jejunum 2 No  (6/127)  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No  (2/2) N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No  (1/2) N/A
Mesenteric adipose tissue 2 No  (2/2) N/A
Mesenteric lymph node 2 No  (2/2) N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 2 No  (2/2) N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Parathyroid gland 2 No N/A
Parotid gland 2 No  (2/2) N/A
Penis 2 No  (1/2) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Quadriceps 2 No  (2/2) N/A
Sciatic nerve 2 No  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Stomach pyloric region 2 No N/A
Striatum 2 No N/A
Sublingual gland 2 No  (2/2) N/A
Submandibular gland 2 No  (2/132)  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584)  (2/2) N/A
Tongue 2 No  (5/127)  (2/2) N/A
Trachea 2 No  (1/2) N/A
Trigeminal V nerve 2 No  (2/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vagina 2 No  (1/2) N/A
Vas deferens 2 No  (15/388)  (1/2) N/A
Vascular system 2 No N/A
Vesicular gland 2 No  (1/2) N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 3  (1/47)  (3/3) N/A
Axial skeleton 3  (1/51)  (3/3) N/A
Brain 3  (6/485)  (3/3) N/A
Central nervous system ganglion 3  (1/51)  (3/3) N/A
Dorsal root ganglion 3  (1/47)  (3/3) N/A
Ear 3  (1/485)  (3/3) N/A
Embryo 3  (1/485)  (3/3) N/A
Eye 3  (1/485)  (3/3) N/A
Foot 3  (1/485) N/A
Forebrain 3  (1/485)  (3/3) N/A
Forelimb 3  (1/485)  (3/3) N/A
Fronto-nasal process 3  (1/48)  (3/3) N/A
Gut 3  (1/50)  (3/3) N/A
Hand 3  (1/485) N/A
Head 3  (5/485)  (3/3) N/A
Head mesenchyme 3  (1/47)  (3/3) N/A
Heart 3  (1/485)  (3/3) N/A
Heart ventricle 3  (1/47)  (3/3) N/A
Hindbrain 3  (6/485)  (1/3) N/A
Hindlimb 3  (1/485)  (3/3) N/A
Liver 3  (1/485)  (3/3) N/A
Lung 3  (1/485)  (3/3) N/A
Mandibular process 3  (1/485)  (3/3) N/A
Maxillary process 3  (1/485)  (3/3) N/A
Meckel's cartilage 1 N/A
Midbrain 3  (1/485)  (3/3) N/A
Nasal septum 3  (1/47) N/A
Nose 3  (1/51)  (3/3) N/A
Oral cavity 3  (1/485)  (3/3) N/A
Outflow tract 3  (1/47)  (3/3) N/A
Pericardium 2  (1/46)  (2/2) N/A
Rib pre-cartilage condensation 3  (1/46)  (3/3) N/A
Skeleton 2  (1/51)  (2/2) N/A
Skin 3  (1/485)  (3/3) N/A
Spinal cord 3  (1/50)  (3/3) N/A
Tail 3  (1/485)  (3/3) N/A
Tail somite 3  (1/485)  (3/3) N/A
Thoracic vertebral cartilage condensation 3  (1/46)  (3/3) N/A
Tongue 1  (1/46)  (1/1) N/A
Trunk mesenchyme 3  (1/47)  (2/3) N/A
Vibrissa 3  (1/47) N/A

 Associated Images

X-ray: XRay Images Dorso Ventral
10 Images
X-ray: XRay Images Lateral Orientation
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Cxcl12tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Cxcl12tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Cxcl12tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cxcl12tm42159(L1L2_st1) Targeting vectors

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