Gene Summary

Name:
T cell lymphoma invasion and metastasis 1
Synonyms:
D16Ium10,  D16Ium10e

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased cornea thickness Tiam1tm1b(EUCOMM)Hmgu HOM Early adult 9.96×10-05
decreased exploration in new environment Tiam1tm1b(EUCOMM)Hmgu HOM Early adult 6.07×10-09
decreased locomotor activity Tiam1tm1b(EUCOMM)Hmgu HOM Early adult 4.65×10-05

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Human diseases caused by Tiam1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Tiam1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Neurodevelopmental Disorder With Language Delay And Seizures
Thin corpus callosum, Diffuse cerebral atrophy, Hypothalamic hamartoma OMIM:619908

The table below shows human diseases predicted to be associated to Tiam1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Melanoma-Pancreatic Cancer Syndrome
Squamous cell carcinoma, Oropharyngeal squamous cell carcinoma, Melanoma, Sarcoma, Pancreatic ade... OMIM:606719
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Epidermodysplasia Verruciformis, Susceptibility To, 3
Verrucae, Basal cell carcinoma, Squamous cell carcinoma OMIM:618267
Congenital Herpes Simplex Virus Infection
Microcephaly, Hydranencephaly ORPHA:293
Squamous Cell Carcinoma, Head And Neck
Squamous cell carcinoma OMIM:275355
Nut Midline Carcinoma
Pancreatic squamous cell carcinoma, Squamous cell carcinoma, Oropharyngeal squamous cell carcinom... ORPHA:443167
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Disseminated Superficial Actinic Porokeratosis
Squamous cell carcinoma ORPHA:79152
Cheilitis Glandularis
Squamous cell carcinoma, Neoplasm ORPHA:1221
Corneal Dystrophy, Congenital Stromal
Band-shaped corneal dystrophy, Corneal dystrophy, Increased corneal thickness, Corneal erosion OMIM:610048
Keratoconus 9
Keratoconus, Decreased corneal thickness OMIM:617928
Corneal Endothelial Dystrophy
Abnormal Descemet membrane morphology, Increased corneal thickness, Corneal dystrophy, Opacificat... OMIM:217700
Hydrocephalus, Congenital, 3, With Brain Anomalies
Hydranencephaly, Hydrocephalus, Dandy-Walker malformation, Holoprosencephaly, Cerebellar agenesis... OMIM:617967
Tumor Predisposition Syndrome 4
Stomach cancer, Glioma, Sarcoma, Meningioma, Breast carcinoma OMIM:609265
Reticulum Cell Sarcoma
Sarcoma, Neoplasm OMIM:267730
Keratoconus 1
Keratoconus, Astigmatism OMIM:148300
Neural Tube Defects, Susceptibility To
Hydrocephalus, Myelomeningocele, Anencephaly, Spina bifida occulta OMIM:182940
Hyperkeratosis Lenticularis Perstans
Basal cell carcinoma, Squamous cell carcinoma ORPHA:409
Nthl1-Related Attenuated Familial Adenomatous Polyposis
Basal cell carcinoma, Pancreatic adenocarcinoma, Neoplasm of the rectum, Squamous cell carcinoma,... ORPHA:454840
Keratoconus 6
Keratoconus OMIM:614623
Keratoconus 5
Keratoconus OMIM:614622
Keratoconus 8
Keratoconus OMIM:614628
Keratoconus 7
Keratoconus OMIM:614629
Myofibromatosis, Infantile, 1
Fibroma, Myofibromatosis OMIM:228550
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Squamous cell carcinoma OMIM:613736
Megalocornea
Corneal arcus, Iris transillumination defect, Iridodonesis, Astigmatism, Mosaic corneal dystrophy... OMIM:309300
Colorectal Cancer, Susceptibility To, 12
Carcinoma, Colorectal polyposis OMIM:615083
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Type II lissencephaly, Neural tube defect OMIM:615041
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Anencephaly 2
Anencephaly OMIM:619452
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Diprosopus
Anencephaly ORPHA:1681
Hydrolethalus Syndrome 2
Hydrocephalus, Anencephaly, Agenesis of corpus callosum OMIM:614120
Schöpf-Schulz-Passarge Syndrome
Basal cell carcinoma, Ovarian neoplasm, Squamous cell carcinoma ORPHA:50944
Cornea Plana 2, Autosomal Recessive
Corneal arcus, Decreased corneal thickness, Corneal opacity, Sclerocornea, Flat cornea OMIM:217300
Xeroderma Pigmentosum Variant
Basal cell carcinoma, Squamous cell carcinoma, Melanoma ORPHA:90342
Brittle Cornea Syndrome 2
Keratoglobus, Keratoconus, Decreased corneal thickness, Megalocornea, Gait disturbance, Sclerocor... OMIM:614170
Schisis Association
Microcephaly, Anencephaly, Encephalocele, Spina bifida ORPHA:63862
Meckel Syndrome, Type 4
Hypoplasia of the corpus callosum, Anencephaly, Encephalocele, Meningocele, Hydrocephalus, Dandy-... OMIM:611134
Schopf-Schulz-Passarge Syndrome
Apocrine hidrocystoma, Poroma, Basal cell carcinoma, Squamous cell carcinoma OMIM:224750
Macular Corneal Dystrophy
Recurrent corneal erosions, Decreased corneal thickness, Punctate opacification of the cornea, Hy... ORPHA:98969
Craniorachischisis
Sirenomelia, Anencephaly, Myelomeningocele, Spinal dysraphism, Cervical spina bifida ORPHA:63260
Congenital Hereditary Endothelial Dystrophy Type Ii
Corneal stromal edema, Corneal opacity, Abnormal Descemet membrane morphology, Increased corneal ... ORPHA:293603
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease
T-cell lymphoma, Acute myeloid leukemia, Squamous cell carcinoma, Hepatocellular carcinoma, Neopl... ORPHA:158057
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Epidermodysplasia Verruciformis, Susceptibility To, 2
Squamous cell carcinoma of the skin, Verruca plana OMIM:618231
Microcephaly, Congenital Heart Disease, Unilateral Renal Agenesis, And Hyposegmented Lungs
Microcephaly, Hydranencephaly OMIM:601355
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Hydranencephaly, Microcephaly, Cerebral cortical atrophy, Holoprosencephaly, Aplasia/Hypoplasia o... ORPHA:2570
Xeroderma Pigmentosum, Complementation Group F
Keratoacanthoma, Basal cell carcinoma, Squamous cell carcinoma, Neoplasm of the skin, Seborrheic ... OMIM:278760
Combined Immunodeficiency Due To Dock8 Deficiency
Verrucae, Squamous cell carcinoma of the vulva, Squamous cell carcinoma, Anal canal squamous carc... ORPHA:217390
Microhydranencephaly
Hydranencephaly, Microcephaly, Agenesis of corpus callosum, Pachygyria, Cerebellar hypoplasia, Hy... OMIM:605013
Aminopterin/Methotrexate Embryofetopathy
Anencephaly, Encephalocele, Meningocele, Hydrocephalus, Aplasia/Hypoplasia of the corpus callosum... ORPHA:1908
Distal Deletion 13Q
Anencephaly, Encephalocele, Microcephaly, Holoprosencephaly, Aplasia/Hypoplasia of the corpus cal... ORPHA:1590
Punctate Palmoplantar Keratoderma Type 1
Esophageal neoplasm, Basal cell carcinoma, Squamous cell carcinoma, Stomach cancer, Renal cell ca... ORPHA:79501
Aprosencephaly Syndrome
Anencephaly, Aprosencephaly OMIM:207770
Meckel Syndrome, Type 5
Occipital encephalocele, Anencephaly OMIM:611561
Meckel Syndrome, Type 2
Dandy-Walker malformation, Anencephaly, Encephalocele, Meningocele OMIM:603194
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Hydranencephaly, Hydrocephalus, Dandy-Walker malformation, Polymicrogyria, Microcephaly, Agenesis... OMIM:225790
Leber Congenital Amaurosis 7
Cataract, Keratoconus OMIM:613829
Epidermodysplasia Verruciformis
Verrucae, Squamous cell carcinoma ORPHA:302
Oral Submucous Fibrosis
Oropharyngeal squamous cell carcinoma ORPHA:357154
Meckel Syndrome, Type 10
Occipital encephalocele, Dandy-Walker malformation, Anencephaly, Cerebellar hypoplasia OMIM:614175
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Cutaneous Neuroendocrine Carcinoma
Basal cell carcinoma, Merkel cell skin cancer, Squamous cell carcinoma of the skin, Brain neoplas... ORPHA:79140
Edict Syndrome
Astigmatism, Anterior polar cataract, Keratoconus, Microcornea, Hypoplasia of the iris OMIM:614303
Corneal Dystrophy, Posterior Polymorphous, 3
Keratoconus, Corneal dystrophy, Ectopia pupillae, Corneal guttata OMIM:609141
Necrobiosis Lipoidica
Squamous cell carcinoma ORPHA:542592
Li-Fraumeni Syndrome
Acute leukemia, Prostate neoplasm, Neoplasm of the pancreas, Soft tissue sarcoma, Choriocarcinoma... OMIM:151623
Leber Congenital Amaurosis 6
Cataract, Keratoconus OMIM:613826
Werner Syndrome
Neoplasm of the oral cavity, Thyroid carcinoma, Renal neoplasm, Ovarian neoplasm, Squamous cell c... ORPHA:902
Xeroderma Pigmentosum, Variant Type
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma OMIM:278750
Ichthyosis, Hystrix-Like, With Deafness
Squamous cell carcinoma OMIM:602540
Palmoplantar Carcinoma, Multiple Self-Healing
Carcinoma, Squamous cell carcinoma OMIM:615225
Hydrolethalus
Hydrocephalus, Absent septum pellucidum, Anencephaly, Agenesis of corpus callosum ORPHA:2189
Cutaneous Telangiectasia And Cancer Syndrome, Familial
Actinic keratosis, Oropharyngeal squamous cell carcinoma, Breast carcinoma OMIM:614564
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Cerebellar hypoplasia, Hypoplasia of the brainstem, Hydranencephaly OMIM:236500
Brittle Cornea Syndrome 1
Keratoconus, Decreased corneal thickness, Abnormal cornea morphology, Keratoglobus OMIM:229200
Corneal Dystrophy, Fuchs Endothelial, 1
Corneal degeneration, Corneal stromal edema, Corneal dystrophy, Descemet Membrane Folds, Corneal ... OMIM:136800
Epidermodysplasia Verruciformis, Susceptibility To, 5
Verrucae, Squamous cell carcinoma of the skin OMIM:618309
Recurrent Respiratory Papillomatosis
Squamous cell carcinoma ORPHA:60032
Joubert Syndrome 15
Exencephaly OMIM:614464
Palmoplantar Keratoderma-Xx Sex Reversal-Predisposition To Squamous Cell Carcinoma Syndrome
Squamous cell carcinoma of the skin ORPHA:85112
Iniencephaly
Anencephaly, Encephalocele, Hydrocephalus, Dandy-Walker malformation, Myelomeningocele, Spina bif... ORPHA:63259
Cerebrocostomandibular Syndrome
Hydranencephaly, Meningocele, Cerebral calcification, Porencephalic cyst, Myelomeningocele, Spina... ORPHA:1393
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 13
Occipital encephalocele, Anencephaly, Hydrocephalus, Dandy-Walker malformation, Type II lissencep... OMIM:615287
Meckel Syndrome, Type 6
Hydrocephalus, Occipital encephalocele, Anencephaly OMIM:612284
Acquired Ichthyosis
Sarcoma, Neoplasm, Lymphoma, Multiple myeloma ORPHA:454
Chromosome 13Q33-Q34 Deletion Syndrome
Anencephaly, Encephalocele, Dandy-Walker malformation, Microcephaly, Agenesis of corpus callosum OMIM:619148
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Hypoplasia of the corpus callosum, Anencephaly, Hydrocephalus, Polymicrogyria, Cerebellar vermis ... OMIM:616546
Leber Congenital Amaurosis 4
Keratoconus OMIM:604393
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Squamous cell carcinoma OMIM:618373
Dermatitis, Atopic
Cataract, Keratoconus, Conjunctivitis OMIM:603165
Maffucci Syndrome
Neoplasm of the parathyroid gland, Hemangiomatosis, Ovarian neoplasm, Neoplasm of the adrenal cor... ORPHA:163634
Neurodevelopmental Disorder With Intracranial Hemorrhage, Seizures, And Spasticity
Periventricular leukomalacia, Thin corpus callosum, Hydranencephaly, Hydrocephalus, Polymicrogyri... OMIM:620371
Chromomycosis
Squamous cell carcinoma, Multiple cutaneous malignancies ORPHA:182
Leber Congenital Amaurosis 2
Cataract, Keratoconus OMIM:204100
Vernal Keratoconjunctivitis
Corneal neovascularization, Corneal ulceration, Keratoconus, Keratoconjunctivitis, Punctate kerat... ORPHA:70476
Pentalogy Of Cantrell
Hydrocephalus, Anencephaly, Encephalocele ORPHA:1335
Pelvis-Shoulder Dysplasia
Hydrocephalus, Spina bifida, Hydranencephaly ORPHA:2839
Paraneoplastic Pemphigus
B-cell lymphoma, Sarcoma, Thymoma ORPHA:63455
Vacterl/Vater Association
Occipital encephalocele, Anencephaly ORPHA:887
Fanconi Anemia, Complementation Group P
Squamous cell carcinoma OMIM:613951
Papillon-Lefèvre Syndrome
Neoplasm of the skin, Squamous cell carcinoma, Melanoma ORPHA:678
Thoracoabdominal Syndrome
Hydrocephalus, Anencephaly OMIM:313850
Keratoconus Posticus Circumscriptus
Keratoconus, Central posterior corneal opacity OMIM:244600
Epidermolysis Bullosa Dystrophica, Autosomal Recessive
Squamous cell carcinoma OMIM:226600
Ollier Disease
Hemangioma, Chondrosarcoma, Sarcoma, Neoplasm, Multiple enchondromatosis, Visceral angiomatosis ORPHA:296
Leber Congenital Amaurosis 1
Cataract, Keratoconus OMIM:204000
Leber Congenital Amaurosis
Cataract, Keratoconus ORPHA:65
Brittle Cornea Syndrome
Corneal erosion, Keratoglobus, Corneal dystrophy, Decreased corneal thickness, Corneal scarring, ... ORPHA:90354
Trisomy 18
Anencephaly, Spina bifida, Microcephaly, Holoprosencephaly, Aplasia/Hypoplasia of the corpus call... ORPHA:3380
Huriez Syndrome
Squamous cell carcinoma of the skin OMIM:181600
Trichothiodystrophy 1, Photosensitive
Basal cell carcinoma, Squamous cell carcinoma OMIM:601675
Familial Adenomatous Polyposis 1
Fibroma, Osteoma, Duodenal polyposis, Adrenocortical adenoma, Adenomatous colonic polyposis, Carc... OMIM:175100
Hyper-Ige Syndrome 2, Autosomal Recessive, With Recurrent Infections
Squamous cell carcinoma OMIM:243700
Leber Congenital Amaurosis 8
Cataract, Keratoconus OMIM:613835
Large Congenital Melanocytic Nevus
Rhabdomyosarcoma, Neoplasm of the skin, Sarcoma, Neoplasm, Cutaneous melanoma ORPHA:626
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Dominant
Squamous cell carcinoma OMIM:148210
Short-Rib Thoracic Dysplasia 12
Hydrocephalus, Holoprosencephaly, Anencephaly OMIM:269860
Apc-Related Attenuated Familial Adenomatous Polyposis
Neoplasm of the pancreas, Lipoma, Odontoma, Desmoid tumors, Fibroadenoma of the breast, Duodenal ... ORPHA:247806
Rothmund-Thomson Syndrome Type 1
Basal cell carcinoma, Squamous cell carcinoma, Neoplasm of the skin, Melanoma, Myelodysplasia, Os... ORPHA:221008
Rothmund-Thomson Syndrome Type 2
Basal cell carcinoma, Squamous cell carcinoma, Neoplasm of the skin, Lymphoma, Melanoma, Myelodys... ORPHA:221016
Xeroderma Pigmentosum, Complementation Group C
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin, Actinic keratosis OMIM:278720
Rothmund-Thomson Syndrome
Basal cell carcinoma, Squamous cell carcinoma, Neoplasm of the skin, Melanoma, Myelodysplasia, Le... ORPHA:2909
Meckel Syndrome
Anencephaly, Encephalocele, Hydrocephalus, Dandy-Walker malformation, Microcephaly, Lobar holopro... ORPHA:564
Limb Body Wall Complex
Short umbilical cord, Anencephaly, Encephalocele, Spina bifida occulta, Hydrocephalus, Myelomenin... ORPHA:2369
Xeroderma Pigmentosum, Complementation Group E
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma OMIM:278740
Progressive Osseous Heteroplasia
Sarcoma ORPHA:2762
Arthrogryposis, Distal, Type 5
Keratoconus, Astigmatism, Keratoglobus OMIM:108145
Bloom Syndrome
Leukemia, Lymphoma, Squamous cell carcinoma OMIM:210900
Cousin Syndrome
Hydrocephalus, Hydranencephaly OMIM:260660
Kid Syndrome
Neoplasm of the tongue, Neoplasm of the skin, Squamous cell carcinoma, Trichilemmoma ORPHA:477
Meckel Syndrome, Type 1
Occipital encephalocele, Large placenta, Anencephaly, Hydrocephalus, Dandy-Walker malformation, C... OMIM:249000
Disabling Pansclerotic Morphea Of Childhood
Squamous cell carcinoma of the skin OMIM:620443
Dyskeratosis Congenita, X-Linked
Acute myeloid leukemia, Squamous cell carcinoma, Carcinoma, Oropharyngeal squamous cell carcinoma... OMIM:305000
Infantile Myofibromatosis
Fibroma, Neoplasm of the pancreas, Gingival fibromatosis, Neoplasm of the skin, Neoplasm of the l... ORPHA:2591
Attenuated Familial Adenomatous Polyposis
Fibroma, Neoplasm of the stomach, Colorectal polyposis, Rectal polyposis, Adenocarcinoma of the c... ORPHA:220460
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form
Squamous cell carcinoma ORPHA:89842
Trichothiodystrophy
Squamous cell carcinoma ORPHA:33364
Rothmund-Thomson Syndrome, Type 2
Osteosarcoma, Basal cell carcinoma, Squamous cell carcinoma OMIM:268400
Mast Cell Sarcoma
Sarcoma ORPHA:66661
Hereditary Acrokeratotic Poikiloderma
Transitional cell carcinoma of the bladder, Squamous cell carcinoma ORPHA:2907
Mental Retardation, Keratoconus, Febrile Seizures, And Sinoatrial Block
Keratoconus OMIM:609438
Oculocutaneous Albinism Type 1B
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:79434
Liposarcoma
Sarcoma ORPHA:69078
Microtriplication 11Q24.1
Keratoconus ORPHA:289522
Xeroderma Pigmentosum, Complementation Group B
Basal cell carcinoma, Squamous cell carcinoma of the skin, Cutaneous melanoma, Neoplasm OMIM:610651
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Abnormal cortical gyration, Encephalocele, Polymicrogyria, Pachygyria, Lissencephaly, Exencephaly ORPHA:2211
Multiple Endocrine Neoplasia, Type Iv
Pancreatic endocrine tumor, Carcinoma, Carcinoid tumor, Pituitary adenoma, Parathyroid adenoma, R... OMIM:610755
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 7
Squamous cell carcinoma of the skin, Myelodysplasia OMIM:620365
Hypogonadotropic Hypogonadism-Severe Microcephaly-Sensorineural Hearing Loss-Dysmorphism Syndrome
Decreased corneal thickness ORPHA:293967
Desmoplastic Small Round Cell Tumor
Neoplasm of the central nervous system, Neoplasm of the pancreas, Ovarian neoplasm, Testicular ne... ORPHA:83469
Neu-Laxova Syndrome 1
Short umbilical cord, Small placenta, Hydranencephaly, Lissencephaly, Dandy-Walker malformation, ... OMIM:256520
Ring Chromosome 13 Syndrome
Microcephaly, Anencephaly, Agenesis of corpus callosum ORPHA:96176
Hydrolethalus Syndrome 1
Abnormal cortical gyration, Anencephaly, Dandy-Walker malformation, Agenesis of corpus callosum, ... OMIM:236680
Optic Atrophy-Intellectual Disability Syndrome
Attention deficit hyperactivity disorder, Keratoconus ORPHA:401777
Rhabdoid Tumor
Neoplasm of the central nervous system, Neoplasm of the liver, Renal neoplasm, Sarcoma ORPHA:69077
Oculocutaneous Albinism Type 1A
Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79431
Leber Congenital Amaurosis 9
Keratoconus OMIM:608553
Kindler Epidermolysis Bullosa
Neoplasm of the urethra, Squamous cell carcinoma ORPHA:2908
Greig Cephalopolysyndactyly Syndrome
Keratoconus OMIM:175700
Severe Generalized Junctional Epidermolysis Bullosa
Renal tubular epithelial necrosis, Squamous cell carcinoma ORPHA:79404
Congenital Erythropoietic Porphyria
Neoplasm of the skin, Squamous cell carcinoma ORPHA:79277
Gastrointestinal Stromal Tumor
Esophageal neoplasm, Neoplasm of the stomach, Neoplasm of the rectum, Neoplasm of the small intes... ORPHA:44890
Dyskeratosis Congenita, Digenic
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma OMIM:620040
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
Esophageal carcinoma, Oropharyngeal squamous cell carcinoma ORPHA:391487
Yellow Nail Syndrome
Renal neoplasm, Neoplasm of the lung, Sarcoma, Biliary tract neoplasm, Neoplasm ORPHA:662
Angelman Syndrome
Astigmatism, Inability to walk, Broad-based gait, Keratoconus, Iris hypopigmentation, Ataxia ORPHA:72
Oncogenic Osteomalacia
Carcinoma, Neoplasm of head and neck, Giant cell tumor of bone, Neoplasm of the skeletal system, ... ORPHA:352540
Xeroderma Pigmentosum, Complementation Group A
Squamous cell carcinoma of the skin, Melanoma OMIM:278700
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form
Cutaneous melanoma, Squamous cell carcinoma ORPHA:79408
Xeroderma Pigmentosum-Cockayne Syndrome Complex
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:220295
Oculocutaneous Albinism Type 2
Basal cell carcinoma, Squamous cell carcinoma of the skin, Cutaneous melanoma ORPHA:79432
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Recessive
Keratoconus, Conjunctivitis OMIM:242150
Dyskeratosis Congenita, Autosomal Dominant 1
Hepatic necrosis, Squamous cell carcinoma of the skin, Myelodysplasia OMIM:127550
Gnb5-Related Intellectual Disability-Cardiac Arrhythmia Syndrome
Keratoconus ORPHA:542306
Nail-Patella Syndrome
Microphakia, Keratoconus, Microcornea, Antecubital pterygium, Cataract, Lester's sign OMIM:161200
Retinoblastoma
Retinoblastoma, Lymphoma, Ewing sarcoma, Osteosarcoma, Pinealoma, Leukemia OMIM:180200
Alagille Syndrome
Keratoconus, Corneal dystrophy, Abnormal pupil morphology ORPHA:52
Warburg-Cinotti Syndrome
Limbal stem cell deficiency, Corneal neovascularization, Symblepharon, Decreased corneal thickness OMIM:618175
Costello Syndrome
Keratoconus ORPHA:3071
Lacrimoauriculodentodigital Syndrome
Recurrent corneal erosions, Corneal neovascularization, Corneal ulceration, Limbal stem cell defi... ORPHA:2363
Lmna-Related Cardiocutaneous Progeria Syndrome
Pulmonary carcinoid tumor, Basal cell carcinoma, Squamous cell carcinoma of the skin, Papillary r... ORPHA:363618
Retinitis Pigmentosa
Keratoconus, Posterior subcapsular cataract ORPHA:791
Gapo Syndrome
Keratoconus ORPHA:2067
Hermansky-Pudlak Syndrome
Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79430
Sacral Defect With Anterior Meningocele
Myeloschisis, Meningocele, Hydrocephalus, Dermal sinus tract, Myelomeningocele OMIM:600145
Down Syndrome
Cataract, Keratoconus, Gait disturbance ORPHA:870
Arterial Tortuosity Syndrome
Keratoconus, Astigmatism OMIM:208050
Neurofibromatosis Type 1
Rhabdomyosarcoma, Multiple lipomas, Spinal neurofibroma, Chronic myelogenous leukemia, Pheochromo... ORPHA:636
Gapo Syndrome
Keratoconus, Shallow anterior chamber, Megalocornea OMIM:230740
Arterial Tortuosity Syndrome
Keratoconus, Keratoglobus ORPHA:3342
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Squamous cell carcinoma of the skin ORPHA:79396
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 1
Keratoconus, Microcornea OMIM:225400
Hypermobile Ehlers-Danlos Syndrome
Depression, Keratoconus, Keratoconjunctivitis sicca ORPHA:285
Vascular Ehlers-Danlos Syndrome
Keratoconus, Abnormal pupil morphology, Cognitive impairment ORPHA:286
Ehlers-Danlos Syndrome, Vascular Type
Keratoconus OMIM:130050
Neurodevelopmental Disorder With Language Delay And Seizures
Thin corpus callosum, Diffuse cerebral atrophy, Hypothalamic hamartoma OMIM:619908

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tiam1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tiam1.

No publications found that use IMPC mice or data for Tiam1.

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MGI Allele Allele Type Produced
Tiam1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Tiam1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Tiam1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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