Gene Summary

Name:
T cell lymphoma invasion and metastasis 1
Synonyms:
D16Ium10,  D16Ium10e

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased cornea thickness Tiam1tm1b(EUCOMM)Hmgu HOM   Early adult 9.96×10-05
decreased exploration in new environment Tiam1tm1b(EUCOMM)Hmgu HOM Early adult 6.07×10-09
decreased locomotor activity Tiam1tm1b(EUCOMM)Hmgu HOM Early adult 4.65×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
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Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Human diseases caused by Tiam1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Tiam1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Neurodevelopmental Disorder With Language Delay And Seizures
Thin corpus callosum, Diffuse cerebral atrophy, Hypothalamic hamartoma OMIM:619908

The table below shows human diseases predicted to be associated to Tiam1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Melanoma-Pancreatic Cancer Syndrome
Oropharyngeal squamous cell carcinoma, Melanoma, Pancreatic squamous cell carcinoma, Squamous cel... OMIM:606719
Lichen Sclerosus Et Atrophicus
Squamous cell carcinoma, Carcinoma OMIM:151590
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Congenital Herpes Simplex Virus Infection
Microcephaly, Hydranencephaly ORPHA:293
Epidermodysplasia Verruciformis, Susceptibility To, 3
Squamous cell carcinoma, Basal cell carcinoma OMIM:618267
Squamous Cell Carcinoma, Head And Neck
Squamous cell carcinoma OMIM:275355
Nut Midline Carcinoma
Ewing sarcoma, Neoplasm, Neuroblastoma, Oropharyngeal squamous cell carcinoma, Pancreatic squamou... ORPHA:443167
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Disseminated Superficial Actinic Porokeratosis
Squamous cell carcinoma ORPHA:79152
Cheilitis Glandularis
Squamous cell carcinoma, Neoplasm ORPHA:1221
Craniotelencephalic Dysplasia
Absent septum pellucidum, Optic nerve hypoplasia, Cerebellar hypoplasia, Arrhinencephaly, Agenesi... OMIM:218670
Corneal Dystrophy, Congenital Stromal
Increased corneal thickness, Band-shaped corneal dystrophy, Corneal erosion, Corneal dystrophy OMIM:610048
Corneal Endothelial Dystrophy
Increased corneal thickness, Opacification of the corneal stroma, Corneal dystrophy, Abnormal Des... OMIM:217700
Li-Fraumeni Syndrome 2
Glioma, Breast carcinoma, Stomach cancer, Meningioma, Sarcoma OMIM:609265
Megalocornea
Lens subluxation, Mosaic corneal dystrophy, Megalocornea, Astigmatism, Iridodonesis, Cataract, Ir... OMIM:309300
Reticulum Cell Sarcoma
Neoplasm, Sarcoma OMIM:267730
Rhabdoid Tumor Predisposition Syndrome 2
Neoplasm of the central nervous system, Carcinoma OMIM:613325
Hydrocephalus, Congenital, 3, With Brain Anomalies
Hydrocephalus, Hydranencephaly, Dandy-Walker malformation, Holoprosencephaly OMIM:617967
Craniotelencephalic Dysplasia
Hydrocephalus, Microcephaly, Arrhinencephaly, Cerebellar hypoplasia, Agenesis of corpus callosum,... ORPHA:1528
Cornea Plana 2, Autosomal Recessive
Flat cornea, Corneal arcus, Decreased corneal thickness OMIM:217300
Neural Tube Defects, Susceptibility To
Myelomeningocele, Hydrocephalus, Anencephaly, Spina bifida occulta OMIM:182940
Keratoconus 1
Keratoconus, Astigmatism OMIM:148300
Schopf-Schulz-Passarge Syndrome
Squamous cell carcinoma, Basal cell carcinoma, Poroma, Apocrine hidrocystoma OMIM:224750
Hyperkeratosis Lenticularis Perstans
Squamous cell carcinoma, Basal cell carcinoma ORPHA:409
Nthl1-Related Attenuated Familial Adenomatous Polyposis
Adenomatous colonic polyposis, Neoplasm of the rectum, Breast carcinoma, Duodenal adenocarcinoma,... ORPHA:454840
Keratoconus 6
Keratoconus OMIM:614623
Keratoconus 5
Keratoconus OMIM:614622
Keratoconus 8
Keratoconus OMIM:614628
Keratoconus 7
Keratoconus OMIM:614629
Colorectal Cancer, Susceptibility To, 12
Colorectal polyposis, Carcinoma OMIM:615083
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Squamous cell carcinoma OMIM:613736
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Squamous cell carcinoma OMIM:618373
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Cerebral Sarcoma
Neoplasm, Fibrosarcoma OMIM:117600
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Spina bifida, Anencephaly ORPHA:2476
Hydrolethalus Syndrome 2
Hydrocephalus, Anencephaly, Agenesis of corpus callosum OMIM:614120
Fetal Akinesia Syndrome, X-Linked
Agenesis of corpus callosum, Arrhinencephaly OMIM:300073
Diprosopus
Anencephaly ORPHA:1681
Brittle Cornea Syndrome 2
Flat cornea, Megalocornea, Gait disturbance, Keratoconus, Keratoglobus, Sclerocornea, Decreased c... OMIM:614170
Anencephaly 2
Anencephaly OMIM:619452
Schöpf-Schulz-Passarge Syndrome
Squamous cell carcinoma, Basal cell carcinoma, Ovarian neoplasm ORPHA:50944
Xeroderma Pigmentosum Variant
Squamous cell carcinoma, Melanoma, Basal cell carcinoma ORPHA:90342
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Hydrocephalus, Microcephaly, Cerebellar hypoplasia, Hydranencephaly, Agenesis of corpus callosum,... OMIM:225790
Corneal Dystrophy, Endothelial, X-Linked
Corneal opacity, Band keratopathy, Corneal dystrophy OMIM:300779
Corneal Dystrophy, Posterior Polymorphous, 2
Corneal opacity, Corneal dystrophy OMIM:609140
Macular Corneal Dystrophy
Punctate opacification of the cornea, Opacification of the corneal stroma, Recurrent corneal eros... ORPHA:98969
Edict Syndrome
Microcornea, Astigmatism, Hypoplasia of the iris, Keratoconus, Developmental cataract OMIM:614303
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 13
Hydrocephalus, Anencephaly, Cortical dysplasia, Cerebellar hypoplasia, Type II lissencephaly, Occ... OMIM:615287
Congenital Hereditary Endothelial Dystrophy Type Ii
Corneal opacity, Irregular astigmatism, Corneal stromal edema, Abnormal Descemet membrane morphol... ORPHA:293603
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease
Burkitt lymphoma, Multiple myeloma, Hodgkin lymphoma, B-cell lymphoma, Prostate cancer, Nephrobla... ORPHA:158057
Schisis Association
Microcephaly, Encephalocele, Spina bifida, Anencephaly ORPHA:63862
Epidermodysplasia Verruciformis, Susceptibility To, 2
Squamous cell carcinoma of the skin, Verruca plana OMIM:618231
Microcephaly, Congenital Heart Disease, Unilateral Renal Agenesis, And Hyposegmented Lungs
Microcephaly, Hydranencephaly OMIM:601355
Meckel Syndrome, Type 4
Hydrocephalus, Microcephaly, Anencephaly, Hypoplasia of the corpus callosum, Agenesis of cerebell... OMIM:611134
Epidermodysplasia Verruciformis, X-Linked
Squamous cell carcinoma of the skin, Verrucae OMIM:305350
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Cerebral cortical atrophy, Holoprosencephaly, Microcephaly, Aplasia/Hypoplasia of the cerebellum,... ORPHA:2570
Xeroderma Pigmentosum, Complementation Group F
Keratoacanthoma, Squamous cell carcinoma, Basal cell carcinoma, Neoplasm of the skin, Seborrheic ... OMIM:278760
Combined Immunodeficiency Due To Dock8 Deficiency
Squamous cell carcinoma, Squamous cell carcinoma of the vulva, Anal canal squamous carcinoma, Ver... ORPHA:217390
Distal Monosomy 13Q
Holoprosencephaly, Microcephaly, Anencephaly, Encephalocele, Aplasia/Hypoplasia of the corpus cal... ORPHA:1590
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Craniorachischisis
Myelomeningocele, Cervical spina bifida, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Punctate Palmoplantar Keratoderma Type 1
Esophageal neoplasm, Hodgkin lymphoma, Breast carcinoma, Stomach cancer, Prostate cancer, Melanom... ORPHA:79501
Microhydranencephaly
Microcephaly, Cerebellar hypoplasia, Pachygyria, Hydranencephaly, Agenesis of corpus callosum, Hy... OMIM:605013
Aminopterin/Methotrexate Embryofetopathy
Hydrocephalus, Holoprosencephaly, Microcephaly, Anencephaly, Aplasia/Hypoplasia of the cerebellum... ORPHA:1908
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Leber Congenital Amaurosis 7
Keratoconus, Cataract OMIM:613829
Epidermodysplasia Verruciformis
Squamous cell carcinoma, Verrucae ORPHA:302
Meckel Syndrome, Type 5
Occipital encephalocele, Anencephaly OMIM:611561
Xeroderma Pigmentosum, Variant Type
Squamous cell carcinoma, Basal cell carcinoma, Cutaneous melanoma OMIM:278750
Meckel Syndrome, Type 2
Encephalocele, Anencephaly, Dandy-Walker malformation, Meningocele OMIM:603194
Meckel Syndrome, Type 10
Occipital encephalocele, Anencephaly, Cerebellar hypoplasia, Dandy-Walker malformation OMIM:614175
Cutaneous Neuroendocrine Carcinoma
Multiple myeloma, Carcinoid tumor, Lymphoid leukemia, Basal cell carcinoma, Neoplasm of the outer... ORPHA:79140
Oral Submucous Fibrosis
Oropharyngeal squamous cell carcinoma ORPHA:357154
Necrobiosis Lipoidica
Squamous cell carcinoma ORPHA:542592
Palmoplantar Carcinoma, Multiple Self-Healing
Squamous cell carcinoma, Carcinoma OMIM:615225
Li-Fraumeni Syndrome
Neoplasm of the pancreas, Lung adenocarcinoma, Choriocarcinoma, Breast carcinoma, Prostate cancer... OMIM:151623
Hydrolethalus
Hydrocephalus, Absent septum pellucidum, Anencephaly, Arrhinencephaly, Agenesis of corpus callosum ORPHA:2189
Corneal Dystrophy, Fuchs Endothelial, 1
Corneal stromal edema, Descemet Membrane Folds, Corneal degeneration, Corneal dystrophy, Corneal ... OMIM:136800
Leber Congenital Amaurosis 6
Keratoconus, Cataract OMIM:613826
Werner Syndrome
Neoplasm, Acral lentiginous melanoma, Ovarian neoplasm, Thyroid carcinoma, Renal neoplasm, Cutane... ORPHA:902
Ichthyosis, Hystrix-Like, With Deafness
Squamous cell carcinoma OMIM:602540
Neuroendocrine Carcinoma Of Salivary Glands, Sensorineural Hearing Loss, And Enamel Hypoplasia
Unilateral vestibular schwannoma, Carcinoma OMIM:603641
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Hydranencephaly, Cerebellar hypoplasia, Hypoplasia of the brainstem OMIM:236500
Brittle Cornea Syndrome 1
Abnormal cornea morphology, Keratoconus, Keratoglobus, Decreased corneal thickness OMIM:229200
Colorectal Cancer, Susceptibility To, 10
Endometrial carcinoma, Colorectal polyposis, Carcinoma OMIM:612591
Epidermodysplasia Verruciformis, Susceptibility To, 5
Squamous cell carcinoma of the skin, Verrucae OMIM:618309
Recurrent Respiratory Papillomatosis
Squamous cell carcinoma ORPHA:60032
Palmoplantar Keratoderma-Xx Sex Reversal-Predisposition To Squamous Cell Carcinoma Syndrome
Squamous cell carcinoma of the skin ORPHA:85112
Hyper-Ige Recurrent Infection Syndrome 2, Autosomal Recessive
Squamous cell carcinoma OMIM:243700
Iniencephaly
Myelomeningocele, Hydrocephalus, Holoprosencephaly, Anencephaly, Spinal dysraphism, Lissencephaly... ORPHA:63259
Acquired Ichthyosis
Neoplasm, Multiple myeloma, Sarcoma, Lymphoma ORPHA:454
Maffucci Syndrome
Chondrosarcoma, Pituitary adenoma, Ovarian neoplasm, Parathyroid adenoma, Breast carcinoma, Exost... ORPHA:163634
Corneal Dystrophy, Fuchs Endothelial, 6
Keratitis, Abnormal Descemet membrane morphology, Corneal stromal edema, Corneal dystrophy, Corne... OMIM:613270
Lattice Corneal Dystrophy Type I
Corneal scarring, Abnormal cornea morphology, Corneal opacity, Subepithelial corneal opacities, C... ORPHA:98964
Meckel Syndrome, Type 6
Occipital encephalocele, Hydrocephalus, Anencephaly OMIM:612284
Leber Congenital Amaurosis 4
Keratoconus OMIM:604393
Chromomycosis
Squamous cell carcinoma, Multiple cutaneous malignancies ORPHA:182
Cerebrocostomandibular Syndrome
Myelomeningocele, Cerebral calcification, Microcephaly, Hydranencephaly, Meningocele, Porencephal... ORPHA:1393
Dermatitis, Atopic
Keratoconus, Cataract, Conjunctivitis OMIM:603165
Ollier Disease
Chondrosarcoma, Neoplasm, Lymphangioma, Hemangioma, Multiple enchondromatosis, Sarcoma, Visceral ... ORPHA:296
Chromosome 13Q33-Q34 Deletion Syndrome
Microcephaly, Anencephaly, Encephalocele, Agenesis of corpus callosum, Dandy-Walker malformation OMIM:619148
Leber Congenital Amaurosis 2
Keratoconus, Cataract OMIM:204100
Acrofacial Dysostosis, Rodríguez Type
Aqueductal stenosis, Arrhinencephaly ORPHA:1788
Fanconi Anemia, Complementation Group P
Squamous cell carcinoma OMIM:613951
Papillon-Lefèvre Syndrome
Squamous cell carcinoma, Melanoma, Neoplasm of the skin ORPHA:678
Paraneoplastic Pemphigus
Thymoma, B-cell lymphoma, Sarcoma ORPHA:63455
Pentalogy Of Cantrell
Hydrocephalus, Anencephaly, Encephalocele ORPHA:1335
Porokeratosis
Squamous cell carcinoma of the skin ORPHA:79358
Microgastria-Limb Reduction Defects Association
Fusion of the left and right thalami, Arrhinencephaly, Polymicrogyria, Porencephalic cyst, Agenes... OMIM:156810
Keratoconus Posticus Circumscriptus
Keratoconus, Central posterior corneal opacity OMIM:244600
49,Xxxxy Syndrome
Arrhinencephaly, Hypoplasia of the corpus callosum, Holoprosencephaly ORPHA:96264
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Cerebellar vermis hypoplasia, Hydrocephalus, Anencephaly, Polymicrogyria OMIM:616546
Pelvis-Shoulder Dysplasia
Hydrocephalus, Spina bifida, Hydranencephaly ORPHA:2839
Leber Congenital Amaurosis 1
Keratoconus, Cataract OMIM:204000
Vacterl/Vater Association
Occipital encephalocele, Anencephaly ORPHA:887
Brittle Cornea Syndrome
Corneal scarring, Gait disturbance, Corneal erosion, Corneal dystrophy, Keratoglobus, Decreased c... ORPHA:90354
Leber Congenital Amaurosis
Keratoconus, Cataract ORPHA:65
Huriez Syndrome
Squamous cell carcinoma of the skin OMIM:181600
Epidermolysis Bullosa Dystrophica, Autosomal Recessive
Squamous cell carcinoma OMIM:226600
Trichothiodystrophy 1, Photosensitive
Squamous cell carcinoma, Basal cell carcinoma OMIM:601675
Familial Adenomatous Polyposis 1
Adenomatous colonic polyposis, Medulloblastoma, Hepatoblastoma, Multiple gastric polyps, Fibroade... OMIM:175100
Thoracoabdominal Syndrome
Hydrocephalus, Anencephaly OMIM:313850
Caudal Regression Syndrome
Arrhinencephaly ORPHA:3027
Large Congenital Melanocytic Nevus
Neoplasm, Cutaneous melanoma, Rhabdomyosarcoma, Sarcoma, Neoplasm of the skin ORPHA:626
Trisomy 18
Holoprosencephaly, Microcephaly, Anencephaly, Spina bifida, Aplasia/Hypoplasia of the corpus call... ORPHA:3380
Leber Congenital Amaurosis 8
Keratoconus, Cataract OMIM:613835
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Dominant
Squamous cell carcinoma OMIM:148210
Apc-Related Attenuated Familial Adenomatous Polyposis
Adrenocortical adenoma, Odontoma, Adrenocortical carcinoma, Lipoma, Multiple gastric polyps, Duod... ORPHA:247806
Rothmund-Thomson Syndrome Type 1
Melanoma, Squamous cell carcinoma, Myelodysplasia, Basal cell carcinoma, Osteosarcoma, Leukemia, ... ORPHA:221008
Rothmund-Thomson Syndrome Type 2
Melanoma, Lymphoma, Squamous cell carcinoma, Myelodysplasia, Basal cell carcinoma, Osteosarcoma, ... ORPHA:221016
Rothmund-Thomson Syndrome
Melanoma, Squamous cell carcinoma, Myelodysplasia, Basal cell carcinoma, Leukemia, Neoplasm of th... ORPHA:2909
Retinitis Pigmentosa
Keratoconus, Cataract ORPHA:791
Arthrogryposis, Distal, Type 5
Keratoconus, Keratoglobus, Astigmatism OMIM:108145
Xeroderma Pigmentosum, Complementation Group E
Squamous cell carcinoma of the skin, Melanoma, Basal cell carcinoma OMIM:278740
Vacterl With Hydrocephalus
Hydrocephalus, Spina bifida, Aqueductal stenosis, Arrhinencephaly ORPHA:3412
Progressive Osseous Heteroplasia
Sarcoma ORPHA:2762
Amoebic Keratitis
Corneal perforation, Corneal ulceration, Abnormal cornea morphology, Abnormal anterior chamber mo... ORPHA:67043
Cousin Syndrome
Hydrocephalus, Hydranencephaly OMIM:260660
Short-Rib Thoracic Dysplasia 12
Hydrocephalus, Anencephaly, Holoprosencephaly OMIM:269860
Xeroderma Pigmentosum, Complementation Group C
Squamous cell carcinoma of the skin, Basal cell carcinoma, Cutaneous melanoma OMIM:278720
Meckel Syndrome
Hydrocephalus, Microcephaly, Anencephaly, Encephalocele, Lobar holoprosencephaly, Dandy-Walker ma... ORPHA:564
Infantile Myofibromatosis
Neoplasm of the pancreas, Neoplasm of the lung, Gingival fibromatosis, Fibroma, Benign neoplasm o... ORPHA:2591
Kid Syndrome
Squamous cell carcinoma, Trichilemmoma, Neoplasm of the skin, Neoplasm of the tongue ORPHA:477
Anterior Segment Dysgenesis 6
Corneal opacity, Abnormal Descemet membrane morphology, Corneal neovascularization, Developmental... OMIM:617315
Attenuated Familial Adenomatous Polyposis
Adenomatous colonic polyposis, Papilloma, Large intestinal polyposis, Duodenal polyposis, Adenoca... ORPHA:220460
Rothmund-Thomson Syndrome, Type 2
Squamous cell carcinoma, Osteosarcoma, Basal cell carcinoma OMIM:268400
Corneal Dystrophy, Posterior Polymorphous, 1
Corneal opacity, Band keratopathy, Thinning of Descemet membrane, Abnormal Descemet membrane morp... OMIM:122000
Trichothiodystrophy
Squamous cell carcinoma ORPHA:33364
Bloom Syndrome
Squamous cell carcinoma, Leukemia, Lymphoma OMIM:210900
Mast Cell Sarcoma
Sarcoma ORPHA:66661
Limb Body Wall Complex
Myelomeningocele, Hydrocephalus, Short umbilical cord, Anencephaly, Spina bifida occulta, Encepha... ORPHA:2369
Meckel Syndrome, Type 1
Cerebral hypoplasia, Hydrocephalus, Microcephaly, Anencephaly, Cerebellar hypoplasia, Occipital e... OMIM:249000
Hereditary Acrokeratotic Poikiloderma
Squamous cell carcinoma, Transitional cell carcinoma of the bladder ORPHA:2907
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Encephalocele, Pachygyria, Abnormal cortical gyration, Polymicrogyria, Lissencephaly, Exencephaly... ORPHA:2211
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form
Squamous cell carcinoma ORPHA:89842
Oculocutaneous Albinism Type 1B
Squamous cell carcinoma of the skin, Melanoma, Basal cell carcinoma ORPHA:79434
Mental Retardation, Keratoconus, Febrile Seizures, And Sinoatrial Block
Keratoconus OMIM:609438
Hydrolethalus Syndrome 1
Anencephaly, Severe hydrocephalus, Arrhinencephaly, Abnormal cortical gyration, Agenesis of corpu... OMIM:236680
Liposarcoma
Sarcoma ORPHA:69078
Microtriplication 11Q24.1
Keratoconus ORPHA:289522
Xeroderma Pigmentosum, Complementation Group B
Squamous cell carcinoma of the skin, Basal cell carcinoma, Neoplasm, Cutaneous melanoma OMIM:610651
Aicardi-Goutières Syndrome
Multifocal cerebral white matter abnormalities, Cerebral calcification, Microcephaly, Arrhinencep... ORPHA:51
Dyskeratosis Congenita, X-Linked
Hodgkin lymphoma, Squamous cell carcinoma, Myelodysplasia, Acute myeloid leukemia, Carcinoma OMIM:305000
Multiple Endocrine Neoplasia, Type Iv
Pituitary adenoma, Parathyroid adenoma, Carcinoid tumor, Renal angiomyolipoma, Pancreatic endocri... OMIM:610755
Hypogonadotropic Hypogonadism-Severe Microcephaly-Sensorineural Hearing Loss-Dysmorphism Syndrome
Decreased corneal thickness ORPHA:293967
Rhabdoid Tumor
Neoplasm of the central nervous system, Neoplasm of the liver, Sarcoma, Renal neoplasm ORPHA:69077
Angelman Syndrome
Broad-based gait, Happy demeanor, Ataxia, Inability to walk, Self-injurious behavior, Anxiety, As... ORPHA:72
Microgastria-Limb Reduction Defect Syndrome
Agenesis of corpus callosum, Arrhinencephaly, Abnormal cortical gyration, Absent septum pellucidum ORPHA:2538
Neu-Laxova Syndrome 1
Microcephaly, Short umbilical cord, Cerebellar hypoplasia, Hydranencephaly, Small placenta, Lisse... OMIM:256520
Desmoplastic Small Round Cell Tumor
Neoplasm of the pancreas, Ovarian neoplasm, Neoplasm of the central nervous system, Neoplasm of t... ORPHA:83469
22Q11.2 Deletion Syndrome
Hydrocephalus, Microcephaly, Arrhinencephaly, Umbilical hernia, Meningocele, Spina bifida, Occipi... ORPHA:567
Oculocutaneous Albinism Type 1A
Squamous cell carcinoma of the skin, Basal cell carcinoma ORPHA:79431
Pallister-Hall Syndrome
Adrenocorticotropic hormone deficiency, Abnormal prolactin level, Hypothalamic hamartoma, Holopro... ORPHA:672
Kindler Epidermolysis Bullosa
Squamous cell carcinoma, Neoplasm of the urethra ORPHA:2908
Ring Chromosome 13 Syndrome
Microcephaly, Anencephaly, Agenesis of corpus callosum ORPHA:96176
Leber Congenital Amaurosis 9
Keratoconus OMIM:608553
Fryns Syndrome
Hypoplasia of the optic tract, Arrhinencephaly, Hypoplasia of olfactory tract, Agenesis of corpus... OMIM:229850
Severe Generalized Junctional Epidermolysis Bullosa
Squamous cell carcinoma, Renal tubular epithelial necrosis ORPHA:79404
Congenital Erythropoietic Porphyria
Squamous cell carcinoma, Neoplasm of the skin ORPHA:79277
Dyskeratosis Congenita, Digenic
Squamous cell carcinoma of the skin, Basal cell carcinoma, Melanoma OMIM:620040
Gastrointestinal Stromal Tumor
Neoplasm of the colon, Neoplasm of the rectum, Esophageal neoplasm, Gastrointestinal stroma tumor... ORPHA:44890
Yunis-Varon Syndrome
Hydrocephalus, Hypoplasia of the frontal lobes, Arrhinencephaly, Cerebellar hypoplasia, Primary m... ORPHA:3472
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
Oropharyngeal squamous cell carcinoma, Esophageal carcinoma ORPHA:391487
Microphthalmia With Limb Anomalies
Hydrocephalus, Arrhinencephaly ORPHA:1106
Oculocutaneous Albinism
Squamous cell carcinoma of the skin, Basal cell carcinoma, Cutaneous melanoma ORPHA:55
Yellow Nail Syndrome
Neoplasm, Renal neoplasm, Neoplasm of the lung, Biliary tract neoplasm, Sarcoma ORPHA:662
Xeroderma Pigmentosum-Cockayne Syndrome Complex
Squamous cell carcinoma of the skin, Basal cell carcinoma, Melanoma ORPHA:220295
Oncogenic Osteomalacia
Giant cell tumor of bone, Neurofibromas, Osteosarcoma, Neoplasm of head and neck, Neoplasm of the... ORPHA:352540
Optic Atrophy-Intellectual Disability Syndrome
Keratoconus ORPHA:401777
Oculocutaneous Albinism Type 2
Squamous cell carcinoma of the skin, Basal cell carcinoma, Cutaneous melanoma ORPHA:79432
Doors Syndrome
Microcephaly, Arrhinencephaly, Spina bifida occulta, Polymicrogyria, Sirenomelia, Dandy-Walker ma... ORPHA:79500
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form
Squamous cell carcinoma, Cutaneous melanoma ORPHA:79408
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Recessive
Keratoconus, Conjunctivitis OMIM:242150
Nail-Patella Syndrome
Microphakia, Microcornea, Keratoconus, Cataract, Lester's sign, Antecubital pterygium OMIM:161200
Retinoblastoma
Ewing sarcoma, Retinoblastoma, Lymphoma, Osteosarcoma, Leukemia, Pinealoma OMIM:180200
Dyskeratosis Congenita, Autosomal Dominant 1
Squamous cell carcinoma of the skin, Myelodysplasia OMIM:127550
Alagille Syndrome
Keratoconus, Abnormal pupil morphology, Corneal dystrophy ORPHA:52
Warburg-Cinotti Syndrome
Symblepharon, Corneal neovascularization, Limbal stem cell deficiency, Decreased corneal thickness OMIM:618175
Charge Syndrome
Decreased response to growth hormone stimulation test, Holoprosencephaly, Microcephaly, Arrhinenc... OMIM:214800
Lacrimoauriculodentodigital Syndrome
Corneal ulceration, Corneal neovascularization, Keratoconjunctivitis, Recurrent corneal erosions,... ORPHA:2363
Gnb5-Related Intellectual Disability-Cardiac Arrhythmia Syndrome
Keratoconus ORPHA:542306
Lmna-Related Cardiocutaneous Progeria Syndrome
Squamous cell carcinoma of the skin, Basal cell carcinoma, Pulmonary carcinoid tumor, Papillary r... ORPHA:363618
Costello Syndrome
Keratoconus ORPHA:3071
Gapo Syndrome
Keratoconus ORPHA:2067
Hermansky-Pudlak Syndrome
Squamous cell carcinoma of the skin, Basal cell carcinoma ORPHA:79430
Yunis-Varon Syndrome
Hypoplasia of the frontal lobes, Microcephaly, Arrhinencephaly, Hypoplasia of the corpus callosum... OMIM:216340
Arterial Tortuosity Syndrome
Keratoconus OMIM:208050
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Squamous cell carcinoma of the skin ORPHA:79396
Arterial Tortuosity Syndrome
Keratoconus, Keratoglobus ORPHA:3342
Gapo Syndrome
Keratoconus OMIM:230740
Neurofibromatosis Type 1
Neoplasm, Chronic myelogenous leukemia, Plexiform neurofibroma, Pheochromocytoma, Multiple lipoma... ORPHA:636
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 1
Keratoconus, Microcornea OMIM:225400
Hypermobile Ehlers-Danlos Syndrome
Keratoconjunctivitis sicca, Keratoconus ORPHA:285
Vascular Ehlers-Danlos Syndrome
Keratoconus, Abnormal pupil morphology, Cognitive impairment ORPHA:286
Ehlers-Danlos Syndrome, Vascular Type
Keratoconus OMIM:130050
Neurodevelopmental Disorder With Language Delay And Seizures
Thin corpus callosum, Diffuse cerebral atrophy, Hypothalamic hamartoma OMIM:619908

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tiam1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tiam1.

No publications found that use IMPC mice or data for Tiam1.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Tiam1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Tiam1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Tiam1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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