Gene Summary

T cell lymphoma invasion and metastasis 1
D16Ium10,  D16Ium10e

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
hypoactivity Tiam1tm1b(EUCOMM)Hmgu HOM Early adult 4.65×10-05
decreased exploration in new environment Tiam1tm1b(EUCOMM)Hmgu HOM Early adult 6.07×10-09
increased cornea thickness Tiam1tm1b(EUCOMM)Hmgu HOM   Early adult 9.96×10-05

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Dorso Ventral

10 Images


XRay Images Whole Body Lateral Orientation

10 Images

Human diseases caused by Tiam1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tiam1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Congenital Herpes Simplex Virus Infection
Microcephaly, Hydranencephaly ORPHA:293
Melanoma-Pancreatic Cancer Syndrome
Pancreatic squamous cell carcinoma, Sarcoma, Oropharyngeal squamous cell carcinoma, Squamous cell... OMIM:606719
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Lichen Sclerosus Et Atrophicus
Squamous cell carcinoma, Carcinoma OMIM:151590
Epidermodysplasia Verruciformis, Susceptibility To, 3
Basal cell carcinoma, Squamous cell carcinoma OMIM:618267
Squamous Cell Carcinoma, Head And Neck
Squamous cell carcinoma OMIM:275355
Nut Midline Carcinoma
Neuroblastoma, Pancreatic squamous cell carcinoma, Neoplasm, Oropharyngeal squamous cell carcinom... ORPHA:443167
Hydrocephalus, Congenital, 3, With Brain Anomalies
Holoprosencephaly, Hydranencephaly, Hydrocephalus, Dandy-Walker malformation OMIM:617967
Neural Tube Defects, Susceptibility To
Myelomeningocele, Hydrocephalus, Anencephaly, Spina bifida occulta OMIM:182940
Disseminated Superficial Actinic Porokeratosis
Squamous cell carcinoma ORPHA:79152
Cheilitis Glandularis
Neoplasm, Squamous cell carcinoma ORPHA:1221
Craniotelencephalic Dysplasia
Absent septum pellucidum, Arrhinencephaly, Cerebellar hypoplasia, Optic nerve hypoplasia, Agenesi... OMIM:218670
Craniotelencephalic Dysplasia
Hydrocephalus, Arrhinencephaly, Cerebellar hypoplasia, Septo-optic dysplasia, Microcephaly, Agene... ORPHA:1528
Corneal Endothelial Dystrophy
Increased corneal thickness, Congenital corneal dystrophy, Opacification of the corneal stroma, A... OMIM:217700
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Spina bifida, Anencephaly ORPHA:2476
Reticulum Cell Sarcoma
Neoplasm, Sarcoma OMIM:267730
Li-Fraumeni Syndrome 2
Glioma, Meningioma, Stomach cancer, Sarcoma, Breast carcinoma OMIM:609265
Anencephaly ORPHA:1681
Hydrolethalus Syndrome 2
Agenesis of corpus callosum, Hydrocephalus, Anencephaly OMIM:614120
Corneal Dystrophy, Congenital Stromal
Increased corneal thickness, Congenital corneal dystrophy OMIM:610048
Rhabdoid Tumor Predisposition Syndrome 2
Neoplasm of the central nervous system, Carcinoma OMIM:613325
Cornea Plana 2, Autosomal Recessive
Flat cornea, Decreased corneal thickness, Corneal arcus OMIM:217300
Decreased corneal thickness, Mosaic corneal dystrophy, Deep anterior chamber, Iridodonesis, Catar... OMIM:309300
Schopf-Schulz-Passarge Syndrome
Basal cell carcinoma, Apocrine hidrocystoma, Poroma, Squamous cell carcinoma OMIM:224750
Hyperkeratosis Lenticularis Perstans
Basal cell carcinoma, Squamous cell carcinoma ORPHA:409
Keratoconus 1
Keratoconus, Astigmatism OMIM:148300
Fetal Akinesia Syndrome, X-Linked
Arrhinencephaly, Agenesis of corpus callosum OMIM:300073
Nthl1-Related Attenuated Familial Adenomatous Polyposis
Basal cell carcinoma, Non-Hodgkin lymphoma, Neoplasm of the rectum, Endometrial carcinoma, Mening... ORPHA:454840
Keratoconus 6
Keratoconus OMIM:614623
Keratoconus 5
Keratoconus OMIM:614622
Keratoconus 8
Keratoconus OMIM:614628
Keratoconus 7
Keratoconus OMIM:614629
Colorectal Cancer, Susceptibility To, 12
Colorectal polyposis, Carcinoma OMIM:615083
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Squamous cell carcinoma OMIM:613736
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Squamous cell carcinoma OMIM:618373
Lethal Intrauterine Growth Restriction-Cortical Malformation-Congenital Contractures Syndrome
Aplasia/Hypoplasia of the cerebellum, Aplasia/Hypoplasia of the corpus callosum, Holoprosencephal... ORPHA:2570
Proliferative Vasculopathy And Hydranencephaly-Hydrocephaly Syndrome
Hypoplasia of the brainstem, Hydrocephalus, Cerebellar hypoplasia, Hydranencephaly, Microcephaly,... OMIM:225790
Corneal Dystrophy, Epithelial Basement Membrane
Map-dot-fingerprint corneal dystrophy, Recurrent corneal erosions, Corneal dystrophy OMIM:121820
Ewing Sarcoma
Ewing sarcoma OMIM:612219
Cerebral Sarcoma
Neoplasm, Fibrosarcoma OMIM:117600
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Cervical spina bifida, Sirenomelia, Spinal dysraphism, Anencephaly, Myelomeningocele ORPHA:63260
Macular Corneal Dystrophy
Decreased corneal sensation, Decreased corneal thickness, Opacification of the corneal stroma, Co... ORPHA:98969
Xeroderma Pigmentosum Variant
Basal cell carcinoma, Squamous cell carcinoma, Melanoma ORPHA:90342
Schöpf-Schulz-Passarge Syndrome
Basal cell carcinoma, Ovarian neoplasm, Squamous cell carcinoma ORPHA:50944
Cheilitis Glandularis
Squamous cell carcinoma, Carcinoma OMIM:118330
Brittle Cornea Syndrome 2
Keratoconus, Decreased corneal thickness, Gait disturbance, Keratoglobus, Megalocornea, Flat corn... OMIM:614170
Microcephaly, Congenital Heart Disease, Unilateral Renal Agenesis, And Hyposegmented Lungs
Microcephaly, Hydranencephaly OMIM:601355
Corneal Hypesthesia, Familial
Decreased corneal sensation, Recurrent corneal erosions OMIM:122450
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 13
Hypoplasia of the brainstem, Agenesis of corpus callosum, Type II lissencephaly, Cerebellar hypop... OMIM:615287
Corneal Dystrophy, Endothelial, X-Linked
Band keratopathy, Corneal opacity, Corneal dystrophy OMIM:300779
Schisis Association
Microcephaly, Spina bifida, Anencephaly ORPHA:63862
Dyskeratosis Congenita, Autosomal Recessive 3
Squamous cell carcinoma OMIM:613988
Corneal Dystrophy, Posterior Polymorphous, 2
Corneal opacity, Corneal dystrophy OMIM:609140
Edict Syndrome
Keratoconus, Developmental cataract, Hypoplasia of the iris, Microcornea, Astigmatism OMIM:614303
Congenital Hereditary Endothelial Dystrophy Type Ii
Irregular astigmatism, Corneal opacity, Increased corneal thickness, Corneal stromal edema, Abnor... ORPHA:293603
Epidermodysplasia Verruciformis, Susceptibility To, 2
Verruca plana, Squamous cell carcinoma of the skin OMIM:618231
Meckel Syndrome, Type 4
Hypoplasia of the corpus callosum, Anencephaly, Meningocele, Microcephaly, Agenesis of cerebellar... OMIM:611134
Epidermodysplasia Verruciformis, X-Linked
Verrucae, Squamous cell carcinoma of the skin OMIM:305350
Hypoplasia of the brainstem, Pachygyria, Cerebellar hypoplasia, Hydranencephaly, Microcephaly, Ag... OMIM:605013
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Distal Monosomy 13Q
Holoprosencephaly, Microcephaly, Aplasia/Hypoplasia of the corpus callosum, Anencephaly ORPHA:1590
Sarcoma, Synovial
Synovial sarcoma OMIM:300813
Alveolar Soft Part Sarcoma
Alveolar soft part sarcoma OMIM:606243
Combined Immunodeficiency Due To Dock8 Deficiency
Anal canal squamous carcinoma, Verrucae, Squamous cell carcinoma of the vulva, Squamous cell carc... ORPHA:217390
Aminopterin/Methotrexate Embryofetopathy
Aplasia/Hypoplasia of the cerebellum, Aplasia/Hypoplasia of the corpus callosum, Holoprosencephal... ORPHA:1908
Meckel Syndrome, Type 10
Anencephaly OMIM:614175
Leber Congenital Amaurosis 7
Keratoconus, Cataract OMIM:613829
Keratosis, Familial Actinic
Neoplasm, Uterine neoplasm, Carcinoma OMIM:148390
Meckel Syndrome, Type 2
Meningocele, Dandy-Walker malformation, Anencephaly OMIM:603194
Ring Dermoid Of Cornea
Abnormal conjunctiva morphology, Corneal astigmatism, Abnormal cornea morphology, Conjunctival de... OMIM:180550
Hydrocephalus, Absent septum pellucidum, Arrhinencephaly, Anencephaly, Agenesis of corpus callosum ORPHA:2189
Xeroderma Pigmentosum, Variant Type
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma OMIM:278750
Epidermodysplasia Verruciformis
Verrucae, Squamous cell carcinoma ORPHA:302
Meckel Syndrome, Type 5
Anencephaly OMIM:611561
Cutaneous Neuroendocrine Carcinoma
Basal cell carcinoma, Multiple myeloma, Neoplasm of the outer ear, Carcinoid tumor, Brain neoplas... ORPHA:79140
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Ichthyosis, Hystrix-Like, With Deafness
Squamous cell carcinoma OMIM:602540
Necrobiosis Lipoidica
Squamous cell carcinoma ORPHA:542592
Palmoplantar Carcinoma, Multiple Self-Healing
Squamous cell carcinoma, Carcinoma OMIM:615225
Oral Submucous Fibrosis
Oropharyngeal squamous cell carcinoma ORPHA:357154
Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly
Hypoplasia of the brainstem, Hydranencephaly, Cerebellar hypoplasia OMIM:236500
Li-Fraumeni Syndrome
Prostate cancer, Prostate neoplasm, Soft tissue sarcoma, Lung adenocarcinoma, Nephroblastoma, Ost... OMIM:151623
Corneal Dystrophy, Fuchs Endothelial, 1
Descemet Membrane Folds, Corneal degeneration, Corneal stromal edema, Corneal guttata, Corneal dy... OMIM:136800
Muir-Torre Syndrome
Laryngeal carcinoma, Basal cell carcinoma, Carcinoma, Sebaceous gland carcinoma, Adenoma sebaceum... OMIM:158320
Leber Congenital Amaurosis 6
Keratoconus, Cataract OMIM:613826
Meckel Syndrome, Type 6
Hydrocephalus, Anencephaly OMIM:612284
Leber Congenital Amaurosis 8
Keratoconus, Cataract OMIM:613835
Neuroendocrine Carcinoma Of Salivary Glands, Sensorineural Hearing Loss, And Enamel Hypoplasia
Unilateral vestibular Schwannoma, Carcinoma OMIM:603641
Coasy Protein-Associated Neurodegeneration
Abnormality of thalamus morphology, Eye of the tiger anomaly of globus pallidus, Abnormal caudate... ORPHA:397725
Brittle Cornea Syndrome 1
Keratoconus, Decreased corneal thickness, Abnormal cornea morphology, Keratoglobus OMIM:229200
Werner Syndrome
Renal neoplasm, Ovarian neoplasm, Neoplasm of the oral cavity, Cutaneous melanoma, Meningioma, Ga... ORPHA:902
Leber Congenital Amaurosis 2
Keratoconus, Cataract OMIM:204100
Epidermodysplasia Verruciformis, Susceptibility To, 5
Verrucae, Squamous cell carcinoma of the skin OMIM:618309
Colorectal Cancer, Susceptibility To, 10
Colorectal polyposis, Endometrial carcinoma, Carcinoma OMIM:612591
Cerebrocostomandibular Syndrome
Spina bifida, Porencephalic cyst, Meningocele, Hydranencephaly, Cerebral calcification, Microceph... ORPHA:1393
Spina bifida, Holoprosencephaly, Spinal dysraphism, Anencephaly, Dandy-Walker malformation, Myelo... ORPHA:63259
Palmoplantar Keratoderma-Xx Sex Reversal-Predisposition To Squamous Cell Carcinoma Syndrome
Squamous cell carcinoma of the skin ORPHA:85112
Lattice Corneal Dystrophy Type I
Decreased corneal sensation, Recurrent corneal erosions, Central posterior corneal opacity, Subep... ORPHA:98964
Recurrent Respiratory Papillomatosis
Squamous cell carcinoma ORPHA:60032
Acrofacial Dysostosis, Rodríguez Type
Arrhinencephaly, Aqueductal stenosis ORPHA:1788
Corneal Dystrophy, Fuchs Endothelial, 6
Corneal stromal edema, Keratitis, Corneal guttata, Abnormal Descemet membrane morphology, Corneal... OMIM:613270
Short-Rib Thoracic Dysplasia 14 With Polydactyly
Polymicrogyria, Cerebellar vermis hypoplasia, Hydrocephalus, Anencephaly OMIM:616546
Acquired Ichthyosis
Neoplasm, Multiple myeloma, Sarcoma, Lymphoma ORPHA:454
Thoracoabdominal Syndrome
Hydrocephalus, Anencephaly OMIM:313850
Maffucci Syndrome
Neoplasm of the parathyroid gland, Chondrosarcoma, Ovarian neoplasm, Hemangiomatosis, Multiple en... ORPHA:163634
Multiple cutaneous malignancies, Squamous cell carcinoma ORPHA:182
Dermatitis, Atopic
Keratoconus, Cataract, Conjunctivitis OMIM:603165
Leber Congenital Amaurosis 1
Keratoconus, Cataract OMIM:204000
Chromosome 13Q33-Q34 Deletion Syndrome
Microcephaly, Agenesis of corpus callosum, Dandy-Walker malformation, Anencephaly OMIM:619148
Bloom Syndrome
Leukemia, Squamous cell carcinoma, Lymphoma OMIM:210900
Leber Congenital Amaurosis 4
Keratoconus OMIM:604393
Paraneoplastic Pemphigus
Thymoma, Sarcoma, B-cell lymphoma ORPHA:63455
Fanconi Anemia, Complementation Group P
Squamous cell carcinoma OMIM:613951
Pentalogy Of Cantrell
Hydrocephalus, Anencephaly ORPHA:1335
Papillon-Lefèvre Syndrome
Neoplasm of the skin, Squamous cell carcinoma, Melanoma ORPHA:678
Pelvis-Shoulder Dysplasia
Spina bifida, Hydranencephaly, Hydrocephalus ORPHA:2839
Microgastria-Limb Reduction Defects Association
Porencephalic cyst, Arrhinencephaly, Fusion of the left and right thalami, Polymicrogyria, Agenes... OMIM:156810
Squamous cell carcinoma of the skin ORPHA:79358
Ollier Disease
Hemangioma, Chondrosarcoma, Multiple enchondromatosis, Neoplasm, Sarcoma, Visceral angiomatosis, ... ORPHA:296
Keratoconus Posticus Circumscriptus
Central posterior corneal opacity, Keratoconus OMIM:244600
49,Xxxxy Syndrome
Holoprosencephaly, Hypoplasia of the corpus callosum, Arrhinencephaly ORPHA:96264
Trisomy 18
Spina bifida, Aplasia/Hypoplasia of the corpus callosum, Holoprosencephaly, Anencephaly, Microcep... ORPHA:3380
Epidermolysis Bullosa Dystrophica, Autosomal Recessive
Squamous cell carcinoma OMIM:226600
Trichothiodystrophy 1, Photosensitive
Basal cell carcinoma, Squamous cell carcinoma OMIM:601675
Vacterl/Vater Association
Anencephaly ORPHA:887
Leber Congenital Amaurosis
Keratoconus, Cataract ORPHA:65
Huriez Syndrome
Squamous cell carcinoma of the skin OMIM:181600
Caudal Regression Sequence
Arrhinencephaly ORPHA:3027
Brittle Cornea Syndrome
Decreased corneal thickness, Corneal erosion, Gait disturbance, Keratoglobus, Corneal scarring, C... ORPHA:90354
Familial Adenomatous Polyposis 1
Multiple gastric polyps, Medulloblastoma, Adrenocortical adenoma, Carcinoma, Fibroma, Osteoma, Sm... OMIM:175100
Amoebic Keratitis
Decreased corneal sensation, Abnormal corneal epithelium morphology, Corneal perforation, Catarac... ORPHA:67043
Large Congenital Melanocytic Nevus
Cutaneous melanoma, Neoplasm, Sarcoma, Rhabdomyosarcoma, Neoplasm of the skin ORPHA:626
Vacterl With Hydrocephalus
Arrhinencephaly, Spina bifida, Hydrocephalus, Aqueductal stenosis ORPHA:3412
Apc-Related Attenuated Familial Adenomatous Polyposis
Adrenocortical adenoma, Fibrosarcoma, Adenomatous colonic polyposis, Breast carcinoma, Adrenocort... ORPHA:247806
Rothmund-Thomson Syndrome Type 1
Basal cell carcinoma, Myelodysplasia, Squamous cell carcinoma, Osteosarcoma, Leukemia, Neoplasm o... ORPHA:221008
Rothmund-Thomson Syndrome Type 2
Basal cell carcinoma, Myelodysplasia, Squamous cell carcinoma, Lymphoma, Osteosarcoma, Leukemia, ... ORPHA:221016
Cousin Syndrome
Hydranencephaly, Hydrocephalus OMIM:260660
Rothmund-Thomson Syndrome
Basal cell carcinoma, Myelodysplasia, Squamous cell carcinoma, Leukemia, Neoplasm of the skin, Me... ORPHA:2909
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Dominant
Squamous cell carcinoma OMIM:148210
Meckel Syndrome, Type 1
Agenesis of corpus callosum, Large placenta, Cerebellar hypoplasia, Anencephaly, Olfactory lobe a... OMIM:249000
Xeroderma Pigmentosum, Complementation Group E
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma OMIM:278740
Retinitis Pigmentosa
Keratoconus, Cataract ORPHA:791
Progressive Osseous Heteroplasia
Sarcoma ORPHA:2762
Meckel Syndrome
Aplasia/Hypoplasia of the corpus callosum, Anencephaly, Lobar holoprosencephaly, Microcephaly, Hy... ORPHA:564
Xeroderma Pigmentosum, Complementation Group C
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin OMIM:278720
Arthrogryposis, Distal, Type 5
Keratoconus, Astigmatism, Keratoglobus OMIM:108145
Short-Rib Thoracic Dysplasia 12
Holoprosencephaly, Hydrocephalus, Anencephaly OMIM:269860
Hydrolethalus Syndrome 1
Agenesis of corpus callosum, Absent septum pellucidum, Arrhinencephaly, Anencephaly, Abnormal cor... OMIM:236680
Infantile Myofibromatosis
Gingival fibromatosis, Benign neoplasm of the central nervous system, Fibroma, Sarcoma, Neoplasm ... ORPHA:2591
Mast Cell Sarcoma
Sarcoma ORPHA:66661
Attenuated Familial Adenomatous Polyposis
Rectal polyposis, Adenocarcinoma of the colon, Fibroma, Uterine leiomyoma, Colorectal polyposis, ... ORPHA:220460
Rothmund-Thomson Syndrome, Type 2
Basal cell carcinoma, Osteosarcoma, Squamous cell carcinoma OMIM:268400
Limb Body Wall Complex
Spina bifida, Short umbilical cord, Anencephaly, Spina bifida occulta, Myelomeningocele, Hydrocep... ORPHA:2369
Squamous cell carcinoma ORPHA:33364
Corneal Dystrophy, Posterior Polymorphous, 1
Uveal ectropion, Corneal opacity, Ectopia pupillae, Iris atrophy, Polymorphous posterior corneal ... OMIM:122000
Anterior Segment Dysgenesis 6
Developmental glaucoma, Corneal opacity, Corneal neovascularization, Posterior synechiae of the a... OMIM:617315
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Pachygyria, Exencephaly, Polymicrogyria, Abnormal cortical gyration, Macrogyria, Lissencephaly ORPHA:2211
Oculocutaneous Albinism Type 1B
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:79434
Mental Retardation, Keratoconus, Febrile Seizures, And Sinoatrial Block
Keratoconus OMIM:609438
Aicardi-Goutières Syndrome
Porencephalic cyst, Hypoplasia of the corpus callosum, Arrhinencephaly, Degeneration of the stria... ORPHA:51
Sarcoma ORPHA:69078
Xeroderma Pigmentosum, Complementation Group B
Neoplasm, Basal cell carcinoma, Cutaneous melanoma, Squamous cell carcinoma of the skin OMIM:610651
Neu-Laxova Syndrome 1
Spina bifida, Short umbilical cord, Cerebellar hypoplasia, Hydranencephaly, Lissencephaly, Microc... OMIM:256520
Microtriplication 11Q24.1
Keratoconus ORPHA:289522
Hereditary Acrokeratotic Poikiloderma
Transitional cell carcinoma of the bladder, Squamous cell carcinoma ORPHA:2907
Angelman Syndrome
Inability to walk, Keratoconus, Iris hypopigmentation, Aggressive behavior, Self-injurious behavi... ORPHA:72
Dyskeratosis Congenita, X-Linked
Myelodysplasia, Carcinoma, Acute myeloid leukemia, Hodgkin lymphoma, Squamous cell carcinoma OMIM:305000
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Intermediate Form
Squamous cell carcinoma ORPHA:89842
Multiple Endocrine Neoplasia, Type Iv
Pancreatic endocrine tumor, Carcinoma, Renal angiomyolipoma, Carcinoid tumor, Parathyroid adenoma... OMIM:610755
Rhabdoid Tumor
Neoplasm of the central nervous system, Renal neoplasm, Sarcoma, Neoplasm of the liver ORPHA:69077
Ring Chromosome 13 Syndrome
Microcephaly, Agenesis of corpus callosum, Anencephaly ORPHA:96176
Hypogonadotropic Hypogonadism-Severe Microcephaly-Sensorineural Hearing Loss-Dysmorphism Syndrome
Decreased corneal thickness ORPHA:293967
Microgastria-Limb Reduction Defect Syndrome
Arrhinencephaly, Abnormal cortical gyration, Agenesis of corpus callosum, Absent septum pellucidum ORPHA:2538
Yunis-Varon Syndrome
Pachygyria, Arrhinencephaly, Cerebellar hypoplasia, Microcephaly, Agenesis of corpus callosum OMIM:216340
Desmoplastic Small Round Cell Tumor
Neoplasm of the central nervous system, Ovarian neoplasm, Sarcoma, Neoplasm of the lung, Testicul... ORPHA:83469
Oculocutaneous Albinism Type 1A
Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79431
Optic Atrophy-Intellectual Disability Syndrome
Keratoconus, Attention deficit hyperactivity disorder ORPHA:401777
22Q11.2 Deletion Syndrome
Spina bifida, Arrhinencephaly, Umbilical hernia, Meningocele, Microcephaly, Hydrocephalus, Occipi... ORPHA:567
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Recessive
Keratoconus, Conjunctivitis OMIM:242150
Kindler Epidermolysis Bullosa
Squamous cell carcinoma, Neoplasm of the urethra ORPHA:2908
Fryns Syndrome
Hypoplasia of the optic tract, Arrhinencephaly, Hypoplasia of olfactory tract, Agenesis of corpus... OMIM:229850
Congenital Erythropoietic Porphyria
Neoplasm of the skin, Squamous cell carcinoma ORPHA:79277
Pallister-Hall Syndrome
Panhypopituitarism, Hypothalamic hamartoma, Holoprosencephaly, Arrhinencephaly, Cerebellar hypopl... ORPHA:672
Severe Generalized Junctional Epidermolysis Bullosa
Renal tubular epithelial necrosis, Squamous cell carcinoma ORPHA:79404
Gastrointestinal Stromal Tumor
Neoplasm of the gastrointestinal tract, Gastrointestinal stroma tumor, Neoplasm of the rectum, Es... ORPHA:44890
Yunis-Varon Syndrome
Pachygyria, Agenesis of corpus callosum, Arrhinencephaly, Cerebellar hypoplasia, Primary microcep... ORPHA:3472
Microphthalmia With Limb Anomalies
Arrhinencephaly, Hydrocephalus ORPHA:1106
Yellow Nail Syndrome
Biliary tract neoplasm, Renal neoplasm, Neoplasm, Sarcoma, Neoplasm of the lung ORPHA:662
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
Esophageal carcinoma, Oropharyngeal squamous cell carcinoma ORPHA:391487
Oculocutaneous Albinism
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:55
Xeroderma Pigmentosum-Cockayne Syndrome Complex
Basal cell carcinoma, Squamous cell carcinoma of the skin, Melanoma ORPHA:220295
Oncogenic Osteomalacia
Neoplasm of head and neck, Neurofibromas, Carcinoma, Giant cell tumor of bone, Neoplasm of the sk... ORPHA:352540
Oculocutaneous Albinism Type 2
Cutaneous melanoma, Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79432
Doors Syndrome
Arrhinencephaly, Sirenomelia, Polymicrogyria, Spina bifida occulta, Microcephaly, Dandy-Walker ma... ORPHA:79500
Autosomal Recessive Generalized Dystrophic Epidermolysis Bullosa, Severe Form
Cutaneous melanoma, Squamous cell carcinoma ORPHA:79408
Charge Syndrome
Gonadotropin deficiency, Holoprosencephaly, Arrhinencephaly, Umbilical hernia, Microcephaly, Decr... OMIM:214800
Lacrimoauriculodentodigital Syndrome
Decreased corneal sensation, Limbal stem cell deficiency, Increased corneal thickness, Keratoconj... ORPHA:2363
Retinoblastoma, Lymphoma, Osteosarcoma, Pinealoma, Leukemia, Ewing sarcoma OMIM:180200
Nail-Patella Syndrome
Keratoconus, Microphakia, Cataract, Microcornea, Antecubital pterygium, Lester's sign OMIM:161200
Dyskeratosis Congenita, Autosomal Dominant 1
Myelodysplasia, Squamous cell carcinoma of the skin OMIM:127550
Alagille Syndrome
Keratoconus, Abnormal pupil morphology, Corneal dystrophy ORPHA:52
Warburg-Cinotti Syndrome
Symblepharon, Limbal stem cell deficiency, Decreased corneal thickness, Corneal neovascularization OMIM:618175
Lmna-Related Cardiocutaneous Progeria Syndrome
Basal cell carcinoma, Papillary renal cell carcinoma, Pulmonary carcinoid tumor, Squamous cell ca... ORPHA:363618
Gnb5-Related Intellectual Disability-Cardiac Arrhythmia Syndrome
Keratoconus ORPHA:542306
Costello Syndrome
Keratoconus ORPHA:3071
Gapo Syndrome
Keratoconus ORPHA:2067
Hermansky-Pudlak Syndrome
Basal cell carcinoma, Squamous cell carcinoma of the skin ORPHA:79430
Kid Syndrome
Neoplasm, Squamous cell carcinoma of the skin ORPHA:477
Arterial Tortuosity Syndrome
Keratoconus OMIM:208050
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Squamous cell carcinoma of the skin ORPHA:79396
Arterial Tortuosity Syndrome
Keratoconus, Keratoglobus ORPHA:3342
Gapo Syndrome
Keratoconus OMIM:230740
Neurofibromatosis Type 1
Lisch nodules, Neoplasm of the gastrointestinal tract, Urinary tract neoplasm, Plexiform neurofib... ORPHA:636
Ehlers-Danlos Syndrome, Kyphoscoliotic Type, 1
Keratoconus, Microcornea OMIM:225400
Hypermobile Ehlers-Danlos Syndrome
Keratoconus, Keratoconjunctivitis sicca ORPHA:285
Vascular Ehlers-Danlos Syndrome
Cognitive impairment, Keratoconus, Abnormal pupil morphology ORPHA:286
Ehlers-Danlos Syndrome, Vascular Type
Keratoconus OMIM:130050


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tiam1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tiam1.

No publications found that use IMPC mice or data for Tiam1.

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MGI Allele Allele Type Produced
Tiam1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Tiam1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice

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