Gene: Cyb561

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Phenotype System Allele Zyg Sex Life Stage P Value
abnormal bone structure Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 9.13×10-06
abnormal cranium morphology Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 7.61×10-06
decreased monocyte cell number Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 9.00×10-05
hypoactivity Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 1.20×10-09
abnormal behavior Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 3.16×10-10
abnormal head size Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 2.24×10-09
decreased fasted circulating glucose level Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 1.26×10-11
abnormal response to new environment Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 1.77×10-05
abnormal retinal blood vessel morphology Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 8.87×10-06
increased circulating alkaline phosphatase level Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 8.79×10-05
increased circulating iron level Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 1.85×10-07
decreased circulating total protein level Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 2.10×10-06
increased circulating fructosamine level Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 1.72×10-05
abnormal maxilla morphology Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 5.91×10-05
increased erythrocyte cell number Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 1.07×10-06
decreased circulating serum albumin level Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 3.97×10-10
increased circulating amylase level Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 1.55×10-09
abnormal gait Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 8.88×10-07
decreased bone mineral content Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 6.37×10-18
abnormal bone structure Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 1.32×10-12
abnormal bone mineralization Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 7.41×10-06
decreased circulating calcium level Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 1.09×10-05
enlarged heart Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 0.00
decreased circulating serum albumin level Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 2.13×10-05
decreased circulating LDL cholesterol level Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 7.30×10-07
abnormal placement of pupils Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 2.35×10-05
hypoactivity Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 5.14×10-05
decreased circulating total protein level Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 1.00×10-08
mammalian phenotype Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 2.85×10-06
increased circulating triglyceride level Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 8.93×10-07
increased hematocrit Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 1.08×10-07
tremors Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 3.93×10-12
abnormal tail length Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 8.08×10-06
narrow eye opening Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 5.52×10-14
abnormal snout morphology Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 4.42×10-08
abnormal posture Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 4.70×10-05
increased circulating magnesium level Cyb561tm1a(EUCOMM)Wtsi HOM postnatal 5.83×10-05
abnormal iris morphology Cyb561tm1b(EUCOMM)Wtsi HOM postnatal 1.64×10-07

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IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 4 No  (2/584)  (2/4)  Wholemount images
Aorta 4 No N/A
Blood vessel 2 No N/A
Bone 4 No N/A
Brain 4 No  (2/4)  Wholemount images
Brainstem 4 No N/A
Brown adipose tissue 4 No N/A
Cartilage tissue 4 No N/A
Cerebellum 4 No N/A
Cerebral cortex 4 No N/A
Esophagus 2 No  (7/415) N/A
Eye 4 No N/A
Gall bladder 4 No N/A
Heart 4 No N/A
Hippocampus 4 No N/A
Hypothalamus 4 No N/A
Kidney 4 No  (18/584)  (1/4)  Wholemount images
Large intestine 4 No  (10/584) N/A
Liver 4 No N/A
Lower urinary tract 4 No N/A
Lung 4 No N/A
Lymph node 4 No  (1/4) N/A
Mammary gland 4 No N/A
Esophagus 2 No N/A
Olfactory lobe 4 No N/A
Oral epithelium 2 No N/A
Ovary 4 No  (1/584) N/A
Oviduct 4 No  (1/4)  Wholemount images
Pancreas 4 No  (5/584) N/A
Parathyroid gland 4 No N/A
Peripheral nervous system 4 No  (2/4) N/A
Peyer's patch 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 4 No N/A
Prostate gland 4 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skeletal muscle tissue 2 No N/A
Skin 4 No N/A
Small intestine 4 No  (9/584) N/A
Spinal cord 4 No N/A
Spleen 4 No  (2/584) N/A
Stomach 4 No  (12/584)  (2/4)  Wholemount images
Striatum 4 No N/A
Testis 4 No  (2/584) N/A
Thymus 4 No N/A
Thyroid gland 4 No  (15/584) N/A
Trachea 4 No N/A
Uterus 4 No N/A
Vascular system 2 No N/A
White adipose tissue 4 No N/A
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 1  (6/485) N/A
Ear 1  (1/485) N/A
Embryo 1  (1/485) N/A
Eye 1  (1/485) N/A
Foot 1  (1/485) N/A
Forebrain 1  (1/485) N/A
Forelimb 1  (1/485) N/A
Hand 1  (1/485) N/A
Head 1  (5/485) N/A
Heart 1  (1/485) N/A
Hindbrain 1  (6/485) N/A
Hindlimb 1  (1/485) N/A
Liver 1  (1/485) N/A
Lung 1  (1/485) N/A
Mandibular process 1  (1/485) N/A
Maxillary process 1  (1/485) N/A
Midbrain 1  (1/485) N/A
Oral cavity 1  (1/485) N/A
Skin 1  (1/485) N/A
Tail 1  (1/485) N/A
Tail somite 1  (1/485) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Echo: M-Mode Images
36 Images
X-ray: XRay Images Dorso Ventral
10 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Adult LacZ: LacZ Images Wholemount
7 Images
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Cyb561tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Cyb561tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Cyb561tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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