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Gene: Acod1 MGI:103206

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Gene Summary

Name:
aconitate decarboxylase 1
Synonyms:
Irg1

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Acod1em1(IMPC)J HOM   Early adult 5.78×10-05

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

8 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

8 Images

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X-ray

XRay Images Forepaw

8 Images

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X-ray

XRay Images Whole Body Lateral Orientation

8 Images

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Eye Morphology

Images Ophthalmoscopy

4 Images

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X-ray

XRay Images Skull Lateral Orientation

8 Images

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PDF thumbnail PDF
Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

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Human diseases caused by Acod1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Acod1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Acod1.

There are 30 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
ACOD1 deficiency offers protection in a mouse model of diet-induced obesity by maintaining a healthy gut microbiota. Cell death & disease (February 2024) Acod1em1(IMPC)J PMC10834593
Itaconate-producing neutrophils regulate local and systemic inflammation following trauma. JCI insight (October 2023) Acod1tm1c(KOMP)Wtsi PMC10619500
An innate granuloma eradicates an environmental pathogen using Gsdmd and Nos2. Nature communications (October 2023) Acod1em1(IMPC)J PMC10590453
Parkinson's disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella. Nature microbiology (August 2023) Acod1tm1a(KOMP)Wtsi 37640963
Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection. Science immunology (August 2023) Acod1em1(IMPC)J 37566679
Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth. Nature metabolism (November 2022) Acod1em1(IMPC)J 36376563
Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency. Molecular oncology (August 2022) Acod1tm1a(KOMP)Wtsi PMC9441003
Aconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice. Obesity (Silver Spring, Md.) (August 2022) Acod1tm1a(KOMP)Wtsi PMC9541899
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages. Nature metabolism (July 2022) Acod1em1(IMPC)J PMC9314259
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages. Nature metabolism (May 2022) Acod1tm1a(KOMP)Wtsi 35655024
Aconitate Decarboxylase 1 Deficiency Exacerbates Mouse Colitis Induced by Dextran Sodium Sulfate. International journal of molecular sciences (April 2022) Acod1em1(IMPC)J PMC9025264
Itaconate indirectly influences expansion of effector T cells following vaccination with Francisella tularensis live vaccine strain. Cellular immunology (February 2022) Acod1em1(IMPC)J 35149415
Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection. PLoS pathogens (January 2022) Acod1tm1a(KOMP)Wtsi PMC8846506
Aconitate decarboxylase 1 suppresses cerebral ischemia-reperfusion injury in mice. Experimental neurology (October 2021) Acod1tm1c(KOMP)Wtsi Acod1tm1a(KOMP)Wtsi 34699789
Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology. Nature immunology (October 2021) Acod1em1(IMPC)J 34686860
IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation. Immunity (October 2021) Acod1tm1e(KOMP)Wtsi 34644537
A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism. Cell reports (September 2021) Acod1tm1c(KOMP)Wtsi 34551300
Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection. Cell reports. Medicine (May 2021) Acod1em1(IMPC)J PMC8149370
Itaconate confers tolerance to late NLRP3 inflammasome activation. Cell reports (March 2021) Acod1tm1a(KOMP)Wtsi PMC8039864
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation. Cell metabolism (August 2020) Acod1em1(IMPC)J PMC7422798
Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella. Science (New York, N.Y.) (July 2020) Acod1tm1a(KOMP)Wtsi 32703879
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome. Cell metabolism (June 2020) Acod1em1(IMPC)J 32516576
Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation. Cell metabolism (May 2020) Acod1em1(IMPC)J 32428444
Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response. eLife (April 2020) Acod1em1(IMPC)J PMC7185992
IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila. mBio (November 2019) Acod1em1(IMPC)J PMC6851286
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects. Nature communications (November 2019) Acod1em1(IMPC)J PMC6841710
The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. Immunity (January 2019) Acod1em1(IMPC)J 30635240
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Nature (April 2018) Acod1tm1a(KOMP)Wtsi PMC6037913
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell metabolism (June 2016) Acod1tm1a(KOMP)Wtsi PMC5108454
Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. The Journal of biological chemistry (May 2016) Acod1tm1a(KOMP)Wtsi PMC4933182

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MGI Allele Allele Type Produced
Acod1em1(IMPC)J Exon Deletion Mice
Acod1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Acod1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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