IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Acod1.
There are 23 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency.||Molecular oncology (August 2022)||Acod1tm1a(KOMP)Wtsi||PMC9441003|
|Aconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice.||Obesity (Silver Spring, Md.) (August 2022)||Acod1tm1a(KOMP)Wtsi||PMC9541899|
|Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.||Nature metabolism (May 2022)||Acod1tm1a(KOMP)Wtsi||35655024|
|Aconitate Decarboxylase 1 Deficiency Exacerbates Mouse Colitis Induced by Dextran Sodium Sulfate.||International journal of molecular sciences (April 2022)||Acod1em1(IMPC)J||PMC9025264|
|Itaconate indirectly influences expansion of effector T cells following vaccination with Francisella tularensis live vaccine strain.||Cellular immunology (February 2022)||Acod1em1(IMPC)J||35149415|
|Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection.||PLoS pathogens (January 2022)||Acod1tm1a(KOMP)Wtsi||PMC8846506|
|Aconitate decarboxylase 1 suppresses cerebral ischemia-reperfusion injury in mice.||Experimental neurology (October 2021)||Acod1tm1c(KOMP)Wtsi Acod1tm1a(KOMP)Wtsi||34699789|
|Mitochondrial complex II in intestinal epithelial cells regulates T cell-mediated immunopathology.||Nature immunology (October 2021)||Acod1em1(IMPC)J||34686860|
|IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.||Immunity (October 2021)||Acod1tm1e(KOMP)Wtsi||34644537|
|A20 deficiency in myeloid cells protects mice from diet-induced obesity and insulin resistance due to increased fatty acid metabolism.||Cell reports (September 2021)||Acod1tm1c(KOMP)Wtsi||34551300|
|Integrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection.||Cell reports. Medicine (May 2021)||Acod1em1(IMPC)J||PMC8149370|
|Itaconate confers tolerance to late NLRP3 inflammasome activation.||Cell reports (March 2021)||Acod1tm1a(KOMP)Wtsi||PMC8039864|
|The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation.||Cell metabolism (August 2020)||Acod1em1(IMPC)J||PMC7422798|
|Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella.||Science (New York, N.Y.) (July 2020)||Acod1tm1a(KOMP)Wtsi||32703879|
|Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome.||Cell metabolism (June 2020)||Acod1em1(IMPC)J||32516576|
|Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation.||Cell metabolism (May 2020)||Acod1em1(IMPC)J||32428444|
|Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response.||eLife (April 2020)||Acod1em1(IMPC)J||PMC7185992|
|IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila.||mBio (November 2019)||Acod1em1(IMPC)J||PMC6851286|
|4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.||Nature communications (November 2019)||Acod1em1(IMPC)J||PMC6841710|
|The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.||Immunity (January 2019)||Acod1em1(IMPC)J||30635240|
|Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.||Nature (April 2018)||Acod1tm1a(KOMP)Wtsi||PMC6037913|
|Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.||Cell metabolism (June 2016)||Acod1tm1a(KOMP)Wtsi||PMC5108454|
|Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels.||The Journal of biological chemistry (May 2016)||Acod1tm1a(KOMP)Wtsi||PMC4933182|
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
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|MGI Allele||Allele Type||Produced|
|Acod1tm1e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|
|Acod1tm1a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
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