Gene Summary

Name:
aconitate decarboxylase 1
Synonyms:
Irg1

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Acod1em1(IMPC)J HOM   Early adult 2.73×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Ophthalmoscopy

4 Images

Human diseases caused by Acod1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Acod1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Acod1.

There are 11 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation. Cell metabolism (August 2020) Acod1em1(IMPC)J PMC7422798
Itaconate is an effector of a Rab GTPase cell-autonomous host defense pathway against Salmonella. Science (New York, N.Y.) (July 2020) Acod1tm1a(KOMP)Wtsi 32703879
Toll-Like Receptors Induce Signal-Specific Reprogramming of the Macrophage Lipidome. Cell metabolism (June 2020) Acod1em1(IMPC)J 32516576
Pseudomonas aeruginosa Utilizes Host-Derived Itaconate to Redirect Its Metabolism to Promote Biofilm Formation. Cell metabolism (May 2020) Acod1em1(IMPC)J 32428444
Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response. eLife (April 2020) Acod1em1(IMPC)J PMC7185992
IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila. mBio (November 2019) Acod1em1(IMPC)J PMC6851286
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects. Nature communications (November 2019) Acod1em1(IMPC)J PMC6841710
The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. Immunity (January 2019) Acod1em1(IMPC)J 30635240
Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis. Nature (April 2018) Acod1tm1a(KOMP)Wtsi PMC6037913
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell metabolism (June 2016) Acod1tm1a(KOMP)Wtsi PMC5108454
Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels. The Journal of biological chemistry (May 2016) Acod1tm1a(KOMP)Wtsi PMC4933182

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MGI Allele Allele Type Produced
Acod1em1(IMPC)J Exon Deletion Mice
Acod1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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