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Gene: Aqp1

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Name
aquaporin 1
MGI ID
MGI:103201
Synonyms
CHIP28
Viability
Data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (19) Measurements chart (226) All data table (789)
Expression & images (67) Disease models (0) Histopathology (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating alkaline phosphatase level Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 6.54×10-27
increased circulating total protein level Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 2.19×10-07
decreased exploration in new environment Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 2.61×10-06
hypoactivity Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 1.79×10-08
decreased eosinophil cell number Aqp1tm1b(EUCOMM)Wtsi HOM   Late adult 2.15×10-06
increased circulating amylase level Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 4.17×10-06
increased lean body mass Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 2.42×10-08
decreased total body fat amount Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 2.47×10-07
increased neutrophil cell number Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 7.30×10-05
hypoactivity Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 2.15×10-24
increased circulating cholesterol level Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 4.07×10-05
decreased grip strength Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 1.01×10-10
decreased bone mineral density Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 7.15×10-06
impaired glucose tolerance Aqp1tm1b(EUCOMM)Wtsi HOM   Early adult 1.89×10-05
decreased exploration in new environment Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 8.82×10-11
increased circulating HDL cholesterol level Aqp1tm1b(EUCOMM)Wtsi HOM Early adult 2.32×10-05
decreased circulating chloride level Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 2.97×10-05
increased circulating serum albumin level Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 5.07×10-05
decreased body weight Aqp1tm1b(EUCOMM)Wtsi HOM Late adult 6.27×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/511)  (2/2)  Wholemount images
Aorta 2 No  (1/499)  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (4/504)  (2/2)  Wholemount images
Brainstem 2 No  (2/498) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/507)  (2/2)  Wholemount images
Cerebellum 2 No  (3/499) N/A
Cerebral cortex 2 No  (2/510) N/A
Esophagus 2 No  (7/354)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/486)  (1/2)  Wholemount images
Hippocampus 2 No  (3/494) N/A
Hypothalamus 2 No  (2/492) N/A
Kidney 2 No  (18/493)  (2/2)  Wholemount images
Large intestine 2 No  (10/483)  (2/2)  Wholemount images
Liver 2 No  (1/2)  Wholemount images
Lower urinary tract 2 No  (1/505)  (2/2)  Wholemount images
Lung 2 No  (1/505)  (2/2)  Wholemount images
Lymph node 2 No  (1/522)  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No  (2/483) N/A
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (4/493) N/A
Parathyroid gland 2 No  (1/477) N/A
Peripheral nervous system 2 No  (2/501)  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (1/509)  (2/2)  Wholemount images
Prostate gland 2 No  (11/507) N/A
Skeletal muscle 2 No  (2/2)  Wholemount images
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (7/504)  (2/2)  Wholemount images
Spinal cord 2 No  (3/492) N/A
Spleen 2 No  (3/499) N/A
Stomach 2 No  (12/496)  (2/2)  Wholemount images
Striatum 2 No  (2/505) N/A
Testis 2 No  (6/490)  (1/2)  Wholemount images
Thymus 2 No  (1/502)  (2/2) N/A
Thyroid gland 2 No  (13/498)  Wholemount images
Trachea 2 No  (2/504)  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No  (1/2)  Wholemount images
LacZ Wholemount Images
adipose tissue (1)
Testis expression
White Adipose Tissue expression
MA:0000058
MA:0000411
cardiovascular system (3)
Heart expression
Aorta expression
MA:0000072
MA:0000062
digestive system (6)
Gall Bladder expression
MA:0000356
endocrine system (2)
Adrenal gland expression
MA:0000116
exocrine system (1)
Mammary gland expression
MA:0000145
immune system (2)
Lymph Node expression
MA:0000139
integumental system (2)
Mammary gland expression
MA:0000145
musculoskeletal system (2)
Skeletal Muscle expression
Vascular System expression
MA:0002718
MA:0003148
nervous system (4)
Brain expression
MA:0000168
postnatal mouse (24)
Adrenal gland expression
MA:0000116
reproductive system (2)
Oviduct expression
Uterus expression
MA:0000389
MA:0000385
respiratory system (3)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (2)
Skeletal Muscle expression
Cartilage tissue expression
Vascular System expression
Bone expression
MA:0002718
MA:0003148
MA:0000104
MA:0001459
trunk (12)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/507)  (4/5) N/A
Ear 2  (1/507) N/A
Embryo 2  (1/508)  (5/5) N/A
Eye 2  (1/507) N/A
Footplate 2  (1/507) N/A
Forebrain 2  (1/507) N/A
Forelimb 2  (1/507) N/A
Handplate 2  (1/507) N/A
Head 2  (5/507)  (4/5) N/A
Heart 2  (1/507)  (2/5) N/A
Hindbrain 2  (6/507) N/A
Hindlimb 2  (1/507) N/A
Liver 2  (1/502)  (1/5) N/A
Lung 2  (1/502) N/A
Mandibular process 2  (1/507) N/A
Maxillary process 2  (1/507) N/A
Midbrain 2  (1/507) N/A
Oral cavity 2  (1/502) N/A
Skin 2  (1/507) N/A
Tail 2  (1/507) N/A
Tail somite group 2  (1/507) N/A

 Associated Images

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X-ray: XRay Images Whole Body Lateral Orientation
10 Images
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Embryo LacZ: LacZ images wholemount
8 Images
thumbnail
Echo: M-Mode Images
32 Images
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X-ray: XRay Images Whole Body Lateral Orientation
12 Images
thumbnail
Adult LacZ: LacZ Images Wholemount
24 Images
thumbnail
Echo: M-Mode Images
48 Images
thumbnail
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
thumbnail
X-ray: XRay Images Whole Body Dorso Ventral
12 Images
thumbnail
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
thumbnail
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Aqp1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Aqp1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Aqp1tm44540(L1L2_st0) Targeting vectors

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