Genes Phenotypes

Gene: Aqp1

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Name
aquaporin 1
MGI ID
MGI:103201
Synonyms
CHIP28
Viability
Homozygous - Viable
View
N/A
Other links
MGI   Ensembl  
Significant phenotypes (10) Measurements chart (230) All data table (349)
Expression & images (67) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating HDL cholesterol level Aqp1tm1b(EUCOMM)Wtsi HOM postnatal 6.37×10-06
decreased grip strength Aqp1tm1b(EUCOMM)Wtsi HOM postnatal 4.12×10-07
decreased bone mineral content Aqp1tm1b(EUCOMM)Wtsi HOM postnatal 5.53×10-06
hypoactivity Aqp1tm1b(EUCOMM)Wtsi HOM postnatal 2.89×10-14
increased circulating total protein level Aqp1tm1b(EUCOMM)Wtsi HOM postnatal 1.44×10-06
increased circulating alkaline phosphatase level Aqp1tm1b(EUCOMM)Wtsi HOM postnatal 5.40×10-31
increased circulating amylase level Aqp1tm1b(EUCOMM)Wtsi HOM postnatal 8.34×10-05
increased circulating cholesterol level Aqp1tm1b(EUCOMM)Wtsi HOM postnatal 3.70×10-05
abnormal behavior Aqp1tm1b(EUCOMM)Wtsi HOM postnatal 1.36×10-12
impaired glucose tolerance Aqp1tm1b(EUCOMM)Wtsi HOM postnatal 6.68×10-06

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/2)  Wholemount images
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No  (1/2)  Wholemount images
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No  (2/2)  Wholemount images
Mammary gland 2 No  (1/2)  Wholemount images
Olfactory lobe 2 No N/A
Oral epithelium 2 No  (2/2)  Wholemount images
Ovary 2 No  (1/584) N/A
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2)  Wholemount images
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No  (2/2)  Wholemount images
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584)  Wholemount images
Trachea 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No  (1/2)  Wholemount images
LacZ Wholemount Images
adipose tissue (1)
Testis expression
White Adipose Tissue expression
MA:0000411
MA:0000058
cardiovascular system (3)
Bone expression
Cartilage tissue expression
Skeletal Muscle expression
Vascular System expression
MA:0001459
MA:0000104
MA:0003148
MA:0002718
digestive system (6)
Gall Bladder expression
MA:0000356
endocrine system (2)
Adrenal gland expression
MA:0000116
exocrine system (1)
Mammary gland expression
MA:0000145
immune system (2)
Lymph Node expression
MA:0000139
integumental system (2)
Mammary gland expression
MA:0000145
musculoskeletal system (2)
Bone expression
Cartilage tissue expression
Skeletal Muscle expression
Vascular System expression
MA:0001459
MA:0000104
MA:0003148
MA:0002718
nervous system (4)
Brain expression
MA:0000168
postnatal mouse (24)
Adrenal gland expression
MA:0000116
reproductive system (2)
Oviduct expression
Uterus expression
MA:0000385
MA:0000389
respiratory system (3)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
set of connective tissues (2)
Bone expression
Cartilage tissue expression
Skeletal Muscle expression
Vascular System expression
MA:0001459
MA:0000104
MA:0003148
MA:0002718
trunk (12)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (4/5) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (5/5) N/A
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (4/5) N/A
Heart 2  (1/485)  (2/5) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485)  (1/5) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
12 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
12 Images
Echo: M-Mode Images
32 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
X-ray: XRay Images Dorso Ventral
12 Images
Adult LacZ: LacZ Images Wholemount
24 Images
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Aqp1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Aqp1tm44540(L1L2_st0) Targeting vectors
Aqp1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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