Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cell division cycle 25A
Synonyms:
D9Ertd393e

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cdc25a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cdc25a by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Cystic Angiomatosis Of Bone, Diffuse
Cystic angiomatosis of bone OMIM:123880
Glutathione Synthetase Deficiency Of Erythrocytes, Hemolytic Anemia Due To
Hemolytic anemia, Reduced glutathione synthetase level, Glyoxalase deficiency OMIM:231900
Distal Osteosclerosis
Diaphyseal sclerosis, Hyperostosis, Craniofacial osteosclerosis OMIM:126250
Melorheostosis, Isolated
Increased bone mineral density, Hyperostosis OMIM:155950
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Rickets of the lower limbs, Delayed epiphyseal ossification, Sparse bone trabeculae, Thin bony co... OMIM:600785
Eiken Syndrome
Delayed epiphyseal ossification, Abnormal bone ossification, Abnormal trabecular bone morphology,... ORPHA:79106
Angioosteohypotrophic Syndrome
Abnormal trabecular bone morphology, Thin bony cortex ORPHA:75508
Florid Cemento-Osseous Dysplasia
Abnormal bone structure, Multiple bony cystic lesions, Abnormal trabecular bone morphology ORPHA:83451
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Delayed epiphyseal ossification, Sparse bone trabeculae, Rickets, Thin bony cortex OMIM:600081
Hypophosphatemic Rickets, X-Linked Recessive
Delayed epiphyseal ossification, Hypophosphatemic rickets, Sparse bone trabeculae, Osteomalacia, ... OMIM:300554
Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Delayed epiphyseal ossification, Hypophosphatemic rickets, Sparse bone trabeculae, Thin bony cort... OMIM:241530
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Delayed epiphyseal ossification, Sparse bone trabeculae, Rickets, Thin bony cortex OMIM:264700
Dent Disease 1
Delayed epiphyseal ossification, Sparse bone trabeculae, Osteomalacia, Thin bony cortex, Rickets OMIM:300009
Autosomal Recessive Hypophosphatemic Rickets
Rickets of the lower limbs, Pseudo-fractures, Hypophosphatemic rickets, Increased bone mineral de... ORPHA:289176
Vitamin D-Dependent Rickets, Type 2A
Delayed epiphyseal ossification, Sparse bone trabeculae, Rickets, Thin bony cortex OMIM:277440
Hypocalcemic Vitamin D-Dependent Rickets
Delayed epiphyseal ossification, Sparse bone trabeculae, Osteomalacia, Thin bony cortex, Rickets ORPHA:289157
Fanconi Anemia, Complementation Group E
Thrombocytopenia, Pancytopenia, Prolonged G2 phase of cell cycle, Neutropenia, Anemia, Leukemia, ... OMIM:600901
Fanconi Anemia, Complementation Group A
Thrombocytopenia, Pancytopenia, Prolonged G2 phase of cell cycle, Neutropenia, Anemia, Leukemia, ... OMIM:227650
Fanconi Anemia, Complementation Group C
Thrombocytopenia, Pancytopenia, Prolonged G2 phase of cell cycle, Neutropenia, Anemia, Leukemia, ... OMIM:227645
Osteopetrosis, Autosomal Recessive 7
Osteopetrosis, Abnormal trabecular bone morphology OMIM:612301
Dent Disease
Delayed epiphyseal ossification, Sparse bone trabeculae, Osteomalacia, Thin bony cortex, Rickets ORPHA:1652
Rothmund-Thomson Syndrome
Osteopenia, Abnormal trabecular bone morphology, Reduced bone mineral density ORPHA:2909
Fanconi Anemia, Complementation Group D2
Thrombocytopenia, Pancytopenia, Prolonged G2 phase of cell cycle, Neutropenia, Anemia, Leukemia, ... OMIM:227646
Rothmund-Thomson Syndrome Type 1
Osteopenia, Abnormal trabecular bone morphology ORPHA:221008
Rothmund-Thomson Syndrome Type 2
Osteopenia, Abnormal trabecular bone morphology ORPHA:221016

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cdc25a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cdc25a.

No publications found that use IMPC mice or data for Cdc25a.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Cdc25atm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cdc25atm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Cdc25atm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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