Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
cell division cycle 25A
Synonyms:
D9Ertd393e

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cdc25a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cdc25a by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Cystic Angiomatosis Of Bone, Diffuse
Cystic angiomatosis of bone OMIM:123880
Superior Transverse Scapular Ligament, Calcification Of, Familial
Ectopic ossification in ligament tissue OMIM:601708
Glutathione Synthetase Deficiency Of Erythrocytes, Hemolytic Anemia Due To
Glyoxalase deficiency, Hemolytic anemia, Reduced glutathione synthetase level OMIM:231900
Distal Osteosclerosis
Hyperostosis, Craniofacial osteosclerosis, Diaphyseal sclerosis OMIM:126250
Melorheostosis, Isolated
Hyperostosis, Increased bone mineral density OMIM:155950
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Generalized bone demineralization, Rickets, Rickets of the lower limbs, Thin bony cortex, Delayed... OMIM:600785
Eiken Syndrome
Abnormal trabecular bone morphology, Abnormal bone ossification, Thin bony cortex, Delayed epiphy... ORPHA:79106
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Rickets, Sparse bone trabeculae, Thin bony cortex, Delayed epiphyseal ossification OMIM:600081
Hypophosphatemic Rickets, X-Linked Recessive
Rickets, Hypophosphatemic rickets, Osteomalacia, Thin bony cortex, Delayed epiphyseal ossificatio... OMIM:300554
Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Rickets, Hypophosphatemic rickets, Thin bony cortex, Delayed epiphyseal ossification, Sparse bone... OMIM:241530
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Rickets, Sparse bone trabeculae, Thin bony cortex, Delayed epiphyseal ossification OMIM:264700
Dent Disease 1
Rickets, Osteomalacia, Thin bony cortex, Delayed epiphyseal ossification, Sparse bone trabeculae OMIM:300009
Vitamin D-Dependent Rickets, Type 2A
Rickets, Sparse bone trabeculae, Thin bony cortex, Delayed epiphyseal ossification OMIM:277440
Autosomal Recessive Hypophosphatemic Rickets
Craniosynostosis, Abnormal trabecular bone morphology, Hypophosphatemic rickets, Increased bone m... ORPHA:289176
Hypocalcemic Vitamin D-Dependent Rickets
Rickets, Osteomalacia, Thin bony cortex, Delayed epiphyseal ossification, Sparse bone trabeculae ORPHA:289157
Fanconi Anemia, Complementation Group E
Neutropenia, Reticulocytopenia, Pancytopenia, Thrombocytopenia, Anemia, Leukemia, Prolonged G2 ph... OMIM:600901
Fanconi Anemia, Complementation Group A
Neutropenia, Reticulocytopenia, Pancytopenia, Thrombocytopenia, Anemia, Leukemia, Prolonged G2 ph... OMIM:227650
Fanconi Anemia, Complementation Group C
Neutropenia, Reticulocytopenia, Pancytopenia, Thrombocytopenia, Anemia, Leukemia, Prolonged G2 ph... OMIM:227645
Dent Disease
Rickets, Osteomalacia, Thin bony cortex, Delayed epiphyseal ossification, Sparse bone trabeculae ORPHA:1652
Rothmund-Thomson Syndrome
Osteopenia, Reduced bone mineral density, Abnormal trabecular bone morphology ORPHA:2909
Osteopetrosis, Autosomal Recessive 7
Osteopetrosis, Abnormal trabecular bone morphology OMIM:612301
Fanconi Anemia, Complementation Group D2
Neutropenia, Reticulocytopenia, Pancytopenia, Thrombocytopenia, Anemia, Leukemia, Prolonged G2 ph... OMIM:227646
Rothmund-Thomson Syndrome Type 1
Osteopenia, Abnormal trabecular bone morphology ORPHA:221008
Rothmund-Thomson Syndrome Type 2
Osteopenia, Abnormal trabecular bone morphology ORPHA:221016

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cdc25a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cdc25a.

No publications found that use IMPC mice or data for Cdc25a.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Cdc25atm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Cdc25atm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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