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Gene: Atrx MGI:103067

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
ATRX, chromatin remodeler
Synonyms:
Rad54,  4833408C14Rik,  alpha thalassemia/mental retardation syndrome X-linked,  Hp1bp2,  XH2,  DXHXS6677E,  HP1-BP38,  Xnp

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Atrx mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Atrx by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Neuroendocrine Tumor Of Stomach
Weight loss ORPHA:100075
Cushing Disease
Fatiguable weakness of proximal limb muscles, Increased body weight, Truncal obesity, Abdominal o... ORPHA:96253
Alpha-Thalassemia/Impaired Intellectual Development Syndrome, X-Linked
Umbilical hernia, Perimembranous ventricular septal defect, Ventricular septal defect OMIM:301040
Intellectual Disability-Hypotonic Facies Syndrome, X-Linked, 1
Obesity OMIM:309580
Alpha-Thalassemia-Myelodysplastic Syndrome
ORPHA:231401
Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
ORPHA:847
Alpha-Thalassemia Myelodysplasia Syndrome
OMIM:300448

The table below shows human diseases predicted to be associated to Atrx by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Neuroendocrine Tumor Of Stomach
Weight loss ORPHA:100075
Cushing Disease
Fatiguable weakness of proximal limb muscles, Increased body weight, Truncal obesity, Abdominal o... ORPHA:96253
Alpha-Thalassemia/Impaired Intellectual Development Syndrome, X-Linked
Umbilical hernia, Perimembranous ventricular septal defect, Ventricular septal defect OMIM:301040
Intellectual Disability-Hypotonic Facies Syndrome, X-Linked, 1
Obesity OMIM:309580
Alpha-Thalassemia-Myelodysplastic Syndrome
ORPHA:231401
Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
ORPHA:847
Alpha-Thalassemia Myelodysplasia Syndrome
OMIM:300448

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Atrx

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Atrx.

No publications found that use IMPC mice or data for Atrx.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Atrxtm47829(pL1L2_GT1_DelLacZ_bsd) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Atrxtm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Atrxtm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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