Gene Summary

Name:
TXK tyrosine kinase
Synonyms:
Rlk,  Btkl,  PTK4,  A130089B16Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
 Section images heterozygote 100% (1 of 1)
 Section images heterozygote 100% (1 of 1)
 Section images heterozygote 100% (1 of 1)
 Section images heterozygote 100% (1 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote Not available
N/A heterozygote Not available
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
N/A heterozygote Not available
N/A heterozygote Not available
N/A heterozygote 0.0% (0 of 1)
N/A heterozygote Not available
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.68% (4 of 584)
aorta 0.17% (1 of 584)
blood 0.0%
bone marrow 0.0%
brain 0.68% (4 of 584)
brainstem 0.34% (2 of 584)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 584)
cecum 2.97% (11 of 370)
cerebellum 0.51% (3 of 584)
cerebral cortex 0.34% (2 of 584)
chest bone Unavailable
colon 8.73% (11 of 126)
diaphragm 0.0%
duodenum 0.79% (1 of 126)
epididymis 12.78% (17 of 133)
esophagus 1.72% (7 of 408)
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland 0.0%
heart 0.34% (2 of 584)
hindlimb 0.0%
hippocampus 0.51% (3 of 584)
hypothalamus 0.34% (2 of 584)
ileum 10.32% (13 of 126)
jejunum 3.97% (5 of 126)
kidney 3.6% (21 of 584)
large intestine 1.71% (10 of 584)
liver 0.0%
lower urinary tract 0.17% (1 of 584)
lung 0.34% (2 of 584)
lymph node 0.17% (1 of 584)
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node 0.0%
midbrain 0.0%
olfactory lobe 0.34% (2 of 584)
ovary 0.17% (1 of 584)
oviduct 0.0%
pancreas 0.86% (5 of 584)
parathyroid gland 0.18% (1 of 562)
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.34% (2 of 584)
peyers patch 0.0%
pituitary gland 0.17% (1 of 584)
prostate gland 2.05% (12 of 584)
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.17% (1 of 584)
small intestine 1.54% (9 of 584)
spinal cord 0.51% (3 of 584)
spleen 0.51% (3 of 584)
stomach 2.05% (12 of 584)
stomach pyloric region 0.0%
striatum 0.51% (3 of 584)
sublingual gland 0.0%
submandibular gland 1.53% (2 of 131)
testis 1.03% (6 of 584)
thymus 0.17% (1 of 584)
thyroid gland 2.74% (16 of 584)
tongue 3.97% (5 of 126)
trachea 0.51% (3 of 584)
trigeminal v nerve 0.0%
urinary bladder 0.0%
uterus 0.0%
vagina 0.0%
vas deferens 3.67% (14 of 381)
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Adult LacZ

LacZ Images Section

6 Images

Human diseases caused by Txk mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Txk by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Ciliary Discoordination Due To Random Ciliary Orientation
Recurrent infections OMIM:215518
Immunodeficiency 31B
Herpes simplex encephalitis, Recurrent mycobacterial infections, Recurrent viral infections OMIM:613796
Immunodeficiency 30
Recurrent infections, Recurrent mycobacterial infections OMIM:614891
Agammaglobulinemia 2, Autosomal Recessive
Recurrent pneumonia, Meningitis, Agammaglobulinemia, Recurrent bacterial infections, Recurrent re... OMIM:613500
Immunodeficiency 35
Increased circulating IgE level, Recurrent fungal infections, Recurrent viral infections, Recurre... OMIM:611521
Agammaglobulinemia 7, Autosomal Recessive
Recurrent infections, Recurrent respiratory infections, Agammaglobulinemia OMIM:615214
Immune Deficiency, Familial Variable
Decreased circulating IgG level, Recurrent infections, Decreased circulating IgA level OMIM:146830
Agammaglobulinemia 8, Autosomal Dominant
Recurrent otitis media, Recurrent infections, Agammaglobulinemia OMIM:616941
Adult Acute Respiratory Distress Syndrome
Increased circulating interleukin 6, Sepsis, Abnormal serum interleukin level, Abnormality of tum... ORPHA:70578
Acute Lung Injury
Increased circulating interleukin 6, Sepsis, Abnormality of serum cytokine level, Abnormality of ... ORPHA:178320
Ectodermal Dysplasia And Immunodeficiency 2
Defective production of NFKB1-dependent cytokines, Recurrent respiratory infections, Recurrent in... OMIM:612132
Parenteral Nutrition-Associated Cholestasis
Abnormality of cytokine secretion ORPHA:567983

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Txk

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Txk.

No publications found that use IMPC mice or data for Txk.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Txktm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Txktm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Txktm2b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter