Gene: Pdx1

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Name
pancreatic and duodenal homeobox 1
MGI ID
MGI:102851
Synonyms
STF-1 IDX-1 Ipf1 IPF-1 Mody4 pdx-1
Embryo viewer
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
pallor Pdx1tm1b(EUCOMM)Wtsi HET E18.5 0.00
abnormal embryo size Pdx1tm1b(EUCOMM)Wtsi HOM E12.5 0.00
abnormal bone mineral density Pdx1tm1b(EUCOMM)Wtsi HET Early adult 8.74×10-05
abnormal placenta size Pdx1tm1b(EUCOMM)Wtsi HET E12.5 0.00
decreased bone mineral density Pdx1tm1b(EUCOMM)Wtsi HET Early adult 7.58×10-05
preweaning lethality, complete penetrance Pdx1tm1b(EUCOMM)Wtsi HOM Early adult 0.00
abnormal glucose tolerance Pdx1tm1b(EUCOMM)Wtsi HET Early adult 5.90×10-05
abnormal embryo size Pdx1tm1b(EUCOMM)Wtsi HET E18.5 0.00
impaired glucose tolerance Pdx1tm1b(EUCOMM)Wtsi HET Early adult 5.80×10-12

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/589) N/A
Aorta 2 No  (1/589) N/A
Bone 2 No N/A
Brain 2 No  (3/589) N/A
Brainstem 2 No  (2/589) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/379) N/A
Cerebellum 2 No  (3/589) N/A
Cerebral cortex 2 No  (2/589) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (1/589) N/A
Hippocampus 2 No  (3/589) N/A
Hypothalamus 2 No  (2/589) N/A
Kidney 2 No  (20/589) N/A
Large intestine 2 No  (10/589) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/589) N/A
Lung 2 No  (1/589) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Mesenteric lymph node 2 No N/A
Olfactory lobe 2 No  (2/589) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/589) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/589)  (2/2)  Wholemount images
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (1/589) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/589) N/A
Prostate gland 2 No  (12/589)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/589) N/A
Spinal cord 2 No  (2/589) N/A
Spleen 2 No  (2/589) N/A
Stomach 2 No  (13/589) N/A
Striatum 2 No  (3/589) N/A
Testis 2 No  (5/589)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (16/589) N/A
Trachea 2 No  (2/589) N/A
Trigeminal V nerve 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vas deferens 2 No  (15/388)  Wholemount images
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/61) N/A
Axial skeleton 2  (1/65) N/A
Brain 2  (6/506) N/A
Central nervous system ganglion 2  (1/74) N/A
Cranium 2  (1/65) N/A
Dorsal root ganglion 2  (1/61) N/A
Ear 2  (1/506) N/A
Embryo 2  (1/507)  (2/2) N/A
Outer ear 2  (1/70) N/A
Eye 2  (1/506) N/A
Femur pre-cartilage condensation 2  (1/56) N/A
Foot 2  (1/506) N/A
Forearm 2  (1/301) N/A
Forebrain 2  (1/506) N/A
Forelimb 2  (1/506) N/A
Fronto-nasal process 2  (1/62) N/A
Gut 2  (1/60) N/A
Hand 2  (1/505) N/A
Head 2  (5/506) N/A
Head mesenchyme 2  (1/61) N/A
Heart 2  (1/506) N/A
Heart ventricle 2  (1/61) N/A
Hindbrain 2  (6/506) N/A
Hindlimb 2  (1/505) N/A
Humerus pre-cartilage condensation 2  (1/65) N/A
Inner ear 2  (1/65) N/A
Intestine 2  (1/59) N/A
Liver 2  (1/506) N/A
Lower leg 2  (1/301) N/A
Lung 2  (1/502) N/A
Mandibular process 2  (1/506) N/A
Maxillary process 2  (1/506) N/A
Mesonephros of female 2  (1/56) N/A
Mesonephros of male 2  (1/56) N/A
Metanephros 2  (1/56) N/A
Midbrain 2  (1/506) N/A
Nasal septum 2  (1/61) N/A
Nose 2  (1/74) N/A
Notochord 2  (1/61) N/A
Oral cavity 2  (1/506) N/A
Outflow tract 2  (1/61) N/A
Pancreas 2  (1/56)  (2/2) N/A
Pericardium 2  (1/56) N/A
Pharynx 2  (1/56) N/A
Radius-ulna pre-cartilage condensation 2  (1/65) N/A
Rib pre-cartilage condensation 2  (1/58) N/A
Skeleton 2  (1/74) N/A
Skin 2  (1/506) N/A
Spinal cord 2  (1/73) N/A
Stomach 2  (1/56) N/A
Tail 2  (1/506) N/A
Tail somite 2  (1/506) N/A
Thoracic vertebral cartilage condensation 2  (1/56) N/A
Tongue 2  (1/56) N/A
Trachea 2  (1/60) N/A
Trunk mesenchyme 2  (1/61) N/A
Umbilical artery embryonic part 2  (1/61) N/A
Umbilical vein embryonic part 2  (1/61) N/A
Upper arm 2  (1/301) N/A
Upper leg 2  (1/301) N/A
Urinary system 2  (1/60) N/A
Vibrissa 2  (1/70) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
Eye Morphology: VIP of left fundus
15 Images
Eye Morphology: VIP of right eye
15 Images
Eye Morphology: VIP of right fundus
15 Images
Eye Morphology: VIP of left eye
15 Images
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

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MGI Allele Allele Type Produced
Pdx1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Pdx1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells