Gene Summary

LIM domain only 1
Rbtn1,  Ttg1,  Rbtn-1

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
hyperactivity Lmo1tm1b(KOMP)Mbp HOM Early adult 2.01×10-07
decreased thigmotaxis Lmo1tm1b(KOMP)Mbp HOM Early adult 3.43×10-06
abnormal retina morphology Lmo1tm1b(KOMP)Mbp HOM Early adult 6.15×10-07
decreased anxiety-related response Lmo1tm1b(KOMP)Mbp HOM Early adult 5.01×10-06
decreased vertical activity Lmo1tm1b(KOMP)Mbp HOM Early adult 3.52×10-12
abnormal behavior Lmo1tm1b(KOMP)Mbp HOM Early adult 4.05×10-05
decreased prepulse inhibition Lmo1tm1b(KOMP)Mbp HOM   Early adult 8.42×10-07

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Whole Body Dorso Ventral

8 Images


XRay Images Whole Body Lateral Orientation

8 Images

Human diseases caused by Lmo1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Lmo1 by orthology or direct annotation.

Disease Similarity of
Matching phenotypes Source

The table below shows human diseases predicted to be associated to Lmo1 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder, Susceptibility To, 7
Attention deficit hyperactivity disorder, Depression OMIM:613003
Severe Primary Trimethylaminuria
Emotional lability, Anxiety, Low self esteem, Aggressive behavior, Negative affectivity, Depression ORPHA:468726
Attention Deficit-Hyperactivity Disorder
Attention deficit hyperactivity disorder, Hyperactivity OMIM:143465
Intellectual Developmental Disorder, Autosomal Recessive 37
Aggressive behavior, Hyperactivity OMIM:615493
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Aggressive behavior, Hyperactivity ORPHA:356996
Intellectual Developmental Disorder, Autosomal Dominant 33
Hyperactivity, Chorioretinal degeneration OMIM:616311
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Self-injurious behavior, Anxiety, Aggressive behavior, Hyperactivity OMIM:619031
Hartnup Disorder
Emotional lability, Episodic ataxia, Attention deficit hyperactivity disorder, Hyperactivity OMIM:234500
Epilepsy, Progressive Myoclonic, 12
Difficulty walking, Ataxia, Anxiety, Attention deficit hyperactivity disorder, Depression, Dysmetria OMIM:619191
Spastic Tetraplegia, Thin Corpus Callosum, And Progressive Microcephaly
Inability to walk, Hyperactivity, Irritability OMIM:616657
Schizophrenia 15
Hyperactivity OMIM:613950
Leukoencephalopathy, Motor Delay, Spasticity, And Dysarthria Syndrome
Bradykinesia, Anxiety, Attention deficit hyperactivity disorder OMIM:618878
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity OMIM:608443
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Glycine Encephalopathy 1
Hyperactivity, Restlessness, Irritability, Lethargy, Aggressive behavior, Impulsivity OMIM:605899
Smith-Magenis syndrome
Self-mutilation, Hyperactivity DECIPHER:8
Dystonia 12
Emotional lability, Unsteady gait, Anxiety, Dysphagia, Bradykinesia, Depression OMIM:128235
Morm Syndrome
Retinal dystrophy, Aggressive behavior, Hyperactivity, Retinal atrophy ORPHA:75858
Developmental And Epileptic Encephalopathy 104
Self-injurious behavior, Hyperactivity, Agitation OMIM:619970
Cone-Rod Synaptic Disorder Syndrome, Congenital Nonprogressive
Ataxia, Anxiety, Optic disc pallor, Retinal thinning OMIM:618970
Emotional lability, Abnormal fear/anxiety-related behavior, Agoraphobia, Claustrophobia, Attentio... ORPHA:66624
Neurodevelopmental Disorder With Motor And Speech Delay And Behavioral Abnormalities
Optic atrophy, Aggressive behavior, Hyperactivity, Broad-based gait OMIM:619470
Intellectual Developmental Disorder, X-Linked 104
Optic atrophy, Aggressive behavior, Hyperactivity, Ataxia OMIM:300983
Retinoschisis 1, X-Linked, Juvenile
Macular atrophy, Retinal atrophy, Retinal detachment, Peripheral cystoid retinal degeneration, Re... OMIM:312700
Hyperprolinemia, Type I
Aggressive behavior, Hyperactivity, Ataxia OMIM:239500
Juvenile Huntington Disease
Progressive cerebellar ataxia, Ataxia, Hyperactivity, Irritability, Bradykinesia, Gait ataxia, De... ORPHA:248111
Intellectual Developmental Disorder, X-Linked 109
Impulsivity, Aggressive behavior, Hyperactivity, Agitation OMIM:309548
Fraxe Intellectual Disability
Hyperactivity, Aggressive behavior, Impulsivity, Agitation ORPHA:100973
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Abnormal fear/anxiety-related behavior, Hyperactivity, Bipolar affective disorder, Irritability, ... ORPHA:3077
Lennox-Gastaut Syndrome
Aggressive behavior, Personality disorder, Hyperactivity, Falls ORPHA:2382
Intellectual Developmental Disorder, Autosomal Recessive 75, With Neuropsychiatric Features And Variant Lissencephaly
Inappropriate behavior, Hyperactivity, Nail-biting, Attention deficit hyperactivity disorder, Sel... OMIM:619827
Landau-Kleffner Syndrome
Emotional lability, Hyperactivity, Steppage gait, Anxiety, Attention deficit hyperactivity disord... ORPHA:98818
Chromosome 3Q29 Deletion Syndrome
Gait ataxia, Anxiety, Aggressive behavior, Hyperactivity OMIM:609425
Developmental And Epileptic Encephalopathy 43
Attention deficit hyperactivity disorder, Hyperactivity, Ataxia, Impulsivity OMIM:617113
Self-mutilation, Hyperactivity, Anxiety, Attention deficit hyperactivity disorder, Irritability, ... OMIM:261600
Guanidinoacetate Methyltransferase Deficiency
Hyperactivity, Ataxia, Athetosis, Self-injurious behavior, Aggressive behavior ORPHA:382
Mannosidosis, Beta A, Lysosomal
Aggressive behavior, Hyperactivity OMIM:248510
Xq25 Microduplication Syndrome
Anxiety, Hyperactivity ORPHA:521258
Obsolete: Early-Onset Schizophrenia
Emotional lability, Polyphagia, Impairment in personality functioning, Suicidal ideation, Abnorma... ORPHA:96369
Succinic Semialdehyde Dehydrogenase Deficiency
Hyperactivity, Ataxia, Anxiety, Self-injurious behavior, Aggressive behavior OMIM:271980
Dihydropyrimidine Dehydrogenase Deficiency
Optic atrophy, Lethargy, Hyperactivity OMIM:274270
Intellectual Developmental Disorder, X-Linked 101
Optic atrophy, Hyperactivity OMIM:300928
Intellectual Developmental Disorder, Autosomal Dominant 67
Bipolar affective disorder, Attention deficit hyperactivity disorder, Hyperactivity OMIM:619927
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency
Hyperactivity, Aggressive behavior, Choreoathetosis, Ataxia OMIM:612716
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Attention deficit hyperactivity disorder, Hyperactivity, Impulsivity OMIM:301008
Usmani-Riazuddin Syndrome, Autosomal Dominant
Hyperactivity, Anxiety, Self-injurious behavior, Depression, Aggressive behavior OMIM:619467
Intellectual Developmental Disorder, Autosomal Recessive 38
Hyperactivity, Self-mutilation, Aggressive behavior, Unsteady gait OMIM:615516
Female Restricted Epilepsy With Intellectual Disability
Abnormal eating behavior, Hyperactivity, Anxiety, Aggressive behavior, Impulsivity ORPHA:101039
Neurodevelopmental Disorder With Epilepsy And Hypoplasia Of The Corpus Callosum
Gait disturbance, Inability to walk, Hyperactivity, Gait ataxia, Dysmetria OMIM:618090
Clcn4-Related X-Linked Intellectual Disability Syndrome
Unsteady gait, Progressive cerebellar ataxia, Hyperactivity, Bipolar affective disorder, Anxiety,... ORPHA:485350
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Polyphagia, Hyperactivity, Ataxia, Happy demeanor, Broad-based gait ORPHA:411515
Chromosome Xq25 Duplication Syndrome
Anxiety, Hyperactivity OMIM:300979
Neurodevelopmental Disorder With Microcephaly, Movement Abnormalities, And Seizures
Inability to walk, Hyperactivity, Self-injurious behavior, Aggressive behavior, Choreoathetosis OMIM:620023
Intellectual Developmental Disorder, X-Linked 107
Anxiety, Attention deficit hyperactivity disorder, Aggressive behavior, Hyperactivity OMIM:301013
Childhood-Onset Motor And Cognitive Regression Syndrome With Extrapyramidal Movement Disorder
Inability to walk, Hyperactivity, Dysphagia, Gait ataxia, Aggressive behavior, Impulsivity ORPHA:500180
Cln5 Disease
Inability to walk, Unsteady gait, Ataxia, Hyperactivity, Anxiety, Dysdiadochokinesis, Aggressive ... ORPHA:228360
Intellectual Developmental Disorder, X-Linked 30
Hyperactivity, Restlessness, Agitation, Anxiety, Aggressive behavior OMIM:300558
X-Linked Intellectual Disability-Hypotonia-Movement Disorder Syndrome
Aggressive behavior, Hyperactivity, Broad-based gait ORPHA:457260
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia
Self-injurious behavior, Inability to walk, Hyperactivity OMIM:618718
Severe Motor And Intellectual Disabilities-Sensorineural Deafness-Dystonia Syndrome
Optic atrophy, Aggressive behavior, Hyperactivity ORPHA:369939
Neurodegeneration With Brain Iron Accumulation 2B
Emotional lability, Hyperactivity, Dysdiadochokinesis, Dysphagia, Bradykinesia, Gait ataxia, Impu... OMIM:610217
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Infantile Neuroaxonal Dystrophy
Emotional lability, Gait disturbance, Unsteady gait, Ataxia, Hyperactivity, Choking episodes, Opt... ORPHA:35069
Late Infantile Neuronal Ceroid Lipofuscinosis
Gait disturbance, Inability to walk, Ataxia, Hyperactivity, Anxiety, Retinal degeneration, Low fr... ORPHA:168491
Developmental Delay, Language Impairment, And Ocular Abnormalities
Attention deficit hyperactivity disorder, Aggressive behavior, Hyperactivity, Impulsivity OMIM:620141
Graves Disease, Susceptibility To, 1
Polyphagia, Hyperactivity, Irritability OMIM:275000
X-Linked Adrenoleukodystrophy
Gait disturbance, Hyperactivity, Disinhibition, Attention deficit hyperactivity disorder, Inappro... ORPHA:43
Neurodevelopmental Disorder With Poor Growth And Behavioral Abnormalities
Hyperactivity, Attention deficit hyperactivity disorder, Dysphoria, Depression, Aggressive behavior OMIM:620242
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Hyperactivity, Anxiety, Attention deficit hyperactivity disorder, Irritability, Self-injurious be... ORPHA:449291
Pitt-Hopkins-Like Syndrome 1
Attention deficit hyperactivity disorder, Aggressive behavior, Hyperactivity, Ataxia OMIM:610042
Adenylosuccinase Deficiency
Self-mutilation, Inability to walk, Hyperactivity, Gait ataxia, Happy demeanor, Aggressive behavior OMIM:103050
Intellectual Developmental Disorder, Autosomal Dominant 45
Anxiety, Attention deficit hyperactivity disorder, Hyperactivity OMIM:617600
X-Linked Creatine Transporter Deficiency
Self-mutilation, Hyperactivity, Ataxia, Athetosis ORPHA:52503
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Aggressive behavior, Hyperactivity ORPHA:85327
Hypomagnesemia, Seizures, And Impaired Intellectual Development 2
Hyperactivity, Self-biting OMIM:618314
Neurodegeneration With Brain Iron Accumulation 1
Gait disturbance, Hyperactivity, Ataxia, Pigmentary retinopathy, Retinal degeneration, Dysphagia,... OMIM:234200
Joubert Syndrome 1
Self-mutilation, Hyperactivity, Ataxia, Optic disc pallor, Chorioretinal coloboma, Retinal dyspla... OMIM:213300
Microcephaly 29, Primary, Autosomal Recessive
Emotional lability, Hyperactivity, Ataxia OMIM:620047
Spastic gait, Hyperactivity, Irritability OMIM:207800
Hyperactivity ORPHA:2157


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lmo1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lmo1.

No publications found that use IMPC mice or data for Lmo1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Lmo1tm1e(KOMP)Mbp Targeted, non-conditional allele ES Cells
Lmo1tm1b(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Mice
Lmo1tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter