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Genes Phenotypes

Gene: Acvr2a

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Name
activin receptor IIA
MGI ID
MGI:102806
Synonyms
ActRIIa tActRII Acvr2
Viability
Subviable
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (9) Measurements chart (218) All data table (908)
Expression & images (72) Disease models (0) Order (5)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Acvr2atm1.1(KOMP)Vlcg HOM   Early adult 0.00
abnormal liver size Acvr2atm1.1(KOMP)Vlcg HET E12.5 0.00
abnormal eye morphology Acvr2atm1.1(KOMP)Vlcg HET E12.5 0.00
abnormal embryo size Acvr2atm1.1(KOMP)Vlcg HOM E15.5 0.00
abnormal craniofacial morphology Acvr2atm1.1(KOMP)Vlcg HOM E15.5 0.00
decreased neutrophil cell number Acvr2atm1.1(KOMP)Vlcg HET Early adult 1.18×10-06
abnormal pericardium morphology Acvr2atm1.1(KOMP)Vlcg HET E12.5 0.00
abnormal embryo size Acvr2atm1.1(KOMP)Vlcg HET E12.5 0.00
decreased eosinophil cell number Acvr2atm1.1(KOMP)Vlcg HET Early adult 2.20×10-05

Download data as:  TSV  XLS

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590) N/A
Aorta 2 No  (1/590)  (2/2)  Section images
Brain 2 No  (3/590)  (2/2)  Section images
Brainstem 2 No  (2/590)  (2/2) N/A
Brown adipose tissue 1 No  (1/1)  Section images
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/590)  (2/2) N/A
Cerebral cortex 2 No  (2/590)  (2/2) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No  (2/2)  Section images
Heart 2 No  (1/590)  (2/2) N/A
Hippocampus 2 No  (3/590) N/A
Hypothalamus 2 No  (2/590) N/A
Kidney 2 No  (20/590)  (2/2) N/A
Large intestine 2 No  (10/590)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590)  (2/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/590) N/A
Ovary 2 No  (1/590)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/590) N/A
Peripheral nervous system 2 No  (1/590) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590) N/A
Prostate gland 2 No  (12/590)  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/590)  (2/2) N/A
Spinal cord 2 No  (2/590)  (2/2)  Section images
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590)  (2/2) N/A
Striatum 2 No  (3/590) N/A
Testis 2 No  (5/590) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (16/590) N/A
Trachea 2 No  (2/590) N/A
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
White adipose tissue 2 No  (1/2) N/A
LacZ Wholemount Images
LacZ Section Images
adipose tissue (2)
Brown adipose tissue expression
MA:0000057
cardiovascular system (2)
Aorta expression
MA:0000062
integumental system (2)
Skin expression
MA:0000151
nervous system (4)
Brain expression
MA:0000168
postnatal mouse (18)
Aorta expression
MA:0000062
respiratory system (2)
Lung expression
MA:0000415
sensory organ (3)
Eye expression
MA:0000261
set of connective tissues (2)
Brown adipose tissue expression
MA:0000057
trunk (10)
Aorta expression
MA:0000062
urinary system (3)
Urinary bladder expression
MA:0000380
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/65)  (2/2) N/A
Brain 4  (6/506)  (2/4) N/A
Central nervous system ganglion 2  (1/74)  (2/2) N/A
Ear 4  (1/506)  (2/4) N/A
Embryo 4  (1/507)  (2/4) N/A
Eye 4  (1/506)  (2/4) N/A
Foot 4  (1/506)  (2/4) N/A
Forebrain 4  (1/506)  (2/4) N/A
Forelimb 4  (1/506)  (2/4) N/A
Gut 2  (1/60)  (2/2) N/A
Hand 4  (1/506)  (2/4) N/A
Head 4  (5/506)  (2/4) N/A
Heart 4  (1/506)  (2/4) N/A
Hindbrain 4  (6/506)  (2/4) N/A
Hindlimb 4  (1/506)  (2/4) N/A
Liver 4  (1/504)  (2/4) N/A
Lung 4  (1/504)  (2/4) N/A
Mandibular process 4  (1/506)  (2/4) N/A
Maxillary process 4  (1/506)  (2/4) N/A
Midbrain 4  (1/506)  (2/4) N/A
Nose 2  (1/76)  (2/2) N/A
Oral cavity 4  (1/504)  (2/4) N/A
Skeleton 2  (1/76)  (2/2) N/A
Skin 4  (1/506)  (2/4) N/A
Spinal cord 2  (1/73)  (2/2) N/A
Tail 4  (1/506)  (2/4) N/A
Tail somite 4  (1/506)  (2/4) N/A
Trachea 2  (1/60)  (2/2) N/A
Urinary system 2  (1/60)  (2/2) N/A

 Associated Images

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Gross Morphology Embryo E14.5-E15.5
8 Images
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X-ray: XRay Images Skull Lateral Orientation
14 Images
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X-ray: XRay Images Whole Body Dorso Ventral
14 Images
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Embryo LacZ: LacZ images wholemount
40 Images
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X-ray: XRay Images Whole Body Lateral Orientation
14 Images
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X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
Adult LacZ: LacZ Images Section
18 Images
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Gross Pathology and Tissue Collection
12 Images
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Eye Morphology: Images Slit Lamp
7 Images
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Eye Morphology: Images Ophthalmoscopy
2 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Acvr2atm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Acvr2atm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Acvr2atm270449(L1L2_Bact_P) Targeting vectors
Acvr2atm378905(L1L2_Bact_P) Targeting vectors
Acvr2atm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells

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