Gene: Acvr2a

Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Acvr2atm1.1(KOMP)Vlcg HOM n/a 0.00
abnormal craniofacial morphology Acvr2atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
abnormal embryo size Acvr2atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
abnormal bone structure Acvr2atm1.1(KOMP)Vlcg HET postnatal 6.10×10-05
microphthalmia Acvr2atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00
anophthalmia Acvr2atm1.1(KOMP)Vlcg HOM embryonic day 15.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No  (2/2)  Section images
Brain 2 No  (2/2)  Section images
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 1 No  (1/1)  Section images
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No  (2/2) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No  (2/2)  Section images
Heart 2 No  (2/2) N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2)  Section images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2) N/A
Vascular system 2 No N/A
White adipose tissue 2 No  (1/2) N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/51)  (2/2) N/A
Brain 4  (6/485)  (2/4) N/A
Central nervous system ganglion 2  (1/51)  (2/2) N/A
Ear 4  (1/485)  (2/4) N/A
Embryo 4  (1/485)  (2/4) N/A
Eye 4  (1/485)  (2/4) N/A
Foot 4  (1/485)  (2/4) N/A
Forebrain 4  (1/485)  (2/4) N/A
Forelimb 4  (1/485)  (2/4) N/A
Gut 2  (1/50)  (2/2) N/A
Hand 4  (1/485)  (2/4) N/A
Head 4  (5/485)  (2/4) N/A
Heart 4  (1/485)  (2/4) N/A
Hindbrain 4  (6/485)  (2/4) N/A
Hindlimb 4  (1/485)  (2/4) N/A
Liver 4  (1/485)  (2/4) N/A
Lung 4  (1/485)  (2/4) N/A
Mandibular process 4  (1/485)  (2/4) N/A
Maxillary process 4  (1/485)  (2/4) N/A
Midbrain 4  (1/485)  (2/4) N/A
Nose 2  (1/51)  (2/2) N/A
Oral cavity 4  (1/485)  (2/4) N/A
Skeleton 2  (1/51)  (2/2) N/A
Skin 4  (1/485)  (2/4) N/A
Spinal cord 2  (1/50)  (2/2) N/A
Tail 4  (1/485)  (2/4) N/A
Tail somite 4  (1/485)  (2/4) N/A
Trachea 2  (1/50)  (2/2) N/A
Urinary system 2  (1/50)  (2/2) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
14 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
Gross Pathology and Tissue Collection
12 Images
Adult LacZ: LacZ Images Section
18 Images
Embryo LacZ: LacZ images wholemount
8 Images
Eye Morphology: Images Slit Lamp
7 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images
X-ray: XRay Images Dorso Ventral
14 Images
Gross Morphology Embryo E14.5-E15.5
8 Images
Eye Morphology: Images Ophthalmoscopy
2 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Acvr2atm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Acvr2atm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Acvr2atm378905(L1L2_Bact_P) Targeting vectors
Acvr2atm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Acvr2atm270449(L1L2_Bact_P) Targeting vectors

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