Ppp5c - protein phosphatase 5, catalytic subunit | International Mouse Phenotyping Consortium

Genes Phenotypes

Gene: Ppp5c

Phenotype	Allele	Zyg	Life Stage	P Value
increased CD8-positive, alpha-beta T cell number	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	9.49×10^-05
decreased circulating triglyceride level	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	1.41×10^-07
vertebral fusion	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	1.23×10^-05
abnormal coat/hair pigmentation	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	1.28×10^-06
abnormal rib morphology	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	3.31×10^-08
increased lean body mass	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	1.59×10^-08
decreased circulating glucose level	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	5.47×10^-06
abnormal bone structure	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	7.82×10^-06
decreased body length	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	2.17×10^-10
decreased body weight	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	4.75×10^-09
increased T cell number	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	3.04×10^-17
increased total body fat amount	Ppp5c^{tm1a(EUCOMM)Wtsi}	HOM	postnatal	1.13×10^-09

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Table Images

Expression No Expression Ambiguous No Tissue Available

Anatomy	#HET Specimens	HOM Images?	WT Expr	Mutant Expr	Images
Adrenal gland	2	No	(2/584)		N/A
Aorta	2	No			N/A
Blood vessel	2	No			N/A
Bone	2	No			N/A
Brain	2	No		(2/2)	N/A
Brainstem	2	No			N/A
Brown adipose tissue	2	No			N/A
Cartilage tissue	2	No			N/A
Cerebellum	2	No			N/A
Cerebral cortex	2	No			N/A
Eye	2	No			N/A
Gall bladder	2	No			N/A
Heart	2	No		(1/2)	N/A
Hippocampus	2	No			N/A
Hypothalamus	2	No			N/A
Kidney	2	No	(18/584)	(1/2)	N/A
Large intestine	2	No	(10/584)		N/A
Liver	2	No			N/A
Lower urinary tract	2	No		(1/2)	N/A
Lung	2	No			N/A
Lymph node	2	No			N/A
Mammary gland	2	No			N/A
Esophagus	2	No			N/A
Olfactory lobe	2	No			N/A
Ovary	2	No	(1/584)	(1/2)	N/A
Oviduct	2	No		(1/2)	N/A
Pancreas	2	No	(5/584)	(1/2)	N/A
Parathyroid gland	2	No		(1/2)	N/A
Peripheral nervous system	2	No			N/A
Peyer's patch	2	No			N/A
Pituitary gland	2	No			N/A
Prostate gland	2	No	(12/584)		N/A
Skeletal muscle tissue	2	No			N/A
Skin	2	No			N/A
Small intestine	2	No	(9/584)		N/A
Spinal cord	2	No		(1/2)	N/A
Spleen	2	No	(2/584)		N/A
Stomach	2	No	(12/584)		N/A
Striatum	2	No			N/A
Testis	2	No	(2/584)	(1/2)	N/A
Thymus	2	No			N/A
Thyroid gland	2	No	(15/584)	(1/2)	N/A
Trachea	2	No			N/A
Uterus	2	No		(1/2)	N/A
White adipose tissue	2	No			N/A

No Embryo expression data was found for this gene.

Phenotype associated images not available

No associations by disease annotation and gene orthology found.

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MGI Allele	Allele Type	Availability
Ppp5c^{tm1a(EUCOMM)Wtsi}	KO first allele (reporter-tagged insertion with conditional potential)	Mice, Targeting vectors, ES Cells

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