Ppp5c | protein phosphatase 5, catalytic subunit

GeneMGI:102666Synonyms: ANP receptor, PP5

Physiological systems

21 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Pigmentation Integument Growth/size/body region Skeleton

16 No significant impact

3 Not tested

Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

abnormal rib morphology2 supporting datasetsPpp5ctm1a(EUCOMM)WtsihomozygoteEarly adult3.31x10-8 
vertebral fusion1 supporting datasetPpp5ctm1a(EUCOMM)WtsihomozygoteEarly adult6.98x10-6 
increased thoracic vertebrae number1 supporting datasetPpp5ctm1a(EUCOMM)WtsihomozygoteEarly adult3.85x10-6 
abnormal coat/hair pigmentation1 supporting datasetPpp5ctm1a(EUCOMM)WtsihomozygoteEarly adult1.28x10-6 
increased lumbar vertebrae number2 supporting datasetsPpp5ctm1a(EUCOMM)WtsihomozygoteEarly adult5.18x10-6 
decreased circulating triglyceride level1 supporting datasetPpp5ctm1a(EUCOMM)WtsihomozygoteEarly adult1.15x10-11 
decreased body length1 supporting datasetPpp5ctm1a(EUCOMM)WtsihomozygoteEarly adult3.39x10-5 
increased rib number2 supporting datasetsPpp5ctm1a(EUCOMM)WtsihomozygoteEarly adult1.09x10-7 
decreased circulating glucose level1 supporting datasetPpp5ctm1a(EUCOMM)WtsihomozygoteEarly adult8.76x10-8 
increased lean body mass1 supporting datasetPpp5ctm1a(EUCOMM)WtsihomozygoteEarly adult3.84x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Ppp5ctm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Ppp5ctm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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