Gene: Tbx4

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Phenotype System Allele Zyg Sex Life Stage P Value
abnormal embryo size Tbx4tm4b(EUCOMM)Wtsi HOM embryonic day 12.5 0.00
abnormal neural tube closure Tbx4tm4b(EUCOMM)Wtsi HET embryonic day 9.5 0.00
abnormal embryo size Tbx4tm4b(EUCOMM)Wtsi HET embryonic day 9.5 0.00
embryonic lethality prior to tooth bud stage Tbx4tm4b(EUCOMM)Wtsi HOM embryonic day 12.5 0.00
preweaning lethality, complete penetrance Tbx4tm4b(EUCOMM)Wtsi HOM n/a 0.00
pale yolk sac Tbx4tm4b(EUCOMM)Wtsi HOM embryonic day 12.5 0.00

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Cartilage tissue 2 No  (1/2) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415)  (1/2)  Section images
Eye 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (1/2) N/A
Large intestine 2 No  (10/584)  (1/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (1/2) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Section images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Trachea 2 No  (1/2)  Section images
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 2  (1/51) N/A
Brain 4  (6/485) N/A
Central nervous system ganglion 2  (1/51) N/A
Ear 4  (1/485) N/A
Embryo 4  (1/485)  (2/4) N/A
Eye 4  (1/485) N/A
Foot 4  (1/485)  (2/4) N/A
Forebrain 4  (1/485) N/A
Forelimb 4  (1/485)  (2/4) N/A
Gut 2  (1/50) N/A
Hand 4  (1/485) N/A
Head 4  (5/485) N/A
Heart 4  (1/485) N/A
Hindbrain 4  (6/485) N/A
Hindlimb 4  (1/485)  (2/4) N/A
Liver 4  (1/485) N/A
Lung 4  (1/485)  (2/4) N/A
Mandibular process 4  (1/485) N/A
Maxillary process 4  (1/485) N/A
Midbrain 4  (1/485) N/A
Nose 2  (1/51) N/A
Oral cavity 4  (1/485) N/A
Skeleton 2  (1/51)  (2/2) N/A
Skin 4  (1/485) N/A
Spinal cord 2  (1/50) N/A
Tail 4  (1/485) N/A
Tail somite 4  (1/485) N/A
Trachea 2  (1/50)  (2/2) N/A
Urinary system 2  (1/50) N/A

 Associated Images

Histopathology
4 Images
X-ray: XRay Images Lateral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Gross Pathology and Tissue Collection
8 Images
X-ray: XRay Images Dorso Ventral
10 Images
Eye Morphology: Images Ophthalmoscopy
1 Images
Embryo LacZ: LacZ images wholemount
8 Images
Adult LacZ: LacZ Images Section
13 Images
Eye Morphology: Images Slit Lamp
1 Images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Knee joint - hyperplasia Tbx4tm4b(EUCOMM)Wtsi HET postnatal
Knee joint - process of degenerative change Tbx4tm4b(EUCOMM)Wtsi HET postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Tbx4tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Tbx4tm48576(L1L2_hubi_P) Targeting vectors
Tbx4tm4a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Tbx4tm4b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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