Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
tenascin C
Synonyms:
Hxb,  hexabrachion,  C130033P17Rik,  TN-C,  TN,  tenascin-C,  cytotactin

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Tnc mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Tnc by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Deafness, Autosomal Dominant 56
OMIM:615629

The table below shows human diseases predicted to be associated to Tnc by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Autism, Susceptibility To, X-Linked 3
Inflexible adherence to routines, Restrictive behavior, Increased serum serotonin, Motor stereotypy OMIM:300496
Autism, Susceptibility To, X-Linked 1
Inflexible adherence to routines, Restrictive behavior, Increased serum serotonin, Motor stereotypy OMIM:300425
Autism, Susceptibility To, 8
Inflexible adherence to routines, Restrictive behavior, Increased serum serotonin, Motor stereotypy OMIM:607373
Autism
Inflexible adherence to routines, Restrictive behavior, Increased serum serotonin, Motor stereotypy OMIM:209850
Chromosome 15Q11-Q13 Duplication Syndrome
Restrictive behavior, Truncal ataxia, Inflexible adherence to routines, Unsteady gait, Motor ster... OMIM:608636
Asperger Syndrome, Susceptibility To, 1
Inflexible adherence to routines, Restrictive behavior, Motor stereotypy OMIM:608638
Asperger Syndrome, Susceptibility To, 2
Inflexible adherence to routines, Restrictive behavior, Motor stereotypy OMIM:608631
Intellectual Developmental Disorder, Autosomal Dominant 50, With Behavioral Abnormalities
Attention deficit hyperactivity disorder, Motor stereotypy OMIM:617787
Autism, Susceptibility To, X-Linked 2
Inflexible adherence to routines, Restrictive behavior, Increased serum serotonin, Motor stereotypy OMIM:300495
Intellectual Developmental Disorder With Autism And Speech Delay
Inability to walk, Motor stereotypy OMIM:606053
Smith-Magenis syndrome
Hyperactivity, Self-mutilation, Motor stereotypy DECIPHER:8
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity, Motor stereotypy OMIM:300271
Intellectual Developmental Disorder, Autosomal Recessive 58
Pica, Motor stereotypy, Self-injurious behavior, Choreoathetosis, Aggressive behavior OMIM:617270
Pandas
Anorexia, Irritability, Obsessive-compulsive trait, Abnormal fear-induced behavior, Depression, E... ORPHA:66624
N-Acetylaspartate Deficiency
Broad-based gait, Truncal ataxia, Unsteady gait, Motor stereotypy, Self-mutilation OMIM:614063
Intellectual Developmental Disorder With Paroxysmal Dyskinesia Or Seizures
Falls, Chorea, Inappropriate laughter, Ataxia, Motor stereotypy, Bruxism, Aggressive behavior OMIM:619150
Neurodevelopmental Disorder With Nonspecific Brain Abnormalities And With Or Without Seizures
Attention deficit hyperactivity disorder, Ataxia, Motor stereotypy OMIM:618709
Hyperprolinemia, Type I
Hyperactivity, Ataxia, Motor stereotypy, Aggressive behavior OMIM:239500
Pheochromocytoma/Paraganglioma Syndrome 6
Elevated circulating catecholamine level, Paraganglioma OMIM:618464
Intellectual Developmental Disorder, X-Linked 109
Agitation, Hyperactivity, Recurrent hand flapping, Compulsive behaviors, Impulsivity, Stereotypic... OMIM:309548
Fraxe Intellectual Disability
Agitation, Hyperactivity, Recurrent hand flapping, Compulsive behaviors, Impulsivity, Stereotypic... ORPHA:100973
Autism, Susceptibility To, 3
Inflexible adherence to routines, Restrictive behavior, Increased serum serotonin, Motor stereotypy OMIM:608049
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Brain Atrophy
Broad-based gait, Recurrent hand flapping, Gait ataxia, Dysphagia, Motor stereotypy OMIM:617862
Neurodevelopmental Disorder With Hypotonia And Impaired Expressive Language And With Or Without Seizures
Agitation, Motor stereotypy, Aggressive behavior OMIM:617171
Bilateral Parasagittal Parieto-Occipital Polymicrogyria
Pseudobulbar paralysis, Abnormal fear-induced behavior, Delirium, Aggressive behavior ORPHA:208441
Developmental And Epileptic Encephalopathy 58
Inability to walk, Motor stereotypy OMIM:617830
Neurodevelopmental Disorder With Motor And Speech Delay And Behavioral Abnormalities
Hyperactivity, Broad-based gait, Motor stereotypy, Aggressive behavior OMIM:619470
Neurodevelopmental Disorder With Or Without Hyperkinetic Movements And Seizures, Autosomal Recessive
Self-injurious behavior, Inability to walk, Motor stereotypy OMIM:617820
Intellectual Developmental Disorder With Language Impairment And With Or Without Autistic Features
Compulsive behaviors, Inflexible adherence to routines, Motor stereotypy, Attention deficit hyper... OMIM:613670
Chromosome 3Q29 Deletion Syndrome
Hyperactivity, Gait ataxia, Motor stereotypy, Aggressive behavior OMIM:609425
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia
Inability to walk, Hyperactivity, Motor stereotypy, Self-injurious behavior, Bruxism, Paroxysmal ... OMIM:618718
Neurodevelopmental Disorder With Language Impairment And Behavioral Abnormalities
Inability to walk, Chorea, Compulsive behaviors, Stereotypical hand wringing, Gait ataxia, Motor ... OMIM:618917
Developmental And Epileptic Encephalopathy 107
Motor stereotypy OMIM:620033
Behavioral Variant Of Frontotemporal Dementia
Inappropriate behavior, Restrictive behavior, Gait disturbance, Collectionism, Disinhibition, Res... ORPHA:275864
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7
Inappropriate behavior, Gait disturbance, Disinhibition, Motor stereotypy, Restlessness, Aggressi... OMIM:600795
Developmental Delay, Behavioral Abnormalities, And Neuropsychiatric Disorders
Attention deficit hyperactivity disorder, Motor stereotypy OMIM:620065
Pick Disease Of Brain
Inappropriate laughter, Disinhibition, Polyphagia, Motor stereotypy OMIM:172700
Intellectual Developmental Disorder With Autistic Features And Language Delay, With Or Without Seizures
Attention deficit hyperactivity disorder, Spastic ataxia, Motor stereotypy OMIM:618906
Baker-Gordon Syndrome
Inability to walk, Ataxia, Motor stereotypy, Self-injurious behavior, Choreoathetosis OMIM:618218
Pontocerebellar Hypoplasia, Type 11
Limb ataxia, Difficulty walking, Inability to walk, Broad-based gait, Ataxia, Dysphagia, Motor st... OMIM:617695
Cortical Dysplasia, Complex, With Other Brain Malformations 2
Self-injurious behavior, Motor stereotypy OMIM:615282
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Anorexia, Irritability, Abnormal fear-induced behavior, Hyperactivity, Abnormal aggressive, impul... ORPHA:3077
Developmental And Epileptic Encephalopathy 30
Motor stereotypy OMIM:616341
Foxg1 Syndrome
Difficulty walking, Inability to walk, Stereotypical hand wringing, Motor stereotypy, Choreoathet... ORPHA:561854
Shukla-Vernon Syndrome
Broad-based gait, Impulsivity, Motor stereotypy, Attention deficit hyperactivity disorder, Aggres... OMIM:301029
Intellectual Developmental Disorder, Autosomal Recessive 39
Hyperactivity, Motor stereotypy, Aggressive behavior OMIM:615541
Neurodevelopmental Disorder With Epilepsy, Cataracts, Feeding Difficulties, And Delayed Brain Myelination
Difficulty walking, Motor stereotypy OMIM:617393
Amyotrophic Lateral Sclerosis 10 With Or Without Frontotemporal Dementia
Disinhibition, Dysphagia, Motor stereotypy OMIM:612069
Brunet-Wagner Neurodevelopmental Syndrome
Self-injurious behavior, Motor stereotypy OMIM:619690
Lopes-Maciel-Rodan Syndrome
Agitation, Unsteady gait, Dysphagia, Motor stereotypy, Bruxism OMIM:617435
Intellectual Developmental Disorder, Autosomal Dominant 7
Hyperactivity, Stereotypical hand wringing, Gait disturbance, Inappropriate laughter, Ataxia, Mot... OMIM:614104
Obesity, Hyperphagia, And Developmental Delay
Polyphagia, Motor stereotypy OMIM:613886
Developmental And Epileptic Encephalopathy 6B
Inability to walk, Chorea, Ataxia, Motor stereotypy, Choreoathetosis OMIM:619317
Developmental Delay, Language Impairment, And Ocular Abnormalities
Hyperactivity, Frequent temper tantrums, Impulsivity, Motor stereotypy, Attention deficit hyperac... OMIM:620141
2Q23.1 Microdeletion Syndrome
Hyperactivity, Polyphagia, Ataxia, Motor stereotypy, Self-injurious behavior, Paroxysmal bursts o... ORPHA:228402
Short Stature, Developmental Delay, And Congenital Heart Defects
Attention deficit hyperactivity disorder, Self-injurious behavior, Compulsive behaviors, Motor st... OMIM:617044
Chromosome 2Q37 Deletion Syndrome
Hyperactivity, Stereotypical hand wringing, Hypothyroidism, Skin-picking, Motor stereotypy, Pain ... OMIM:600430
Primary Dystonia, Dyt13 Type
Motor stereotypy ORPHA:98807
Intellectual Developmental Disorder, Autosomal Dominant 45
Hyperactivity, Chorea, Recurrent hand flapping, Motor stereotypy, Attention deficit hyperactivity... OMIM:617600
Intellectual Developmental Disorder, Autosomal Dominant 63, With Macrocephaly
Obsessive-compulsive trait, Pain insensitivity, Motor stereotypy, Attention deficit hyperactivity... OMIM:618825
Autism Spectrum Disorder Due To Auts2 Deficiency
Hyperactivity, Compulsive behaviors, Repetitive compulsive behavior, Motor stereotypy, Attention ... ORPHA:352490
Severe Intellectual Disability And Progressive Spastic Paraplegia
Difficulty walking, Waddling gait, Motor stereotypy ORPHA:280763
Neurodevelopmental Disorder With Or Without Variable Movement Or Behavioral Abnormalities
Chorea, Ataxia, Motor stereotypy, Motor tics, Attention deficit hyperactivity disorder OMIM:619725
Christianson Syndrome
Truncal ataxia, Gait ataxia, Inappropriate laughter, Dysphagia, Motor stereotypy ORPHA:85278
Neurodevelopmental Disorder With Microcephaly, Impaired Language, Epilepsy, And Gait Abnormalities
Impaired tactile sensation, Ataxia, Motor stereotypy, Gait ataxia OMIM:619092
Smith-Magenis Syndrome
Hyperactivity, Head-banging, Impaired pain sensation, Self hugging, Motor stereotypy, Pain insens... OMIM:182290
Xq28 (MECP2) duplication
Inability to walk, Dysphagia, Motor stereotypy, Gait ataxia DECIPHER:45
Pheochromocytoma/Paraganglioma Syndrome 1
Vagal paraganglioma, Extraadrenal pheochromocytoma, Adrenal pheochromocytoma, Glomus jugular tumo... OMIM:168000
Rett Syndrome
Agitation, Difficulty walking, Inability to walk, Stereotypical hand wringing, Gait disturbance, ... ORPHA:778
Pheochromocytoma/Paraganglioma Syndrome 3
Chemodectoma, Adrenal pheochromocytoma, Glomus jugular tumor, Paraganglioma, Elevated circulating... OMIM:605373
Neurodevelopmental Disorder With Impaired Language And Ataxia And With Or Without Seizures
Inability to walk, Tongue thrusting, Recurrent hand flapping, Impulsivity, Gait ataxia, Ataxia, M... OMIM:619580
Neurodevelopmental Disorder With Language Delay And Behavioral Abnormalities, With Or Without Seizures
Hyperactivity, Attention deficit hyperactivity disorder, Motor stereotypy, Aggressive behavior OMIM:620292
Pitt-Hopkins-Like Syndrome 1
Hyperactivity, Ataxia, Motor stereotypy, Attention deficit hyperactivity disorder, Aggressive beh... OMIM:610042
Intellectual Developmental Disorder With Abnormal Behavior, Microcephaly, And Short Stature
Hyperactivity, Motor stereotypy, Attention deficit hyperactivity disorder, Bruxism, Aggressive be... OMIM:618342
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Abnormal temper tantrums, Hyperactivity, Recurrent hand flapping, Hypothyroidism, Hyperthyroidism... ORPHA:449291
Lamb-Shaffer Syndrome
Hyperactivity, Abnormal temper tantrums, Ataxia, Motor stereotypy ORPHA:530983
Dentici-Novelli Neurodevelopmental Syndrome
Precocious puberty, Inability to walk, Motor stereotypy OMIM:619877
Inverted Duplicated Chromosome 15 Syndrome
Hyperactivity, Precocious puberty, Hypogonadism, Motor stereotypy, Self-biting, Aggressive behavior ORPHA:3306
Neurodevelopmental Disorder With Cardiomyopathy, Spasticity, And Brain Abnormalities
Spastic gait, Scissor gait, Truncal ataxia, Motor stereotypy, Attention deficit hyperactivity dis... OMIM:619121
Intellectual Developmental Disorder, X-Linked, Syndromic, Bain Type
Recurrent hand flapping, Compulsive behaviors, Gait disturbance, Ataxia, Motor stereotypy, Attent... OMIM:300986
Porphyria Due To Ala Dehydratase Deficiency
Agitation, Abnormal fear-induced behavior, Depression, Confusion, Restlessness, Delirium ORPHA:100924
Intellectual Developmental Disorder, Autosomal Recessive 41
Self-injurious behavior, Motor stereotypy OMIM:615637
Hijazi-Reis Syndrome
Gait disturbance, Motor stereotypy OMIM:301094
Galloway-Mowat Syndrome 6
Hypothyroidism, Decreased response to growth hormone stimulation test, Motor stereotypy, Paroxysm... OMIM:618347
Gm2 Gangliosidosis, Ab Variant
Inappropriate behavior, Abnormal fear-induced behavior, Cognitive impairment ORPHA:309246
Pure Autonomic Failure
Abnormality of circulating catecholamine level ORPHA:441
Developmental And Speech Delay Due To Sox5 Deficiency
Attention deficit hyperactivity disorder, Self-injurious behavior, Motor stereotypy, Aggressive b... ORPHA:313892
Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements, And Impaired Language
Inability to walk, Motor stereotypy OMIM:613443
Developmental Delay With Variable Intellectual Impairment And Behavioral Abnormalities
Hyperactivity, Compulsive behaviors, Ataxia, Motor stereotypy, Aggressive behavior OMIM:618430
X-Linked Intellectual Disability-Short Stature-Overweight Syndrome
Gait disturbance, Decreased response to growth hormone stimulation test, Self-mutilation, Motor s... ORPHA:457240
Neurodevelopmental Disorder With Language Delay And Variable Cognitive Abnormalities
Attention deficit hyperactivity disorder, Motor stereotypy OMIM:620502
Developmental And Epileptic Encephalopathy 64
Inability to walk, Chorea, Motor stereotypy, Self-injurious behavior, Bruxism OMIM:618004
Potocki-Lupski Syndrome
Hyperactivity, Hypothyroidism, Motor stereotypy, Oral-pharyngeal dysphagia OMIM:610883
Intellectual Developmental Disorder, X-Linked 98
Hyperactivity, Recurrent hand flapping, Stereotypical hand wringing, Central hypothyroidism, Ster... OMIM:300912
Neurodevelopmental Disorder With Ataxic Gait, Absent Speech, And Decreased Cortical White Matter
Difficulty walking, Broad-based gait, Motor stereotypy, Gait ataxia OMIM:617807
48,Xxyy Syndrome
Hypergonadotropic hypogonadism, Ataxia, Type II diabetes mellitus, Motor stereotypy, Attention de... ORPHA:10
Intellectual Developmental Disorder, X-Linked, Syndromic, Lubs Type
Inability to walk, Chorea, Ataxia, Dysphagia, Repetitive compulsive behavior, Motor stereotypy, P... OMIM:300260
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Inability to walk, Motor stereotypy ORPHA:411986
Late Infantile Neuronal Ceroid Lipofuscinosis
Obsessive-compulsive trait, Inability to walk, Hyperactivity, Gait disturbance, Ataxia, Motor ste... ORPHA:168491
Intellectual Developmental Disorder, Autosomal Dominant 34
Bruxism, Motor stereotypy, Broad-based gait OMIM:616351
Snijders Blok-Campeau Syndrome
Attention deficit hyperactivity disorder, Unsteady gait, Motor stereotypy, Broad-based gait OMIM:618205
Cystinosis
Polydipsia, Delayed puberty, Gait disturbance, Nephrogenic diabetes insipidus, Hypothyroidism, Mo... ORPHA:213
Coffin-Siris Syndrome 6
Attention deficit hyperactivity disorder, Tics, Motor stereotypy OMIM:617808
Ritscher-Schinzel Syndrome 4
Chorea, Athetosis, Impulsivity, Ataxia, Dysphagia, Motor stereotypy, Aggressive behavior OMIM:619435
X-Linked Intellectual Disability, Cantagrel Type
Motor stereotypy ORPHA:85277
Intellectual Developmental Disorder, Autosomal Recessive 71
Attention deficit hyperactivity disorder, Motor stereotypy OMIM:618504
Neurodevelopmental Disorder With Poor Growth And Behavioral Abnormalities
Hyperactivity, Attention deficit hyperactivity disorder, Motor stereotypy, Aggressive behavior OMIM:620242
Severe Intellectual Disability-Short Stature-Behavioral Abnormalities-Facial Dysmorphism Syndrome
Hyperactivity, Motor stereotypy, Aggressive behavior ORPHA:391307
Developmental And Epileptic Encephalopathy 66
Motor stereotypy, Broad-based gait OMIM:618067
Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency
Agitation, Ataxia, Motor stereotypy ORPHA:927
Radio-Tartaglia Syndrome
Gait imbalance, Impulsivity, Precocious puberty, Ataxia, Dysphagia, Motor stereotypy, Attention d... OMIM:619312
Alazami Syndrome
Self-mutilation, Abnormal eating behavior, Motor stereotypy, Stereotypical hand wringing ORPHA:319671
Juvenile Neuronal Ceroid Lipofuscinosis
Loss of ambulation, Dysphagia, Motor stereotypy ORPHA:79264
Cri-Du-Chat Syndrome
Difficulty walking, Hyperactivity, Oppositional defiant disorder, Overfriendliness, Motor stereot... OMIM:123450
Bilateral Generalized Polymicrogyria
Self-injurious behavior, Motor stereotypy, Oral-pharyngeal dysphagia ORPHA:208447
Intellectual Developmental Disorder, Autosomal Dominant 44, With Microcephaly
Compulsive behaviors, Dysphagia, Motor stereotypy, Pain insensitivity, Attention deficit hyperact... OMIM:617061
Neuroblastoma
Elevated circulating catecholamine level, Ataxia, Antalgic gait ORPHA:635
Coffin-Siris Syndrome 7
Hyperactivity, Severe temper tantrums, Compulsive behaviors, Motor stereotypy OMIM:618027
5Q14.3 Microdeletion Syndrome
Motor stereotypy ORPHA:228384
Smith-Magenis Syndrome
Delayed puberty, Impaired pain sensation, Gait disturbance, Hypothyroidism, Precocious puberty, M... ORPHA:819
Neurodevelopmental Disorder With Hypotonia, Impaired Language, And Dysmorphic Features
Gait ataxia, Impaired pain sensation, Motor stereotypy, Overfriendliness OMIM:616579
Intellectual Developmental Disorder, Autosomal Dominant 52
Obsessive-compulsive trait, Hyperactivity, Hypothyroidism, Motor stereotypy, Pica OMIM:617796
Intellectual Developmental Disorder, X-Linked, Syndromic, Billuart Type
Hyperactivity, Self-mutilation, Motor stereotypy, Gait ataxia OMIM:300486
22Q11.2 Duplication Syndrome
Attention deficit hyperactivity disorder, Aplasia/Hypoplasia of the thymus, Compulsive behaviors,... ORPHA:1727
Neurodevelopmental Disorder With Microcephaly, Seizures, And Cortical Atrophy
Inability to walk, Dysphagia, Motor stereotypy OMIM:617802
Focal Segmental Glomerulosclerosis And Neurodevelopmental Syndrome
Ataxia, Motor stereotypy OMIM:619428
Childhood Disintegrative Disorder
Motor stereotypy ORPHA:168782
Houge-Janssens Syndrome 3
Attention deficit hyperactivity disorder, Self-injurious behavior, Motor stereotypy OMIM:618354
Neurodevelopmental, Jaw, Eye, And Digital Syndrome
Self-injurious behavior, Motor stereotypy, Impulsivity, Aggressive behavior OMIM:618914
Intellectual Developmental Disorder, Autosomal Dominant 48
Hyperactivity, Motor stereotypy OMIM:617751
Intellectual Developmental Disorder, Autosomal Dominant 38
Hair-pulling, Ataxia, Motor stereotypy, Self-injurious behavior, Bruxism, Aggressive behavior OMIM:616393
Transketolase Deficiency
Compulsive behaviors, Motor stereotypy, Attention deficit hyperactivity disorder, Self-injurious ... ORPHA:488618
4Q21 Microdeletion Syndrome
Self-injurious behavior, Motor stereotypy ORPHA:238750
Microcephaly-Corpus Callosum And Cerebellar Vermis Hypoplasia-Facial Dysmorphism-Intellectual Disability Syndrom
Diabetes mellitus, Motor stereotypy ORPHA:500159
Rett Syndrome, Congenital Variant
Tongue thrusting, Chorea, Athetosis, Motor stereotypy, Bruxism OMIM:613454
Cerebral Creatine Deficiency Syndrome 1
Broad-based gait, Gait disturbance, Motor stereotypy, Attention deficit hyperactivity disorder, A... OMIM:300352
Macrocephaly-Developmental Delay Syndrome
Self-injurious behavior, Motor stereotypy ORPHA:397612
Blepharophimosis-Impaired Intellectual Development Syndrome
Attention deficit hyperactivity disorder, Motor stereotypy, Overfriendliness OMIM:619293
Chromosome 5P13 Duplication Syndrome
Self-injurious behavior, Compulsive behaviors, Motor stereotypy OMIM:613174
Intellectual Disability-Autism-Speech Apraxia-Craniofacial Dysmorphism Syndrome
Motor stereotypy ORPHA:529965
Micrognathia-Recurrent Infections-Behavioral Abnormalities-Mild Intellectual Disability Syndrome
Compulsive behaviors, Gait ataxia, Motor stereotypy, Attention deficit hyperactivity disorder, Se... ORPHA:476126
Joubert Syndrome 6
Ataxia, Motor stereotypy OMIM:610688
Posterior-Predominant Lissencephaly-Broad Flat Pons And Medulla-Midline Crossing Defects Syndrome
Dysphagia, Motor stereotypy ORPHA:572013
Neurodevelopmental Disorder With Dysmorphic Facies, Sleep Disturbance, And Brain Abnormalities
Head-banging, Attention deficit hyperactivity disorder, Motor stereotypy, Frequent temper tantrums OMIM:619103
Neurodevelopmental Disorder With Dysmorphic Facies And Skeletal And Brain Abnormalities
Attention deficit hyperactivity disorder, Precocious puberty, Motor stereotypy OMIM:620073
Chromosome 15Q11.2 Deletion Syndrome
Attention deficit hyperactivity disorder, Ataxia, Compulsive behaviors, Motor stereotypy OMIM:615656
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
Attention deficit hyperactivity disorder, Motor stereotypy ORPHA:98784
3P25.3 Microdeletion Syndrome
Attention deficit hyperactivity disorder, Ataxia, Motor stereotypy ORPHA:435638
White-Sutton Syndrome
Hyperactivity, Waddling gait, Tics, Overfriendliness, Motor stereotypy, Self-injurious behavior, ... OMIM:616364
Phelan-Mcdermid Syndrome
Tongue thrusting, Broad-based gait, Impaired pain sensation, Unsteady gait, Motor stereotypy, Bru... OMIM:606232
Pilarowski-Bjornsson Syndrome
Motor stereotypy OMIM:617682
Intellectual Disability-Macrocephaly-Hypotonia-Behavioral Abnormalities Syndrome
Abnormal temper tantrums, Unsteady gait, Ataxia, Motor stereotypy, Aggressive behavior ORPHA:457279
Megalocornea-Intellectual Disability Syndrome
Hypothyroidism, Ataxia, Motor stereotypy ORPHA:2479
Proximal 16P11.2 Microdeletion Syndrome
Attention deficit hyperactivity disorder, Choreoathetosis, Motor stereotypy ORPHA:261197
Hydroxykynureninuria
Motor stereotypy ORPHA:79155
Congenital Disorder Of Glycosylation, Type Iia
Stereotypical hand wringing, Unsteady gait, Motor stereotypy, Self-mutilation, Aggressive behavior OMIM:212066
Den Hoed-De Boer-Voisin Syndrome
Agitation, Inability to walk, Stereotypical hand wringing, Ataxia, Dysphagia, Motor stereotypy OMIM:619229
Rauch-Steindl Syndrome
Hyperactivity, Motor stereotypy, Aggressive behavior OMIM:619695
Infantile Hypotonia-Oculomotor Anomalies-Hyperkinetic Movements-Developmental Delay Syndrome
Chorea, Ataxia, Repetitive compulsive behavior, Motor stereotypy, Choreoathetosis, Self-mutilatio... ORPHA:522077
Pituitary Adenoma 4, Acth-Secreting
Emotional lability, Abnormal fear-induced behavior OMIM:219090
Neurodevelopmental Disorder With Impaired Language, Behavioral Abnormalities, And Dysmorphic Facies
Compulsive behaviors, Motor stereotypy, Attention deficit hyperactivity disorder, Self-injurious ... OMIM:620494
2Q37 Microdeletion Syndrome
Attention deficit hyperactivity disorder, Compulsive behaviors, Motor stereotypy ORPHA:1001
Microcephaly-Intellectual Disability-Sensorineural Hearing Loss-Epilepsy-Abnormal Muscle Tone Syndrome
Self-injurious behavior, Inability to walk, Motor stereotypy ORPHA:457351
Bainbridge-Ropers Syndrome
Inability to walk, Recurrent hand flapping, Precocious puberty, Motor stereotypy, Self-injurious ... OMIM:615485
Kleefstra Syndrome 1
Compulsive behaviors, Motor stereotypy, Aggressive behavior OMIM:610253
Developmental And Epileptic Encephalopathy 2
Inability to walk, Motor stereotypy OMIM:300672
Foxg1 Syndrome Due To 14Q12 Microdeletion
Motor stereotypy ORPHA:261144
Cortical Dysgenesis With Pontocerebellar Hypoplasia Due To Tubb3 Mutation
Spastic ataxia, Inability to walk, Motor stereotypy ORPHA:300570
Neurodevelopmental Disorder With Dysmorphic Features, Spasticity, And Brain Abnormalities
Inappropriate laughter, Motor stereotypy OMIM:615802
Niemann-Pick Disease, Type C2
Ataxia, Dysphagia, Motor stereotypy OMIM:607625
White-Sutton Syndrome
Hyperactivity, Compulsive behaviors, Motor stereotypy, Self-injurious behavior, Aggressive behavior ORPHA:468678
Early-Onset Progressive Diffuse Brain Atrophy-Microcephaly-Muscle Weakness-Optic Atrophy Syndrome
Ataxia, Dysphagia, Motor stereotypy ORPHA:496641
Prader-Willi Syndrome Due To Translocation
Abnormal temper tantrums, Decreased response to growth hormone stimulation test, Head-banging, An... ORPHA:177907
7Q11.23 Microduplication Syndrome
Hyperactivity, Polyphagia, Collectionism, Unsteady gait, Motor stereotypy, Self-injurious behavio... ORPHA:96121
Developmental Delay With Or Without Intellectual Impairment Or Behavioral Abnormalities
Head-banging, Frequent temper tantrums, Motor stereotypy, Attention deficit hyperactivity disorde... OMIM:619575
Neurodevelopmental Disorder With Dysmorphic Facies, Impaired Speech, And Hypotonia
Attention deficit hyperactivity disorder, Impaired pain sensation, Self-mutilation, Motor stereotypy OMIM:619005
Hypotonia, Ataxia, And Delayed Development Syndrome
Broad-based gait, Truncal ataxia, Gait ataxia, Ataxia, Dysphagia, Motor stereotypy, Pain insensit... OMIM:617330
Kleefstra Syndrome
Self-injurious behavior, Self-mutilation, Motor stereotypy, Aggressive behavior ORPHA:261494
Pitt-Hopkins Syndrome
Self-injurious behavior, Motor stereotypy, Gait ataxia OMIM:610954
Developmental Delay, Impaired Speech, And Behavioral Abnormalities
Tip-toe gait, Delayed puberty, Agitation, Restrictive behavior, Broad-based gait, Hyperactivity, ... OMIM:619475
Developmental And Epileptic Encephalopathy 100
Chorea, Gait ataxia, Dysphagia, Motor stereotypy, Choreoathetosis OMIM:619777
Cerebellar Dysfunction With Variable Cognitive And Behavioral Abnormalities
Broad-based gait, Hyperactivity, Gait ataxia, Ataxia, Unsteady gait, Motor stereotypy, Attention ... OMIM:614756
Wiedemann-Steiner Syndrome
Decreased response to growth hormone stimulation test, Hyperactivity, Dysphagia, Motor stereotypy... ORPHA:319182
Von Hippel-Lindau Disease
Pancreatic endocrine tumor, Adrenal pheochromocytoma, Pancreatic islet cell adenoma, Elevated cir... ORPHA:892
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome
Hyperactivity, Motor stereotypy, Hair-pulling, Dysphagia ORPHA:447997
Neurodevelopmental Disorder With Hypotonia And Brain Abnormalities
Hyperactivity, Compulsive behaviors, Frequent temper tantrums, Motor stereotypy, Self-injurious b... OMIM:619512
Intellectual Disability Syndrome Due To A Dyrk1A Point Mutation
Attention deficit hyperactivity disorder, Posterior pituitary hypoplasia, Gait disturbance, Motor... ORPHA:464311
Van Esch-O'Driscoll Syndrome
Attention deficit hyperactivity disorder, Hypogonadotropic hypogonadism, Motor stereotypy, Impuls... OMIM:301030
Helsmoortel-Van Der Aa Syndrome
Decreased response to growth hormone stimulation test, Hyperactivity, Polyphagia, Compulsive beha... OMIM:615873
Dyrk1A-Related Intellectual Disability Syndrome
Hyperactivity, Anterior pituitary hypoplasia, Gait disturbance, Motor stereotypy ORPHA:464306
Intellectual Developmental Disorder, Autosomal Dominant 71, With Behavioral Abnormalities
Hair-pulling, Nail-biting, Broad-based gait, Polyphagia, Fixated interests, Motor stereotypy, Pai... OMIM:620330
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome
Inability to walk, Motor stereotypy ORPHA:508533
Intellectual Disability-Seizures-Abnormal Gait-Facial Dysmorphism Syndrome
Broad-based gait, Gait ataxia, Stereotypical body rocking, Repetitive compulsive behavior, Motor ... ORPHA:513456
Oculocerebrorenal Syndrome Of Lowe
Delayed puberty, Abnormal circulating calcium-phosphate regulating hormone concentration, Diabete... ORPHA:534
Alpha-Thalassemia/Impaired Intellectual Development Syndrome, X-Linked
Motor stereotypy OMIM:301040
Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies
Precocious puberty, Motor stereotypy, Aggressive behavior OMIM:301066
Rubinstein-Taybi Syndrome Due To 16P13.3 Microdeletion
Abnormal fear-induced behavior, Emotional lability, Hyperactivity, Compulsive behaviors, Impulsiv... ORPHA:353281
Nmda Receptor Encephalitis
Agitation, Chorea, Neoplasm of the thymus, Motor stereotypy, Choreoathetosis, Hypersexuality ORPHA:217253
Mucopolysaccharidosis Type 2
Abnormal temper tantrums, Hyperactivity, Impulsivity, Oppositional defiant disorder, Motor stereo... ORPHA:580
Seizures, Scoliosis, And Macrocephaly/Microcephaly Syndrome
Loss of ambulation, Precocious puberty, Unsteady gait, Motor stereotypy OMIM:616682
Kinsship Syndrome
Bruxism, Motor stereotypy OMIM:619297
Intellectual Developmental Disorder With Impaired Language And Dysmorphic Facies
Difficulty walking, Motor stereotypy OMIM:618653
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Self-injurious behavior, Motor stereotypy ORPHA:468631
1P36 Deletion Syndrome
Polyphagia, Gait disturbance, Hypothyroidism, Dysphagia, Motor stereotypy, Hypogonadism, Self-inj... ORPHA:1606
Arboleda-Tham Syndrome
Gait imbalance, Dysphagia, Motor stereotypy OMIM:616268
Primrose Syndrome
Delayed puberty, Tics, Hypergonadotropic hypogonadism, Hypothyroidism, Ataxia, Motor stereotypy, ... OMIM:259050
Ogden Syndrome
Maternal diabetes, Dysphagia, Motor stereotypy OMIM:300855
Rubinstein-Taybi Syndrome Due To Ep300 Haploinsufficiency
Abnormal fear-induced behavior, Emotional lability, Hyperactivity, Compulsive behaviors, Impulsiv... ORPHA:353284
Rubinstein-Taybi Syndrome Due To Crebbp Mutations
Abnormal fear-induced behavior, Emotional lability, Hyperactivity, Compulsive behaviors, Impulsiv... ORPHA:353277
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Motor stereotypy ORPHA:508498
Intellectual Developmental Disorder, X-Linked, Syndromic, Turner Type
Hyperactivity, Motor stereotypy OMIM:309590
Developmental And Epileptic Encephalopathy 85 With Or Without Midline Brain Defects
Motor stereotypy OMIM:301044
Norrie Disease
Delayed puberty, Motor stereotypy, Attention deficit hyperactivity disorder, Self-injurious behav... ORPHA:649
Chromosome 1Q21.1 Deletion Syndrome, 1.35-Mb
Self-injurious behavior, Motor stereotypy OMIM:612474
Coffin-Siris Syndrome 12
Hypothyroidism, Motor stereotypy OMIM:619325
Wolf-Hirschhorn Syndrome
Precocious puberty, Motor stereotypy OMIM:194190
Lowe Oculocerebrorenal Syndrome
Motor stereotypy, Aggressive behavior OMIM:309000
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Attention deficit hyperactivity disorder, Dysphagia, Motor stereotypy OMIM:619522
Mowat-Wilson Syndrome
Inability to walk, Broad-based gait, Impaired pain sensation, Ataxia, Dysphagia, Motor stereotypy... ORPHA:2152
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Inability to walk, Broad-based gait, Impaired pain sensation, Dysphagia, Motor stereotypy, Bruxism ORPHA:261537
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Inability to walk, Broad-based gait, Impaired pain sensation, Dysphagia, Motor stereotypy, Bruxism ORPHA:261552
Deafness, Autosomal Dominant 56
OMIM:615629

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tnc

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tnc.

No publications found that use IMPC mice or data for Tnc.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Tnctm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Tnctm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Tnctm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Tnctm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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