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Gene: Tubg1 MGI:101834

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Gene Summary

Name:
tubulin, gamma 1
Synonyms:
1500010O08Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased locomotor activity Tubg1tm1dIcs HET Early adult 2.97×10-07

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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FCS thumbnail FCS
Immunophenotyping

Panel A FCS file(s)

5 Images

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FCS thumbnail FCS
Immunophenotyping

Panel B FCS file(s)

5 Images

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Human diseases caused by Tubg1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Tubg1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
15Q11.2 Microdeletion Syndrome
Ataxia ORPHA:261183
Cortical Dysplasia, Complex, With Other Brain Malformations 4
OMIM:615412

The table below shows human diseases predicted to be associated to Tubg1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Intellectual Developmental Disorder, X-Linked 110
Bradykinesia OMIM:301095
Fanconi Anemia, Complementation Group E
Prolonged G2 phase of cell cycle OMIM:600901
Fanconi Anemia, Complementation Group A
Prolonged G2 phase of cell cycle OMIM:227650
Fanconi Anemia, Complementation Group C
Prolonged G2 phase of cell cycle OMIM:227645
Fanconi Anemia, Complementation Group D2
Prolonged G2 phase of cell cycle OMIM:227646
15Q11.2 Microdeletion Syndrome
Ataxia ORPHA:261183
Cortical Dysplasia, Complex, With Other Brain Malformations 4
OMIM:615412

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tubg1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tubg1.

No publications found that use IMPC mice or data for Tubg1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Tubg1tm1aIcs KO first allele (reporter-tagged insertion with conditional potential) Mice, ES Cells
Tubg1tm1dIcs Deletion allele (post-Flp and Cre with no reporter) Mice
Tubg1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Tubg1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Tubg1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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