Gene: Mtf1

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Name
metal response element binding transcription factor 1
MGI ID
MGI:101786
Synonyms
Thyls metalloregulatory transcription factor MTF-1 metal response element-binding transcription factor 1
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic growth retardation Mtf1tm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal forebrain morphology Mtf1tm1b(KOMP)Wtsi HOM E12.5 0.00
preweaning lethality, complete penetrance Mtf1tm1b(KOMP)Wtsi HOM Early adult 0.00
anophthalmia Mtf1tm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal embryo size Mtf1tm1b(KOMP)Wtsi HOM E12.5 0.00
hemorrhage Mtf1tm1b(KOMP)Wtsi HET E15.5 0.00
abnormal craniofacial morphology Mtf1tm1b(KOMP)Wtsi HOM E12.5 0.00
decreased circulating glucose level Mtf1tm1b(KOMP)Wtsi HET Early adult 1.06×10-10
microphthalmia Mtf1tm1b(KOMP)Wtsi HOM E12.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2) N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No  (2/2) N/A
Epididymis 2 No  (18/134)  (1/2) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No  (2/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No  (2/2) N/A
Olfactory lobe 2 No  (2/2) N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2) N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No  (2/2) N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No  (2/2) N/A
Submandibular gland 2 No  (2/132) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thalamus 2 No  (2/2) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No  (2/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vascular system 2 No  (2/2) N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (2/3) N/A
Dorsal root ganglion 2  (1/57) Image Only N/A
Ear 2  (1/504) Image Only N/A
Embryo 2  (1/505)  (2/3)  Wholemount images
Eye 2  (1/504)  (2/3) N/A
Foot 2  (1/504)  (2/3) N/A
Forebrain 2  (1/504)  (2/3) N/A
Forelimb 2  (1/504)  (2/3) N/A
Fronto-nasal process 2  (1/58) Image Only N/A
Hand 2  (1/503)  (2/3) N/A
Head 2  (5/504)  (2/3) N/A
Heart 2  (1/504)  (2/3) N/A
Hindbrain 2  (6/504)  (2/3) N/A
Hindlimb 2  (1/503)  (2/3) N/A
Liver 2  (1/504)  (2/3) N/A
Lung 2  (1/500) Image Only N/A
Mandibular process 2  (1/504)  (2/3) N/A
Maxillary process 2  (1/504)  (2/3) N/A
Midbrain 2  (1/504)  (2/3) N/A
Nose 2  (1/70)  (2/3) N/A
Oral cavity 2  (1/504) Image Only N/A
Skin 2  (1/504) Image Only N/A
Spinal cord 2  (1/69)  (2/3) N/A
Tail 2  (1/504)  (2/3) N/A
Tail somite 2  (1/504) Image Only N/A

 Associated Images

Electroretinography 2: Rod and cone PDF
4 Images
X-ray: XRay Images Forepaw
11 Images
X-ray: XRay Images Skull Lateral Orientation
11 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Whole Body Lateral Orientation
11 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
Sleep Wake: Wake state (bmp file)
12 Images
Eye Morphology: Images Ophthalmoscopy
19 Images
Embryo LacZ: LacZ images wholemount
12 Images
Gross Morphology Embryo E12.5
6 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Mtf1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Mtf1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Mtf1tm36746(L1L2_Bact_P) Targeting vectors

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