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Gene: Serpine2 MGI:101780

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
serine (or cysteine) peptidase inhibitor, clade E, member 2
Synonyms:
Spi4,  PI7,  protease nexin 1,  nexin,  PN-1,  B230326M24Rik

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Serpine2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Serpine2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
46,Xy Ovotesticular Difference Of Sex Development
Bifid scrotum, Ambiguous genitalia, True hermaphroditism, Abnormal labia morphology, Fused labia ... ORPHA:325345
46,Xy Sex Reversal 6
Hypospadias, Sex reversal, Gonadal dysgenesis, Chordee, Dysgerminoma, Gonadoblastoma, Clitoral hy... OMIM:613762
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia
Epididymitis, Prostatitis, Decreased response to growth hormone stimulation test OMIM:307200
Igg4-Related Submandibular Gland Disease
Prostatitis, Enlarged lacrimal glands, Abnormal pancreas morphology, Xerostomia, Enlargement of p... ORPHA:449432
Melioidosis
Prostatitis, Parotitis, Abnormal parotid gland morphology ORPHA:31202
Sickle Cell Disease
Cholelithiasis, Priapism OMIM:603903
Cryptococcosis
Seizure, Prostatitis ORPHA:1546
Microsporidiosis
Abnormality of the parathyroid gland, Abnormal endometrium morphology, Thyroiditis, Seizure, Abno... ORPHA:2552
Agammaglobulinemia, X-Linked
Epididymitis, Prostatitis OMIM:300755
Alkaptonuria
Prostatitis ORPHA:56
Igg4-Related Ophthalmic Disease
Orchitis, Abnormality of the anterior pituitary, Enlarged lacrimal glands, Thyroiditis, Sialadeni... ORPHA:449563
Granulomatosis With Polyangiitis
Seizure, Prostatitis, Pancreatitis ORPHA:900
Scorpion Envenomation
Hemifacial spasm, Acute pancreatitis, Hyperhidrosis, Seizure, Myoclonus, Priapism ORPHA:466677
Acute Transverse Myelitis
Priapism, Abnormal libido ORPHA:139417
Igg4-Related Kidney Disease
Abnormality of the anterior pituitary, Thyroiditis, Sialadenitis, Prostatitis, Pancreatitis ORPHA:449395

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Serpine2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Serpine2.

No publications found that use IMPC mice or data for Serpine2.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Serpine2tm47174(L1L2_st1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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