Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

serine (or cysteine) peptidase inhibitor, clade E, member 2
Spi4,  PI7,  protease nexin 1,  nexin,  PN-1,  B230326M24Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Serpine2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Serpine2 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
46,Xy Ovotesticular Disorder Of Sex Development
Urogenital sinus anomaly, Chordee, Abnormality of the clitoris, Micropenis, Bifid scrotum, Abnorm... ORPHA:325345
46,Xy Sex Reversal 6
Chordee, Sex reversal, Hypospadias, Clitoral hypertrophy, Dysgerminoma, Gonadoblastoma OMIM:613762
Priapism, Familial Idiopathic
Priapism OMIM:176620
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia
Epididymitis, Prostatitis, Decreased response to growth hormone stimulation test OMIM:307200
Prostatitis, Abnormal parotid gland morphology, Parotitis ORPHA:31202
Igg4-Related Submandibular Gland Disease
Prostatitis, Abnormal pancreas morphology, Sialadenitis, Xerostomia, Abnormal salivary gland morp... ORPHA:449432
Sickle Cell Anemia
Cholelithiasis, Priapism OMIM:603903
Prostatitis, Pancreatitis, Abnormal endometrium morphology, Urethritis, Abnormality of the parath... ORPHA:2552
Prostatitis, Seizure ORPHA:1546
Prostatitis ORPHA:56
Igg4-Related Ophthalmic Disease
Sialadenitis, Prostatitis, Orchitis, Pancreatitis, Enlarged lacrimal glands, Abnormality of the a... ORPHA:449563
Agammaglobulinemia, X-Linked
Epididymitis, Prostatitis OMIM:300755
Granulomatosis With Polyangiitis
Prostatitis, Pancreatitis, Seizure ORPHA:900
Scorpion Envenomation
Priapism, Myoclonus, Hemifacial spasm, Acute pancreatitis, Seizure, Hyperhidrosis ORPHA:466677
Igg4-Related Kidney Disease
Sialadenitis, Prostatitis, Pancreatitis, Urethritis, Abnormality of the anterior pituitary, Thyro... ORPHA:449395
Acute Transverse Myelitis
Abnormal libido, Priapism ORPHA:139417


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Serpine2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Serpine2.

No publications found that use IMPC mice or data for Serpine2.

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MGI Allele Allele Type Produced
Serpine2tm47174(L1L2_st1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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