Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

serine (or cysteine) peptidase inhibitor, clade E, member 2
Spi4,  PI7,  protease nexin 1,  nexin,  PN-1,  B230326M24Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Serpine2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Serpine2 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
46,Xy Ovotesticular Difference Of Sex Development
Epispadias, Abnormal labia morphology, Abnormality of the female genitalia, Hyperpigmented genita... ORPHA:325345
46,Xy Sex Reversal 6
Gonadal dysgenesis, Clitoral hypertrophy, Hypospadias, Chordee, Gonadoblastoma, Dysgerminoma, Sex... OMIM:613762
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia
Decreased response to growth hormone stimulation test, Prostatitis, Epididymitis OMIM:307200
Parotitis, Prostatitis, Abnormal parotid gland morphology ORPHA:31202
Igg4-Related Submandibular Gland Disease
Enlarged lacrimal glands, Abnormal salivary gland morphology, Prostatitis, Abnormal pancreas morp... ORPHA:449432
Sickle Cell Disease
Priapism, Cholelithiasis OMIM:603903
Seizure, Prostatitis ORPHA:1546
Prostatitis, Pancreatitis, Abnormal fallopian tube morphology, Thyroiditis, Seizure, Abnormal end... ORPHA:2552
Sickle Cell Anemia
Priapism, Cholelithiasis, Pigment gallstones ORPHA:232
Agammaglobulinemia, X-Linked
Prostatitis, Epididymitis OMIM:300755
Igg4-Related Ophthalmic Disease
Enlarged lacrimal glands, Prostatitis, Pancreatitis, Sialadenitis, Thyroiditis, Orchitis, Abnorma... ORPHA:449563
Granulomatosis With Polyangiitis
Seizure, Prostatitis, Pancreatitis ORPHA:900
Scorpion Envenomation
Seizure, Acute pancreatitis, Hemifacial spasm, Hyperhidrosis, Priapism, Myoclonus ORPHA:466677
Hypothyroidism, Black pigment gallstones, Prostatitis ORPHA:56
Progressive Multifocal Leukoencephalopathy
Abnormal oligodendroglia morphology ORPHA:217260
Igg4-Related Kidney Disease
Prostatitis, Pancreatitis, Sialadenitis, Thyroiditis, Abnormality of the anterior pituitary ORPHA:449395
Acute Transverse Myelitis
Abnormal libido, Priapism ORPHA:139417


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Serpine2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Serpine2.

No publications found that use IMPC mice or data for Serpine2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Serpine2tm47174(L1L2_st1) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter