Phenotype: abnormal dental arch morphology

Definition
any structural anomaly of either of the two arches (crescent arrangements) of teeth, one on each jaw, that together constitute the dentition
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal dental arch morphology

Total number of significant genotype-phenotype associations: 62

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Mex3b
Mex3btm1b(KOMP)Wtsi
HOM Early adult abnormal tooth morphology Gross Pathology and Tissue Collection | Tooth CCP-IMG | IMPC 0.00
Mink1
Mink1em1(IMPC)Tcp
HOM Early adult abnormal tooth morphology Gross Pathology and Tissue Collection | Tooth TCP | IMPC 0.00
Tent5a
Tent5aem1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Gross Pathology and Tissue Collection | Tooth CCP-IMG | IMPC 0.00
Tmem273
Tmem273em1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Gross Pathology and Tissue Collection | Tooth CCP-IMG | IMPC 0.00
Lamb3
Lamb3tm1b(KOMP)Wtsi
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Lower teeth appearance MRC Harwell | IMPC 1.32×10-21
Bnip2
Bnip2tm1b(EUCOMM)Wtsi
HOM Early adult abnormal incisor color Combined SHIRPA and Dysmorphology | Incisor colour WTSI | IMPC 3.85×10-17
Itga11
Itga11em1(IMPC)H
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Upper teeth appearance MRC Harwell | IMPC 5.45×10-16
Ftl1
Ftl1em1(IMPC)Rbrc
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Upper teeth appearance RBRC | IMPC 5.02×10-15
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Lower teeth appearance MRC Harwell | IMPC 8.59×10-15
Ncoa3
Ncoa3tm1b(EUCOMM)Wtsi
HET Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Lower teeth appearance MRC Harwell | IMPC 1.33×10-13
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Upper teeth appearance HMGU | IMPC 3.64×10-12
Cabp5
Cabp5tm1b(KOMP)Wtsi
HOM Middle aged adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Lower teeth appearance MRC Harwell | IMPC 6.51×10-12
Slc20a2
Slc20a2tm1a(EUCOMM)Wtsi
HOM Early adult abnormal incisor color Combined SHIRPA and Dysmorphology | Incisor colour WTSI | IMPC 3.25×10-11
Adam23
Adam23tm1b(EUCOMM)Hmgu
HET Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Lower teeth appearance MRC Harwell | IMPC 6.77×10-10
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Early adult absent teeth Combined SHIRPA and Dysmorphology | Teeth presence MRC Harwell | IMPC 9.67×10-10
Gfpt2
Gfpt2tm1b(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Upper teeth appearance HMGU | IMPC 4.02×10-09
Sparc
Sparctm1a(EUCOMM)Wtsi
HOM Early adult abnormal incisor color Dysmorphology | Incisor colour WTSI | EuroPhenome 5.12×10-09
Pdss2
Pdss2tm1b(EUCOMM)Hmgu
HET Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Lower teeth appearance MRC Harwell | IMPC 1.35×10-08
Pitx2
Pitx2tm1b(EUCOMM)Wtsi
HET Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Lower teeth appearance MRC Harwell | IMPC 1.35×10-08
Pbx3
Pbx3tm1b(EUCOMM)Wtsi
HET Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Upper teeth appearance MRC Harwell | IMPC 8.33×10-08
Rgs2
Rgs2em1(IMPC)H
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Upper teeth appearance MRC Harwell | IMPC 8.33×10-08
Tmem189
Tmem189tm1a(KOMP)Wtsi
HOM Early adult abnormal incisor color Combined SHIRPA and Dysmorphology | Incisor colour WTSI | IMPC 2.40×10-07
Apoe
Apoetm1Unc
HOM Early adult abnormal tooth morphology X-Ray | Teeth WTSI | EuroPhenome 2.51×10-07
Atg4b
Atg4btm1b(EUCOMM)Hmgu
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Lower teeth appearance MRC Harwell | IMPC 2.56×10-07
Aff3
Aff3tm1a(EUCOMM)Wtsi
HOM Early adult malocclusion Combined SHIRPA and Dysmorphology | Incisors morphology WTSI | IMPC 3.59×10-07
Ide
Idetm1a(EUCOMM)Wtsi
HOM Early adult abnormal incisor morphology Dysmorphology | Incisor WTSI | EuroPhenome 1.73×10-06
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi
HOM Early adult abnormal incisor morphology Dysmorphology | Incisor WTSI | EuroPhenome 1.73×10-06
Slc25a21
Slc25a21tm1a(KOMP)Wtsi
HOM Early adult abnormal incisor morphology Dysmorphology | Incisor WTSI | EuroPhenome 1.73×10-06
Exoc3l2
Exoc3l2tm1a(KOMP)Wtsi
HOM Early adult abnormal tooth morphology X-ray | Teeth WTSI | IMPC 2.05×10-06
Aff3
Aff3tm1a(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology X-ray | Teeth WTSI | IMPC 2.38×10-06
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Lower teeth appearance MRC Harwell | IMPC 3.70×10-06
Setd5
Setd5tm1a(EUCOMM)Wtsi
HET Early adult abnormal tooth morphology X-ray | Teeth WTSI | IMPC 4.08×10-06
Cyp2e1
Cyp2e1tm1b(KOMP)Wtsi
HOM Early adult abnormal tooth morphology X-ray | Teeth MRC Harwell | IMPC 4.78×10-06
Rlbp1
Rlbp1tm1b(EUCOMM)Hmgu
HOM Early adult abnormal tooth morphology X-ray | Teeth MRC Harwell | IMPC 6.36×10-06
Exoc3l2
Exoc3l2tm1a(KOMP)Wtsi
HOM Early adult malocclusion Combined SHIRPA and Dysmorphology | Incisors morphology WTSI | IMPC 8.41×10-06
Setd5
Setd5tm1a(EUCOMM)Wtsi
HET Early adult malocclusion Combined SHIRPA and Dysmorphology | Incisors morphology WTSI | IMPC 8.41×10-06
Hsp90aa1
Hsp90aa1tm1(KOMP)Wtsi
HOM Early adult malocclusion Combined SHIRPA and Dysmorphology | Incisors morphology WTSI | IMPC 1.29×10-05
Fam160a2
Fam160a2em1(IMPC)Tcp
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Upper teeth appearance TCP | IMPC 1.43×10-05
Ypel2
Ypel2em1(IMPC)Tcp
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Upper teeth appearance TCP | IMPC 1.43×10-05
Chd1
Chd1tm1b(KOMP)Wtsi
HET Early adult abnormal tooth morphology X-ray | Teeth TCP | IMPC 1.58×10-05
Lima1
Lima1tm1b(KOMP)Wtsi
HOM Early adult absent teeth Combined SHIRPA and Dysmorphology | Teeth presence JAX | IMPC 2.24×10-05
Fmc1
Fmc1tm1b(EUCOMM)Wtsi
HET Early adult abnormal tooth morphology X-ray | Teeth BCM | IMPC 2.76×10-05
Zzef1
Zzef1tm2.1(KOMP)Vlcg
HOM Early adult absent teeth Combined SHIRPA and Dysmorphology | Teeth presence JAX | IMPC 3.58×10-05
Tead1
Tead1tm1b(KOMP)Wtsi
HET Early adult abnormal tooth morphology X-ray | Teeth BCM | IMPC 5.27×10-05
Zc3hc1
Zc3hc1tm1a(KOMP)Wtsi
HOM Early adult abnormal tooth morphology X-ray | Teeth WTSI | MGP 6.52×10-05
Tchp
Tchptm1a(EUCOMM)Wtsi
HOM Early adult malocclusion Combined SHIRPA and Dysmorphology | Incisors morphology WTSI | IMPC 6.66×10-05
Sdha
Sdhatm2b(KOMP)Wtsi
HET Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Upper teeth appearance JAX | IMPC 7.16×10-05
Ddc
Ddcem1(IMPC)Hmgu
HET Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Lower teeth appearance HMGU | IMPC 7.91×10-05
Ppp2r1b
Ppp2r1btm1b(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology Combined SHIRPA and Dysmorphology | Lower teeth appearance MARC | IMPC 9.14×10-05
Agap1
Agap1tm1a(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology X-ray | Teeth WTSI | IMPC 9.48×10-05
Os9
Os9tm1a(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology X-ray | Teeth WTSI | IMPC 9.48×10-05
Ropn1l
Ropn1ltm1b(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology X-ray | Teeth WTSI | IMPC 9.48×10-05

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 The way we measure

 Phenotype associations stats

0.83% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal dental arch morphology (48/5811)

0.35% females (20/5789) 0.47% males (27/5796)

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