Phenotype: abnormal dental arch morphology

Definition
any structural anomaly of either of the two arches (crescent arrangements) of teeth, one on each jaw, that together constitute the dentition
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal dental arch morphology

Total number of significant genotype-phenotype associations: 129

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Amelx
Amelxem1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Amelx
Amelxem1(IMPC)Ccpcz
HEM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Amelx
Amelxem1(IMPC)Ccpcz
HEM Early adult abnormal tooth color Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Amelx
Amelxem1(IMPC)Ccpcz
HOM Early adult abnormal tooth color Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Asphd1
Asphd1em1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Fam122b
Fam122bem1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Fam122b
Fam122bem1(IMPC)Ccpcz
HEM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Fam122b
Fam122bem1(IMPC)Ccpcz
HEM Early adult abnormal tooth color Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Fam122b
Fam122bem1(IMPC)Ccpcz
HOM Early adult abnormal tooth color Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Fam219a
Fam219aem1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Fbxw16
Fbxw16em1(IMPC)Ccpcz
HET Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Fbxw18
Fbxw18em1(IMPC)Ccpcz
HET Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Fbxw20
Fbxw20em1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Krtap9-5
Krtap9-5em1(IMPC)Ccpcz
HOM Early adult abnormal tooth color Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Krtap9-5
Krtap9-5em1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Lgr6
Lgr6em1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Lhx5
Lhx5em1(IMPC)Ccpcz
HET Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Meis3
Meis3tm1b(EUCOMM)Hmgu
HOM Early adult abnormal tooth color Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Meis3
Meis3tm1b(EUCOMM)Hmgu
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Mex3b
Mex3btm1b(KOMP)Wtsi
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Mink1
Mink1em1(IMPC)Tcp
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
TCP
IMPC
0.00
Mmp20
Mmp20em1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Mmp20
Mmp20em1(IMPC)Ccpcz
HOM Early adult abnormal tooth color Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Nfam1
Nfam1em1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Odaph
Odaphem1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Prdm8
Prdm8em1(IMPC)Wtsi
HET Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Prss47
Prss47em1(IMPC)Ccpcz
HOM Early adult abnormal tooth color Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Prss47
Prss47em1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Tent5a
Tent5aem1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Tmem273
Tmem273em1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Zfat
Zfatem1(IMPC)Ccpcz
HET Early adult abnormal tooth morphology Tooth
Gross Pathology and Tissue Collection
CCP-IMG
IMPC
0.00
Lamb3
Lamb3tm1b(KOMP)Wtsi
HOM Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
6.51×10-22
Npepps
Npeppsem1(IMPC)Hmgu
HOM Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
HMGU
IMPC
8.16×10-20
Amelx
Amelxem1(IMPC)Ccpcz
HEM Early adult absent teeth Teeth presence
Combined SHIRPA and Dysmorphology
CCP-IMG
IMPC
5.52×10-19
Amelx
Amelxem1(IMPC)Ccpcz
HOM Early adult absent teeth Teeth presence
Combined SHIRPA and Dysmorphology
CCP-IMG
IMPC
2.00×10-18
Camk4
Camk4em1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
CCP-IMG
IMPC
2.31×10-18
Bnip2
Bnip2tm1b(EUCOMM)Wtsi
HOM Early adult abnormal incisor color Incisor colour
Combined SHIRPA and Dysmorphology
WTSI
IMPC
2.23×10-17
Itga11
Itga11em1(IMPC)H
HOM Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
1.37×10-15
Ftl1
Ftl1em1(IMPC)Rbrc
HOM Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
RBRC
IMPC
3.48×10-15
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
4.99×10-15
Spred1
Spred1em1(IMPC)Ccpcz
HOM Early adult abnormal tooth morphology Teeth
X-ray
CCP-IMG
IMPC
6.14×10-15
Ncoa3
Ncoa3tm1b(EUCOMM)Wtsi
HET Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
8.35×10-14
Ftl1
Ftl1em1(IMPC)Rbrc
HOM Late adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
RBRC
IMPC
1.06×10-13
Cabp5
Cabp5tm1b(KOMP)Wtsi
HOM Middle aged adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
1.39×10-12
Wsb2
Wsb2tm1b(EUCOMM)Hmgu
HOM Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
HMGU
IMPC
3.49×10-12
Slc20a2
Slc20a2tm1a(EUCOMM)Wtsi
HOM Early adult abnormal incisor color Incisor colour
Combined SHIRPA and Dysmorphology
WTSI
IMPC
2.26×10-11
Adam23
Adam23tm1b(EUCOMM)Hmgu
HET Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
4.75×10-10
Lrrk1
Lrrk1tm1b(KOMP)Wtsi
HOM Early adult absent teeth Teeth presence
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
7.09×10-10
Eif3k
Eif3kem1(IMPC)Hmgu
HET Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
HMGU
IMPC
2.20×10-09
Gfpt2
Gfpt2tm1b(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
HMGU
IMPC
3.88×10-09
Sparc
Sparctm1a(EUCOMM)Wtsi
HOM Early adult abnormal incisor color Incisor colour
Dysmorphology
WTSI
EuroPhenome
5.12×10-09
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology Teeth
X-ray
WTSI
MGP
5.59×10-09
Miga2
Miga2tm1a(KOMP)Wtsi
HOM Early adult abnormal tooth morphology Teeth
X-ray
WTSI
MGP
8.73×10-09
Pdss2
Pdss2tm1b(EUCOMM)Hmgu
HET Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
9.91×10-09
Pitx2
Pitx2tm1b(EUCOMM)Wtsi
HET Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
9.91×10-09
Slc25a21
Slc25a21tm1a(KOMP)Wtsi
HOM Early adult abnormal tooth morphology Teeth
X-ray
WTSI
MGP
3.75×10-08
Rhobtb3
Rhobtb3tm1a(KOMP)Wtsi
HOM Early adult abnormal tooth morphology Teeth
X-ray
WTSI
MGP
1.22×10-07
Pbx3
Pbx3tm1b(EUCOMM)Wtsi
HET Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
1.65×10-07
Atg4b
Atg4btm1b(EUCOMM)Hmgu
HOM Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
1.88×10-07
Ltbp1
Ltbp1tm1a(EUCOMM)Wtsi
HOM   Early adult abnormal incisor morphology Incisor
Dysmorphology
WTSI
MGP
1.97×10-07
Peds1
Tmem189tm1a(KOMP)Wtsi
HOM Early adult abnormal incisor color Incisor colour
Combined SHIRPA and Dysmorphology
WTSI
IMPC
2.40×10-07
Apoe
Apoetm1Unc
HOM Early adult abnormal tooth morphology Teeth
X-Ray
WTSI
MGP
2.51×10-07
Aff3
Aff3tm1a(EUCOMM)Wtsi
HOM Early adult abnormal incisor morphology Incisors morphology
Combined SHIRPA and Dysmorphology
WTSI
IMPC
2.74×10-07
Sparc
Sparctm1a(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology Teeth
X-ray
WTSI
EuroPhenome
4.92×10-07
Slc6a3
Slc6a3tm1b(KOMP)Wtsi
HOM Early adult absent teeth Teeth presence
Combined SHIRPA and Dysmorphology
JAX
IMPC
5.59×10-07
Ide
Idetm1a(EUCOMM)Wtsi
HOM Early adult abnormal incisor morphology Incisor
Dysmorphology
WTSI
MGP
9.93×10-07
Rgs2
Rgs2em1(IMPC)H
HOM Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
1.06×10-06
Hsd17b4
Hsd17b4em1(IMPC)Tcp
HOM   Early adult abnormal tooth morphology Teeth
X-ray
TCP
IMPC
1.59×10-06
Bcorl1
Bcorl1em1(IMPC)Tcp
HEM Early adult abnormal tooth morphology Teeth
X-ray
TCP
IMPC
1.60×10-06
Hipk2
Hipk2tm2b(EUCOMM)Hmgu
HOM   Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
1.62×10-06
Slc25a21
Slc25a21tm1a(KOMP)Wtsi
HOM Early adult abnormal incisor morphology Incisor
Dysmorphology
WTSI
MGP
1.73×10-06
Exoc3l2
Exoc3l2tm1a(KOMP)Wtsi
HOM Early adult abnormal tooth morphology Teeth
X-ray
WTSI
IMPC
1.98×10-06
Aff3
Aff3tm1a(EUCOMM)Wtsi
HOM   Early adult abnormal tooth morphology Teeth
X-ray
WTSI
IMPC
2.26×10-06
Bbx
Bbxtm1a(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology Teeth
X-ray
WTSI
EuroPhenome
2.37×10-06
Itch
Itchtm1b(EUCOMM)Hmgu
HOM Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
2.94×10-06
Slc6a3
Slc6a3tm1b(KOMP)Wtsi
HOM Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
JAX
IMPC
3.35×10-06
Sirt1
Sirt1tm1b(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology Teeth
X-ray
MRC Harwell
IMPC
3.42×10-06
Setd5
Setd5tm1a(EUCOMM)Wtsi
HET Early adult abnormal tooth morphology Teeth
X-ray
WTSI
IMPC
3.90×10-06
Cyp2e1
Cyp2e1tm1b(KOMP)Wtsi
HOM   Early adult abnormal tooth morphology Teeth
X-ray
MRC Harwell
IMPC
4.25×10-06
Rlbp1
Rlbp1tm1b(EUCOMM)Hmgu
HOM   Early adult abnormal tooth morphology Teeth
X-ray
MRC Harwell
IMPC
5.65×10-06
Fam160a2
Fam160a2em1(IMPC)Tcp
HOM Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
TCP
IMPC
6.14×10-06
Ypel2
Ypel2em1(IMPC)Tcp
HOM Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
TCP
IMPC
6.14×10-06
Exoc3l2
Exoc3l2tm1a(KOMP)Wtsi
HOM   Early adult abnormal incisor morphology Incisors morphology
Combined SHIRPA and Dysmorphology
WTSI
IMPC
6.43×10-06
Setd5
Setd5tm1a(EUCOMM)Wtsi
HET   Early adult abnormal incisor morphology Incisors morphology
Combined SHIRPA and Dysmorphology
WTSI
IMPC
6.43×10-06
Jmjd4
Jmjd4em1(IMPC)Wtsi
HOM   Early adult abnormal incisor morphology Incisors morphology
Combined SHIRPA and Dysmorphology
WTSI
IMPC
8.02×10-06
Hsp90aa1
Hsp90aa1tm1(KOMP)Wtsi
HOM   Early adult abnormal incisor morphology Incisors morphology
Combined SHIRPA and Dysmorphology
WTSI
IMPC
9.85×10-06
Chd1
Chd1tm1b(KOMP)Wtsi
HET Early adult abnormal tooth morphology Teeth
X-ray
TCP
IMPC
1.58×10-05
Ncoa3
Ncoa3tm1b(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
MRC Harwell
IMPC
2.90×10-05
Anks4b
Anks4btm2a(EUCOMM)Wtsi
HOM   Early adult abnormal tooth morphology Teeth
X-ray
WTSI
MGP
3.52×10-05
Ptbp2
Ptbp2em1(IMPC)Hmgu
HET Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
HMGU
IMPC
3.62×10-05
Evc2
Evc2em1(IMPC)Mbp
HOM Early adult absent teeth Teeth presence
Combined SHIRPA and Dysmorphology
UC Davis
IMPC
3.92×10-05
Gkn1
Gkn1tm1.1(KOMP)Vlcg
HOM   Early adult abnormal tooth morphology Teeth
X-ray
UC Davis
IMPC
3.97×10-05
Fmc1
Fmc1tm1b(EUCOMM)Wtsi
HET   Early adult abnormal tooth morphology Teeth
X-ray
BCM
IMPC
4.00×10-05
Zdhhc20
Zdhhc20em1(IMPC)Hmgu
HOM Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
HMGU
IMPC
5.15×10-05
Tchp
Tchptm1a(EUCOMM)Wtsi
HOM Early adult abnormal incisor morphology Incisors morphology
Combined SHIRPA and Dysmorphology
WTSI
IMPC
5.55×10-05
Npepps
Npeppsem1(IMPC)Hmgu
HOM Early adult absent teeth Teeth presence
Combined SHIRPA and Dysmorphology
HMGU
IMPC
5.62×10-05
Tead1
Tead1tm1b(KOMP)Wtsi
HET Early adult abnormal tooth morphology Teeth
X-ray
BCM
IMPC
5.81×10-05
Ddc
Ddcem1(IMPC)Hmgu
HET Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
HMGU
IMPC
7.29×10-05
Slc38a10
Slc38a10tm1a(EUCOMM)Wtsi
HOM Early adult abnormal tooth morphology Teeth
X-ray
WTSI
MGP
8.62×10-05
Agap1
Agap1tm1a(EUCOMM)Wtsi
HOM   Early adult abnormal tooth morphology Teeth
X-ray
WTSI
IMPC
9.12×10-05
Os9
Os9tm1a(EUCOMM)Wtsi
HOM   Early adult abnormal tooth morphology Teeth
X-ray
WTSI
IMPC
9.12×10-05
Ropn1l
Ropn1ltm1b(EUCOMM)Wtsi
HOM   Early adult abnormal tooth morphology Teeth
X-ray
WTSI
IMPC
9.12×10-05
Pvr
Pvrem1(IMPC)Wtsi
HOM   Early adult abnormal incisor morphology Incisors morphology
Combined SHIRPA and Dysmorphology
WTSI
IMPC
9.18×10-05
Ppp2r1b
Ppp2r1btm1b(EUCOMM)Wtsi
HOM   Early adult abnormal tooth morphology Lower teeth appearance
Combined SHIRPA and Dysmorphology
MARC
IMPC
9.85×10-05
Sdha
Sdhatm2b(KOMP)Wtsi
HET   Early adult abnormal tooth morphology Upper teeth appearance
Combined SHIRPA and Dysmorphology
JAX
IMPC
9.95×10-05

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 The way we measure

 Phenotype associations stats

1.07% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal dental arch morphology (82/7673)

0.57% females (39/6810) 0.75% males (51/6817)

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