Phenotype: abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number

Definition
anomaly in the number of KLRG1+ CD4+, CD25+, alpha-beta regulatory T cell number positive for KLRG1, a marker associated with activation
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number

Total number of significant genotype-phenotype associations: 7

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Arhgef1
Arhgef1tm1a(EUCOMM)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Arpc1b
Arpc1btm1a(EUCOMM)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Bach2
Bach2tm1a(EUCOMM)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Cog6
Cog6tm1a(EUCOMM)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Dph6
Dph6tm1a(KOMP)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Spleen Immunophenotyping
WTSI
3i
0.00
Il27
Il27tm1b(EUCOMM)Wtsi
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of CD45+
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00
Sik3
Sik3tm1a(EUCOMM)Hmgu
HOM   Early adult increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number KLRG1+ Treg cells - % of Treg
Mesenteric Lymph Node Immunophenotyping
WTSI
3i
0.00

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 The way we measure

 Phenotype associations stats

1.28% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number (7/549)

0.00% females (0/7) 0.00% males (0/7)

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