MP:0011951 (increased cardiac stroke volume) | IMPC Phenotype Information | International Mouse Phenotyping Consortium

Phenotype: increased cardiac stroke volume

Definition

increase in the volume of blood pushed into the aorta with each beat of the heart

of tested genes

significant genes

tested genes

Total number of significant genotype-phenotype associations: 10

Gene / Allele	Zygosity	Life Stage	Phenotype	Parameter	Phenotyping Center	P Value
Hells Hells^{tm1b(EUCOMM)Wtsi}	HET	Early adult	increased cardiac stroke volume	Stroke Volume Echo	HMGU IMPC	3.98×10^-11
Psd3 Psd3^em1(IMPC)H	HOM	Late adult	increased cardiac stroke volume	Stroke Volume Echo	MRC Harwell IMPC	1.81×10^-10
Grem2 Grem2^em1(IMPC)Bay	HET	Early adult	increased cardiac stroke volume	Stroke Volume Echo	BCM IMPC	5.04×10^-10
Pla2g2e Pla2g2e^{tm1b(EUCOMM)Wtsi}	HOM	Early adult	increased cardiac stroke volume	Stroke Volume Echo	HMGU IMPC	2.42×10^-06
Lep Lep^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased cardiac stroke volume	Stroke Volume Echo	BCM IMPC	2.59×10^-06
Gdf11 Gdf11^{tm2b(EUCOMM)Hmgu}	HET	Early adult	increased cardiac stroke volume	Stroke Volume Echo	BCM IMPC	3.04×10^-06
Fam53b Fam53b^{tm1b(EUCOMM)Hmgu}	HOM	Early adult	increased cardiac stroke volume	Stroke Volume Echo	HMGU IMPC	1.27×10^-05
Hycc1 Hycc1^{em1(IMPC)Ccpcz}	HOM	Early adult	increased cardiac stroke volume	Stroke Volume Echo	CCP-IMG IMPC	3.06×10^-05
Rsad2 Rsad2^em1(IMPC)H	HOM	Late adult	increased cardiac stroke volume	Stroke Volume Echo	MRC Harwell IMPC	9.33×10^-05
Emsy Emsy^{em1(IMPC)Ccpcz}	HET	Early adult	increased cardiac stroke volume	Stroke Volume Echo	CCP-IMG IMPC	9.33×10^-05

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Procedure
Echo

0.54% of tested genes with null mutations on a B6N genetic background have a phenotype association to increased cardiac stroke volume (10/1836)

0.28% females (5/1817) 0.20% males (3/1534)

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