Phenotype: abnormal heart left ventricle size

Definition
anomaly of the average size of the left ventricle compared to the average for a particular population
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart left ventricle size

Total number of significant genotype-phenotype associations: 94

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Alpk3
Alpk3tm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle size Echo | LVPWd MRC Harwell | IMPC 2.78×10-15
Shox2
Shox2em1(IMPC)Bay
HET Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 1.51×10-11
Usp26
Usp26em1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVAWs MARC | IMPC 3.50×10-11
Nr1d1
Nr1d1tm1(KOMP)Vlcg
HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 5.57×10-11
Slc10a2
Slc10a2tm1b(KOMP)Mbp
HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 8.11×10-10
Gngt2
Gngt2em1(IMPC)Bay
HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 1.34×10-09
Adtrp
Adtrpem1(IMPC)Bay
HOM Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 3.88×10-09
Apol10b
Apol10btm1b(KOMP)Wtsi
HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 7.34×10-09
Ints6l
Ints6lem1(IMPC)Marc
HEM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 2.36×10-08
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi
HET Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 7.05×10-08
Fzd8
Fzd8em1(IMPC)Bay
HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 1.28×10-07
Adtrp
Adtrpem1(IMPC)Bay
HOM Early adult decreased heart left ventricle size Echo | LVPWs BCM | IMPC 2.14×10-07
Nudt5
Nudt5tm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 2.41×10-07
Ints6l
Ints6lem1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 4.93×10-07
Phf21b
Phf21bem1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 5.49×10-07
Efcab14
Efcab14tm1b(KOMP)Wtsi
HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 8.64×10-07
Phf8
Phf8em1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVAWs MARC | IMPC 8.91×10-07
Ascc2
Ascc2tm1b(EUCOMM)Wtsi
HET Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 1.05×10-06
Suv39h2
Suv39h2em1(IMPC)Marc
HOM Early adult decreased heart left ventricle size Echo | LVAWd MARC | IMPC 1.57×10-06
Skil
Skiltm1b(EUCOMM)Hmgu
HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 2.03×10-06
Nr1d1
Nr1d1tm1.1(KOMP)Vlcg
HET Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 2.07×10-06
Lsm1
Lsm1tm1b(EUCOMM)Hmgu
HET Early adult abnormal heart left ventricle size Echo | LVPWd HMGU | IMPC 2.16×10-06
Vav2
Vav2em1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 2.21×10-06
Esr2
Esr2em1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 2.23×10-06
Slc2a12
Slc2a12em2(IMPC)Bay
HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 2.55×10-06
Mybbp1a
Mybbp1atm1b(EUCOMM)Hmgu
HET Early adult abnormal heart left ventricle size Echo | LVPWd HMGU | IMPC 2.94×10-06
Pja2
Pja2tm1b(EUCOMM)Wtsi
HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 3.45×10-06
Bsdc1
Bsdc1em1(IMPC)Bay
HOM Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 4.14×10-06
Gsdmd
Gsdmdem1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVPWs MARC | IMPC 4.14×10-06
Slc2a12
Slc2a12em2(IMPC)Bay
HOM Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 4.70×10-06
Erg
Ergem1(IMPC)Bay
HET Early adult increased heart left ventricle size Echo | LVAWd BCM | IMPC 6.57×10-06
Fbxo22
Fbxo22tm1b(EUCOMM)Wtsi
HET Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 6.98×10-06
Ube2z
Ube2zem1(IMPC)Marc
HET Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 7.22×10-06
Prmt6
Prmt6em1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 7.52×10-06
Chst12
Chst12em1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 7.78×10-06
Zfp235
Zfp235tm1b(KOMP)Wtsi
HOM Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 8.33×10-06
Fcrl6
Fcrl6tm1b(KOMP)Wtsi
HOM Early adult abnormal heart left ventricle size Echo | LVAWs MRC Harwell | IMPC 9.04×10-06
Arhgap24
Arhgap24tm1b(KOMP)Wtsi
HOM Early adult abnormal heart left ventricle size Echo | LVAWd ICS | IMPC 1.00×10-05
Nos1ap
Nos1aptm1b(KOMP)Wtsi
HOM Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 1.13×10-05
Kdm2b
Kdm2bem1(IMPC)Marc
HET Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 1.39×10-05
Taok2
Taok2tm1b(EUCOMM)Hmgu
HET Early adult abnormal heart left ventricle size Echo | LVAWd ICS | IMPC 1.67×10-05
Siva1
Siva1tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 1.69×10-05
Map3k12
Map3k12tm1b(EUCOMM)Hmgu
HET Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 1.70×10-05
Ccdc83
Ccdc83em1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 2.08×10-05
Atad5
Atad5em1(IMPC)Bay
HET Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 2.14×10-05
Zfp488
Zfp488em1(IMPC)Bay
HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 2.31×10-05
Rnf10
Rnf10em1(IMPC)Bay
HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 2.45×10-05
Usp31
Usp31em1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 2.80×10-05
Polr1a
Polr1atm1b(EUCOMM)Hmgu
HET Early adult abnormal heart left ventricle size Echo | LVPWd BCM | IMPC 2.92×10-05
Trim37
Trim37em1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 2.95×10-05
Emc10
Emc10tm1b(EUCOMM)Wtsi
HOM Early adult abnormal heart left ventricle size Echo | LVPWd MRC Harwell | IMPC 3.09×10-05
Hilpda
Hilpdaem1(IMPC)Mhzh
HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 3.21×10-05
Ppp2r5e
Ppp2r5eem1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 4.08×10-05
Gm17359
Gm17359tm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 5.65×10-05
Acsm1
Acsm1em1(IMPC)Mhzh
HOM Early adult abnormal heart left ventricle size Echo | LVAWs MARC | IMPC 5.78×10-05
Khdrbs3
Khdrbs3tm1b(EUCOMM)Hmgu
HOM Early adult decreased heart left ventricle size Echo | LVPWs HMGU | IMPC 6.01×10-05
Ccdc178
Ccdc178tm1b(EUCOMM)Wtsi
HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 6.21×10-05
Arhgap40
Arhgap40tm1b(KOMP)Wtsi
HOM Early adult decreased heart left ventricle size Echo | LVAWd BCM | IMPC 6.32×10-05
Oscar
Oscartm1b(KOMP)Wtsi
HOM Early adult abnormal heart left ventricle size Echo | LVPWd BCM | IMPC 6.37×10-05
Khdrbs3
Khdrbs3tm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle size Echo | LVPWs HMGU | IMPC 8.02×10-05
Bcl7a
Bcl7atm1b(EUCOMM)Wtsi
HET Early adult abnormal heart left ventricle size Echo | LVPWs BCM | IMPC 8.32×10-05
Cntn3
Cntn3em1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVAWs MARC | IMPC 8.36×10-05
Snai3
Snai3tm2b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle size Echo | LVAWs BCM | IMPC 8.58×10-05
Scn2b
Scn2bem1(IMPC)Bay
HOM Early adult abnormal heart left ventricle size Echo | LVAWd BCM | IMPC 8.61×10-05
Leprotl1
Leprotl1tm1b(EUCOMM)Hmgu
HOM Early adult abnormal heart left ventricle size Echo | LVAWs MRC Harwell | IMPC 9.27×10-05
Abhd3
Abhd3em1(IMPC)Marc
HOM Early adult abnormal heart left ventricle size Echo | LVAWd MARC | IMPC 9.77×10-05
Fbxo36
Fbxo36tm1b(KOMP)Wtsi
HOM Early adult abnormal heart left ventricle size Echo | LVPWd MARC | IMPC 9.98×10-05

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 The way we measure

Procedure
Echo

 Phenotype associations stats

3.88% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart left ventricle size (62/1597)

1.29% females (20/1548) 0.78% males (10/1286)

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