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Phenotype: abnormal heart left ventricle size

Definition
anomaly of the average size of the left ventricle compared to the average for a particular population
Synonyms
abnormal left ventricle size
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal heart left ventricle size

Total number of significant genotype-phenotype associations: 45

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Eftud2
Eftud2tm1b(KOMP)Wtsi 		HET Early adult increased heart left ventricle size LVAWd
Echo		 ICS
IMPC		 1.47×10-11
Erg
Ergem1(IMPC)Bay 		HET Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 1.77×10-08
Ints6l
Ints6lem1(IMPC)Marc 		HEM Early adult decreased heart left ventricle size LVPWs
Echo		 MARC
IMPC		 4.42×10-08
Alpk3
Alpk3tm1b(EUCOMM)Hmgu 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 MRC Harwell
IMPC		 4.96×10-08
Oxa1l
Oxa1lem1(IMPC)Bay 		HET Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 1.33×10-07
Gcdh
Gcdhtm2b(EUCOMM)Hmgu 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 1.37×10-07
Rai2
Rai2em1(IMPC)Bay 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 1.46×10-07
Iqcb1
Iqcb1em1(IMPC)Bay 		HET Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 3.63×10-07
Slc10a2
Slc10a2tm1b(KOMP)Mbp 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 4.23×10-07
Scn2b
Scn2bem1(IMPC)Bay 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 8.24×10-07
Gngt2
Gngt2em1(IMPC)Bay 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 9.51×10-07
Ascc2
Ascc2tm1b(EUCOMM)Wtsi 		HET Early adult decreased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 1.05×10-06
Arhgap24
Arhgap24tm1b(KOMP)Wtsi 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 ICS
IMPC		 1.49×10-06
Tonsl
Tonslem1(IMPC)Bay 		HET Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 2.38×10-06
Eftud2
Eftud2tm1b(KOMP)Wtsi 		HET Late adult decreased heart left ventricle size LVAWd
Echo		 ICS
IMPC		 4.82×10-06
Abhd3
Abhd3em1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size LVPWs
Echo		 MARC
IMPC		 4.90×10-06
Atp1a1
Atp1a1em1(IMPC)Ccpcz 		HET Early adult increased heart left ventricle size LVAWd
Echo		 CCP-IMG
IMPC		 4.91×10-06
Mthfd2
Mthfd2tm1b(EUCOMM)Wtsi 		HET   Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 5.75×10-06
Ints6l
Ints6lem1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size LVAWd
Echo		 MARC
IMPC		 8.58×10-06
Gsdmd
Gsdmdem1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size LVPWs
Echo		 MARC
IMPC		 9.94×10-06
Man1b1
Man1b1em1(IMPC)Bay 		HET Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 1.55×10-05
Kdm2b
Kdm2bem1(IMPC)Marc 		HET   Early adult decreased heart left ventricle size LVAWd
Echo		 MARC
IMPC		 1.93×10-05
Trim37
Trim37em1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size LVPWs
Echo		 MARC
IMPC		 1.96×10-05
Ube2z
Ube2zem1(IMPC)Marc 		HET   Early adult decreased heart left ventricle size LVAWd
Echo		 MARC
IMPC		 2.18×10-05
Prmt6
Prmt6em1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size LVAWd
Echo		 MARC
IMPC		 2.33×10-05
Dnd1
Dnd1em1(IMPC)Bay 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 2.41×10-05
Slc2a12
Slc2a12em2(IMPC)Bay 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 2.95×10-05
Vav2
Vav2em1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size LVAWd
Echo		 MARC
IMPC		 3.07×10-05
Phf21b
Phf21bem1(IMPC)Marc 		HOM Early adult decreased heart left ventricle size LVAWd
Echo		 MARC
IMPC		 3.09×10-05
Fzd8
Fzd8em1(IMPC)Bay 		HOM   Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 4.09×10-05
Apol10b
Apol10btm1b(KOMP)Wtsi 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 4.77×10-05
Col11a1
Col11a1em1(IMPC)Bay 		HET Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 5.32×10-05
Prdm15
Prdm15tm1b(EUCOMM)Wtsi 		HET Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 5.43×10-05
Hilpda
Hilpdaem1(IMPC)Mhzh 		HOM   Early adult decreased heart left ventricle size LVPWs
Echo		 MARC
IMPC		 5.46×10-05
Ccdc83
Ccdc83em1(IMPC)Marc 		HOM   Early adult decreased heart left ventricle size LVAWd
Echo		 MARC
IMPC		 5.91×10-05
Map3k12
Map3k12tm1b(EUCOMM)Hmgu 		HET Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 6.06×10-05
Rxfp3
Rxfp3em1(IMPC)Bay 		HOM   Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 6.20×10-05
Skil
Skiltm1b(EUCOMM)Hmgu 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 BCM
IMPC		 6.22×10-05
Btbd8
Btbd8em1(IMPC)Ccpcz 		HOM Early adult increased heart left ventricle size LVAWd
Echo		 CCP-IMG
IMPC		 7.61×10-05
Fbxo22
Fbxo22tm1b(EUCOMM)Wtsi 		HET   Early adult decreased heart left ventricle size LVAWd
Echo		 MARC
IMPC		 8.13×10-05
Emc4
Emc4tm1(KOMP)Wtsi 		HET Early adult decreased heart left ventricle size LVPWs
Echo		 MARC
IMPC		 8.24×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Echo

 Phenotype associations stats

1.77% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal heart left ventricle size (39/2203)

0.75% females (17/2261) 0.76% males (15/1974)

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