Phenotype: shortened ST segment

Definition
reduction in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized
Synonyms
reduced ST segment,  decreased ST segment
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with shortened ST segment

Total number of significant genotype-phenotype associations: 28

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Gnb2
Gnb2em1(IMPC)J
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
6.83×10-11
Dnajc5b
Dnajc5btm1b(EUCOMM)Hmgu
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
ICS
IMPC
9.74×10-10
Pitx3
Pitx3tm1.1(KOMP)Vlcg
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
1.38×10-08
Trip13
Trip13tm1.1(KOMP)Vlcg
HET Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
2.50×10-08
Rundc3a
Rundc3atm1b(EUCOMM)Wtsi
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
BCM
IMPC
2.72×10-08
Rrad
Rradtm1.1(KOMP)Vlcg
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
3.54×10-07
Zfp395
Zfp395tm1b(EUCOMM)Wtsi
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
BCM
IMPC
8.11×10-07
Loxl1
Loxl1tm1.1(KOMP)Vlcg
HET Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
1.60×10-06
Vsig8
Vsig8tm1.1(KOMP)Mbp
HOM   Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
2.96×10-06
Pcdh18
Pcdh18tm1.1(KOMP)Vlcg
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
3.18×10-06
Trip13
Trip13tm1.1(KOMP)Vlcg
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
4.30×10-06
Col20a1
Col20a1em1(IMPC)Mbp
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
4.49×10-06
Wnt6
Wnt6tm1b(NCOM)Mfgc
HET   Early adult shortened ST segment ST
Electrocardiogram (ECG)
TCP
IMPC
9.75×10-06
Pja2
Pja2tm1b(EUCOMM)Wtsi
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
BCM
IMPC
1.48×10-05
Hnrnpc
Hnrnpctm1b(EUCOMM)Hmgu
HET Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
1.84×10-05
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM   Early adult shortened ST segment ST
Electrocardiogram (ECG)
CCP-IMG
IMPC
2.44×10-05
Thra
Thratm1b(EUCOMM)Wtsi
HET   Late adult shortened ST segment ST
Electrocardiogram (ECG)
ICS
IMPC
3.18×10-05
Rac2
Rac2em1(IMPC)Mbp
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
4.12×10-05
Ncald
Ncaldtm1.1(KOMP)Vlcg
HOM   Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
5.30×10-05
Pacsin2
Pacsin2tm1b(EUCOMM)Hmgu
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
5.55×10-05
Paqr6
Paqr6tm1b(KOMP)Wtsi
HOM   Early adult shortened ST segment ST
Electrocardiogram (ECG)
BCM
IMPC
5.82×10-05
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
7.33×10-05
Igfbp3
Igfbp3tm1b(KOMP)Wtsi
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
MRC Harwell
IMPC
8.17×10-05
Tmem256
Tmem256tm1.1(KOMP)Vlcg
HOM Early adult shortened ST segment ST
Electrocardiogram (ECG)
UC Davis
IMPC
9.16×10-05
Cldn19
Cldn19tm1.1(KOMP)Vlcg
HOM   Early adult shortened ST segment ST
Electrocardiogram (ECG)
JAX
IMPC
9.87×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.59% of tested genes with null mutations on a B6N genetic background have a phenotype association to shortened ST segment (24/4035)

0.25% females (10/3970) 0.25% males (10/3966)

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