Phenotype: prolonged RR interval

Definition
increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate
Synonyms
widened RR interval,  increased RR interval
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged RR interval

Total number of significant genotype-phenotype associations: 99

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Pla2g10
Pla2g10tm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
6.29×10-26
Maged1
Maged1em1(IMPC)Mbp
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
1.77×10-15
Ndufa8
Ndufa8tm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
8.71×10-14
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
2.41×10-13
Hcn1
Hcn1em1(IMPC)H
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
2.05×10-12
Dmp1
Dmp1tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
8.11×10-12
Nfix
Nfixem6(IMPC)H
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
4.42×10-10
Six1
Six1em1(IMPC)Mbp
HET Late adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
9.80×10-10
Dennd5b
Dennd5bem1(IMPC)Tcp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
3.44×10-09
Lamtor3
Lamtor3em1(IMPC)Hmgu
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
6.56×10-09
Tmem203
Tmem203em1(IMPC)H
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
7.58×10-09
Nadsyn1
Nadsyn1tm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
1.03×10-08
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
4.49×10-08
Maged1
Maged1em1(IMPC)Mbp
HEM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
4.93×10-08
Cap2
Cap2tm1b(EUCOMM)Wtsi
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
8.90×10-08
Nav1
Nav1em1(IMPC)Mbp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
9.33×10-08
Tfap4
Tfap4tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
9.35×10-08
Zfp280d
Zfp280dem1(IMPC)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
1.21×10-07
Try10
Try10em1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
1.61×10-07
Slfn1
Slfn1tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
2.33×10-07
Slc6a6
Slc6a6em1(IMPC)Mbp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
2.36×10-07
Zfp541
Zfp541em1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
2.46×10-07
Scarb1
Scarb1tm1b(EUCOMM)Wtsi
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
BCM
IMPC
2.46×10-07
Smo
Smotm1b(KOMP)Wtsi
HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
BCM
IMPC
3.51×10-07
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
3.84×10-07
Uhrf2
Uhrf2tm1b(EUCOMM)Wtsi
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
4.13×10-07
Mindy2
Mindy2em1(IMPC)H
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
4.14×10-07
Ablim3
Ablim3em1(IMPC)Tcp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
5.25×10-07
Lmtk2
Lmtk2em1(IMPC)Mbp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
5.42×10-07
Gabre
Gabreem1(IMPC)H
HEM   Late adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
5.59×10-07
Pepd
Pepdtm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
7.46×10-07
Ndufa6
Ndufa6em1(IMPC)Bay
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
BCM
IMPC
8.37×10-07
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
1.01×10-06
Gabra2
Gabra2em1(IMPC)H
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.22×10-06
Tat
Tatem1(IMPC)J
HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
1.41×10-06
Insig2
Insig2em1(IMPC)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
1.60×10-06
Rab4a
Rab4atm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
2.37×10-06
Gbp2
Gbp2tm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
2.54×10-06
Ubap2l
Ubap2lem1(IMPC)Bay
HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
BCM
IMPC
2.79×10-06
Gria1
Gria1em1(IMPC)H
HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
3.19×10-06
Wbp1l
Wbp1ltm2b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
BCM
IMPC
3.80×10-06
Dgkb
Dgkbem1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
4.32×10-06
Scarb2
Scarb2em2(IMPC)Tcp
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
6.64×10-06
Chmp2b
Chmp2bem1(IMPC)Mbp
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
6.79×10-06
Il18r1
Il18r1em1(IMPC)Mbp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
8.05×10-06
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
8.11×10-06
Btnl4
Btnl4em1(IMPC)Tcp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
9.88×10-06
Efhb
Efhbem1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
9.91×10-06
Pak2
Pak2em1(IMPC)H
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.06×10-05
Agpat1
Agpat1tm1.1(KOMP)Vlcg
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
1.10×10-05
Il33
Il33tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
1.33×10-05
P3h1
P3h1tm1b(EUCOMM)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
1.40×10-05
Asic4
Asic4tm1b(KOMP)Mbp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
1.41×10-05
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
1.57×10-05
Gcsh
Gcshem1(IMPC)H
HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.66×10-05
Slc29a1
Slc29a1tm2b(NCOM)Mfgc
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
1.67×10-05
Pygm
Pygmem1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
1.75×10-05
Smarcc2
Smarcc2em1(IMPC)J
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
1.84×10-05
Ist1
Ist1em1(IMPC)J
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
2.32×10-05
Ccdc28a
Ccdc28atm3b(EUCOMM)Wtsi
HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
2.47×10-05
Arl5a
Arl5aem1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
2.68×10-05
Tox
Toxtm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
2.78×10-05
Tor1a
Tor1aem1(IMPC)H
HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
2.81×10-05
Ogn
Ogntm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
2.99×10-05
Eif3k
Eif3kem1(IMPC)Hmgu
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
3.05×10-05
Spock1
Spock1em1(IMPC)H
HOM   Late adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
3.09×10-05
Poli
Politm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
3.36×10-05
Arv1
Arv1em1(IMPC)J
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
3.79×10-05
Atp2b3
Atp2b3em1(IMPC)J
HOM   Late adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
3.86×10-05
Masp1
Masp1tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
3.96×10-05
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
CCP-IMG
IMPC
4.04×10-05
Myo6
Myo6em1(IMPC)Tcp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
4.28×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
4.42×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
4.46×10-05
Got1
Got1tm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
4.57×10-05
Ndrg1
Ndrg1tm2b(KOMP)Wtsi
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
4.83×10-05
Dcps
Dcpstm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
5.20×10-05
Pcm1
Pcm1em1(IMPC)Tcp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
5.51×10-05
Tex2
Tex2em1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
5.56×10-05
Zbtb37
Zbtb37em1(IMPC)J
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
5.76×10-05
Tpgs2
Tpgs2tm1.1(KOMP)Vlcg
HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
6.09×10-05
Ccr6
Ccr6tm1.1(KOMP)Vlcg
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
6.15×10-05
Spock1
Spock1em1(IMPC)H
HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
6.76×10-05
Ubl7
Ubl7em1(IMPC)Tcp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
7.27×10-05
Vgf
Vgfem1(IMPC)H
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
7.34×10-05
Trip13
Trip13tm1.1(KOMP)Vlcg
HOM   Late adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
7.66×10-05
Lsm1
Lsm1tm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
HMGU
IMPC
7.81×10-05
Stoml2
Stoml2tm1(KOMP)Vlcg
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
7.95×10-05
Nfat5
Nfat5tm1b(KOMP)Wtsi
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
JAX
IMPC
8.20×10-05
Smpdl3a
Smpdl3aem1(IMPC)Tcp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
TCP
IMPC
8.50×10-05
Usp38
Usp38tm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
9.60×10-05
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)
MRC Harwell
IMPC
9.66×10-05
Rnd2
Rnd2em1(IMPC)Mbp
HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)
UC Davis
IMPC
9.99×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

1.75% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged RR interval (91/5208)

0.76% females (39/5155) 0.86% males (44/5141)

Select a parameter    



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