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Phenotype: prolonged RR interval

Definition
increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate
Synonyms
widened RR interval,  increased RR interval
Significant gene associations The way we measure Phenotype stats
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged RR interval

Total number of significant genotype-phenotype associations: 112

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center		 P Value
Pla2g10
Pla2g10tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 6.29×10-26
Mmaa
Mmaaem1(IMPC)J 		HOM   Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 6.38×10-15
Hcn1
Hcn1em1(IMPC)H 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 3.05×10-14
Gatm
Gatmtm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 3.52×10-14
Ndufa8
Ndufa8tm1b(EUCOMM)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 8.71×10-14
Trim55
Trim55tm2b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 2.35×10-13
Maged1
Maged1em1(IMPC)Mbp 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 2.43×10-13
Dmp1
Dmp1tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 6.77×10-12
Tmem203
Tmem203em1(IMPC)H 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 7.52×10-12
Six1
Six1em1(IMPC)Mbp 		HET Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.28×10-10
Nfix
Nfixem6(IMPC)H 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 4.33×10-10
Slc6a6
Slc6a6em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 9.58×10-10
Psors1c2
Psors1c2em1(IMPC)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 1.30×10-09
Mmab
Mmabem1(IMPC)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 2.76×10-09
Nadsyn1
Nadsyn1tm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 5.40×10-09
Dennd5b
Dennd5bem1(IMPC)Tcp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 1.06×10-08
Nav1
Nav1em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.25×10-08
Rab4a
Rab4atm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.56×10-08
Tfap4
Tfap4tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 3.95×10-08
Hipk3
Hipk3tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 4.49×10-08
Dpp8
Dpp8em1(IMPC)J 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 5.17×10-08
Cap2
Cap2tm1b(EUCOMM)Wtsi 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 8.90×10-08
Zdhhc22
Zdhhc22em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.31×10-07
Try10
Try10em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.47×10-07
Maged1
Maged1em1(IMPC)Mbp 		HEM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.78×10-07
Lamtor3
Lamtor3em1(IMPC)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 1.89×10-07
Lcorl
Lcorlem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.96×10-07
Slfn1
Slfn1tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 2.11×10-07
Scarb1
Scarb1tm1b(EUCOMM)Wtsi 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 2.46×10-07
Hcrt
Hcrttm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 2.76×10-07
Zfp280d
Zfp280dem1(IMPC)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 2.89×10-07
Smo
Smotm1b(KOMP)Wtsi 		HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 3.51×10-07
Anapc7
Anapc7em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.73×10-07
Uhrf2
Uhrf2tm1b(EUCOMM)Wtsi 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 4.13×10-07
Tat
Tatem1(IMPC)J 		HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 4.38×10-07
Spa17
Spa17em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 5.10×10-07
Pepd
Pepdtm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 7.40×10-07
Ndufa6
Ndufa6em1(IMPC)Bay 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 8.12×10-07
Bbox1
Bbox1tm1a(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 8.62×10-07
Lmtk2
Lmtk2em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 9.19×10-07
Gabre
Gabreem1(IMPC)H 		HEM   Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 9.63×10-07
Tnfrsf17
Tnfrsf17tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.03×10-06
Zbed6
Zbed6em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.12×10-06
Cpa5
Cpa5em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.68×10-06
Smarcc2
Smarcc2em1(IMPC)J 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.84×10-06
Zfp541
Zfp541em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.47×10-06
Gbp2
Gbp2tm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 2.54×10-06
Mindy2
Mindy2em1(IMPC)H 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 2.79×10-06
Il18r1
Il18r1em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 3.75×10-06
Wbp1l
Wbp1ltm2b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 3.80×10-06
Vgf
Vgfem1(IMPC)H 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 6.57×10-06
Dgkb
Dgkbem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 7.28×10-06
Brd3
Brd3em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 7.33×10-06
Got1
Got1tm1b(EUCOMM)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 8.31×10-06
Btnl4
Btnl4em1(IMPC)Tcp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 9.88×10-06
Efhb
Efhbem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 9.91×10-06
Gabra2
Gabra2em1(IMPC)H 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.02×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.04×10-05
Pygm
Pygmem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.20×10-05
Il33
Il33tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.26×10-05
Pak2
Pak2em1(IMPC)H 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 1.32×10-05
P3h1
P3h1tm1b(EUCOMM)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.34×10-05
Agpat1
Agpat1tm1.1(KOMP)Vlcg 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.48×10-05
Chmp2b
Chmp2bem1(IMPC)Mbp 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 1.58×10-05
Slc29a1
Slc29a1tm2b(NCOM)Mfgc 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 1.67×10-05
1700030J22Rik
1700030J22Rikem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 1.91×10-05
Scarb2
Scarb2em2(IMPC)Tcp 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 2.11×10-05
Afap1l2
Afap1l2tm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 2.38×10-05
Poli
Politm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 2.40×10-05
Rfc5
Rfc5em1(IMPC)J 		HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.59×10-05
Arv1
Arv1em1(IMPC)J 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.76×10-05
Tmem60
Tmem60em1(IMPC)Ccpcz 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 CCP-IMG
IMPC		 2.76×10-05
Spty2d1
Spty2d1em1(IMPC)J 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 2.95×10-05
Myo6
Myo6em1(IMPC)Tcp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 3.05×10-05
Arl5a
Arl5aem1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.13×10-05
Ogn
Ogntm1b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.29×10-05
Ccdc28a
Ccdc28atm3b(EUCOMM)Wtsi 		HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.34×10-05
Tex21
Tex21em1(IMPC)J 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.63×10-05
Tor1a
Tor1aem1(IMPC)H 		HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 3.79×10-05
Ubap2l
Ubap2lem1(IMPC)Bay 		HET   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 3.94×10-05
Scoc
Scocem1(IMPC)J 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 3.97×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 4.17×10-05
Masp1
Masp1tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 4.28×10-05
Ndrg1
Ndrg1tm2b(KOMP)Wtsi 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 4.36×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 4.42×10-05
Gm5127
Gm5127em1(IMPC)J 		HEM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 4.63×10-05
Eif3k
Eif3kem1(IMPC)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 5.10×10-05
Dcps
Dcpstm1b(EUCOMM)Hmgu 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 5.55×10-05
Ptpn18
Ptpn18em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 5.94×10-05
Ist1
Ist1em1(IMPC)J 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 6.06×10-05
Ccr6
Ccr6tm1.1(KOMP)Vlcg 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 6.09×10-05
Atp8b1
Atp8b1em1(IMPC)Tcp 		HOM Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 6.29×10-05
Ubl7
Ubl7em1(IMPC)Tcp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 6.54×10-05
Kcna7
Kcna7em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 7.27×10-05
Pcm1
Pcm1em1(IMPC)Tcp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 7.69×10-05
Lsm1
Lsm1tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 HMGU
IMPC		 7.81×10-05
Tex2
Tex2em1(IMPC)J 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 7.87×10-05
Smpdl3a
Smpdl3aem1(IMPC)Tcp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 TCP
IMPC		 8.50×10-05
Tox
Toxtm1b(KOMP)Wtsi 		HOM   Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 8.87×10-05
Rnd2
Rnd2em1(IMPC)Mbp 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 UC Davis
IMPC		 9.20×10-05
Sppl3
Sppl3em1(IMPC)Bay 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 BCM
IMPC		 9.30×10-05
Nfat5
Nfat5tm1b(KOMP)Wtsi 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 9.41×10-05
Tbcc
Tbccem1(IMPC)J 		HET Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 JAX
IMPC		 9.41×10-05
Usp38
Usp38tm1b(EUCOMM)Hmgu 		HOM Early adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 9.60×10-05
Spock1
Spock1em1(IMPC)H 		HOM   Late adult prolonged RR interval RR
Electrocardiogram (ECG)		 MRC Harwell
IMPC		 9.91×10-05

Download data as:   TSV   XLS

 The way we measure

Procedure
Electrocardiogram (ECG)

 Phenotype associations stats

1.91% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged RR interval (104/5452)

0.72% females (39/5417) 1.02% males (55/5406)

Select a parameter    



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