Phenotype: abnormal RR interval

Definition
anomaly in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with abnormal RR interval

Total number of significant genotype-phenotype associations: 190

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Rrad
Rradtm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 0.00
Wdr6
Wdr6em1(IMPC)J
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 6.66×10-16
Gnb2
Gnb2em1(IMPC)J
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.53×10-14
Cdk9
Cdk9tm1.1(KOMP)Vlcg
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 7.11×10-12
Fam161a
Fam161atm1b(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.54×10-11
Phf19
Phf19tm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 4.54×10-11
Rrad
Rradtm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.22×10-10
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR CCP-IMG | IMPC 5.53×10-10
Far2
Far2tm2b(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.47×10-09
Fam161a
Fam161atm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 6.16×10-09
Atp6v0d1
Atp6v0d1tm1b(EUCOMM)Hmgu
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR TCP | IMPC 6.35×10-09
Hcn1
Hcn1em1(IMPC)H
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 2.34×10-08
Bzw2
Bzw2tm1b(KOMP)Mbp
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.66×10-08
Atp2b3
Atp2b3em1(IMPC)J
HOM Late adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 6.42×10-08
Mbd5
Mbd5tm1b(EUCOMM)Wtsi
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR ICS | IMPC 7.67×10-08
Ppp2r2b
Ppp2r2btm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR TCP | IMPC 9.97×10-08
Sbno1
Sbno1tm1b(EUCOMM)Hmgu
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.00×10-07
Mbd5
Mbd5tm1b(EUCOMM)Wtsi
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR ICS | IMPC 1.09×10-07
H1f10
H1f10tm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.10×10-07
Hunk
Hunktm1b(EUCOMM)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 1.35×10-07
D5Ertd579e
D5Ertd579eem1(IMPC)J
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.53×10-07
Bbox1
Bbox1tm1a(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.53×10-07
Gabra2
Gabra2em1(IMPC)H
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.81×10-07
Lin28b
Lin28btm1b(EUCOMM)Hmgu
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.08×10-07
Paqr6
Paqr6tm1b(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR BCM | IMPC 3.06×10-07
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.39×10-07
Hspb1
Hspb1tm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.77×10-07
Maats1
Maats1em1(IMPC)Mbp
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 4.76×10-07
Ppfia3
Ppfia3em1(IMPC)J
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.05×10-07
Ppp1r9b
Ppp1r9btm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.75×10-07
Ap4e1
Ap4e1em2(IMPC)Mbp
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 6.26×10-07
Vsig8
Vsig8tm1.1(KOMP)Mbp
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 6.65×10-07
Nsf
Nsftm1b(KOMP)Mbp
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 7.62×10-07
Prkab1
Prkab1tm1b(KOMP)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR CCP-IMG | IMPC 8.12×10-07
Nkg7
Nkg7tm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 9.10×10-07
Trip13
Trip13tm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 9.20×10-07
Wnk2
Wnk2em1Murr
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.11×10-06
Trh
Trhem1(IMPC)Tcp
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR TCP | IMPC 1.26×10-06
Nox4
Nox4em1(IMPC)Mbp
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.26×10-06
Trip13
Trip13tm1.1(KOMP)Vlcg
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.28×10-06
Btbd17
Btbd17em1(IMPC)Mbp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.53×10-06
Lin28b
Lin28btm1b(EUCOMM)Hmgu
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.84×10-06
Mindy2
Mindy2em1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.90×10-06
Gnb2
Gnb2em1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.93×10-06
Rbm22
Rbm22tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.11×10-06
Cbln3
Cbln3tm1.1(KOMP)Vlcg
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.22×10-06
Cdk9
Cdk9tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 2.69×10-06
Esd
Esdem1(IMPC)J
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.80×10-06
C9
C9tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.17×10-06
Rest
Resttm2b(EUCOMM)Wtsi
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 3.27×10-06
Zfp275
Zfp275tm1.1(NCOM)Mfgc
HEM Early adult abnormal RR interval Electrocardiogram (ECG) | RR TCP | IMPC 3.30×10-06
Rec8
Rec8tm1b(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.47×10-06
Pacsin2
Pacsin2tm1b(EUCOMM)Hmgu
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.79×10-06
Sorbs2
Sorbs2tm1.1(KOMP)Mbp
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.83×10-06
Ano3
Ano3em2(IMPC)Mbp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 4.36×10-06
Ndufa6
Ndufa6em1(IMPC)Bay
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR BCM | IMPC 4.43×10-06
Vgf
Vgfem1(IMPC)H
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 4.56×10-06
Dock11
Dock11tm2b(KOMP)Wtsi
HEM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 4.57×10-06
Il6st
Il6sttm1b(KOMP)Mbp
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 4.90×10-06
Zfp395
Zfp395tm1b(EUCOMM)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR BCM | IMPC 4.98×10-06
Emc6
Emc6tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 5.01×10-06
Vsig4
Vsig4tm1b(EUCOMM)Hmgu
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.16×10-06
Cldn19
Cldn19tm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.93×10-06
Pak2
Pak2em1(IMPC)H
HET Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 6.80×10-06
Ccdc30
Ccdc30em1(IMPC)J
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 8.41×10-06
Zfp395
Zfp395tm1b(EUCOMM)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR BCM | IMPC 8.45×10-06
Ccl9
Ccl9tm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 9.51×10-06
Gcsh
Gcshem1(IMPC)H
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.13×10-05
Pja2
Pja2tm1b(EUCOMM)Wtsi
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR BCM | IMPC 1.18×10-05
Tnip1
Tnip1tm1b(EUCOMM)Hmgu
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.44×10-05
Trip13
Trip13tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 1.56×10-05
Cnnm2
Cnnm2tm1.1(KOMP)Vlcg
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.62×10-05
Tmem203
Tmem203em1(IMPC)H
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 1.71×10-05
Aebp1
Aebp1tm1.1(KOMP)Wtsi
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 1.87×10-05
Psme3ip1
Psme3ip1em1(IMPC)Bay
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR BCM | IMPC 2.06×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR BCM | IMPC 2.11×10-05
Dnajc28
Dnajc28tm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.13×10-05
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR CCP-IMG | IMPC 2.16×10-05
Hipk3
Hipk3tm1b(EUCOMM)Hmgu
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 2.18×10-05
Bzw2
Bzw2tm1b(KOMP)Mbp
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.21×10-05
Kcnh3
Kcnh3tm1.1(KOMP)Vlcg
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.26×10-05
Tafa4
Tafa4em1(IMPC)Mbp
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 2.27×10-05
Pcdh12
Pcdh12em2(IMPC)J
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.33×10-05
Atp6v0d1
Atp6v0d1tm1b(EUCOMM)Hmgu
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR TCP | IMPC 2.35×10-05
Slc25a3
Slc25a3tm1b(EUCOMM)Wtsi
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 2.55×10-05
Cldn19
Cldn19tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 2.59×10-05
Cyp4f14
Cyp4f14tm1b(EUCOMM)Hmgu
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 2.67×10-05
Lama4
Lama4tm1.1(KOMP)Vlcg
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 2.94×10-05
Unc45a
Unc45atm1b(EUCOMM)Hmgu
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 2.99×10-05
Rnd2
Rnd2em1(IMPC)Mbp
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 3.14×10-05
Rnmt
Rnmttm1b(KOMP)Mbp
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.34×10-05
Clcnkb
Clcnkbem1(IMPC)Mbp
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 3.43×10-05
Cgref1
Cgref1em1(IMPC)J
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.50×10-05
Psmc6
Psmc6tm1b(KOMP)Wtsi
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.64×10-05
Acap1
Acap1tm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.85×10-05
Rab3gap2
Rab3gap2tm1b(KOMP)Wtsi
HOM Early adult prolonged RR interval Electrocardiogram (ECG) | RR JAX | IMPC 3.90×10-05
Spta1
Spta1em1(IMPC)Bay
HET Early adult shortened RR interval Electrocardiogram (ECG) | RR BCM | IMPC 4.08×10-05
Tmem60
Tmem60em1(IMPC)Ccpcz
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR CCP-IMG | IMPC 4.08×10-05
Chmp2b
Chmp2bem1(IMPC)Mbp
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 4.19×10-05
Syce1
Syce1tm1b(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 4.21×10-05
Nmral1
Nmral1tm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 4.92×10-05
Wdr6
Wdr6em1(IMPC)J
HOM Early adult shortened RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.02×10-05
Fgf9
Fgf9tm1b(KOMP)Wtsi
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.08×10-05
Chtf18
Chtf18tm1b(KOMP)Wtsi
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.13×10-05
Lrrc15
Lrrc15tm1b(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.18×10-05
Fmnl2
Fmnl2em2(IMPC)Tcp
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR TCP | IMPC 5.38×10-05
Chek2
Chek2tm1b(EUCOMM)Hmgu
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.73×10-05
Wdr70
Wdr70em1(IMPC)J
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 5.84×10-05
Rundc3a
Rundc3atm1b(EUCOMM)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR BCM | IMPC 6.18×10-05
Gls
Glsem1(IMPC)H
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 6.52×10-05
Spock1
Spock1em1(IMPC)H
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR MRC Harwell | IMPC 6.61×10-05
Sycp3
Sycp3tm1.1(KOMP)Vlcg
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 6.78×10-05
Entr1
Entr1em1(IMPC)Mbp
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 7.27×10-05
Gk2
Gk2em1(IMPC)J
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 7.32×10-05
Cbx4
Cbx4tm1.1(KOMP)Vlcg
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR TCP | IMPC 8.24×10-05
Dzank1
Dzank1tm1b(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR UC Davis | IMPC 8.67×10-05
Ubap2l
Ubap2lem1(IMPC)Bay
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR BCM | IMPC 8.83×10-05
Dnase1l2
Dnase1l2tm1.1(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 8.87×10-05
Pax7
Pax7tm1.1(KOMP)Vlcg
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 8.95×10-05
Espnl
Espnltm1b(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR JAX | IMPC 9.39×10-05
Cyp4b1
Cyp4b1tm1b(KOMP)Wtsi
HOM Early adult abnormal RR interval Electrocardiogram (ECG) | RR HMGU | IMPC 9.55×10-05
Ddx39a
Ddx39atm1b(KOMP)Wtsi
HET Early adult abnormal RR interval Electrocardiogram (ECG) | RR BCM | IMPC 9.82×10-05

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 The way we measure

 Phenotype associations stats

2.56% of tested genes with null mutations on a B6N genetic background have a phenotype association to abnormal RR interval (106/4139)

1.16% females (47/4051) 0.89% males (36/4042)

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