Phenotype: shortened QRS complex duration

Definition
decrease in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart
Synonyms
shortened QRS duration,  shortened QRS interval,  narrow QRS complex
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with shortened QRS complex duration

Total number of significant genotype-phenotype associations: 24

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Acad11
Acad11em1(IMPC)J
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
7.02×10-08
Ggnbp2
Ggnbp2tm1b(KOMP)Wtsi
HET Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
2.62×10-07
Ttc29
Ttc29em1(IMPC)J
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
2.63×10-07
Mgrn1
Mgrn1em1(IMPC)Tcp
HET Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
1.06×10-06
Zc3h7b
Zc3h7bem1(IMPC)J
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
9.34×10-06
Nhs
Nhsem1(IMPC)Tcp
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
9.83×10-06
Fastkd5
Fastkd5em1(IMPC)J
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
1.38×10-05
Cyp27a1
Cyp27a1tm1.1(KOMP)Vlcg
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
1.71×10-05
Elovl5
Elovl5em1(IMPC)Tcp
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
2.06×10-05
Sccpdh
Sccpdhem1(IMPC)J
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
2.06×10-05
Thoc6
Thoc6em5(IMPC)Tcp
HET   Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
2.19×10-05
Rbl1
Rbl1tm1b(EUCOMM)Hmgu
HET Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
HMGU
IMPC
2.31×10-05
Prdm12
Prdm12tm2b(EUCOMM)Hmgu
HET Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
2.56×10-05
Atp1b1
Atp1b1em1(IMPC)Mbp
HET Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
2.62×10-05
Rcan3
Rcan3em1(IMPC)J
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
4.24×10-05
Plscr1
Plscr1tm1b(EUCOMM)Hmgu
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
ICS
IMPC
4.37×10-05
AB124611
AB124611tm1.1(KOMP)Vlcg
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
4.84×10-05
Snx12
Snx12em1(IMPC)J
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
4.98×10-05
Ptp4a2
Ptp4a2em1(IMPC)Tcp
HOM   Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
6.06×10-05
Clcnkb
Clcnkbem1(IMPC)Mbp
HOM Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
6.48×10-05
Tagln2
Tagln2em1(IMPC)Tcp
HOM   Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
6.48×10-05
Pipox
Pipoxtm1b(EUCOMM)Wtsi
HOM   Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
8.14×10-05
Ecrg4
Ecrg4tm1b(EUCOMM)Hmgu
HOM   Early adult shortened QRS complex duration QRS
Electrocardiogram (ECG)
ICS
IMPC
8.75×10-05

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 The way we measure

 Phenotype associations stats

0.37% of tested genes with null mutations on a B6N genetic background have a phenotype association to shortened QRS complex duration (23/6186)

0.23% females (14/6127) 0.08% males (5/6127)



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