Phenotype: prolonged QRS complex duration

Definition
increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart
Synonyms
widened QRS complex,  prolonged QRS duration,  prolonged QRS interval,  QRS interval elongation
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged QRS complex duration

Total number of significant genotype-phenotype associations: 18

Gene / Allele Zygosity Sex Life Stage Phenotype Procedure | Parameter Phenotyping Center | Source P Value
Hddc3
Hddc3tm1.1(KOMP)Vlcg
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 7.54×10-09
Tssk5
Tssk5tm1.1(KOMP)Vlcg
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS JAX | IMPC 3.11×10-08
Ldb3
Ldb3tm2b(EUCOMM)Hmgu
HET Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS MRC Harwell | IMPC 1.32×10-06
Kcnd1
Kcnd1tm1.1(KOMP)Vlcg
HEM   Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 4.97×10-06
Zbtb48
Zbtb48em1(IMPC)Mbp
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 6.72×10-06
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM   Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS MRC Harwell | IMPC 1.02×10-05
Vrk1
Vrk1em1(IMPC)Mbp
HET Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 1.54×10-05
Gsk3a
Gsk3atm1b(EUCOMM)Hmgu
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS HMGU | IMPC 2.28×10-05
Stbd1
Stbd1tm1b(KOMP)Wtsi
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS TCP | IMPC 2.82×10-05
Sfmbt2
Sfmbt2em1(IMPC)Mbp
HET Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 3.12×10-05
Panx3
Panx3tm1b(KOMP)Wtsi
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 3.35×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM   Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS BCM | IMPC 3.46×10-05
Foxo4
Foxo4tm1.1(KOMP)Vlcg
HEM   Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 4.92×10-05
Amigo1
Amigo1tm1.1(KOMP)Vlcg
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS JAX | IMPC 5.33×10-05
Setd2
Setd2tm1b(NCOM)Mfgc
HOM Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS TCP | IMPC 6.13×10-05
E130311K13Rik
E130311K13Rikem1(IMPC)J
HOM   Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS JAX | IMPC 6.59×10-05
4933428G20Rik
4933428G20Riktm1.1(KOMP)Vlcg
HOM   Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 6.96×10-05
Tdo2
Tdo2tm1b(KOMP)Mbp
HET Early adult prolonged QRS complex duration Electrocardiogram (ECG) | QRS UC Davis | IMPC 9.53×10-05

Download data as:   TSV   XLS

 The way we measure

 Phenotype associations stats

0.38% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged QRS complex duration (18/4792)

0.06% females (3/4754) 0.19% males (9/4739)



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