Phenotype: prolonged QRS complex duration

Definition
increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart
Synonyms
widened QRS complex,  prolonged QRS duration,  prolonged QRS interval,  QRS interval elongation
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged QRS complex duration

Total number of significant genotype-phenotype associations: 23

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Tssk5
Tssk5tm1.1(KOMP)Vlcg
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
3.05×10-08
Ldb3
Ldb3tm2b(EUCOMM)Hmgu
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.49×10-06
4933428G20Rik
4933428G20Riktm1.1(KOMP)Vlcg
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
1.57×10-06
Ythdf3
Ythdf3em1(IMPC)Mbp
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
2.81×10-06
Zbtb48
Zbtb48em1(IMPC)Mbp
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
3.90×10-06
Kcnd1
Kcnd1tm1.1(KOMP)Vlcg
HEM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
4.14×10-06
Stbd1
Stbd1tm1b(KOMP)Wtsi
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
9.78×10-06
Trim55
Trim55tm2b(EUCOMM)Hmgu
HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
9.93×10-06
Sfmbt2
Sfmbt2em1(IMPC)Mbp
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
1.36×10-05
Kiss1r
Kiss1rtm1.1(KOMP)Vlcg
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
1.42×10-05
Gsk3a
Gsk3atm1b(EUCOMM)Hmgu
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
HMGU
IMPC
2.41×10-05
Setd2
Setd2tm1b(NCOM)Mfgc
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
2.49×10-05
Sgsh
Sgshem3(IMPC)Tcp
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
2.56×10-05
Ercc3
Ercc3tm1b(NCOM)Mfgc
HET   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
2.96×10-05
Tdo2
Tdo2tm1b(KOMP)Mbp
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
3.25×10-05
Mtmr11
Mtmr11em1(IMPC)Tcp
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
3.40×10-05
Lep
Leptm1b(EUCOMM)Hmgu
HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
BCM
IMPC
3.46×10-05
Foxo4
Foxo4tm1.1(KOMP)Vlcg
HEM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
3.92×10-05
Npr2
Npr2em1(IMPC)H
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
4.89×10-05
Amigo1
Amigo1tm1.1(KOMP)Vlcg
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
5.06×10-05
E130311K13Rik
E130311K13Rikem1(IMPC)J
HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
6.23×10-05
Ino80
Ino80tm1a(EUCOMM)Hmgu
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
ICS
IMPC
7.74×10-05
Afap1l2
Afap1l2tm1b(KOMP)Wtsi
HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
9.76×10-05

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 The way we measure

 Phenotype associations stats

0.44% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged QRS complex duration (23/5199)

0.12% females (6/5141) 0.19% males (10/5130)



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