Definition
increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart
Synonyms
widened QRS complex,
prolonged QRS duration,
prolonged QRS interval,
QRS interval elongation
0%
of tested genes
0
significant genes
0
tested genes
IMPC Gene variants with prolonged QRS complex duration
Total number of significant genotype-phenotype associations: 41
| Gene / Allele | Zygosity | Sex | Life Stage | Phenotype | Parameter | Phenotyping Center |
P Value |
|---|---|---|---|---|---|---|---|
| Eva1a Eva1aem1(IMPC)J |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
1.74×10-13 | |
| Gba1 Gba1em1(IMPC)H |
HET | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
MRC Harwell IMPC |
3.94×10-09 | |
| Fbrsl1 Fbrsl1em1(IMPC)Tcp |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
TCP IMPC |
4.22×10-09 | |
| Slc41a2 Slc41a2em1(IMPC)J |
HOM | Late adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
6.99×10-09 | |
| Ntf5 Ntf5tm1b(EUCOMM)Hmgu |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
ICS IMPC |
3.34×10-08 | |
| Gria2 Gria2em1(IMPC)H |
HET | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
MRC Harwell IMPC |
1.50×10-07 | |
| Ing5 Ing5em1(IMPC)J |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
6.30×10-07 | |
| Pcdhb9 Pcdhb9em1(IMPC)J |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
7.76×10-07 | |
| Gde1 Gde1tm1b(EUCOMM)Hmgu |
HET | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
HMGU IMPC |
1.39×10-06 | |
| Zfp280d Zfp280dem1(IMPC)Hmgu |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
HMGU IMPC |
1.49×10-06 | |
| Pcm1 Pcm1em1(IMPC)Tcp |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
TCP IMPC |
1.86×10-06 | |
| Ldb3 Ldb3tm2b(EUCOMM)Hmgu |
HET | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
MRC Harwell IMPC |
2.03×10-06 | |
| Trmt1 Trmt1tm1b(EUCOMM)Hmgu |
HET | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
ICS IMPC |
2.91×10-06 | |
| Nsun5 Nsun5tm2b(EUCOMM)Wtsi |
HOM | Late adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
MRC Harwell IMPC |
3.59×10-06 | |
| Usp35 Usp35em1(IMPC)J |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
4.41×10-06 | |
| Mxd4 Mxd4em1(IMPC)J |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
5.19×10-06 | |
| Lep Leptm1b(EUCOMM)Hmgu |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
BCM IMPC |
9.81×10-06 | |
| Chrdl1 Chrdl1em1(IMPC)H |
HOM | Late adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
MRC Harwell IMPC |
1.05×10-05 | |
| Psd3 Psd3em1(IMPC)H |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
MRC Harwell IMPC |
1.27×10-05 | |
| Fbxo42 Fbxo42em1(IMPC)J |
HET | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
1.39×10-05 | |
| Gatm Gatmtm1b(KOMP)Wtsi |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
HMGU IMPC |
1.58×10-05 | |
| Klf16 Klf16em1(IMPC)J |
HET | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
1.82×10-05 | |
| Gsk3a Gsk3atm1b(EUCOMM)Hmgu |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
HMGU IMPC |
1.93×10-05 | |
| Setd2 Setd2tm1b(NCOM)Mfgc |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
TCP IMPC |
1.96×10-05 | |
| Smim20 Smim20em1(IMPC)J |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
2.09×10-05 | |
| Asxl2 Asxl2tm1b(EUCOMM)Hmgu |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
TCP IMPC |
2.48×10-05 | |
| Il25 Il25em1(IMPC)Mbp |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
UC Davis IMPC |
3.68×10-05 | |
| Mphosph8 Mphosph8em1(IMPC)J |
HET | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
4.27×10-05 | |
| Ino80 Ino80tm1a(EUCOMM)Hmgu |
HET | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
ICS IMPC |
4.42×10-05 | |
| Cct3 Cct3em1(IMPC)Tcp |
HET | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
TCP IMPC |
4.56×10-05 | |
| Foxo3 Foxo3tm1.1(KOMP)Vlcg |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
4.73×10-05 | |
| Hif1an Hif1anem1(IMPC)Mbp |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
UC Davis IMPC |
6.08×10-05 | |
| Homer2 Homer2em1(IMPC)J |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
6.72×10-05 | |
| Dusp11 Dusp11tm1b(EUCOMM)Wtsi |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
ICS IMPC |
6.96×10-05 | |
| Nalf1 Nalf1em1(IMPC)H |
HET | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
MRC Harwell IMPC |
6.99×10-05 | |
| Pierce2 Pierce2em1(IMPC)H |
HOM | Late adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
MRC Harwell IMPC |
7.20×10-05 | |
| Adgrg4 Adgrg4em1(IMPC)J |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
9.76×10-05 | |
| Svep1 Svep1tm1b(EUCOMM)Hmgu |
HET | Late adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
JAX IMPC |
9.76×10-05 | |
| Plce1 Plce1em1(IMPC)Mbp |
HOM | Early adult | prolonged QRS complex duration | QRS Electrocardiogram (ECG) |
UC Davis IMPC |
9.83×10-05 |