Phenotype: prolonged QRS complex duration

Definition
increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart
Synonyms
widened QRS complex,  prolonged QRS duration,  prolonged QRS interval,  QRS interval elongation
0%
of tested genes
0
significant genes
0
tested genes

IMPC Gene variants with prolonged QRS complex duration

Total number of significant genotype-phenotype associations: 40

Gene / Allele Zygosity Sex Life Stage Phenotype Parameter Phenotyping
Center
P Value
Eva1a
Eva1aem1(IMPC)J
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
1.74×10-13
Gba1
Gba1em1(IMPC)H
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
3.94×10-09
Fbrsl1
Fbrsl1em1(IMPC)Tcp
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
5.05×10-09
Slc41a2
Slc41a2em1(IMPC)J
HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
6.99×10-09
Ntf5
Ntf5tm1b(EUCOMM)Hmgu
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
ICS
IMPC
3.34×10-08
Gria2
Gria2em1(IMPC)H
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.50×10-07
Ing5
Ing5em1(IMPC)J
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
8.89×10-07
Pcdhb9
Pcdhb9em1(IMPC)J
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
1.25×10-06
Gde1
Gde1tm1b(EUCOMM)Hmgu
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
HMGU
IMPC
1.39×10-06
Zfp280d
Zfp280dem1(IMPC)Hmgu
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
HMGU
IMPC
1.54×10-06
Pcm1
Pcm1em1(IMPC)Tcp
HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
1.88×10-06
Ldb3
Ldb3tm2b(EUCOMM)Hmgu
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
2.03×10-06
Trmt1
Trmt1tm1b(EUCOMM)Hmgu
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
ICS
IMPC
2.91×10-06
Nsun5
Nsun5tm2b(EUCOMM)Wtsi
HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
4.09×10-06
Usp35
Usp35em1(IMPC)J
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
5.75×10-06
Lep
Leptm1b(EUCOMM)Hmgu
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
BCM
IMPC
9.81×10-06
Chrdl1
Chrdl1em1(IMPC)H
HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.05×10-05
Mxd4
Mxd4em1(IMPC)J
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
1.20×10-05
Psd3
Psd3em1(IMPC)H
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
1.27×10-05
Gatm
Gatmtm1b(KOMP)Wtsi
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
HMGU
IMPC
1.58×10-05
Klf16
Klf16em1(IMPC)J
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
1.82×10-05
Gsk3a
Gsk3atm1b(EUCOMM)Hmgu
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
HMGU
IMPC
1.93×10-05
Setd2
Setd2tm1b(NCOM)Mfgc
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
1.96×10-05
Fbxo42
Fbxo42em1(IMPC)J
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
2.11×10-05
Asxl2
Asxl2tm1b(EUCOMM)Hmgu
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
2.48×10-05
Gtf2h3
Gtf2h3em1(IMPC)J
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
3.69×10-05
Ino80
Ino80tm1a(EUCOMM)Hmgu
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
ICS
IMPC
4.42×10-05
Smim20
Smim20em1(IMPC)J
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
4.67×10-05
Foxo3
Foxo3tm1.1(KOMP)Vlcg
HOM   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
4.75×10-05
Cct3
Cct3em1(IMPC)Tcp
HET   Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
TCP
IMPC
4.78×10-05
Hif1an
Hif1anem1(IMPC)Mbp
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
6.08×10-05
Il25
Il25em1(IMPC)Mbp
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
6.96×10-05
Dusp11
Dusp11tm1b(EUCOMM)Wtsi
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
ICS
IMPC
6.96×10-05
Nalf1
Nalf1em1(IMPC)H
HET Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
6.99×10-05
Pierce2
Pierce2em1(IMPC)H
HOM Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
MRC Harwell
IMPC
7.20×10-05
Homer2
Homer2em1(IMPC)J
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
8.58×10-05
Svep1
Svep1tm1b(EUCOMM)Hmgu
HET Late adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
JAX
IMPC
9.76×10-05
Plce1
Plce1em1(IMPC)Mbp
HOM Early adult prolonged QRS complex duration QRS
Electrocardiogram (ECG)
UC Davis
IMPC
9.82×10-05

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 The way we measure

 Phenotype associations stats

0.61% of tested genes with null mutations on a B6N genetic background have a phenotype association to prolonged QRS complex duration (38/6186)

0.28% females (17/6127) 0.33% males (20/6127)

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